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mismatch

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Autophagy (3) DNA Alkylator/Crosslinker (3) DNA/RNA Synthesis (4) Endogenous Metabolite (3) Molecular Glues (1) Nucleoside Antimetabolite/Analog (3) Reference Standards (1)
By Research Areas:	Cancer (8) Inflammation/Immunology (1)
Oligonucleotides:	A (1) Nucleoside Phosphoramidites (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116887

N6-Methyladenine	Endogenous Metabolite Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Cancer
N6-Methyladenine is a modified purine that is widely present in prokaryotes. In prokaryotes, N6-Methyladenine plays an important role in distinguishing host DNA from exogenous DNA and controls many biological functions, such as DNA replication, transcription, mismatch repair, and chromosome replication .

HY-156581

WRN inhibitor 5	DNA/RNA Synthesis	Cancer
WRN inhibitor 5, a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor. WRN inhibitor 5 can be used for the research of cancer, including cancers characterized by microsatellite instability (MSI) and/or defective DNA mismatch repair system (dMMR) .

HY-17364

Temozolomide 130+ Cited Publications NSC 362856; CCRG 81045; TMZ	DNA Alkylator/Crosslinker Autophagy Apoptosis	Cancer
Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .

HY-17364S

Temozolomide-d3	DNA Alkylator/Crosslinker Autophagy Apoptosis	Cancer
Temozolomide-d₃ is the deuterium labeled Temozolomide. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .

HY-164496

KL-50	DNA/RNA Synthesis	Cancer
KL-50 is a selective toxin toward tumors that lack the DNA repair protein O ⁶-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O ⁶-alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair (MMR). KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT .

HY-153805

Z-NCTS	Molecular Glues	Cancer
Z-NCTS is an RNA mismatch binding molecule that recognizes the 5’-r(XGG)-3’/5’-r(XGG)-3’ sequence (X=U or A) and acts as a molecular glue for RNA .

HY-116887R

N6-Methyladenine (Standard)	Endogenous Metabolite Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Cancer
N6-Methyladenine (Standard) is the analytical standard of N6-Methyladenine. This product is intended for research and analytical applications. N6-Methyladenine is a modified purine that is widely present in prokaryotes. In prokaryotes, N6-Methyladenine plays an important role in distinguishing host DNA from exogenous DNA and controls many biological functions, such as DNA replication, transcription, mismatch repair, and chromosome replication .

HY-160641

isoG Nucleoside-1	Others	Others
isoG Nucleoside-1 (compound 15) is an isoguanine (isoG) nucleoside. In the HNA(h)-DNA(d) mosaic scaffold, h-isoG base mismatches follow the order G>C>T, while h-isoG base mismatches follow the order G>C>T .

HY-17364R

Temozolomide (Standard) NSC 362856 (Standard); CCRG 81045 (Standard); TMZ (Standard)	Reference Standards DNA Alkylator/Crosslinker Autophagy Apoptosis	Cancer
Temozolomide (Standard) is the analytical standard of Temozolomide. This product is intended for research and analytical applications. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .

HY-115464

NC1153	Endogenous Metabolite	Inflammation/Immunology
NC1153 is a Mannich base with the activity to block IL-2-induced JAK3 activation and its downstream substrate STAT5a/b. NC1153 effectively prolongs the survival of kidney transplants in MHC/non-MHC mismatched rats. NC1153 promotes long-term graft survival and includes multiple toxicity protection for recipients. NC1153 combined with cyclosporine A (CsA) can synergistically prolong graft survival without producing nephrotoxicity, myelotoxicity or lipotoxicity .

HY-148503

5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)	Nucleoside Antimetabolite/Analog	Others
5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer used to synthesize locked nucleic acid (LNA) analog oligonucleotides. It can be used as a building block of antisense oligonucleotides (ASOs) to target complementary RNA sequences. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) locks the furanose ring into an N-type conformation through 2',4'-constrained ethyl (cEt) modification, enhancing hybridization affinity and mismatch discrimination with RNA, while significantly improving the resistance of oligonucleotides to exonuclease digestion. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) mediates RNase H-dependent mRNA degradation or inhibits translation by forming a stable hybrid with RNA, thereby achieving gene expression regulation. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is mainly used in the development of antisense drugs, gene function research and oligonucleotide synthesis related to disease treatment .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-116887

N6-Methyladenine	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Nucleoside Antimetabolite/Analog DNA/RNA Synthesis
N6-Methyladenine is a modified purine that is widely present in prokaryotes. In prokaryotes, N6-Methyladenine plays an important role in distinguishing host DNA from exogenous DNA and controls many biological functions, such as DNA replication, transcription, mismatch repair, and chromosome replication .

HY-116887R

N6-Methyladenine (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite Nucleoside Antimetabolite/Analog DNA/RNA Synthesis
N6-Methyladenine (Standard) is the analytical standard of N6-Methyladenine. This product is intended for research and analytical applications. N6-Methyladenine is a modified purine that is widely present in prokaryotes. In prokaryotes, N6-Methyladenine plays an important role in distinguishing host DNA from exogenous DNA and controls many biological functions, such as DNA replication, transcription, mismatch repair, and chromosome replication .

Species:	Human (2)
Tag:	His (2) GST (1)
Source:	Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P702783

	TDG Protein, Human (His) G/T mismatch-specific thymine DNA glycosylase; Thymine-DNA glycosylase; EC:3.2.2.29	Human	E. coli
	TDG Protein, Human (His) is the recombinant human-derived TDG, expressed by E. coli , with N-10*His labeled tag.

HY-P73803

	MSH2 Protein, Human (sf9, His-GST) DNA mismatch repair protein Msh2; hMSH2; MSH2	Human	Sf9 insect cells
	MSH2 protein is a key component of the DNA mismatch repair system, which can recognize and bind DNA mismatches to initiate repair. MSH2 forms heterodimers MutS α and MutS β that target various mismatches. MSH2 Protein, Human (sf9, His-GST) is the recombinant human-derived MSH2 protein, expressed by Sf9 insect cells , with C-His, N-GST labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-17364S

Temozolomide-d3
Temozolomide-d₃ is the deuterium labeled Temozolomide. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .

Temozolomide-d3

Temozolomide-d₃ is the deuterium labeled Temozolomide. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82011

	MSH6 Antibody (YA1756) MSH6; GTBP; DNA mismatch repair protein Msh6; hMSH6; G/T mismatch-binding protein; GTBP; GTMBP; MutS-alpha 160 kDa subunit; p160	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	MSH6 Antibody (YA1756) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1756), targeting MSH6, with a predicted molecular weight of 153 kDa (observed band size: 163 kDa). MSH6 Antibody (YA1756) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, mouse, rat background.

HY-P82029

	MSH2 Antibody (YA1774) DNA mismatch repair protein Msh2; MutS protein homolog 2	WB	Human, Rat
	MSH2 Antibody (YA1774) is a non-conjugated IgG antibody, targeting MSH2, with a predicted molecular weight of 105 kDa (observed band size: 105 kDa). MSH2 Antibody (YA1774) can be used for WB experiment in human, rat background.

HY-P80753

	MLH1 Antibody (YA703) MLH1; COCA2; DNA mismatch repair protein Mlh1; MutL protein homolog 1	WB, ICC/IF	Human, Monkey
	MLH1 Antibody (YA703) is a non-conjugated and Mouse origined monoclonal antibody about 85 kDa, targeting to MLH1 (4C1). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Monkey.

HY-P86648

	PMS2 Antibody (YA6340) mismatch repair endonuclease PMS2; DNA mismatch repair protein PMS2; PMS1 protein homolog 2	WB, IHC-P, ICC/IF, IP, ELISA	Human
	PMS2 Antibody (YA6340) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PMS2. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human.

HY-P82027

	PMS2 Antibody (YA1772) DNA mismatch repair gene; DNA mismatch repair protein PMS2; HNPCC4; PMS1 protein homolog 2	WB, IHC-P, ICC/IF	Human
	PMS2 Antibody (YA1772) is a mouse-derived non-conjugated IgG2b antibody (Clone NO.: YA1772), targeting PMS2, with a predicted molecular weight of 96 kDa (observed band size: 150 kDa). PMS2 Antibody (YA1772) can be used for WB, IHC-P, ICC/IF experiment in human background.

HY-P86964

	MSH3 Antibody (YA6657) Divergent upstream protein antibody; DNA mismatch repair protein antibody; DNA mismatch repair protein Msh 3 antibody; DNA mismatch repair protein MSH3 antibody; DUC 1 antibody; DUC1 antibody; DUG antibody; DUP antibody; hMSH3 antibody; MGC163306 antibody; Divergent upstream protein antibody; DNA mismatch repair protein antibody; DNA mismatch repair protein Msh 3 antibody; DNA mismatch repair protein MSH3 antibody; DUC 1 antibody; DUC1 antibody; DUG antibody; DUP antibody; hMSH3 antibody; MGC163306 antibody; MGC163308 antibody; mismatch repair protein 1 antibody; MRP 1 antibody; MRP1 antibody; MSH 3 antibody; MSH3 antibody; MSH3_HUMAN antibody; MutS homolog 3 (E. coli) antibody; MutS homolog 3 antibody	WB, ICC/IF, IHC-P	Human, Mouse, Rat

HY-P85961

	MLH1 Antibody (YA5653) DNA mismatch repair protein Mlh1; MutL protein homolog 1; MLH1	IHC-P, WB, ICC/IF, ELISA	Human
	MLH1 Antibody (YA5653) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MLH1. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human.

HY-P85962

	MSH2 Antibody (YA5654) DNA mismatch repair protein Msh2; MutS protein homolog 2; MSH2; hMSH2	IHC-P, WB, ICC/IF, ELISA	Human
	MSH2 Antibody (YA5654) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MSH2. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human.

HY-P85919

	MSH6 Antibody (YA5611) DNA mismatch repair protein Msh6; G/T mismatch binding protein; G/T mismatch-binding protein; GTBP; GTMBP; hMSH6; HNPCC 5; HNPCC5; HSAP; MSH 6; MSH6; MSH6_HUMAN; mutS; E. coli; homolog 6; MutS alpha 160 kDa subunit; MutS homolog 6; E. coli; mutS homolog 6; MutS-alpha 160 kDa subunit; p160; Sperm associated protein	IHC-P, WB, ICC/IF, ELISA	Human
	MSH6 Antibody (YA5611) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MSH6. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human.