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impurity synthesis

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By Targets:	5-HT Receptor (2) Antibiotic (1) Bacterial (2) Biochemical Assay Reagents (5) Btk (4) Cannabinoid Receptor (1) COX (2) Drug Derivative (3) Drug Intermediate (22) Drug Metabolite (8) Interleukin Related (1) Isotope-Labeled Compounds (2) Parasite (3) Phosphatase (1) Prostaglandin Receptor (1) Reference Standards (6) VD/VDR (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (2) Endocrinology (1) Infection (6) Inflammation/Immunology (5) Neurological Disease (8)
Oligonucleotides:	Nucleosides and their Analogs (1) C (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: DNA/RNA Synthesis

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Z8863

Citalopram impurity-1	Biochemical Assay Reagents	Others
Citalopram impurity-1 (Compound iv) is an amide impurity generated during the synthesis of Citalopram (HY-121203) .

HY-131280

Devaleryl Valsartan Impurity	Drug Metabolite	Others
Devaleryl Valsartan Impurity is an intermediate in the synthesis of Valsartan .

HY-76937

Impurity of Doxercalciferol	VD/VDR	Endocrinology
Impurity of Doxercalciferol is an impurity of doxercalciferol, which is a synthetic analog of ergocalciferol (vitamin D2), used as a agent for secondary hyperparathyroidism and metabolic bone disease, and it suppresses parathyroid synthesis and secretion.

HY-W072385

1,2-Dibromo-4,5-methylenedioxybenzene	Drug Derivative	Neurological Disease
1,2-Dibromo-4,5-methylenedioxybenzene is an impurity in the synthesis of amphetamines .

HY-131391

m-Isobutyl Ibuprofen	Drug Intermediate	Others
m-Isobutyl Ibuprofen (Compound IMP-A) is the impurity found during synthesis of Ibuprofen (HY-78131) .

HY-130784

Dihydro montelukast	Drug Intermediate	Others
Dihydro montelukast (Impurity-3) is an impurity found during the synthesis of Montelukast sodium (HY-13315) .

HY-131965

Imidacloprid impurity 1	Drug Intermediate	Others
Imidacloprid impurity 1 (IMP-2) is the impurity found during the synthesis of Ivermectin (HY-15310) .

HY-118515

ATM4 4-Acetoxy analog	Drug Derivative	Neurological Disease
ATM4 4-Acetoxy analog is an impurity in the synthesis of Heroin.

HY-43384

Chloromethyl methyl carbonate Tenofovir impurity 66	Drug Intermediate	Others
Chloromethyl methyl carbonate (Tenofovir Impurity 66) is a drug intermediate for synthesis of various active compounds.

HY-119326

N-Formylmethamphetamine	Drug Intermediate	Neurological Disease
N-Formylmethamphetamine is an impurity in the synthesis of methamphetamine. N-Formylmethamphetamine is also a by-product of the Nagai reaction .

HY-W587927

α-Hydroxymethyl atropine	Drug Intermediate	Others
α-Hydroxymethyl atropine is the impurity, that could be produced in process of Atropine (HY-B1205) synthesis .

HY-W018697

3-Bromo-4-chlorobenzoic acid Dapagliflozin impurity 50	Drug Intermediate	Others
3-Bromo-4-chlorobenzoic acid (Dapagliflozin Impurity 50) is a drug intermediate for synthesis of various active compounds.

HY-W016194

1-(Carboxymethyl)cyclohexanecarboxylic acid 1-Carboxycyclohexaneacetic acid; Gabapentin impurity E; Gabapentin Related Compound E	5-HT Receptor	Neurological Disease
1-(Carboxymethyl)cyclohexanecarboxylic acid (1-Carboxycyclohexaneacetic acid; Gabapentin Impurity E) is a potential impurity in commercial preparations of the antiepileptic agent Gabapentin (HY-A0057). It is also used as a precursor for the synthesis of a serotonin (5-HT) receptor subtype 5-HT2A antagonist.

HY-Z9064

1-epi-Regadenoson ethyl ester	Drug Intermediate	Others
1-epi-Regadenoson ethyl ester is an intermediate in the synthesis of αisomer impurity of Regadenoson which is a highly selective adenosine A2A receptor agonist .

HY-Z9065

1-epi-Regadenoson hydrazone	Drug Intermediate	Others
1-epi-Regadenoson hydrazone is an intermediate in the synthesis of αisomer impurity of Regadenoson which is a highly selective adenosine A2A receptor agonist .

HY-59121A

Isopropyl ((R)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate	Drug Intermediate	Infection
Isopropyl ((R)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate can be used to synthesis Sofosbuvir (HY-15005) to avoid the production of sofibuvir degradation impurities .

HY-W036175

4-Acetamido-5-chloro-2-methoxybenzoic acid Metoclopramide impurity 12	Drug Intermediate	Others
4-Acetamido-5-chloro-2-methoxybenzoic acid (Metoclopramide Impurity 12) is a drug intermediate for synthesis of various active compounds.

HY-134554

5′-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine	Drug Derivative	Cancer
5′-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine is an impurity in the synthesis of Capecitabine (HY-B0016) .

HY-79716

2,3-Dimethyl-6-nitro-2H-indazole Pazopanib impurity	Drug Intermediate	Others
2,3-Dimethyl-6-nitro-2H-indazole (Pazopanib Impurity) is a drug intermediate for synthesis of various active compounds.

HY-135397

(R)-Linezolid (R)-PNU-100766	Drug Metabolite	Infection
(R)-Linezolid is an impurity of Linezolid (PNU-100766). Linezolid, the first member of the class of oxazolidinone synthetic antibiotic, acts by inhibiting the initiation of bacterial protein synthesis .

HY-W016644

(S)-1-Benzylpyrrolidin-3-ol	Drug Intermediate	Cardiovascular Disease Others
(S)-1-Benzylpyrrolidin-3-ol (Compound 14) can be used to synthesis impurities of the anti-hypertensive agent Barnidipine hydrochloride (HY-107322) .

HY-59121C

Isopropyl ((R)-(perfluorophenoxy)(phenoxy)phosphoryl)-D-alaninate Sofosbuvir impurity 4/Isopropyl ((R)-(perfluorophenoxy)(phenoxy)phosphoryl)-D-alaninate	Drug Intermediate	Others
Isopropyl ((R)-(perfluorophenoxy)(phenoxy)phosphoryl)-D-alaninate (Sofosbuvir impurity 4/Isopropyl ((R)-(perfluorophenoxy)(phenoxy)phosphoryl)-D-alaninate) is a drug intermediate for synthesis of various active compounds.

HY-W036121

(1H-Indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone UR-144 impurity 3	Cannabinoid Receptor	Neurological Disease
(1H-Indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone (UR-144 Impurity 3) is a precursor in the synthesis of synthetic cannabinoids.

HY-13036B

IBT6A hydrochloride	Btk	Cancer
IBT6A hydrochloride is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct . Ibrutinib is a selective, irreversible Btk inhibitor with an IC₅₀ of 0.5 nM .

HY-13036A

IBT6A	Btk	Cancer
IBT6A is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct . Ibrutinib is a selective, irreversible Btk inhibitor with an IC₅₀ of 0.5 nM .

HY-Z0275

HOAT	Biochemical Assay Reagents	Others
HOAT is a commonly used peptide bond forming agent that may become an impurity in drug synthesis, but is not mutagenic. HOAT can be used for peptide fragment polycondensation and can also inhibit the racemization of peptide polycondensation .

HY-133624

1,1,3-Tribromoacetone 1 Publications Verification	Drug Metabolite	Cancer
1,1,3-Tribromoacetone is an impurity of Methotrexate (HY-14519) . Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .

HY-75318

(5-Amino-2-butylbenzofuran-3-yl)(4-(3-(dibutylamino)propoxy)phenyl)methanone Dronedarone impurity A	Drug Intermediate	Others
(5-Amino-2-butylbenzofuran-3-yl)(4-(3-(dibutylamino)propoxy)phenyl)methanone (Dronedarone impurity A) is a drug intermediate for synthesis of various active compounds.

HY-120955

(+)-5-trans Cloprostenol	Prostaglandin Receptor	Others
Cloprostol, a synthetic derivative of prostaglandin F2α, is used as an ossified in veterinary medicine and the research of reproductive disorders in cattle, pigs and horses. (+)-5-trans Cloprostenol is a secondary impurity produced during the synthesis of (+) -cloprostenol .

HY-135774R

6-Hydroxybenzbromarone (Standard)	Reference Standards Drug Metabolite Phosphatase	Cardiovascular Disease
1-(Carboxymethyl)cyclohexanecarboxylic acid (Standard) is the analytical standard of 1-(Carboxymethyl)cyclohexanecarboxylic acid. This product is intended for research and analytical applications. 1-(Carboxymethyl)cyclohexanecarboxylic acid (1-Carboxycyclohexaneacetic acid; Gabapentin Impurity E) is a potential impurity in commercial preparations of the antiepileptic agent Gabapentin (HY-A0057). It is also used as a precursor for the synthesis of a serotonin (5-HT) receptor subtype 5-HT2A antagonist.

HY-W016194R

1-(Carboxymethyl)cyclohexanecarboxylic acid (Standard) 1-Carboxycyclohexaneacetic acid (Standard); Gabapentin impurity E (Standard); Gabapentin Related Compound E (Standard)	5-HT Receptor Reference Standards	Neurological Disease
1-(Carboxymethyl)cyclohexanecarboxylic acid (Standard) is the analytical standard of 1-(Carboxymethyl)cyclohexanecarboxylic acid. This product is intended for research and analytical applications. 1-(Carboxymethyl)cyclohexanecarboxylic acid (1-Carboxycyclohexaneacetic acid; Gabapentin Impurity E) is a potential impurity in commercial preparations of the antiepileptic agent Gabapentin (HY-A0057). It is also used as a precursor for the synthesis of a serotonin (5-HT) receptor subtype 5-HT2A antagonist.

HY-78066

Abemaciclib Impurity 1 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole	Drug Intermediate	Others
Abemaciclib Impurity 1 (6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole) is a drug intermediate for synthesis of various active compounds.

HY-W767047

α-Hydroxymethyl atropine-d5	Isotope-Labeled Compounds Drug Intermediate	Others
α-Hydroxymethyl atropine-d₅ is the deuterium labeled α-Hydroxymethyl atropine (HY-W587927). α-Hydroxymethyl atropine is the impurity, that could be produced in process of Atropine (HY-B1205) synthesis .

HY-W043676

Dibenzosuberol	Parasite Drug Intermediate	Infection
Dibenzosuberol (Compound 2) is a key intermediate in the synthesis of compounds associated with inhibiting Trypanosoma thiol reductase (TryR). Dibenzosuberol also shows inhibition of T. brucei with an EC₅₀ value of 51.3 μM. Dibenzosuberol is also an impurity of Amitriptyline (HY-B0527) .

HY-13036C

(Rac)-IBT6A hydrochloride	Btk	Cancer
(Rac)-IBT6A hydrochloride is a racemate of IBT6A hydrochloride. IBT6A is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct . Ibrutinib is a selective, irreversible Btk inhibitor with an IC₅₀ of 0.5 nM .

HY-13036

(Rac)-IBT6A	Btk	Cancer
(Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct . Ibrutinib is a selective, irreversible Btk inhibitor with an IC₅₀ of 0.5 nM .

HY-135397R

(R)-?Linezolid (Standard) (R)-PNU-100766 (Standard)	Drug Metabolite Reference Standards	Infection
(R)-Linezolid (Standard) is the analytical standard of (R)-Linezolid. This product is intended for research and analytical applications. (R)-Linezolid is an impurity of Linezolid (PNU-100766). Linezolid, the first member of the class of oxazolidinone synthetic antibiotic, acts by inhibiting the initiation of bacterial protein synthesis .

HY-133624R

1,1,3-Tribromoacetone (Standard)	Drug Metabolite Reference Standards	Cancer
1,1,3-Tribromoacetone (Standard) is the analytical standard of 1,1,3-Tribromoacetone. This product is intended for research and analytical applications. 1,1,3-Tribromoacetone is an impurity of Methotrexate (HY-14519)[1]. Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1].

HY-W394935

Dixylyl disulphide Disulfide,bis(2,4-dimethylphenyl)	Biochemical Assay Reagents	Others
Dixylyl disulphide (Disulfide, bis(2,4-dimethylphenyl)) is a 1,2-bis(2,4-dimethylphenyl) thioether that can serve as an impurity reference standard for hydrobromide vortioxetine, used for monitoring impurities in the synthesis process. Hydrobromide vortioxetine is a 5-HT3, 5-HT7, and 5-HT1D receptor antagonist and a 5-HT1A receptor agonist, exhibiting antidepressant activity .

HY-66004

4-Acetamidophenyl acetate Diacetamate	Drug Intermediate Bacterial Parasite	Inflammation/Immunology Cancer
4-Acetamidophenyl acetate is an impurity of Acetaminophen (HY-66005). 4-Acetamidophenyl acetate acts as an intermediate in the synthesis of Acetaminophen. Acetaminophen is a selective COX-2 inhibitor (IC₅₀=25.8 μM), and is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-42045

Pyrimidine-5-boronic acid pinacol ester	Biochemical Assay Reagents	Others
Pyrimidine-5-boronic acid pinacol ester is a derivative of Boronic acid. Boronic acid is an intermediate commonly used in organic synthesis reactions and can be used as a key reagent in the Suzuki-Miyaura reaction. It generates organic free radicals through oxygen-mediated oxidation and exhibits potential mutagenic activity. Boronic acid is mainly used in research in the fields of drug synthesis and catalytic reactions. At the same time, it should be noted that it may be a genotoxic impurity (GTIs) .

HY-42476

Tolvaptan Impurity 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one	Drug Intermediate	Others
Tolvaptan Impurity (1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one) is a drug intermediate for synthesis of various active compounds.

HY-135397S

(R)-Linezolid-d3	Isotope-Labeled Compounds	Infection
(R)-Linezolid-d₃ ((R)-PNU-100766-d₃) is the deuterium labeled (R)-?Linezolid. (R)-Linezolid is an impurity of Linezolid (PNU-100766). Linezolid, the first member of the class of oxazolidinone synthetic antibiotic, acts by inhibiting the initiation of bacterial protein synthesis .

HY-78558

Tofacitinib Impurity T 3-((3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanamide	Drug Intermediate	Others
Tofacitinib Impurity T (3-((3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanamide) is a drug intermediate for synthesis of various active compounds.

HY-17626B

Alalevonadifloxacin hydrochloride WCK-2349 hydrochloride	Antibiotic	Infection
Alalevonadifloxacin (hydrochloride) (WCK-2349 (hydrochloride)) is a oraaly active anti-methicillin-resistant Staphylococcus aureus (MRSA) antibiotic .

HY-66004R

4-Acetamidophenyl acetate (Standard) Diacetamate (Standard)	Reference Standards Drug Intermediate Bacterial Parasite	Inflammation/Immunology Cancer
4-Acetamidophenyl acetate (Standard) is the analytical standard of 4-Acetamidophenyl acetate (HY-66004). This product is intended for research and analytical applications. 4-Acetamidophenyl acetate is an impurity of Acetaminophen (HY-66005). 4-Acetamidophenyl acetate acts as an intermediate in the synthesis of Acetaminophen. Acetaminophen is a selective COX-2 inhibitor (IC₅₀=25.8 μM), and is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-B2121

6-Methoxy-2-naphthoic acid 6-MNA; Naproxen impurity O	Drug Metabolite COX	Neurological Disease Inflammation/Immunology
6-Methoxy-2-naphthoic acid (6-MNA) is the active metabolite of Nabumetone (HY-B0559). 6-Methoxy-2-naphthoic acid is also an inhibitor of COX-1 and COX-2. 6-Methoxy-2-naphthoic acid can inhibit the synthesis of gastric mucosal prostaglandin E₂. 6-Methoxy-2-naphthoic acid can be used in the research of inflammation and pain-related diseases. In addition, 6-Methoxy-2-naphthoic acid is an impurity in Naproxen (HY-15030) and can also be used in the synthesis of other active compounds .

HY-W585843

1,1′-Ethylidenebis[L-tryptophan]	Interleukin Related	Inflammation/Immunology
1,1′-Ethylidenebis[L-tryptophan] is an impurity in the synthesis of L-tryptophan. 1,1′-Ethylidenebis[L-tryptophan] promotes the proliferation of eosinophilic leukemia cells, induces the release of eosinophil cationic protein from eosinophils, and stimulates T cells to produce IL-5. 1,1′-Ethylidenebis[L-tryptophan] (40 µg/kg) can induce fascia thickening, mast cell infiltration, and fibrosis in adipose and subcutaneous muscle tissues in mice. 1,1′-Ethylidenebis[L-tryptophan] can be used in immunology and inflammation research .

HY-B2121R

6-Methoxy-2-naphthoic acid (Standard) 6-MNA (Standard); Naproxen impurity O (Standard)	Reference Standards Drug Metabolite COX	Neurological Disease Inflammation/Immunology
6-Methoxy-2-naphthoic acid (Standard) (6-MNA (Standard)) is the analytical standard of 6-Methoxy-2-naphthoic acid (HY-B2121). This product is intended for research and analytical applications. 6-Methoxy-2-naphthoic acid (6-MNA) is the active metabolite of Nabumetone (HY-B0559). 6-Methoxy-2-naphthoic acid is also an inhibitor of COX-1 and COX-2. 6-Methoxy-2-naphthoic acid can inhibit the synthesis of gastric mucosal prostaglandin E₂. 6-Methoxy-2-naphthoic acid can be used in the research of inflammation and pain-related diseases. In addition, 6-Methoxy-2-naphthoic acid is an impurity in Naproxen (HY-15030) and can also be used in the synthesis of other active compounds.

HY-W035903

Ethanolamine hydrochloride 2-Aminoethanol hydrochloride	Biochemical Assay Reagents	Others
Ethanolamine hydrochloride, is an organic compound used in various industrial applications. It is a white or colorless solid that is soluble in water and has a faint odor. One of the major uses of Ethanolamine hydrochloride is in the production of detergents and surfactants. Used as a raw material in the manufacture of compounds such as ethylenediaminetetraacetic acid (EDTA) and diethanolamine, which are commonly used in household and industrial cleaning products. Ethanolamine hydrochloride is also used in the synthesis of pharmaceuticals, agrochemicals and rubber processing agents. It acts as a buffer in certain chemical reactions, helping to adjust pH and maintain stability. Ethanolamine hydrochloride can be used for gas purification and metal corrosion inhibitor. Its ability to react with acid gases such as carbon dioxide and sulfur dioxide makes it useful for removing impurities from natural gas and other industrial gases. Overall, Ethanolamine hydrochloride is a multifunctional compound with many potential industrial applications. Its ability to act as a buffer, chelating agent, and corrosion inhibitor makes it an important tool in a variety of industries.

Cat. No.	Product Name	Type

HY-42045

Pyrimidine-5-boronic acid pinacol ester

Biochemical Assay Reagents

Pyrimidine-5-boronic acid pinacol ester is a derivative of Boronic acid. Boronic acid is an intermediate commonly used in organic synthesis reactions and can be used as a key reagent in the Suzuki-Miyaura reaction. It generates organic free radicals through oxygen-mediated oxidation and exhibits potential mutagenic activity. Boronic acid is mainly used in research in the fields of drug synthesis and catalytic reactions. At the same time, it should be noted that it may be a genotoxic impurity (GTIs) .

HY-W035903

Ethanolamine hydrochloride

2-Aminoethanol hydrochloride

Buffer Reagents

Ethanolamine hydrochloride, is an organic compound used in various industrial applications. It is a white or colorless solid that is soluble in water and has a faint odor. One of the major uses of Ethanolamine hydrochloride is in the production of detergents and surfactants. Used as a raw material in the manufacture of compounds such as ethylenediaminetetraacetic acid (EDTA) and diethanolamine, which are commonly used in household and industrial cleaning products. Ethanolamine hydrochloride is also used in the synthesis of pharmaceuticals, agrochemicals and rubber processing agents. It acts as a buffer in certain chemical reactions, helping to adjust pH and maintain stability. Ethanolamine hydrochloride can be used for gas purification and metal corrosion inhibitor. Its ability to react with acid gases such as carbon dioxide and sulfur dioxide makes it useful for removing impurities from natural gas and other industrial gases. Overall, Ethanolamine hydrochloride is a multifunctional compound with many potential industrial applications. Its ability to act as a buffer, chelating agent, and corrosion inhibitor makes it an important tool in a variety of industries.

Cat. No.	Product Name	Chemical Structure

HY-W767047

α-Hydroxymethyl atropine-d5
α-Hydroxymethyl atropine-d₅ is the deuterium labeled α-Hydroxymethyl atropine (HY-W587927). α-Hydroxymethyl atropine is the impurity, that could be produced in process of Atropine (HY-B1205) synthesis .

HY-135397S

(R)-Linezolid-d3
(R)-Linezolid-d₃ ((R)-PNU-100766-d₃) is the deuterium labeled (R)-?Linezolid. (R)-Linezolid is an impurity of Linezolid (PNU-100766). Linezolid, the first member of the class of oxazolidinone synthetic antibiotic, acts by inhibiting the initiation of bacterial protein synthesis .

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