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Results for "

p35

" in MedChemExpress (MCE) Product Catalog:

29

Inhibitors & Agonists

1

Peptides

1

Inhibitory Antibodies

27

Recombinant Proteins

8

Antibodies

9

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-18299
    Purvalanol B
    1 Publications Verification

    NG 95

    CDK Parasite Infection Cancer
    Purvalanol B (NG 95) is a potent, selective, reversible and ATP-competitive inhibitor CDK, with IC50s of 6 nM, 6 nM, 9 nM, 6 nM for cdc2-cyclin B, CDK2-cyclin A, CDK2-cyclin E and CDK5-p35, respectively. Purvalanol B shows selectivity for CDK over a range of other protein kinases (IC50>1000 nM). Purvalanol B inhibits the growth a chloroquine-resistant strain of P. falciparum .
    Purvalanol B
  • HY-108359
    Alsterpaullone
    1 Publications Verification

    9-Nitropaullone; NSC 705701

    CDK GSK-3 Apoptosis Cancer
    Alsterpaullone (9-Nitropaullone) is a potent CDK inhibitor, with IC50s of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also competes with ATP for binding to GSK-3alpha/GSK-3beta with IC50s of both 4 nM. Alsterpaullone has antitumor activity, and possesses potential for the study in neurodegenerative and proliferative disorders . Alsterpaullone induces apoptosis in leukemia cell line .
    Alsterpaullone
  • HY-18299A
    Purvalanol A
    2 Publications Verification

    NG-60

    CDK Autophagy Apoptosis Cancer
    Purvalanol A is a potent CDK inhibitor, which inhibits cdc2-cyclin B, cdk2-cyclin A, cdk2-cyclin E, cdk4-cyclin D1, and cdk5-p35 with IC50s of 4, 70, 35, 850, 75 nM, resepctively.
    Purvalanol A
  • HY-136726

    CINK4

    CDK Cancer
    GP-82996 (CINK4) is a pharmacological inhibitor of CDK4/6. GP-82996 has IC50s of 1.5, 5.6 and 25 μM for CDK4/cyclin D1, CDK6/cyclin D1 and Cdk5/p35, respectively. GP-82996 induces the apoptosis of cancer cells U2OS. GP-82996 can be used in the research of cancer .
    CGP-82996
  • HY-119715

    CDK Apoptosis Cancer
    AG-012986 is a multitargeted CDK inhibitor. AG-012986 is active against CDK1/2/4/6/5/9, with Kis of 9.2 nM (CDK4/cyclin), 94 nM (CDK2/cyclin A), and 44 nM (CDK1/cyclin B), IC50s of 4 nM (CDK9/cyclin T) and 22 nM (CDK5/p35). AG-012986 has antiproliferative activities against cancer cells. AG-012986 induces cell cycle arrest, and apoptosis .
    AG-012986
  • HY-P990226

    Interleukin Related Infection Inflammation/Immunology
    Anti-Mouse IL-12 p35 Antibody (C18.2) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-12 p35. Anti-Mouse IL-12 p35 Antibody (C18.2) can neutralize IL-12. Anti-Mouse IL-12 p35 Antibody (C18.2) can be used for the researches of infection, inflammation and immunology, such as airway inflammation and F. tularensis infection .
    Anti-Mouse IL-12 p35 Antibody (C18.2)
  • HY-18299AR

    CDK Autophagy Apoptosis Cancer
    Purvalanol A (Standard) is the analytical standard of Purvalanol A. This product is intended for research and analytical applications. Purvalanol A is a potent CDK inhibitor, which inhibits cdc2-cyclin B, cdk2-cyclin A, cdk2-cyclin E, cdk4-cyclin D1, and cdk5-p35 with IC50s of 4, 70, 35, 850, 75 nM, resepctively.
    Purvalanol A (Standard)
  • HY-173347

    CDK Neurological Disease
    BLINK11 is a BBB-penetrant CDK5 inhibitor. BLINK11 lowers CDK5 activity for both complexes CDK5/p35 (IC50 = 17.09 nM) and CDK5/p25 (IC50 = 14.69 nM). BLINK11 offers anti-diabetic and neuroprotective benefits. BLINK11 lowers blood glucose, enhances cognition, and reduces neurodegeneration in T2D mice .
    BLINK11
  • HY-173348

    CDK Neurological Disease
    BLINK15 is a BBB-penetrant CDK5 inhibitor. BLINK15 lowers CDK5 activity for both complexes CDK5/p35 (IC50 = 29.34 nM) and CDK5/p25 (IC50 = 12.08 nM). BLINK15 offers anti-diabetic and neuroprotective benefits. BLINK15 lowers blood glucose, enhances cognition, and reduces neurodegeneration in T2D mice .
    BLINK15
  • HY-111932

    CDK GSK-3 Cancer
    Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively . Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β .
    Indirubin-5-sulfonate
  • HY-15504A
    RGB-286638 free base
    3 Publications Verification

    CDK GSK-3 MEK JAK Cancer
    RGB-286638 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.
    RGB-286638 free base
  • HY-15504
    RGB-286638
    3 Publications Verification

    CDK GSK-3 MEK JAK Cancer
    RGB-286638 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.
    RGB-286638
  • HY-176287

    Dopamine Receptor GSK-3 PKA P-glycoprotein Neurological Disease
    ARN25657 is a dual-acting D3R/GSK-3β modulator. ARN25657 has both partial D3R agonist activity (EC50 = 15.2 nM, Ki =1.5 nM) and potent GSK-3β inhibitor activity (IC50 = 19.3 nM). ARN25657 exhibits excellent GSK-3β selectivity over FYN, PKA, and CDK5/p35. ARN25657 inhibits P-glycoprotein (P-gP)-mediated acetoxymethyl calcein efflux and improves in vitro ADME properties while maintaining a balanced dual-target profile. ARN25657 is useful for studying bipolar disorder and related neuropsychiatric disorders .
    ARN25657
  • HY-W011428

    CDK Others Cancer
    Olomoucine is an ATP competitive inhibitor of CDKs. Olomoucine is a purine (HY-34431) derivative and inhibits CDC2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E (both IC50=7 μM), CDK/p35 kinase (IC50=3 μM) and ERK1/p44 MAP kinase (IC50=25 μM) . Olomoucine regulates cell cycle and shows anti-melanin tumor activity .
    Olomoucine
  • HY-W011428R

    CDK Others Cancer
    Olomoucine is an ATP competitive inhibitor of CDKs. Olomoucine is a purine (HY-34431) derivative and inhibits CDC2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E (both IC50=7 μM), CDK/p35 kinase (IC50=3 μM) and ERK1/p44 MAP kinase (IC50=25 μM) . Olomoucine regulates cell cycle and shows anti-melanin tumor activity .
    Olomoucine (Standard)
  • HY-112363

    RP107

    CDK GSK-3 ERK JNK CFTR Inflammation/Immunology Cancer
    Aloisine A (RP107) is a a potent cyclin-dependent kinase (CDK) inhibitor with IC50s of 0.15 μM, 0.12 μM, 0.4 μM, 0.16 μM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK5/p35, respectively. Aloisine A ininhibits GSK-3α (IC50=0.5 μM) and GSK-3β (IC50=1.5 μM). Aloisine A stimulates wild-type CFTR and mutated CFTR, with submicromolar affinity by a cAMP-independent mechanism. Aloisine A has the potential for CFTR-related diseases, including cystic fibrosis research .
    Aloisine A
  • HY-E70666

    CDK Neurological Disease
    CDK17 is highly expressed in terminally differentiated neurons, particularly those found in hippocampal regions and olfactory bulbs. CDK17/p35NCK Recombinant Human Active Protein Kinase is an ortholog of CDK17 .
    CDK17/p35NCK Recombinant Human Active Protein Kinase
  • HY-E70685

    CDK Neurological Disease Cancer
    CDK5 can be mapped to chromosome 7q36 and its expression is upregulated by the transcription factors Fos and CREB through the MEK/ERK pathway and by δFosB. CDK5 plays a vital role in the central nervous system but has functions in other cell types. CDK5 has recently been implicated in diseases, including the development and progression of cancer and neurodegenerative diseases. CDK5/p35NCK Recombinant Human Active Protein Kinase is an ortholog of CDK5 .
    CDK5/p35NCK Recombinant Human Active Protein Kinase
  • HY-RS27045

    Small Interfering RNA (siRNA) Others

    Cdk5r1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cdk5r1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cdk5r1 Rat Pre-designed siRNA Set A
    Cdk5r1 Rat Pre-designed siRNA Set A
  • HY-RS23081

    Small Interfering RNA (siRNA) Others

    Anxa1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Anxa1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Anxa1 Rat Pre-designed siRNA Set A
    Anxa1 Rat Pre-designed siRNA Set A
  • HY-RS05328

    Small Interfering RNA (siRNA) Others

    GCHFR Human Pre-designed siRNA Set A contains three designed siRNAs for GCHFR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    GCHFR Human Pre-designed siRNA Set A
    GCHFR Human Pre-designed siRNA Set A
  • HY-RS15489

    Small Interfering RNA (siRNA) Others

    UPK3B Human Pre-designed siRNA Set A contains three designed siRNAs for UPK3B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    UPK3B Human Pre-designed siRNA Set A
    UPK3B Human Pre-designed siRNA Set A
  • HY-RS06678

    Small Interfering RNA (siRNA) Others

    Il12a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il12a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Il12a Mouse Pre-designed siRNA Set A
    Il12a Mouse Pre-designed siRNA Set A
  • HY-RS04840

    Small Interfering RNA (siRNA) Others

    FCN2 Human Pre-designed siRNA Set A contains three designed siRNAs for FCN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    FCN2 Human Pre-designed siRNA Set A
    FCN2 Human Pre-designed siRNA Set A
  • HY-RS20536

    Small Interfering RNA (siRNA) Others

    Cdk5r1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cdk5r1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cdk5r1 Mouse Pre-designed siRNA Set A
    Cdk5r1 Mouse Pre-designed siRNA Set A
  • HY-170522

    HIF/HIF Prolyl-Hydroxylase Inflammation/Immunology
    ISM012-042 is an orally active PHD1 and PHD2 inhibitor with IC50 values of 1.9 and 2.5 nM, respectively. ISM012-042 (2.5 μM) can protect Caco-2 cells from DSS-induced barrier disruption. In lipopolysaccharide (LPS)-induced mouse bone marrow-derived dendritic cells (BMDC), ISM012-042 has anti-inflammatory effects and can dose-dependently reduce the expression of IL-12 subunit IL-12p35 and TNF. ISM012-042 restores intestinal barrier function and alleviates intestinal inflammation in various experimental colitis models. ISM012-042 can be used for intestinal mucosal repair and research into immune diseases .
    ISM012-042
  • HY-RS06677

    Small Interfering RNA (siRNA) Others

    IL12A Human Pre-designed siRNA Set A contains three designed siRNAs for IL12A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    IL12A Human Pre-designed siRNA Set A
    IL12A Human Pre-designed siRNA Set A
  • HY-RS02387

    Small Interfering RNA (siRNA) Others

    CDK5R1 Human Pre-designed siRNA Set A contains three designed siRNAs for CDK5R1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CDK5R1 Human Pre-designed siRNA Set A
    CDK5R1 Human Pre-designed siRNA Set A
  • HY-P11109

    Bacterial Antibiotic Infection
    RL-37 is an alpha-helical antimicrobial peptide. RL-37 can be isolated for rhesus monkey bone marrow. RL-37 rapidly permeabilizes the membranes of Escherichia coli ML-35p and lysed liposomes. RL-37 has effective antibacterial activity against staphylococci, such as wild-type and Methicillin (HY-121544)-resistant S. aureus strains and S. epidermidis ATCC 49741. RL-37 can be used for human skin infections research .
    RL-37

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