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pH sensitive

" in MedChemExpress (MCE) Product Catalog:

41

Inhibitors & Agonists

18

Fluorescent Dye

7

Biochemical Assay Reagents

5

Peptides

1

Click Chemistry

3

Oligonucleotides

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D1563
    CypHer 5

    		Fluorescent Dye Others
    CypHer 5 is a pH-sensitive cyanine derivative and a environmental sensitive fluorophore. CypHer 5 has a pH-sensitive maximal absorption at 644 nm and emission at 664 nm. CypHer 5 has been used as a pH sensor of lysosomal compartments .
    CypHer 5
  • HY-W133967
    Calcium alginate

    		Biochemical Assay Reagents Inflammation/Immunology
    Calcium alginate is a biopolymer that can be used for developing oral agent-delivery systems . Calcium alginate is a pH sensitive hydrogel stable in acidic media and soluble in basic media .
    Calcium alginate
  • HY-W110898
    Nile blue chloride

    		Fluorescent Dye Others
    Nile blue chloride is a highly fluorescent and photostable organic dye. Nile blue chloride and fluorescein isothiocyanate (FITC) can be used to construct a ratiometric pH sensitive probe for tracking the pH of the extracellular fluid between cancer cells in realtime. Nile Blue chloride has the potential for the research of nonlinear optics .
    Nile blue chloride
  • HY-118155
    9-Amino-6-chloro-2-methoxyacridine

    ACMA

    		 Fluorescent Dye Others
    9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H +/solute antiport system .
    9-Amino-6-chloro-2-methoxyacridine
  • HY-D1457
    DND-189

    		Fluorescent Dye Others
    DND-189, a low-pH fluorescent probe, is sensitive to neutral and low pH range. DND-189 can be used to measure the pH of acidic organelles .
    DND-189
  • HY-157036
    INSA

    		Fluorescent Dye Others
    INSA is a a pH-sensitive fluorescent probe. INSA can simultaneously light up mitochondria (red emission) and lysosomes (green emission) for their internal pH differences .
    INSA
  • HY-D0075
    DHPDS disodium salt

    		Fluorescent Dye Others
    DHPDS disodium salt is a pH-sensitive fluorescent dye. DHPDS disodium salt is used to measure intracellular pH (pHi) from the surface fluorescence of the isolated perfused rat liver .
    DHPDS disodium salt
  • HY-101882
    BCECF
    1 Publications Verification

    2′,7′-Bis(2-carboxyethyl)-5(6)-carboxyfluorescein

    		 Fluorescent Dye Others
    BCECF is a pH-sensitive fluorescent dye. BCECF allows measurements in the physiological pH range 6.0–8.0. Excitation ratio: 490/440 nm; Emission intensity: 535 nm.
    BCECF
  • HY-145616
    Sudocetaxel

    		Microtubule/Tubulin Cancer
    Sudocetaxel is a microtubule depolymerization inhibitor for pH-sensitive docetaxel delivery.
    Sudocetaxel
  • HY-W353607A
    Bromochlorophenol Blue sodium salt

    		Biochemical Assay Reagents Others
    Bromochlorophenol Blue sodium salt, an acid-sensitive dye, is a pH-indicating dye .
    Bromochlorophenol Blue sodium salt
  • HY-144025
    DOBAQ

    		Liposome Others
    DOBAQ, a cationic lipid, is a pH-sensitive lipid. DOBAQ can be used for liposomes applied in drug delivery .
    DOBAQ
  • HY-D1094
    Carboxy-SNARF 1 (5/6-mixture)

    SNARF 1

    		 Fluorescent Dye Others
    Carboxy-SNARF 1 (5/6-mixture) (SNARF 1) is a fluorescent probe that is sensitive to pH. Carboxy-SNARF 1 (5/6-mixture) can be used for measurement pH .
    Carboxy-SNARF 1 (5/6-mixture)
  • HY-147104
    Fmoc-Lys(5-FITC)-OH

    		Fluorescent Dye Others
    Fmoc-Lys(5-FITC)-OH is a marker for polypeptides or proteins. FITC is a fluorescence probe for the labeling of amines. FITC is a pH- and Cu 2+-sensitive fluorescence dye .
    Fmoc-Lys(5-FITC)-OH
  • HY-D1093
    Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture)

    		Fluorescent Dye Others
    Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture) is a fluorescent probe that is sensitive to pH. Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture) can be used for measurement of intracellular pH .
    Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture)
  • HY-Y0699
    Methyl red

    		Fluorescent Dye Others
    Methyl red is a pH-sensitive acid-base indicator and colorimetric reagent with a pKa of 5.1. Methyl red achieves visual judgment of the titration endpoint through reversible structural changes of protonation (red, pH <4.4) and deprotonation (yellow, pH >6.2). Methyl red is widely used in acid-base titration in chemical analysis and buffer pH monitoring in biochemistry .
    Methyl red
  • HY-172385
    16:0 DGS

    1,2-Dipalmitoyl-sn-glycero-3-succinate

    		 Biochemical Assay Reagents Others
    16:0 DGS (1,2-Dipalmitoyl-sn-glycero-3-succinate) can be used for the preparation of pH-sensitive liposomes .
    16:0 DGS
  • HY-D1556
    18:1 PE CF

    1,2-dioleoyl-sn-glycero-3-pHospHoethanolamine-N-(carboxyfluorescein) ammonium

    		 Fluorescent Dye Others
    DOPE-CF is a pH-sensitive fluorescent membrane labelled probe with a fluorescein moiety that is a weak acid and a conjugated base that is highly fluorescent and can be attached to phospholipid ethanolamine lipids .
    18:1 PE CF
  • HY-129563
    CGP 57813

    		HIV HIV Protease Infection
    CGP 57813 is a peptidomimetic inhibitor of HIV protease that can be encapsulated by nanoparticles composed of poly(D,L-lactic acid) (PLA) and pH-sensitive methacrylic acid copolymers and delivered into the body .
    CGP 57813
  • HY-W250149
    Chlorophosphonazo III

    		Biochemical Assay Reagents Others
    Chlorophosphonazo III is a sensitive reagent for both calcium and magnesium. It is possible to determine calcium alone at pH 2.2 and calcium and magnesium at pH 7.0. Chlorophosphonazo III can also be used for the spectrophotometric determination of titanium, zirconium, thorium, and scandium, quinquevalent actinide elements, and protactinium .
    Chlorophosphonazo III
  • HY-D0023
    Pyranine
    1 Publications Verification

    HPTS; Solvent Green 7

    		 Fluorescent Dye Others
    Pyranine (HPTS; Solvent Green 7) is a pH-sensitive fluorescent indicator. Pyranine acts as a class of fluorescent chemosensor for the Cu + ion(λex=450 nm, λem=510 nm) .
    Pyranine
  • HY-W040291
    7-Hydroxy-4-methylcoumarin-3-acetic acid, SE

    		Fluorescent Dye Cancer
    7-Hydroxy-4-methylcoumarin-3-acetic acid, SE is a blue fluorophore that has pH-dependent and environment-sensitive fluorescence. It is widely used for preparing bioconjugates of blue fluorescence.
    7-Hydroxy-4-methylcoumarin-3-acetic acid, SE
  • HY-155717
    NDBM

    		Autophagy Pim Cancer
    NDBM is a probe and binds to tumor-specific Pim-1 kinase, releases strong fluorescence, and produces cytotoxicity, thus achieving cell screening and killing effects. NDBM can specifically target lysosomes and sensitively respond to pH. NDBM can be used to track the pH changes in the intracellular environment under conditions of autophagy and external stimulation .
    NDBM
  • HY-D1593
    BODIPY TMR-X alkyne

    		Fluorescent Dye Others
    BODIPY TMR-X alkyne, an orange-fluorescent dye, is an alkyne modified BODIPY TMR-X. BODIPY TMR-X alkyne can react with azides by the copper-catalyzed click reaction. BODIPY TMR-X alkyne is not sensitive to pH.
    BODIPY TMR-X alkyne
  • HY-139305
    CL4H6

    		Liposome Cancer
    CL4H6 is a pH-sensitive cationic lipid. CL4H6 is the main component of lipid nanoparticles (LNPs), which can be used to target and deliver siRNA, and induces a potent gene-silencing response .
    CL4H6
  • HY-W040144
    Bromocresol green

    		Fluorescent Dye Others
    Bromocresol green is a pH-sensitive triphenylmethane dye commonly used for the determination of protein and albumin in serum. Bromocresol green is a bio-based dye with a yellow-green to blue-green color. Bromocresol green turns yellow (λmax=435 nm, protonated form) when placed in acidic solution (e.g. pH=4.15), and turns blue in basic solution (λmax=615 nm, deprotonated form). Bromocresol green is widely used as a pH indicator in the field of biochemical analysis. In addition, Bromocresol green is also used to detect the concentration of molecules such as creatinine, and to judge the viability of cells .
    Bromocresol green
  • HY-W923198
    Fluorescein O-methacrylate

    Methacryloyloxy fluorescein

    		 Fluorescent Dye Others
    Fluorescein O-methacrylate (Methacryloyloxy fluorescein) is a pH-sensitive dye featuring a fluorescent monomer, characterized by an excitation spectrum at 490 nm and an emission spectrum at 520 nm. With fluorescein serving as an indicator that possesses minimal negative charges, it exhibits properties such as biocompatibility, non-toxicity, and excellent dispersion in aqueous solutions.
    Fluorescein O-methacrylate
  • HY-P10742
    CBX-12

    		Peptide-Drug Conjugates (PDCs) Topoisomerase Cancer
    CBX-12 is a PDC (peptide drug conjugate) that targets tumors in an antigen-independent manner and exhibits antitumor activity. CBX-12 consists of a pH-sensitive peptide (pHLIP), a self-immolating linker, and a topoisomerase 1 (TOP1) inhibitor Exatecan (HY-13631) .
    CBX-12
  • HY-P99681
    Labetuzumab govitecan

    IMMU 130; hMN-14-SN-38

    		 Antibody-Drug Conjugates (ADCs) Cancer
    Labetuzumab govitecan (IMMU 130) is an Anti-CEACAM5/SN-38 antibody-drug conjugate (ADC). Labetuzumab govitecan consists of the antibody Labetuzumab, SN-38, and a pH-sensitive Linker. Labetuzumab govitecan can be used for research of cancers, such as colorectal cancer .
    Labetuzumab govitecan
  • HY-20794
    8-Hydroxyjulolidine

    		Fluorescent Dye Others
    8-Hydroxyjulolidine is a chromophore moiety of a fluorescent probe for the detection of weak acid ions. 8-Hydroxyjulolidine can be used to synthesize the salicylaldehyde derivative 9-formyl-8-hydroxyjulolidine, which exhibits sensitive detection ability to pH changes of hydrogen sulfide and silicate in aqueous solution .
    8-Hydroxyjulolidine
  • HY-168913
    CTT2274

    		PSMA Cancer
    CTT2274 is a prodrug of MMAE (HY-15162). CTT2274 is composed of a prostate-specific membrane antigen (PSMA)-binding scaffold, a biphenyl motif, a pH-sensitive phosphoramidate linker, and MMAE payload. CTT2274 shows selective binding to PSMA and delivers MMAE. CTT2274 inhibits prostate cancer .
    CTT2274
  • HY-15940
    5(6)-Carboxyfluorescein
    3 Publications Verification

    5(6)-FAM; 5-(and-6)-Carboxyfluorescein mixed isomers

    		 Fluorescent Dye Cancer
    5(6)-Carboxyfluorescein (5(6)-FAM) is an amine-reactive pH-sensitive green fluorescent probe. 5(6)-Carboxyfluorescein (5(6)-FAM) can be used to label proteins, peptides and nucleotides. 5(6)-Carboxyfluorescein can be used for the detection of tumour areas in vivo .
    5(6)-Carboxyfluorescein
  • HY-124473
    Naphthofluorescein

    NapHthafluorescein

    		 HIF/HIF Prolyl-Hydroxylase Cancer
    Naphthofluorescein inhibits the interaction between HIF-1 and Mint3. Naphthofluorescein suppresses Mint3-dependent HIF-1 activity and glycolysis in cancer cells and macrophages without cytotoxicity in vitro and adverse effect in vivo . Naphthofluorescein is also a fluorescent pH-sensitive probe that can be used for functional Cerenkov imaging .
    Naphthofluorescein
  • HY-147087
    YSK 05

    		Liposome Cancer
    YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .
    YSK 05
  • HY-D2768
    BP Fluor 430 NHS ester

    		Fluorescent Dye Others
    BP Fluor 430 NHS Ester is a water-soluble, green-fluorescent dye that is often used in multi-color applications, including flow cytometry and super-resolution microscopy using STORM. Its excitation is ideally suited for the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode. BP Fluor 405 conjugates are pH-insensitive from pH 4 to pH 10. The NHS ester (or succinimidyl ester) is the most popular amine reactive group for labeling the primary amines of proteins (Lys), amine-modified oligonucleotides, and other amine-containing molecules. Proteins can be labeled with BP Fluor 430 NHS Ester at high molar ratios without significant self-quenching, leading to brighter conjugates and more sensitive detection.
    BP Fluor 430 NHS ester
  • HY-D2745
    BP Fluor 594 NHS ester

    		Fluorescent Dye Others
    BP Fluor 594 NHS ester is the most popular tool for modifying proteins or antibodies through the primary amines (Lys), amine-modified oligonucleotides, and other amine-containing biomolecules with BP Fluor 594 label. The labeling occurs most efficiently at pH 7-9 and forms a stable, covalent amide bond. BP Fluor 594 dye can be used for proteins labeling at high molar ratios without significant self-quenching, enabling brighter conjugates and more sensitive detection. BP Fluor 594 is bright, water-soluble, and pH-insensitive from pH 4 to pH 10 red-fluorescent dye with absorption and emission maxima at 590 and 617 nm, respectively. It can be used with the 561 nm and 594 nm laser lines. BP Fluor 594 dye conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates often used for generation of stable signal in imaging and flow cytometry.
    BP Fluor 594 NHS ester
  • HY-D2771
    BP Fluor 405 NHS ester

    		Fluorescent Dye Others
    BP Fluor 405 NHS Ester is a water-soluble, blue-fluorescent dye that is often used in multi-color applications, including flow cytometry and super-resolution microscopy using STORM. Its excitation is ideally suited for the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode. BP Fluor 405 conjugates are pH-insensitive from pH 4 to pH 10. The NHS ester (or succinimidyl ester) is the most popular amine reactive group for labeling with the primary amines of proteins (Lys), amine-modified oligonucleotides, and other amine-containing molecules. Proteins can be labeled with BP Fluor 405 NHS Ester at high molar ratios without significant self-quenching, leading to brighter conjugates and more sensitive detection. BP Fluor 405 conjugates can also be used for the detection of abundance targets.
    BP Fluor 405 NHS ester
  • HY-113621B
    Ageladine A dihydrochloride

    		Fluorescent Dye MMP Cancer
    Ageladine A dihydrochloride is an inhibitor of matrix metalloproteinase (MMP) isolated from the marine sponge Agelas nakamurai, possessing anti-angiogenic activity. Ageladine A dihydrochloride not only inhibits MMP-2 but also MMP-1, MMP-8, MMP-9, MMP-12, and MMP-13, with IC50 values of 4.65 μM, 2.79 μM, 907.12 nM, 1.83 μM, 767.57 nM, and 1.09 μM, respectively. Additionally, Ageladine A dihydrochloride is a pH-sensitive membrane-permeable dye that emits fluorescence in the blue-green range upon UV excitation, featuring a maximum absorption peak at 370 nm. Furthermore, Ageladine A dihydrochloride serves as a reliable and stable fluorescent pH sensor for detecting changes in intracellular pH values .
    Ageladine A dihydrochloride
  • HY-P4108
    TAT-HA2 Fusion Peptide

    		Influenza Virus Infection
    TAT-HA2 Fusion Peptide is a peptide-based delivery agent that combines the pH-sensitive HA2 fusion peptide from Influenza and the cell-penetrating peptide TAT from HIV. TAT-HA2 Fusion Peptide is a transactivator of transcription and hemaglutanin for endosomal release. TAT-HA2 Fusion Peptide enhances cellular uptake of macromolecules .
    TAT-HA2 Fusion Peptide
  • HY-E70565
    O-Glycoprotease

    		Endonuclease Inflammation/Immunology
    O-Glycoprotease is an O-glycoprotein-specific endoprotease that catalyzes the hydrolysis of peptide bonds directly adjacent to the O-polymer in native mucin-type O-glycosylated proteins. O-Glycoprotease sequence is from Akkermansia muciniphila, recombinantly expressed in E.coli, with a 6×His tag at the C-terminus.
    The enzyme maintains high activity between pH 5.5-7.5 and is resistant to 1M NaCl, but is highly sensitive to EDTA (0.5 mM EDTA) and can be inhibited by Zn 2+.
    O-Glycoprotease
  • HY-156514
    MC-GGFG-AM-(10NH2-11F-Camptothecin)

    		Drug-Linker Conjugates for ADC Cancer
    MC-GGFG-AM-(10NH2-11F-Camptothecin) is an antibody drug conjugates (ADC). MC-GGFG-AM-(10NH2-11F-Camptothecin) binds to the anti-TROp-2 antibody sacituzumab via a hydrolysable pH-sensitive linker and has anti-tumor activity. MC-GGFG-AM-(10NH2-11F-Camptothecin) can be used for cancer research .
    MC-GGFG-AM-(10NH2-11F-Camptothecin)
  • HY-150175
    HKSOX-1

    		Fluorescent Dye Inflammation/Immunology
    HKSOX-1 and its derivatives (HKSOX-1r and HKSOX-1m) are novel fluorescent probes designed for highly sensitive and selective detection of the superoxide anion radical (O2 •−) in cellular environments. These probes utilize an aryl trifluoromethanesulfonate group that undergoes O2 •−-mediated cleavage, releasing a free phenol and emitting fluorescence. They demonstrate excellent specificity and sensitivity across various pH ranges, withstand interference from strong oxidants and reductants typical in cellular contexts. HKSOX-1r, optimized for cellular retention, has been effectively employed in diverse assays including confocal imaging, flow cytometry, and zebrafish embryo studies, highlighting its utility in investigating O2 •− roles in inflammation, mitochondrial stress, and other physiological processes .
    HKSOX-1

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