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Results for "

gangliosides

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (5) Biochemical Assay Reagents (11) Complement System (1) Drug Derivative (1) EGFR (1) Endogenous Metabolite (6) ERK (1) FAK (1) Ferroptosis (1) Insulin Receptor (2) Integrin (1) Isotope-Labeled Compounds (9) p38 MAPK (1) Parasite (1) Src (1) TET Protein (1) Toll-like Receptor (TLR) (1) Trk Receptor (1) VEGFR (1)
By Research Areas:	Cancer (17) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (6) Metabolic Disease (8) Neurological Disease (13)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70043

Ganglioside sialidase (AuSialidase S) Sialidase isoenzyme S; AuSialidase S	Endogenous Metabolite	Metabolic Disease
Ganglioside sialidase (AuSialidase S) is an endogenous metabolite. Ganglioside sialidases have been implicated in neuronal differentiation processes, including neurite outgrowth .

HY-114456

Ganglioside GM3	Insulin Receptor	Metabolic Disease
Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia .

HY-E70073

Ganglioside sialidase (AuSialidase M2) Sialidase isoenzyme M2; AuSialidase M2	Biochemical Assay Reagents	Others
Ganglioside sialidase (AuSialidase M2) from Arthrobacter ureafaciens. Ganglioside sialidase is a highly specific N-acetylneuraminidase. Ganglioside sialidase can hydrolyze the internal sialic acid of GM1 under optimal condition with sodium cholate .

HY-N10511

*GM1a Ganglioside* oligosaccharide**	Others	Inflammation/Immunology
GM1a Ganglioside oligosaccharide is a semisynthetic form of ganglioside GM1. Ganglioside GM1 is the natural receptor for cholera toxin and plays an important role not only in general growth regulation but also in the coupling of hormone-induced responses .

HY-157343A

*GD3 Ganglioside* sodium**	Apoptosis	Neurological Disease Cancer
GD3 Ganglioside sodium is a prominent ganglioside of human melanoma. GD3 Ganglioside sodium is an inducer of mitochondrial permeability. GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashion. GD3 ganglioside is rapidly synthesized from accumulated ceramide after the clustering of death-inducing receptors and triggers apoptosis .

HY-157343

GD3 Ganglioside	Apoptosis	Neurological Disease Cancer
GD3 Ganglioside is a prominent ganglioside of human melanoma. GD3 Ganglioside is an inducer of mitochondrial permeability. GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashion. GD3 ganglioside is rapidly synthesized from accumulated ceramide after the clustering of death-inducing receptors and triggers apoptosis .

HY-157343B

*GD3 Ganglioside* ammonium**	Apoptosis	Neurological Disease Cancer
GD3 Ganglioside ammonium is a prominent ganglioside of human melanoma. GD3 Ganglioside ammonium is an inducer of mitochondrial permeability. GD3 ganglioside ammonium directly targets mitochondria in a bcl-2-controlled fashion. GD3 ganglioside ammonium is rapidly synthesized from accumulated ceramide after the clustering of death-inducing receptors and triggers apoptosis .

HY-P10529

Ganglioside GM1-binding peptides p3	Trk Receptor	Infection
Ganglioside GM1-binding peptides p3 is a synthetic peptide that can specifically bind to the pentasaccharide part of GM1 ganglioside. The dynamic transformation of Ganglioside GM1-binding peptides p3 may play an important role in the function of GM1 as a multiple receptor, such as in the classical pathway of cholera toxin infection. Ganglioside GM1-binding peptides p3 can be used to study the interaction between GM1 and its ligands .

HY-P99743

Mitumomab	Biochemical Assay Reagents	Cancer
Mitumomab is an anti-idiotypic mouse IgG2b monoclonal antibody that mimics the ganglioside GD3. Mitumomab can be used for the research of small-cell lung carcinoma .

HY-171443

Lyso-Monosialoganglioside GM3 Lyso-GM3	EGFR Drug Derivative	Cancer
Lyso-Monosialoganglioside GM3 (Lyso-GM3) is an analogue of Ganglioside GM3 (HY-114456) with antitumor activities. Lyso-Monosialoganglioside inhibits EGF-induced increases in EGFR kinase activity in A431 epithelial cancer cells .

HY-166325A

Ganglioside GD3-d3 ammonium	Biochemical Assay Reagents	Metabolic Disease
Ganglioside GD3-d₃ ammonium is the deuterium labeled Ganglioside GD3 ammonium. Ganglioside GD3 ammonium is an ester product.

HY-N10546

Ganglioside GM1	Others	Neurological Disease
Ganglioside GM1 is a member of the ganglioside family that can be used for neurological disease research. Ganglioside GM1 is a functional tissue receptor for the Cholera Toxin1 .

HY-146876S

*C18:0 GM1 Ganglioside-d5 ammonium*	Isotope-Labeled Compounds	Others
C18:0 GM1 Ganglioside-d₅ (ammonium) is deuterium labeled C18:0 GM1 Ganglioside (ammonium).

HY-114456S

Ganglioside GM3-d7	Isotope-Labeled Compounds Others	Metabolic Disease
Ganglioside GM3-d₇ is deuterium labeled Ganglioside GM3. Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia .

HY-N10546A

Ganglioside GM1 (bovine) ammonium	Endogenous Metabolite	Neurological Disease
Ganglioside GM1 (bovine) ammonium is a member of the ganglioside family that can be used for neurological disease research. Ganglioside GM1 (bovine) ammonium is a functional tissue receptor for the Cholera Toxin1 .

HY-W714151

Ganglioside ga1 Gg4cer; Asialoganglioside gm1; Asialo gm1, Gangliotetraosylceramide; Asialo ganglioside gm1a [...]; Ganglio-n-tetraosylceramide; Asialo gm1 ganglioside; Asialoganglioside gt1b	Biochemical Assay Reagents	Metabolic Disease
Ganglioside ga1 (Gg4cer; Asialoganglioside gm1; Asialo gm1, Gangliotetraosylceramide; Asialo ganglioside gm1a [...]; Ganglio-n-tetraosylceramide; Asialo gm1 ganglioside; Asialoganglioside gt1b) is an ester product.

HY-152002S

Ganglioside GM3-d3 ammonium	Isotope-Labeled Compounds	Others
Ganglioside GM3-d3 ammonium is a deuterated labeled Ganglioside GM3 ammonium .

HY-165740

Ganglioside GD2 Disialoganglioside GD2	Biochemical Assay Reagents	Cancer
Ganglioside GD2 (Disialoganglioside GD2), a member of the ganglioside family, is a tumor-associated antigen that is highly expressed in almost all neuroblastomas, as well as in most melanomas and retinoblastomas. Ganglioside GD2 contributes to tumor development by enhancing cell proliferation, motility, migration, adhesion, and invasion. Anti-Ganglioside GD2 strategies hold promise for research in the field of anti-tumor therapy .

HY-152003S

Ganglioside GM2-d3 ammonium	Isotope-Labeled Compounds	Others
Ganglioside GM2-d₃ (ammonium) is the deuterium labeled Ganglioside GM2 (HY-148385). Ganglioside GM2 is a human tumor antigen predominantly found in human tumor cells and fetal brain tissue. As a sialylated glycosphingolipid, Ganglioside GM2 is involved in processes such as cell signaling, adhesion, and motility. Ganglioside GM2 abnormal expression and accumulation are associated with tumors and neurodegenerative disorders. Ganglioside GM2 promotes tumor cell migration and invasion by directly binding to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, and inducing actin cytoskeleton remodeling .

HY-114456AS

Ganglioside GM3-d5 Bovine Milk ammonium salt	Isotope-Labeled Compounds	Others
Ganglioside GM3-d₅ (Bovine Milk ammonium salt) is deuterium labeled Ganglioside GM3 (Bovine Milk ammonium salt).

HY-165665S

*C16 Ganglioside* GM3-d9 ammonium salt**	Isotope-Labeled Compounds	Others
C16 Ganglioside GM3-d₉ (ammonium salt) is deuterium labeled C16 Ganglioside GM3 (ammonium salt) .

HY-152000S

*C18 Ganglioside* GM1-d3 ammonium**	Isotope-Labeled Compounds	Others
C18 Ganglioside GM1-d₃ (ammonium) is deuterium labeled C18 Ganglioside GM1 (ammonium) .

HY-131139

Ganglioside GD3 disodium salt	Apoptosis	Neurological Disease Cancer
Ganglioside GD3 disodium salt is an acidic glycosphingolipid. Ganglioside GD3 disodium salt inhibits the proliferation of cancer cells, affects the opening of the mitochondrial permeability transition pore (PTPC), induces apoptosis and activates caspase family. Ganglioside GD3 disodium salt can be used in research about cancer and neurodegenerative diseases .

HY-131139A

Ganglioside GD3 diammonium	Apoptosis	Neurological Disease Cancer
Ganglioside GD3 diammonium is an acidic glycosphingolipid. Ganglioside GD3 diammonium inhibits the proliferation of cancer cells, affects the opening of the mitochondrial permeability transition pore (PTPC), induces apoptosis and activates caspase family. Ganglioside GD3 diammonium can be used in research about cancer and neurodegenerative diseases .

HY-W747597

Ganglioside GD1b Disodium Salt (Bovine Brain) Disialoganglioside GD1b; Ganglioside C1; Ganglioside G2	Endogenous Metabolite	Cancer
Ganglioside GD1b Disodium Salt (Bovine Brain) (Disialoganglioside GD1b; Ganglioside C1) is an acidic glycosphingolipid containing two sialic acid residues linked to an internal galactose unit. Ganglioside GD1b Disodium Salt tightly packs with cholesterol to form lipid microdomains that modulate intracellular and intercellular signaling events. Concentrations of Ganglioside GD1b Disodium Salt (Bovine Brain) in the human brain increase with age and are positively correlated with pilocytic astrocytoma tumor grade. Ganglioside GD1b Disodium Salt has been detected in various other gliomas, including primitive neuroectodermal tumors, glioblastomas, and anaplastic astrocytomas.

HY-W747599

Ganglioside GQ1b (bovine) sodium Tetrasialoganglioside GQ1b sodium	Biochemical Assay Reagents	Neurological Disease
Ganglioside GQ1b (bovine) sodium promotes neurite outgrowth during early neuronal differentiation. Ganglioside GQ1b (bovine) sodium controls the neuronal differentiation process in mESCs .

HY-148385

Ganglioside GM2	Endogenous Metabolite Integrin FAK Src ERK p38 MAPK	Neurological Disease Cancer
Ganglioside GM2 is a human tumor antigen predominantly found in human tumor cells and fetal brain tissue. As a sialylated glycosphingolipid, Ganglioside GM2 is involved in processes such as cell signaling, adhesion, and motility. Ganglioside GM2 abnormal expression and accumulation are associated with tumors and neurodegenerative disorders. Ganglioside GM2 promotes tumor cell migration and invasion by directly binding to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, and inducing actin cytoskeleton remodeling .

HY-165160

*N-Glycolyl-ganglioside* GM3 ammonium** GM3-Neugc ammonium; NeuGc-GM3 ammonium	Biochemical Assay Reagents	Others
N-Glycolyl-ganglioside GM3 ammonium is a biochemical reagent.

HY-171908A

GD3βSph ammonium GD3 Sphingosine (d18:1) ammonium	Biochemical Assay Reagents	Neurological Disease Cancer
GD3βSph (ammonium) (GD3 Sphingosine (d18:1) (ammonium)) is a form of ganglioside G_D3 without the fatty acyl group. GD3βSph (ammonium) can be studied in ganglioside cancer research .

HY-141569

Ganglioside GD1a	Toll-like Receptor (TLR)	Inflammation/Immunology
Ganglioside GD1a modulates toxic and inflammatory effects of E. coli lipopolysaccharide by preventing TLR4 translocation into lipid rafts. Ganglioside GD1a significantly reduces the effect of LPS on the decrease of cell survival and on stimulation of reactive oxygen species production .

HY-165650S

*C16 Ganglioside* GM1-d9 (d18:1/16:0) ammonium** C16-GM1-d₉ ammonium; N-Hexadecaoyl-d₉ (13,13,14,14,15,15,16,16,16)-moosialogaglioside GM1 ammonium	Isotope-Labeled Compounds	Others
C16 Ganglioside GM1-d₉ (d₁₈:1/16:0) (C16 GM1-d₉) ammonium salt is deuterium labeled C16 Ganglioside GM1 (d18:1/16:0) (ammonium) .

HY-165676AS

*C16 Ganglioside* GM2-d9 (d18:1/16:0-d9) ammonium salt** C16 GM2-dN_{; N-CD}N_{-Palmitoyl-GM2, N-Hexadecaoyl-d}N_{(13,13,14,14,15,15,16,16,16)-Moosialogaglioside GM2; N-Palmitoyl Moosialogaglioside GM2-d₉}	Isotope-Labeled Compounds	Others
C16 Ganglioside GM2-d₉ (d₁₈:1/16:0-d₉) (C16 GM2-d₉) ammonium saltis deuterium labeled C16 Ganglioside GM2 (d18:1/16:0) (ammonium salt) .

HY-W127324

Ganglioside GM3 (phyto-type) NeuAcα(2-3)Galβ(1-4)Glc-ceramide (phyto-type)	Biochemical Assay Reagents	Others
Ganglioside GM3 (phyto-type) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W127461

Ganglioside GM2, Asialo Gangliotriosylceramide	Biochemical Assay Reagents	Others
Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length.

HY-P10998

Tet1 peptide	TET Protein	Neurological Disease
Tet1 peptide is neuron-specific ligand for GT1B gangliosides. Tet1 peptide can be used as a ligand for targeted delivery of functionalized polymersomes .

HY-N7575

Lacto-N-fucopentaose II LNFP II	Endogenous Metabolite	Metabolic Disease Cancer
Lacto-N-fucopentaose II (LNFP II) is a sialyl-Lewis, hapten of human Lewis bloodgroup determinant. Lacto-N-fucopentaose II monosialo-ganglioside/glycolipid and sialyl derivative, CA 19-9, is a molecular tumour markers (TM) for biliopancreatic malignancy .

HY-N7390

Cholesterol glucuronide	Endogenous Metabolite	Metabolic Disease
Cholesterol glucuronide is an endogenous metabolite of lipid generated in the liver by UDP glucuonyltransferase .

HY-N10526

Isoglobotriaose Gala-3Galb-4Glc	Others	Others
Isoglobotriaose (Gala-3Galb-4Glc) is a glycosphingolipid found in mammalian tissues. Isoglobotriaose is an analogue of Globotriaose, the ganglioside derivatives of them locate in difference position of small intestine, isoglobotriaosylceramide is restricted to the nonepithelial residue, while globotriaosylceramide is in both compartments .

HY-P3394

Cholera toxin B subunit, from vibrio cholerae CTB, from vibrio cholerae	Biochemical Assay Reagents	Others
Cholera toxin B subunit, from vibrio cholerae (CTB, from vibrio cholerae) is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. Cholera toxin B subunit, from vibrio cholerae attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. Cholera toxin B subunit, from vibrio cholerae has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Cholera toxin B subunit, from vibrio cholerae has been widely used as a marker of membrane lipid rafts .

HY-P9914

Eculizumab 1 Publications Verification Anti-Human C5, Humanized Antibody	Complement System	Cardiovascular Disease Neurological Disease
Eculizumab (Anti-Human C5, Humanized Antibody) is a long-acting humanized monoclonal antibody targeted against complement C5. Eculizumab inhibits the cleavage of C5 into C5a and C5b and inhibits deployment of the terminal complement system including the formation of membrane attack complex (MAC). Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in mice. Eculizumab can be used in hemolysis studies .

HY-E70049

beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) GM2/GD2 synthase	Others	Neurological Disease
beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) (GM2/GD2 synthase) is a key enzyme which catalyzes the conversion of GM3, GD3 and lactosylceramide (LacCer) to GM2, GD2 and asialo-GM2 (GA2), respectively. beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) is a key enzyme to control the synthesis of brain-enriched complex gangliosides .

HY-W342441

Monosialoganglioside GM3 (bovine)	VEGFR Akt Ferroptosis Insulin Receptor	Metabolic Disease Cancer
Monosialoganglioside GM3 (bovine) is a monosialoganglioside and an inhibitor of VEGFR2 and Akt. At a concentration of 20 μM, Monosialoganglioside GM3 inhibits angiogenesis and reduces the proliferation and migration of human umbilical vein endothelial cells (HUVECs) by inhibiting VEGFR2 and Akt phosphorylation. Ganglioside GM3 also inhibits ferroptosis, providing protective effects during the formation of abdominal aortic aneurysms. Additionally, Monosialoganglioside GM3 (bovine) acts as an inhibitor of insulin signaling, inducing the dissociation of the insulin receptor (IR)-Caveolin-1 complex from lipid microdomains and causing insulin resistance in adipocytes. Monosialoganglioside GM3 (bovine) can be used in cancer and metabolic disease research .

HY-N10534

Lewis X trisaccharide Lewis X	Parasite	Infection Inflammation/Immunology Cancer
Lewis X trisaccharide (Lewis X, Le ^x) is a potent T_H2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis .

Cat. No.	Product Name	Type

HY-P3394

Cholera toxin B subunit, from vibrio cholerae CTB, from vibrio cholerae	Native Proteins
Cholera toxin B subunit, from vibrio cholerae (CTB, from vibrio cholerae) is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. Cholera toxin B subunit, from vibrio cholerae attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. Cholera toxin B subunit, from vibrio cholerae has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Cholera toxin B subunit, from vibrio cholerae has been widely used as a marker of membrane lipid rafts .

Cholera toxin B subunit, from vibrio cholerae

CTB, from vibrio cholerae

Native Proteins

Cholera toxin B subunit, from vibrio cholerae (CTB, from vibrio cholerae) is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. Cholera toxin B subunit, from vibrio cholerae attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. Cholera toxin B subunit, from vibrio cholerae has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Cholera toxin B subunit, from vibrio cholerae has been widely used as a marker of membrane lipid rafts .

HY-W127324

Ganglioside GM3 (phyto-type) NeuAcα(2-3)Galβ(1-4)Glc-ceramide (phyto-type)	Biochemical Assay Reagents
Ganglioside GM3 (phyto-type) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W127461

Ganglioside GM2, Asialo

Gangliotriosylceramide

Drug Delivery

Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length.

HY-E70147

ST3 β-Gal α-2,3-Sialyltransferase 6

EC:2.4.99.; ST3GAL6; Type 2 lactosamine α-2,3-sialyltransferase

Enzyme Substrates

ST3 beta-Gal alpha-2,3-Sialyltransferase 6 (EC:2.4.99., ST3GAL6; SIAT10, Type 2 lactosamine alpha-2,3-sialyltransferase) transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. ST3 beta-Gal alpha-2,3-Sialyltransferase 6 play an important role in cancer .

Cat. No.	Product Name	Target	Research Area

HY-P10529

Ganglioside GM1-binding peptides p3	Trk Receptor	Infection
Ganglioside GM1-binding peptides p3 is a synthetic peptide that can specifically bind to the pentasaccharide part of GM1 ganglioside. The dynamic transformation of Ganglioside GM1-binding peptides p3 may play an important role in the function of GM1 as a multiple receptor, such as in the classical pathway of cholera toxin infection. Ganglioside GM1-binding peptides p3 can be used to study the interaction between GM1 and its ligands .

HY-P10998

Tet1 peptide	TET Protein	Neurological Disease
Tet1 peptide is neuron-specific ligand for GT1B gangliosides. Tet1 peptide can be used as a ligand for targeted delivery of functionalized polymersomes .

Cat. No.	Product Name	Target	Research Area

HY-P99873

Ecromeximab KM 871; KW 2871	Inhibitory Antibodies	Others
Ecromeximab (KM 871; KW 2871) is a mouse-derived IgG-κ chimeric antibody targeting ganglioside GD3. Ecromeximab is expressed by YB2/0 rat hybridoma cells .

HY-P99254

Racotumomab 1E10	Inhibitory Antibodies	Inflammation/Immunology Cancer
Racotumomab (Anti-Human NGcGM3 Recombinant Antibody) is an anti-idiotype monoclonal antibody (MAb). Racotumomab reacts to Neu-glycolyl (NeuGc)-containing gangliosides, sulfatides, and other antigens expressed in tumors. Racotumomab is an active anticancer agent for lung cancer .

HY-P9914

Eculizumab 1 Publications Verification Anti-Human C5, Humanized Antibody	Complement System	Cardiovascular Disease Neurological Disease
Eculizumab (Anti-Human C5, Humanized Antibody) is a long-acting humanized monoclonal antibody targeted against complement C5. Eculizumab inhibits the cleavage of C5 into C5a and C5b and inhibits deployment of the terminal complement system including the formation of membrane attack complex (MAC). Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in mice. Eculizumab can be used in hemolysis studies .

HY-P99743

Mitumomab	Biochemical Assay Reagents	Cancer
Mitumomab is an anti-idiotypic mouse IgG2b monoclonal antibody that mimics the ganglioside GD3. Mitumomab can be used for the research of small-cell lung carcinoma .

HY-P990902A

Atigotatug (FUT8-KO) BMS-986012 (FUT8-KO)	Inhibitory Antibodies	Cancer
Atigotatug (FUT8-KO) is an anti-fuc-GM1 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out, and fucose deficiency enhances the ADCC effect of the antibody. Atigotatug (HY-P990902) is a *Fucosyl ganglioside* GM1 (fuc-GM1)**-targeting IgG1κ type humanized antibody. Atigotatug can induce immune-mediated tumor cell death, such as small cell lung cancer .

HY-P990845

*Anti-Ganglioside* GD2 Antibody (14G2a)**	Inhibitory Antibodies	Others
Anti-Ganglioside GD2 Antibody (14G2a) is a kind of mouse IgG2a, κ chimeric antibody, targeting to human Ganglioside GD2. The recommend isotype control of Anti-Ganglioside GD2 Antibody (14G2a): Mouse IgG2a kappa, Isotype Control (HY-P99978).

HY-P990916

Donitabart	Inhibitory Antibodies	Inflammation/Immunology
HY-P990916 is an ganglioside GD2-targeting IgG1κ type chimeric humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990902

Atigotatug BMS-986012	Inhibitory Antibodies	Inflammation/Immunology
HY-P990902 is an *Fucosyl ganglioside* GM1 (fuc-GM1)**-targeting IgG1κ type humanized antibody. Atigotatug can induce immune-mediated tumor cell death, such as small cell lung cancer . The recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10546

Ganglioside GM1	Structural Classification Natural Products Animals	Others
Ganglioside GM1 is a member of the ganglioside family that can be used for neurological disease research. Ganglioside GM1 is a functional tissue receptor for the Cholera Toxin1 .

HY-N7575

Lacto-N-fucopentaose II LNFP II	Structural Classification Polysaccharides Classification of Application Fields Source classification Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Cancer	Endogenous Metabolite
Lacto-N-fucopentaose II (LNFP II) is a sialyl-Lewis, hapten of human Lewis bloodgroup determinant. Lacto-N-fucopentaose II monosialo-ganglioside/glycolipid and sialyl derivative, CA 19-9, is a molecular tumour markers (TM) for biliopancreatic malignancy .

HY-N10534

Lewis X trisaccharide Lewis X	Infection Structural Classification Natural Products Polysaccharides Animals Classification of Application Fields Inflammation/Immunology Disease Research Fields Saccharides Cancer	Parasite
Lewis X trisaccharide (Lewis X, Le ^x) is a potent T_H2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis .

HY-N10511

*GM1a Ganglioside* oligosaccharide**	Structural Classification Natural Products Polysaccharides Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides	Others
GM1a Ganglioside oligosaccharide is a semisynthetic form of ganglioside GM1. Ganglioside GM1 is the natural receptor for cholera toxin and plays an important role not only in general growth regulation but also in the coupling of hormone-induced responses .

HY-N7390

Cholesterol glucuronide	Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Cholesterol glucuronide is an endogenous metabolite of lipid generated in the liver by UDP glucuonyltransferase .

HY-N10526

Isoglobotriaose Gala-3Galb-4Glc	Structural Classification Natural Products Microorganisms	Others
Isoglobotriaose (Gala-3Galb-4Glc) is a glycosphingolipid found in mammalian tissues. Isoglobotriaose is an analogue of Globotriaose, the ganglioside derivatives of them locate in difference position of small intestine, isoglobotriaosylceramide is restricted to the nonepithelial residue, while globotriaosylceramide is in both compartments .

Cat. No.	Product Name	Chemical Structure

HY-146876S

*C18:0 GM1 Ganglioside-d5 ammonium*
C18:0 GM1 Ganglioside-d₅ (ammonium) is deuterium labeled C18:0 GM1 Ganglioside (ammonium).

HY-166325A

Ganglioside GD3-d3 ammonium
Ganglioside GD3-d₃ ammonium is the deuterium labeled Ganglioside GD3 ammonium. Ganglioside GD3 ammonium is an ester product.

HY-114456S

Ganglioside GM3-d7

Ganglioside GM3-d₇ is deuterium labeled Ganglioside GM3. Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia .

HY-152002S

Ganglioside GM3-d3 ammonium
Ganglioside GM3-d3 ammonium is a deuterated labeled Ganglioside GM3 ammonium .

HY-152003S

Ganglioside GM2-d3 ammonium

Ganglioside GM2-d₃ (ammonium) is the deuterium labeled Ganglioside GM2 (HY-148385). Ganglioside GM2 is a human tumor antigen predominantly found in human tumor cells and fetal brain tissue. As a sialylated glycosphingolipid, Ganglioside GM2 is involved in processes such as cell signaling, adhesion, and motility. Ganglioside GM2 abnormal expression and accumulation are associated with tumors and neurodegenerative disorders. Ganglioside GM2 promotes tumor cell migration and invasion by directly binding to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, and inducing actin cytoskeleton remodeling .

HY-114456AS

Ganglioside GM3-d5 Bovine Milk ammonium salt
Ganglioside GM3-d₅ (Bovine Milk ammonium salt) is deuterium labeled Ganglioside GM3 (Bovine Milk ammonium salt).

HY-165665S

*C16 Ganglioside* GM3-d9 ammonium salt**
C16 Ganglioside GM3-d₉ (ammonium salt) is deuterium labeled C16 Ganglioside GM3 (ammonium salt) .

HY-152000S

*C18 Ganglioside* GM1-d3 ammonium**
C18 Ganglioside GM1-d₃ (ammonium) is deuterium labeled C18 Ganglioside GM1 (ammonium) .

HY-165650S

*C16 Ganglioside* GM1-d9 (d18:1/16:0) ammonium**
C16 Ganglioside GM1-d₉ (d₁₈:1/16:0) (C16 GM1-d₉) ammonium salt is deuterium labeled C16 Ganglioside GM1 (d18:1/16:0) (ammonium) .

HY-165676AS

*C16 Ganglioside* GM2-d9 (d18:1/16:0-d9) ammonium salt**
C16 Ganglioside GM2-d₉ (d₁₈:1/16:0-d₉) (C16 GM2-d₉) ammonium saltis deuterium labeled C16 Ganglioside GM2 (d18:1/16:0) (ammonium salt) .

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