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human polymorphonuclear leukocytes

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Apoptosis (2) Beta-lactamase (1) Calcium Channel (2) Caspase (2) COX (2) Dopamine Receptor (1) Drug Intermediate (1) Drug Metabolite (1) Elastase (2) Endogenous Metabolite (5) Influenza Virus (1) Leukotriene Receptor (3) Lipoxygenase (3) MMP (1) NF-κB (1) Phosphodiesterase (PDE) (2) Phospholipase (1) Platelet-activating Factor Receptor (PAFR) (3) Reference Standards (1) TRP Channel (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (14) Metabolic Disease (2)

By Targets:

Adrenergic Receptor (1)

Apoptosis (2)

Beta-lactamase (1)

Calcium Channel (2)

Caspase (2)

COX (2)

Dopamine Receptor (1)

Drug Intermediate (1)

Drug Metabolite (1)

Elastase (2)

Endogenous Metabolite (5)

Influenza Virus (1)

Leukotriene Receptor (3)

Lipoxygenase (3)

MMP (1)

NF-κB (1)

Phosphodiesterase (PDE) (2)

Phospholipase (1)

Platelet-activating Factor Receptor (PAFR) (3)

Reference Standards (1)

TRP Channel (1)

By Research Areas:

Cancer (1)

Cardiovascular Disease (2)

Infection (1)

Inflammation/Immunology (14)

Metabolic Disease (2)

Inhibitors & Agonists

Natural
Products

Targets Recommended: Human leukocyte immunoglobulin (Ig)-like receptors (LILR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125527A

17(R)-Resolvin D1 1 Publications Verification 17(R)-RvD1; AT-RvD1	TRP Channel	Inflammation/Immunology
17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells . 17R-Resolvin D1 specificially inhibits TRPV3 with an IC₅₀ of 398 nM and exhibits peripheral anti-nociceptive efficacy .

HY-129905

L-Leucyl-L-Leucine methyl ester hydrochloride Maximum Cited Publications 13 Publications Verification LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride	Endogenous Metabolite	Inflammation/Immunology
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress .

HY-129905A

L-Leucyl-L-Leucine methyl ester hydrobromide Maximum Cited Publications 13 Publications Verification LLOMe hydrobromide; Leu-Leu methyl ester hydrobromide; H-Leu-Leu-OMe hydrobromide	Endogenous Metabolite	Inflammation/Immunology
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrobromide also can induce endolysosomal pathway stress .

HY-120876

L-680833	Beta-lactamase Elastase	Inflammation/Immunology
L-680833 is a monocyclic β-lactam inhibitor of human polymorphonuclear leukocyte elastase (PMNE) inhibitor. L-680833 can be used for the study of PMNE-damaged tissue diseases .

HY-105933

L-652343	Lipoxygenase COX Leukotriene Receptor	Inflammation/Immunology
L-652343 is a dual cyclooxygenase/lipoxygenase inhibitor. L-652343 can inhibit the production of LTB₄ in isolated human polymorphonuclear leukocytes treated with Calcimycin (HY-N6687) (IC₅₀: 1.4 μM), but it is inactive in whole blood. L-652343 can be used in the research of inflammatory and immune diseases .

HY-112553

HZ52	Lipoxygenase	Inflammation/Immunology
HZ52 is a potent, reversible 5-lipoxygenase inhibitor, blocking leukotriene synthesis with an IC₅₀ of 0.7 μM in intact human polymorphonuclear leukocytes .

HY-118261

L 659286	Elastase	Inflammation/Immunology
L 659286 is an inhibitor of human polymorphonuclear leukocyte elastase (PMN elastase) (Ki=0.4 μM). Intratracheal injection of L 659286 can induce lung injury in hamsters.

HY-105176A

(R)-Ontazolast (R)-BIRM-270	Leukotriene Receptor	Inflammation/Immunology
(R)-Ontazolast ((R)-BIRM-270) is a potent inhibitor of leukotriene biosynthesis, effectively blocking the release of arachidonic acid and demonstrating an impressive IC50 value of 0.001 microM in human polymorphonuclear leukocytes.

HY-157253

13(S)-HODE-biotin	Drug Metabolite	Metabolic Disease
13(S)-HODE is the lipoxygenase metabolite of Linoleic acid (HY-N0729). 13(S)-HODE modulates the platelet-activating factor, leukotriene B4, and formyl-Met-Leu-Phe-induced calcium influx in human polymorphonuclear leukocytes.

HY-101579

LY 178002	COX Lipoxygenase Phospholipase	Inflammation/Immunology
LY 178002 is a potent inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2, with IC₅₀ of 0.6 μM for 5-lipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase.

HY-134123

Lipoxin B4 methyl ester LXB4 methyl ester	Drug Intermediate Leukotriene Receptor	Metabolic Disease
Lipoxin B4 (LXB4) methyl ester is a lipid soluble prodrug form of the transcellular metabolite LXB4. LXB4 is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 (LTB4; Item No. 20110) and inhibits LTB4-induced adhesion of PMNs with an IC₅₀ value of 0.3 nM.

HY-106899A

(rel)-MK 287 (rel)-L-680573	Platelet-activating Factor Receptor (PAFR)	Others
(rel)-MK 287 ((rel)-L-680573) is a relative configuration of MK 287. MK 287, a tetrahydrofuran analog, potently inhibited [ ³H]C18-PAF binding to human platelet, polymorphonuclear leukocyte (PMN) and lung membranes with K_is of 6.1 nM, 3.2 nM and 5.49 nM, respectively. MK 287 inhibits PAF-induced lethality in mice and PAF-induced bronchoconstriction in guinea pigs .

HY-145474

17(R)-Resolvin D1 methyl ester	Endogenous Metabolite	Inflammation/Immunology
17(R)-Resolvin D1 methyl ester is the methyl ester of Resolvin D1 (RvD1) (HY-125527) induced by Aspirin (HY-14654) with the 17R epimer (AT-RvD1). RvD is a regulator of transendothelial migration of human polymorphonuclear leukocytes and an anti-inflammatory agent. The 17R-trihydroxy-4Z of RvD1 also blocks transendothelial migration of human neutrophils (EC₅₀ approximately 30 nM). AT-RvD1 is an effective form that protects against the rapid inactivation of Resolvin D1 .

HY-N3945R

Glaucine (Standard) O,O-Dimethylisoboldine (Standard); S-(+)-Glaucine (Standard); NSC 34396 (Standard)	Reference Standards Phosphodiesterase (PDE) Calcium Channel Adrenergic Receptor Dopamine Receptor Influenza Virus	Infection Inflammation/Immunology
Glaucine (Standard) is the analytical standard of Glaucine. This product is intended for research and analytical applications. Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 μM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities .

HY-106899

MK 287	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
MK 287 is a potent, selective and orally active antagonist of platelet-activating factor receptor (PAFR). MK 287 can inhibit [3H]C18-PAF binding to human platelet, polymorphonuclear leukocyte (PMN) and lung membranes with K1 values of 6.1, 3.2, and 5.49 nM, respectively. MK 287 can inhibit PAF-induced aggregation of platelets in plasma or gel-filtered platelets and elastase release from PMNs with ED₅₀ values of 56, 1.5 and 4.4 nM. MK 287 can be used for the research of cardiovascular disease, such as thrombosis .

HY-N3945

Glaucine O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396	Phosphodiesterase (PDE) Calcium Channel MMP NF-κB	Inflammation/Immunology Cancer
Glaucine (O,O-Dimethylisoboldine) is an alkaloid extracted from Glaucium flavum that possesses various activities, including cough relief, bronchodilation, anti-inflammatory effects, analgesia, antipyretic properties, and anticancer effects. Glaucine acts as a selective and orally active inhibitor of phosphodiesterase 4 (PDE4), with a K_i of 3.4 µM in human bronchial tissues and polymorphonuclear leukocytes. Glaucine induces relaxation of human isolated bronchi by antagonizing calcium channels. Additionally, Glaucine inhibits the activation of NF-κB, leading to a reduction in the expression of the MMP-9 gene, thereby suppressing the migration and invasion of breast cancer cells. Therefore, Glaucine holds potential for research in asthma and breast cancer .

HY-120314

GEA 3162	Apoptosis Caspase Endogenous Metabolite	Inflammation/Immunology
GEA 3162 is an orally active compound that acts as a NO/ONOO⁻ donor. GEA 3162 significantly inhibits the activation of human polymorphonuclear leukocytes (PMNs) through the cGMP pathway, inhibits the release of inflammatory mediators, and exerts anti-inflammatory and protective effects. GEA 3162 induces apoptosis of neutrophils and bone marrow cells by activating caspase-2/3/8/9 through the ONOO⁻ pathway. GEA 3162 has a bidirectional effect in the rat gastric ulcer model: at low doses, it significantly reduces gastric mucosal damage, while at high doses, it aggravates the ulcer area. GEA 3162 can be used for research on inflammatory conditions such as gastric ulcers .

HY-120314A

GEA 3162 hydrochloride	Apoptosis Caspase Endogenous Metabolite	Inflammation/Immunology
GEA 3162 hydrochloride is an orally active compound that acts as a NO/ONOO⁻ donor. GEA 3162 hydrochloride significantly inhibits the activation of human polymorphonuclear leukocytes (PMNs) through the cGMP pathway, inhibits the release of inflammatory mediators, and exerts anti-inflammatory and protective effects. GEA 3162 hydrochloride induces apoptosis of neutrophils and bone marrow cells by activating caspase-2/3/8/9 through the ONOO⁻ pathway. GEA 3162 hydrochloride has a bidirectional effect in the rat gastric ulcer model: at low doses, it significantly reduces gastric mucosal damage, while at high doses, it aggravates the ulcer area. GEA 3162 hydrochloride can be used for research on inflammatory conditions such as gastric ulcers .

HY-117811

(R,R)-MK 287 L-680574	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
(R,R)-MK 287 (L-680574) is a tetrahydrofuran derivative that potently inhibits the binding of [3H]C18-PAF to human platelets, polymorphonuclear leukocytes (PMNs), and lung membranes with Ki values of 6.1, 3.2, and 5.49 nM, respectively. (R,R)-MK 287 potently and selectively inhibits PAF-induced platelet aggregation (ED₅₀=56 nM) and elastase release from PMNs (ED₅₀=4.4 nM). (R,R)-MK 287 inhibits PAF-induced lethality in mice (ED₅₀=0.8 mg/kg, po) and PAF-induced bronchospasm in guinea pigs (ED₅₀=0.18 mg/kg) .

L-Leucyl-L-Leucine methyl ester hydrochloride 10+ Cited Publications LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride	Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress .

L-Leucyl-L-Leucine methyl ester hydrobromide 10+ Cited Publications LLOMe hydrobromide; Leu-Leu methyl ester hydrobromide; H-Leu-Leu-OMe hydrobromide	Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrobromide also can induce endolysosomal pathway stress .

Glaucine O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396	Infection Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Glaucium flavum Inflammation/Immunology Disease Research Fields Papaveraceae	Phosphodiesterase (PDE) Calcium Channel MMP NF-κB
Glaucine (O,O-Dimethylisoboldine) is an alkaloid extracted from Glaucium flavum that possesses various activities, including cough relief, bronchodilation, anti-inflammatory effects, analgesia, antipyretic properties, and anticancer effects. Glaucine acts as a selective and orally active inhibitor of phosphodiesterase 4 (PDE4), with a K_i of 3.4 µM in human bronchial tissues and polymorphonuclear leukocytes. Glaucine induces relaxation of human isolated bronchi by antagonizing calcium channels. Additionally, Glaucine inhibits the activation of NF-κB, leading to a reduction in the expression of the MMP-9 gene, thereby suppressing the migration and invasion of breast cancer cells. Therefore, Glaucine holds potential for research in asthma and breast cancer .

Glaucine (Standard) O,O-Dimethylisoboldine (Standard); S-(+)-Glaucine (Standard); NSC 34396 (Standard)	Alkaloids other families Source classification Plants Isoquinoline Alkaloids Glaucium flavum Papaveraceae	Reference Standards Phosphodiesterase (PDE) Calcium Channel Adrenergic Receptor Dopamine Receptor Influenza Virus
Glaucine (Standard) is the analytical standard of Glaucine. This product is intended for research and analytical applications. Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 μM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities .

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human polymorphonuclear leukocytes

Inhibitors & Agonists

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