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Results for "

protein thiols

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (2) Bacterial (5) Biochemical Assay Reagents (29) Drug Derivative (1) Drug Intermediate (1) Endogenous Metabolite (2) Epigenetic Reader Domain (1) Fluorescent Dye (29) Fungal (2) Huntingtin (1) Isotope-Labeled Compounds (3) Ligands for E3 Ligase (1) Liposome (3) MMP (1) Parasite (1) PDI (1) Phosphatase (1) PROTACs (1) Radionuclide-Drug Conjugates (RDCs) (1) Reference Standards (2)
By Research Areas:	Cancer (11) Infection (6) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (4)
Click Chemistry:	Azide (1) Alkynes (2)
Oligonucleotides:	Pegylated Lipids (1) Polymers (4)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1260

FM-red PSH-red	Fluorescent Dye	Neurological Disease
FM-red (PSH-red) is a red-emitting and environment-sensitive probe for selectively detecting and labeling protein thiols. FM-red can be used to image protein sulfhydryl groups in live cells and in vivo. FM-red also could be used to measure of the redox states of thioredoxin (Trx) .

HY-W012184

CDAP	Biochemical Assay Reagents	Inflammation/Immunology
CDAP is an organic cyanylating reagent that can be used for preparation of solid phase affinity reagents, modification of protein thiols and nucleotide delivery. CDAP also activates polysaccharides with a variety of chemical properties. CDAP can be used to prepare conjugate vaccines and other immune reagents .

HY-D1261

Naph-EA-mal 1 Publications Verification Thiol-green 1	Fluorescent Dye	Others
Naph-EA-mal (Thiol-green 1) is a rapid detect and ultrafast turn-on thiol fluorescence probe for protein labeling and bioimaging. Naph-EA-mal (Thiol-green 1) can be used to detect thiols in living cells, label the protein thiols, quantify the concentration of total thiols in cell lysate, and determine the reversible protein thiols oxidation in fixed cells . Ex: 488 nM; Em: 540 nM.

HY-119493

MSBN	Fluorescent Dye	Others
MSBN is a highly selective fluorogenic probe for thiols. MSBN can be used to image thiols in live cells selectively and specifically label protein thiols with a signal to determine various reversible protein thiol modifications .

HY-130509

MTSSL Otmpmms	Biochemical Assay Reagents	Others
MTSSL (Otmpmms) is highly reactive thiol-specific spin label, which is used to label protein thiol residues for protein structure and dynamics determination and protein-protein interaction studies .

HY-148263

Biotin-PEG-Thiol (MW 2000)	Fluorescent Dye	Cancer
Biotin-PEG-Thiol (MW 2000) is an active compound. Biotin-PEG-Thiol (MW 2000) is pegylated by binding to streptavidin or antibiotin with high affinity and specificity. Biotin-PEG-Thiol (MW 2000) can modify biomolecules, proteins, peptides and other small molecule materials. Biotin-PEG-Thiol (MW 2000) is widely used in the research of agent release and nano new materials .

HY-D1526

N-(4-Anilino-1-naphthyl)maleimide	Fluorescent Dye	Others
N-(4-Anilino-1-naphthyl)maleimide is a fluorescent probe that can be used to detect thiol groups in proteins. N-(4-Anilino-1-naphthyl)maleimide reacts with thiol groups and immediately produces a stable fluorescent compound with the λ_ex=355 nm, λ_em=448 nm .

HY-135133

S-Phenylsulfonylcysteine	Biochemical Assay Reagents	Others
S-Phenylsulfonylcysteine is a reagent for blocking thiol (-SH) groups on proteins and peptides .

HY-129846

IBTP iodide	Biochemical Assay Reagents	Others
IBTP iodide is a lipophilic cation and can be accumulated by mitochondria and yields stable thioether adducts in a thiol-specific reaction. IBTP iodide can be used for specific labeling of mitochondrial protein thiols .

HY-D1363

BDP R6G maleimide	Fluorescent Dye	Others
BDP R6G maleimide is a borodipyrromethane fluorophore with absorption and emission wavelengths similar to those of R6G rhodamine. Sulfhydryl labelling is a common protein modification where the cysteine residues in the protein allow more site-specific labelling than the NHS ester of the amine group. BDP R6G maleimide is a thiol reactive dye that reacts with thiol groups to form thioester bonds .

HY-D1781

NTPAN-MI	Fluorescent Dye	Others
NTPAN-MI is a fluorescent probe. NTPAN-MI is selectively activated upon labeling unfolded proteins with exposed thiols, thereby reporting on the extent of proteostasis .

HY-E70264

16:0 Coenzyme A triammonium	Endogenous Metabolite	Metabolic Disease
16:0 Coenzyme A triammonium is palmitoyl-CoA, which can serve as a reaction substrate to transfer the palmitoyl group to the free thiol group of the target protein through palmitoylation catalyzed by protein acyl transferases (PATs) .

HY-D1390A

Sulfo-Cy5-Mal	Fluorescent Dye	Others
Sulfo-Cy5-Mal is a fluorescent dye with the form of active ester that reacts with thiol groups in proteins to form stable conjugates. Sulfo-Cy5-Mal that can be used to label protein .

HY-118112

4-N-Maleimidobenzoicacid-NHS	Biochemical Assay Reagents	Others
4-N-Maleimidobenzoicacid-NHS is a PEG linker that finds utility in bioconjugation endeavors and protein labeling ventures. Specifically designed for selective reaction with thiol groups, the maleimide group establishes covalent linkages, thereby facilitating the coupling of proteins, peptides, or diverse molecules to thiol-bearing biomolecules. The NHS ester is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic conditions to form a covalent bond.

HY-W440905

DSPE-PEG-Vinylsulfone (MW 2000)	Biochemical Assay Reagents	Others
DSPE-PEG-Vinylsulfone, MW 2000 is a phospholipid PEG which can self-assemble to form lipid bilayer in water. The polymer can be used to encapsulate therapeutics, such as nucleic acid (mRNA/DNA) or protein, in drug delivery system. The vinyl sulfone is reactive with thiol molecule via thiol-ene reaction for bioconjugation. Reagent grade, for research use only.

HY-W440904

DSPE-PEG-Vinylsulfone (MW 1000)	Biochemical Assay Reagents	Others
DSPE-PEG-Vinylsulfone, MW 1000 is a self-assembling PEG reagent which forms lipid bilayer. The amphiphilic polymer can be used to prepare liposome for delivering therapeutics, such as nucleic acid (mRNA/DNA) or protein. The vinyl sulfone moiety is reactive with cysteine or other thiol molecule via thiol-ene chemistry. Reagent grade, for research use only.

HY-W998680

Fluorescein-maleimide 5-FITC-Maleimide	Fluorescent Dye	Others
Fluorescein-maleimide is a fluorescein dye linker containing a maleimide group. The maleimides in Fluorescein-maleimide react with thiol-containing compounds or biomolecules to form thioester bonds between pH 6.5 and 7.5. Fluorescein-maleimide is specifically designed for fluorescent labeling of proteins, nucleic acids, or other molecules containing one or more thiol groups .

HY-D1605

BODIPY FL L-Cystine	Fluorescent Dye	Others
BODIPY FL L-Cystine is a thiol-reactive, green-fluorescent dye. BODIPY FL L-Cystine can be the labeling of membrane proteins, proteins with hydrophobic binding sites, or hydrophobic ligands. (λ_ex=504 nm, λ_em=511 nm) .

HY-W020780C

mPEG-Mal (MW 3400) mPEG-Maleimide (MW 3400)	Biochemical Assay Reagents	Others
mPEG-Mal (MW 3400) is a PEG derivative used for thiol pegylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.

HY-W020780A

mPEG-Mal (MW 350) mPEG-Maleimide (MW 350)	Biochemical Assay Reagents	Others
mPEG-Mal (MW 350) is a PEG derivative used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.

HY-D2498

Cy7 maleimide	Fluorescent Dye	Others
Cy7 maleimide is a fluorescent dye containing a Maleimide (HY-W007324) functional group. Maleimide can be used to label thiol groups on antibodies, proteins and peptides .

HY-W020780B

mPEG-Mal (MW 750) mPEG-Maleimide (MW 750)	Biochemical Assay Reagents	Others
mPEG-Mal (MW 750) is a PEG derivative used for thiol pegylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.

HY-D1527

N-(3-Fluoranthenyl)maleimide	Fluorescent Dye	Others
N-(3-Fluoranthyl)maleimide is a thiol fluorescent probe with a lifetime of 20 nsec. N-(3-Fluoranthyl)maleimide has a maximum excitation wavelength of 370 nm and can be used to study the time-dependent processes of biopolymers .

HY-114350

BDP FL maleimide	Fluorescent Dye	Others
BDP FL maleimide is a thiol-reactive dye (Ex: 503 nm; Em: 509 nm). BDP FL maleimide can be used for protein labeling, peptide modification, and can replace fluorescein (FAM) for microscopy .

HY-W674381

5-(2-Chloroacetamide) thalidomide	Ligands for E3 Ligase	Cancer
5-(2-Chloroacetamide) thalidomide is a Thalidomide analogue. Thalidomide recruits E3 Ligase for the ubiquitinylation and subsequent destruction of a given protein. This structure features a chloroacetamide, which is a thiol-specific reactive group.

HY-D1403

L-Biotin-NH-5MP	Fluorescent Dye	Cancer
L-Biotin-NH-5MP is a biotin-conjugated 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation .

HY-157919

Biotin-PEAC5-maleimide hydrochloride N-6-(Biotinylamino)hexanoyl-N'-[2-(N-maleimido)ethyl]piperazine, hydrochloride	Biochemical Assay Reagents	Others
Biotin-PEAC5-maleimide hydrochloride is a biochemical assay reagent, and can be used in biotin-PEAC5-maleimide (BPM)-labeling assay to assess modification of protein thiols by electrophiles .

HY-D2488

Sulfo Cy5.5-maleimide	Fluorescent Dye	Others
Sulfo Cy5.5-maleimide is a fluorescent dye containing a Maleimide (HY-W007324) functional group. Maleimide can be used to label thiol groups on antibodies, proteins and peptides.

HY-D1406

L-Biotin-NH-5MP-Br	Fluorescent Dye	Others
L-Biotin-NH-5MP-Br is a biotin-conjugated 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation .

HY-D2381

AF 488 maleimide	Fluorescent Dye	Others
AF 488 maleimide is a thiol-reactive dye for labeling of protein SH groups, and it can be used to attach AF 488 fluorophore to proteins and peptides containing cysteine residues, as well as to other thiolated molecules. AF488 exhibits the λ_em and λ_ex wavelength of 520 nm and 470 nm, respectively .

HY-W011500

TCEP hydrochloride Maximum Cited Publications 8 Publications Verification Tris(2-carboxyethyl)phosphine hydrochloride	Drug Derivative	Others
TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry .

HY-W800682

Bis-sulfone-PEG4-acid	Biochemical Assay Reagents	Others
Bis-Sulfone-PEG4-acid is a reagent with a sulfone and an acid. The sulfone group can be conjugated with thiol groups of proteins. The terminal acid reacts with primary amines with the help of activators (EDC or HATU) to from stable amide bonds.

HY-173390

BCN-E-BCN	Drug Intermediate Biochemical Assay Reagents	Others
BCN-E-BCN is a strained cycloalkyne-based probe designed for detecting protein sulfenylation, the primary intermediate in protein oxidation. This structurally constrained cycloalkyne compound specifically recognizes sulfenic acid groups formed during thiol oxidation, while remaining completely unreactive toward other oxidative states (such as free thiols, sulfinic, or sulfonic acid groups). Researchers can leverage its efficient conjugation with azide-bearing tags through copper-free click chemistry to amplify detection signals. Compared to conventional detection methods, BCN-E-BCN demonstrates superior reaction kinetics and enhanced sensitivity. With these advantages, BCN-E-BCN shows great promise as an effective tool for protein oxidation research .

HY-D0807

5-IAF 1 Publications Verification 5-Iodoacetamidofluorescein	Fluorescent Dye	Cancer
5-IAF (5-Iodoacetamidofluorescein) is an idoacetamide derivate of fluoresceine. 5-IAF can be used as fluorescent probe that labels proteins and other molecules having free thiols (cysteine side chains) .

HY-136769

Biotin-HPDP	Biochemical Assay Reagents	Others
Biotin-HPDP is a biochemical reagent. Biotin-HPDP can couple with GMPS and label free protein thiols. Biotin-HPDP can be used as a biological material or organic compound for life science related research .

HY-D1590

BODIPY Green 8-P2M	Fluorescent Dye	Others
ODIPY Green 8-P2M is a novel thiol-reactive fluorescence probe based on the BODIPY fluorophore, the fluorescence is strongly quenched by d-PeT and then can be restored after reaction with thiol, resulting in an extremely high signal-to-noise ratio. ODIPY Green 8-P2M can be useful for detecting extremely low concentrations of protein in the gel after SDS-PAGE .

HY-B1217

Bronopol BNPD; BNPK	Bacterial	Infection
Bronopol is an antibacterial agent with low toxicity (to mammals) and high activity (especially against Gram-negative bacteria). Bronopol oxidizes protein thiols, inhibits enzymatic activity, and exhibits antibacterial activity. Bronopol is also a formaldehyde releaser .

HY-155901

Mal-NH-PEG-NH2 TFA (MW 2000) Maleimide-NH-PEG-amine TFA (MW 2000)	Biochemical Assay Reagents	Others
Mal-NH-PEG-NH2 (TFA) (MW 2000) is a PEG derivative that may be used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.

HY-W011500S

TCEP-d16 hydrochloride 1 Publications Verification	Isotope-Labeled Compounds	Others
TCEP-d₁₆ (hydrochloride) is the deuterium labeled TCEP hydrochloride . TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry .

HY-D2094

PerCP Maleimide	Fluorescent Dye	Inflammation/Immunology Cancer
PerCP Maleimide is a fluorescent dye that reacts with free sulfhydryl groups on proteins. PerCP is a red fluorescence albuminous dye for immunostaining and Maleimide can be leveraged for the preparation of fluorogenic probe, which is mainly used for the specific detection of thiol analytes .

HY-W394551

Methyl 3,4-dibromo-2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate	Biochemical Assay Reagents	Others
Methyl 3,4-dibromo-2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate is a small pyrrolidone molecule which features two bromine atoms and a methyl ester. The unsaturated dibromo motif is a covalent ligand for thiol groups, and may be used to label cysteine residues in proteins. The presence of two leaving groups on this molecule allows this linker to bind two thiols at a time. The methyl ester can be saponified to link this molecule to amines to form larger structures.

HY-123749

Tetramethylrhodamine-5-iodoacetamide 5-TMRIA	Fluorescent Dye	Others
Tetramethylrhodamine-5-iodoacetamide (5-TMRIA) is a thiol-selective reactive dye that is used to non-specifically label proteins via the cysteine residues. Tetramethylrhodamine-5-iodoacetamide (5-TMRIA) can be used to covalently label DNA fragments .

HY-B1217S

Bronopol-d4 BNPD-d₄; BNPK-d₄	Isotope-Labeled Compounds Bacterial	Infection
Bronopol-d₄ is deuterium labeled Bronopol. Bronopol is an antibacterial agent with low toxicity (to mammals) and high activity (especially against Gram-negative bacteria). Bronopol oxidizes protein thiols, inhibits enzymatic activity, and exhibits antibacterial activity. Bronopol is also a formaldehyde releaser ^.

HY-157920

Biotin-PE-maleimide N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine	Biochemical Assay Reagents	Others
Biotin-PE-maleimide (N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine) is a bulky, membrane-impermeable, sulfhydryl-containing reagent with a relatively large molecular size. Biotin-PE-maleimide can be used for biotin labeling (such as thiol groups) and detection of proteins or other biomolecules .

HY-W700621

TCEP-d12 hydrochloride Tris(2-carboxyethyl)phosphine hydrochloride-d₁₂	Isotope-Labeled Compounds Others	Others
TCEP-d₁₂ (hydrochloride) (Tris(2-?carboxyethyl)?phosphine hydrochloride-d₁₂) is deuterium labeled TCEP (hydrochloride). TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry .

HY-D1654

BDP 581/591 maleimide	Fluorescent Dye	Others
BDP 581/591 maleimide is a linker of the BDP 581/591 dye. It has a long fluorescence lifetime and can be used for fluorescence polarization assays. The maleimide group can react with thiol groups to form thioester bonds between pH 6.5 to 7.5, for the labeling of sulfhydryl groups of proteins and peptides.

HY-137541

2-Nitro-5-thiocyanatobenzoic acid NTCB	Biochemical Assay Reagents	Others
2-Nitro-5-thiocyanatobenzoic acid (NTCB) is a highly reactive reagent that transfers its cyano group rapidly to a nucleophilic thiolate. 2-Nitro-5-thiocyanatobenzoic acid has been proposed as a reagent for converting thiol groups in proteins into their S-cyano derivatives .

HY-D1404

5MP-Propargyl	Fluorescent Dye	Others
5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . 5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-157977

DOTA-GA-maleimide	Radionuclide-Drug Conjugates (RDCs) Biochemical Assay Reagents MMP	Cancer
DOTA-GA-maleimide is a bifunctional chelator containing a DOTA macrocycle chelator, a GA linker, and a maleimide reactive group. DOTA-GA-maleimide can achieve radiolabeling of proteins by forming a stable coordination complex between the DOTA macrocycle and radioactive metal ions (such as ¹¹¹In) through the specific binding of maleimide to protein thiol groups. DOTA-GA-maleimide can be used for SPECT imaging studies of MMP activity-related cancers .

HY-B1217R

Bronopol (Standard) BNPD (Standard); BNPK (Standard)	Reference Standards Bacterial	Infection
Bronopol (Standard) is the analytical standard of Bronopol. This product is intended for research and analytical applications. Bronopol is an antibacterial agent with low toxicity (to mammals) and high activity (especially against Gram-negative bacteria). Bronopol oxidizes protein thiols, inhibits enzymatic activity, and exhibits antibacterial activity. Bronopol is also a formaldehyde releaser .

Cat. No.	Product Name	Type

HY-D1260

FM-red PSH-red	Fluorescent Dyes/Probes
FM-red (PSH-red) is a red-emitting and environment-sensitive probe for selectively detecting and labeling protein thiols. FM-red can be used to image protein sulfhydryl groups in live cells and in vivo. FM-red also could be used to measure of the redox states of thioredoxin (Trx) .

HY-D1261

Naph-EA-mal

1 Publications Verification

Thiol-green 1

Fluorescent Dyes/Probes

Naph-EA-mal (Thiol-green 1) is a rapid detect and ultrafast turn-on thiol fluorescence probe for protein labeling and bioimaging. Naph-EA-mal (Thiol-green 1) can be used to detect thiols in living cells, label the protein thiols, quantify the concentration of total thiols in cell lysate, and determine the reversible protein thiols oxidation in fixed cells . Ex: 488 nM; Em: 540 nM.

HY-D1781

NTPAN-MI	Fluorescent Dyes/Probes
NTPAN-MI is a fluorescent probe. NTPAN-MI is selectively activated upon labeling unfolded proteins with exposed thiols, thereby reporting on the extent of proteostasis .

HY-D1390A

Sulfo-Cy5-Mal	Fluorescent Dyes/Probes
Sulfo-Cy5-Mal is a fluorescent dye with the form of active ester that reacts with thiol groups in proteins to form stable conjugates. Sulfo-Cy5-Mal that can be used to label protein .

HY-D1605

BODIPY FL L-Cystine	Fluorescent Dyes/Probes
BODIPY FL L-Cystine is a thiol-reactive, green-fluorescent dye. BODIPY FL L-Cystine can be the labeling of membrane proteins, proteins with hydrophobic binding sites, or hydrophobic ligands. (λ_ex=504 nm, λ_em=511 nm) .

HY-D1526

N-(4-Anilino-1-naphthyl)maleimide	Fluorescent Dyes/Probes
N-(4-Anilino-1-naphthyl)maleimide is a fluorescent probe that can be used to detect thiol groups in proteins. N-(4-Anilino-1-naphthyl)maleimide reacts with thiol groups and immediately produces a stable fluorescent compound with the λ_ex=355 nm, λ_em=448 nm .

HY-D1363

BDP R6G maleimide

Fluorescent Dyes/Probes

BDP R6G maleimide is a borodipyrromethane fluorophore with absorption and emission wavelengths similar to those of R6G rhodamine. Sulfhydryl labelling is a common protein modification where the cysteine residues in the protein allow more site-specific labelling than the NHS ester of the amine group. BDP R6G maleimide is a thiol reactive dye that reacts with thiol groups to form thioester bonds .

HY-W998680

Fluorescein-maleimide 5-FITC-Maleimide	Fluorescent Dyes/Probes
Fluorescein-maleimide is a fluorescein dye linker containing a maleimide group. The maleimides in Fluorescein-maleimide react with thiol-containing compounds or biomolecules to form thioester bonds between pH 6.5 and 7.5. Fluorescein-maleimide is specifically designed for fluorescent labeling of proteins, nucleic acids, or other molecules containing one or more thiol groups .

HY-D2498

Cy7 maleimide	Fluorescent Dyes/Probes
Cy7 maleimide is a fluorescent dye containing a Maleimide (HY-W007324) functional group. Maleimide can be used to label thiol groups on antibodies, proteins and peptides .

HY-D1527

N-(3-Fluoranthenyl)maleimide	Fluorescent Dyes/Probes
N-(3-Fluoranthyl)maleimide is a thiol fluorescent probe with a lifetime of 20 nsec. N-(3-Fluoranthyl)maleimide has a maximum excitation wavelength of 370 nm and can be used to study the time-dependent processes of biopolymers .

HY-114350

BDP FL maleimide	Fluorescent Dyes/Probes
BDP FL maleimide is a thiol-reactive dye (Ex: 503 nm; Em: 509 nm). BDP FL maleimide can be used for protein labeling, peptide modification, and can replace fluorescein (FAM) for microscopy .

HY-D1403

L-Biotin-NH-5MP	Protein Labeling
L-Biotin-NH-5MP is a biotin-conjugated 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation .

HY-D2488

Sulfo Cy5.5-maleimide	Fluorescent Dyes/Probes
Sulfo Cy5.5-maleimide is a fluorescent dye containing a Maleimide (HY-W007324) functional group. Maleimide can be used to label thiol groups on antibodies, proteins and peptides.

HY-D1406

L-Biotin-NH-5MP-Br	Protein Labeling
L-Biotin-NH-5MP-Br is a biotin-conjugated 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation .

HY-D2381

AF 488 maleimide	Fluorescent Dyes/Probes
AF 488 maleimide is a thiol-reactive dye for labeling of protein SH groups, and it can be used to attach AF 488 fluorophore to proteins and peptides containing cysteine residues, as well as to other thiolated molecules. AF488 exhibits the λ_em and λ_ex wavelength of 520 nm and 470 nm, respectively .

HY-D0807

5-IAF 1 Publications Verification 5-Iodoacetamidofluorescein	Fluorescent Dyes/Probes
5-IAF (5-Iodoacetamidofluorescein) is an idoacetamide derivate of fluoresceine. 5-IAF can be used as fluorescent probe that labels proteins and other molecules having free thiols (cysteine side chains) .

HY-D2094

PerCP Maleimide	Protein Labeling
PerCP Maleimide is a fluorescent dye that reacts with free sulfhydryl groups on proteins. PerCP is a red fluorescence albuminous dye for immunostaining and Maleimide can be leveraged for the preparation of fluorogenic probe, which is mainly used for the specific detection of thiol analytes .

HY-123749

Tetramethylrhodamine-5-iodoacetamide 5-TMRIA	Dyes
Tetramethylrhodamine-5-iodoacetamide (5-TMRIA) is a thiol-selective reactive dye that is used to non-specifically label proteins via the cysteine residues. Tetramethylrhodamine-5-iodoacetamide (5-TMRIA) can be used to covalently label DNA fragments .

HY-D1654

BDP 581/591 maleimide	Fluorescent Dyes/Probes
BDP 581/591 maleimide is a linker of the BDP 581/591 dye. It has a long fluorescence lifetime and can be used for fluorescence polarization assays. The maleimide group can react with thiol groups to form thioester bonds between pH 6.5 to 7.5, for the labeling of sulfhydryl groups of proteins and peptides.

HY-D1404

5MP-Propargyl

Protein Labeling

5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . 5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-D2763

BP Fluor 532 maleimide

Fluorescent Dyes/Probes

BP Fluor 532 maleimide is a photostable, bright yellow-fluorescent dye with pH insensitive emission from pH 4 to pH 10. The excitation of BP Fluor 532 is ideally suited for the frequency-doubled Nd:YAG laser line. BP Fluor 532 dye can be conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, and is often used for the generation of stable signals in imaging and flow cytometry. Maleimide is the most popular sulfhydryl-reactive group for conjugating the dye to a thiol group on a protein, oligonucleotide thiophosphate, or low molecular weight ligand. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5 to 7.5 to form a stable thioether bond. The resulting conjugates exhibit brighter fluorescence and greater photostability than the conjugates of many other spectrally similar fluorophores.

HY-D1407

Br-5MP-Propargyl

Protein Labeling

Br-5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . Br-5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-143218

TPE-MI

3 Publications Verification

Tetraphenylethene maleimide

Fluorescent Dyes/Probes

TPE-MI (Tetraphenylethene maleimide) is a thiol probe for measuring unfolded protein load and proteostasis in cells (the excitation wavelength is 350 nm and the emission wavelength is 470 nm). TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasitesPlasmodium falciparum .

HY-172721

Cy3B maleimide

Fluorescent Dyes/Probes

Cy3B maleimide is a mono-reactive dye containing maleimide group, which can selectively and efficiently attach Cyanine3 fluorophore (an analog of Cy3) to proteins and peptides containing cysteine residues, as well as to other thiolated molecules (such as thiol-containing oligonucleotides). Cy3B is an improved version of Cy3 dyes with significantly increased fluorescence quantum yield and photostability.

HY-15941

5(6)-FITC

2 Publications Verification

Fluorescein 5(6)-isothiocyanate; Fluorescein isothiocyanate 5- and 6- isomers

Fluorescent Dyes/Probes

5(6)-FITC (Fluorescein 5(6)-isothiocyanate) is an amine-reactive derivative of a fluorescent dye, characterized by high absorbance and excellent fluorescence quantum yield. The isothiocyanate group of FITC can react with various functional groups on proteins, including amines, thiols, imidazoles, tyrosines and carbonyls, enabling the labeling of proteins such as antibodies and lectins. 5(6)-FITC has a wide range of applications, including flow cytometry, immunofluorescence, protease assays and conjugation. The maximum excitation/emission wavelengths are 492/518 nm .

HY-D1871

Cy3 maleimide chloride

Fluorescent Dyes/Probes

Cy3 maleimide chloride is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing maleimide functional groups. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The alkyne functional group of Cy3 maleimide chloride can undergo a "thiol-acrylamide" reaction with molecules containing sulfur-oxygen functional groups to form covalent bonds. Cy3 maleimide chloride can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.

HY-D0098

Fluorescein-5-maleimide

3 Publications Verification

N-(5-Fluoresceinyl)maleimide

Fluorescent Dyes/Probes

Fluorescein-5-maleimide (N-(5-Fluoresceinyl)maleimide) is a fluorescent dye. Fluorescein-5-maleimide can be used to detect the redox state of thiols in eukaryotic cells. Fluorescein-5-maleimide can label peptides and is used to detect negatively charged nanoparticles. Fluorescein-5-maleimide can also label actin to explore its interaction with cardiac myosin-binding protein C (cMyBP-C), which helps in developing small molecule modulators for heart failure. Fluorescein-5-maleimide can screen mutant proteins that contain cysteine residues. The excitation wavelength of Fluorescein-5-maleimide is 494 nm, and the emission wavelength is 519 nm .

Cat. No.	Product Name	Type

HY-W012184

CDAP	Biochemical Assay Reagents
CDAP is an organic cyanylating reagent that can be used for preparation of solid phase affinity reagents, modification of protein thiols and nucleotide delivery. CDAP also activates polysaccharides with a variety of chemical properties. CDAP can be used to prepare conjugate vaccines and other immune reagents .

HY-W020780C

mPEG-Mal (MW 3400) mPEG-Maleimide (MW 3400)	Drug Delivery
mPEG-Mal (MW 3400) is a PEG derivative used for thiol pegylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.

HY-136769

Biotin-HPDP	Biochemical Assay Reagents
Biotin-HPDP is a biochemical reagent. Biotin-HPDP can couple with GMPS and label free protein thiols. Biotin-HPDP can be used as a biological material or organic compound for life science related research .

HY-W440905

DSPE-PEG-Vinylsulfone (MW 2000)	Drug Delivery
DSPE-PEG-Vinylsulfone, MW 2000 is a phospholipid PEG which can self-assemble to form lipid bilayer in water. The polymer can be used to encapsulate therapeutics, such as nucleic acid (mRNA/DNA) or protein, in drug delivery system. The vinyl sulfone is reactive with thiol molecule via thiol-ene reaction for bioconjugation. Reagent grade, for research use only.

HY-W440904

DSPE-PEG-Vinylsulfone (MW 1000)	Drug Delivery
DSPE-PEG-Vinylsulfone, MW 1000 is a self-assembling PEG reagent which forms lipid bilayer. The amphiphilic polymer can be used to prepare liposome for delivering therapeutics, such as nucleic acid (mRNA/DNA) or protein. The vinyl sulfone moiety is reactive with cysteine or other thiol molecule via thiol-ene chemistry. Reagent grade, for research use only.

HY-W020780A

mPEG-Mal (MW 350) mPEG-Maleimide (MW 350)	Drug Delivery
mPEG-Mal (MW 350) is a PEG derivative used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.

HY-W020780B

mPEG-Mal (MW 750) mPEG-Maleimide (MW 750)	Drug Delivery
mPEG-Mal (MW 750) is a PEG derivative used for thiol pegylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.

HY-157919

Biotin-PEAC5-maleimide hydrochloride N-6-(Biotinylamino)hexanoyl-N'-[2-(N-maleimido)ethyl]piperazine, hydrochloride	Biochemical Assay Reagents
Biotin-PEAC5-maleimide hydrochloride is a biochemical assay reagent, and can be used in biotin-PEAC5-maleimide (BPM)-labeling assay to assess modification of protein thiols by electrophiles .

HY-155901

Mal-NH-PEG-NH2 TFA (MW 2000) Maleimide-NH-PEG-amine TFA (MW 2000)	Drug Delivery
Mal-NH-PEG-NH2 (TFA) (MW 2000) is a PEG derivative that may be used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.

HY-157920

Biotin-PE-maleimide N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine	Biochemical Assay Reagents
Biotin-PE-maleimide (N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine) is a bulky, membrane-impermeable, sulfhydryl-containing reagent with a relatively large molecular size. Biotin-PE-maleimide can be used for biotin labeling (such as thiol groups) and detection of proteins or other biomolecules .

HY-W010572

1-Thioglycerol

alpha-Thioglycerol

Biochemical Assay Reagents

1-Thioglycerol, commonly used as a reducing agent in various biochemical and biophysical applications, especially in protein chemistry and molecular biology, it can protect proteins from oxidation and denaturation, and can reduce disulfide bonds to thiols base, which can then be modified or analyzed. In addition, 1-Thioglycerol has been investigated for potential medical applications, including as an inhibitor of cystic fibrosis, which may help improve the function of lung cells, and has also been studied for Used in the preparation of metal nanoparticles and as a stabilizer for certain pharmaceutical preparations.

HY-W440901

DSPE-PEG-SPDP (MW 5000)

Drug Delivery

DSPE-PEG-SPDP, MW 5000 is an amphiphilic polyPEG which forms lipid bilayer in water. It can be used to encapsualte therapeutic agents. The core can encapsulate hydrophilic nutrients, such as protein/peptide and mRNA/DNA/siRNA etc. while the lipid bilayer can solubilize hydrophobic drugs, such as doxorubicin, curcumin etc. The SPDP moiety can react with thiol molecule to form a disulfide bond. Reagent grade, for research use only.

HY-W010572R

1-Thioglycerol (Standard)

Biochemical Assay Reagents

1-Thioglycerol (Standard) is the analytical standard of 1-Thioglycerol. This product is intended for research and analytical applications. 1-Thioglycerol, commonly used as a reducing agent in various biochemical and biophysical applications, especially in protein chemistry and molecular biology, it can protect proteins from oxidation and denaturation, and can reduce disulfide bonds to thiols base, which can then be modified or analyzed. In addition, 1-Thioglycerol has been investigated for potential medical applications, including as an inhibitor of cystic fibrosis, which may help improve the function of lung cells, and has also been studied for Used in the preparation of metal nanoparticles and as a stabilizer for certain pharmaceutical preparations.

HY-140739

DSPE-PEG2000-Maleimide

2 Publications Verification

Drug Delivery

DSPE-PEG2000-Maleimide is a phospholipid-PEG conjugate. DSPE-PEG2000-Maleimide utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles. DSPE-PEG2000-Maleimide covalently couples to the sulfhydryl (-SH) of ligands (such as antibodies, peptides, or proteins) via thiol-maleimide click chemistry, giving the particles targeting capabilities. DSPE-PEG2000-Maleimide can be used in the researches of breast cancer, lymphoma, and inherited retinal degeneration .

Cat. No.	Product Name	Chemical Structure

HY-W011500S

TCEP-d16 hydrochloride

1 Publications Verification

TCEP-d₁₆ (hydrochloride) is the deuterium labeled TCEP hydrochloride . TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry .

HY-W700621

TCEP-d12 hydrochloride

TCEP-d₁₂ (hydrochloride) (Tris(2-?carboxyethyl)?phosphine hydrochloride-d₁₂) is deuterium labeled TCEP (hydrochloride). TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry .

HY-B1217S

Bronopol-d4
Bronopol-d₄ is deuterium labeled Bronopol. Bronopol is an antibacterial agent with low toxicity (to mammals) and high activity (especially against Gram-negative bacteria). Bronopol oxidizes protein thiols, inhibits enzymatic activity, and exhibits antibacterial activity. Bronopol is also a formaldehyde releaser ^.

Cat. No.	Product Name		Classification

HY-D1404

5MP-Propargyl		Alkynes
5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . 5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-D1407

Br-5MP-Propargyl		Alkynes
Br-5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . Br-5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W591360

Iodoacetamido-PEG6-azide		Azide
Iodoacetamido-PEG6-azide is an aqueous soluble PEG linker containing an azide and a terminal Iodoacetamido group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Iodoacetamido moiety is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds.

Cat. No.	Product Name		Classification

HY-W020780C

mPEG-Mal (MW 3400) mPEG-Maleimide (MW 3400)		Polymers
mPEG-Mal (MW 3400) is a PEG derivative used for thiol pegylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.

HY-140739

DSPE-PEG2000-Maleimide 2 Publications Verification		Pegylated Lipids
DSPE-PEG2000-Maleimide is a phospholipid-PEG conjugate. DSPE-PEG2000-Maleimide utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles. DSPE-PEG2000-Maleimide covalently couples to the sulfhydryl (-SH) of ligands (such as antibodies, peptides, or proteins) via thiol-maleimide click chemistry, giving the particles targeting capabilities. DSPE-PEG2000-Maleimide can be used in the researches of breast cancer, lymphoma, and inherited retinal degeneration .

HY-W020780A

mPEG-Mal (MW 350) mPEG-Maleimide (MW 350)		Polymers
mPEG-Mal (MW 350) is a PEG derivative used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.

HY-W020780B

mPEG-Mal (MW 750) mPEG-Maleimide (MW 750)		Polymers
mPEG-Mal (MW 750) is a PEG derivative used for thiol pegylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.

HY-155901

Mal-NH-PEG-NH2 TFA (MW 2000) Maleimide-NH-PEG-amine TFA (MW 2000)		Polymers
Mal-NH-PEG-NH2 (TFA) (MW 2000) is a PEG derivative that may be used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.

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