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endonuclease-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Endonuclease (1) AP-1 (1) Apoptosis (1) ATM/ATR (1) Autophagy (3) DNA/RNA Synthesis (7) FLAP (7) HIF/HIF Prolyl-Hydroxylase (1) MDM-2/p53 (1) NF-κB (1) Parasite (5) Reactive Oxygen Species (ROS) (1) Topoisomerase (2) VEGFR (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (1) Infection (2) Neurological Disease (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Targets Recommended: Endonuclease

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1099

Hycanthone 2 Publications Verification	DNA/RNA Synthesis Topoisomerase Parasite	Infection
Hycanthone is a thioxanthenone DNA intercalator and inhibits RNA synthesis as well as the DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibits apurinic endonuclease-1 (APE1) by direct protein binding with a K_D of 10 nM. Hycanthone is a bioactive metabolite of Lucanthone (HY-B2098) and has anti-schistosomal agent ^[1].

HY-B2098

Lucanthone	Autophagy Parasite	Cancer
Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).

HY-136485

FEN1-IN-4 1 Publications Verification	FLAP	Cancer
FEN1-IN-4 (Compound 2) is a human flap endonuclease-1 (hFEN1) inhibitor ^[1].

HY-153790

FEN1-IN-5	FLAP	Cancer
FEN1-IN-5 (compound 12A) is a potent inhibitor of Flap *endonuclease-1* (FEN1, IC₅₀=12 nM), involving in DNA repair ^[1].

HY-136484

FEN1-IN-3	FLAP	Cancer
FEN1-IN-3 (Compound 4) is a human flap endonuclease-1 (hFEN1) inhibitor. FEN1-IN-3 stabilizes hFEN1 with an EC₅₀ of 6.8 μM ^[1].

HY-B1099R

Hycanthone (Standard)	DNA/RNA Synthesis Topoisomerase Parasite	Infection
Hycanthone (Standard) is the analytical standard of Hycanthone. This product is intended for research and analytical applications. Hycanthone is a thioxanthenone DNA intercalator and inhibits RNA synthesis as well as the DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibits apurinic endonuclease-1 (APE1) by direct protein binding with a KD of 10 nM. Hycanthone is a bioactive metabolite of Lucanthone (HY-B2098) and has anti-schistosomal agent ^[1].

HY-B2098A

Lucanthone hydrochloride	Autophagy Parasite	Cancer
Lucanthone hydrochloride is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).

HY-133795

Lucanthone N-oxide	DNA/RNA Synthesis	Others
Lucanthone N-oxide is the nitrogen oxide of Lucanthone (HY-B2098), an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1) ^[1].

HY-B2098R

Lucanthone (Standard)	Autophagy Parasite	Cancer
Lucanthone (Standard) is the analytical standard of Lucanthone. This product is intended for research and analytical applications. Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).

HY-153791

FEN1-IN-6	FLAP	Cancer
FEN1-IN-6 (compound 9) is a potent inhibitor of Flap *endonuclease-1* (FEN1, IC₅₀=10 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-6 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC₅₀ value of 23 nM ^[1].

HY-153792

FEN1-IN-7	FLAP	Cancer
FEN1-IN-7 (compound 16) is a selective inhibitor of Flap *endonuclease-1* (FEN1, IC₅₀=18 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-7 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC₅₀ value of 3.04 μM. FEN1-IN-7 increases the cellular sensitivity of cancer cells to potent DNA alkylating agents or methylating agents ^[1].

HY-122695

FEN1-IN-2 1 Publications Verification	FLAP	Cancer
FEN1-IN-2 (compound 20) is a flap endonuclease 1 (FEN1) inhibitor, with IC50 values of 3 nM and 226 nM for FEN1 and XPG, respectively ^[1].

HY-145758

FEN1-IN-SC13 1 Publications Verification	Endonuclease	Cancer
FEN1-IN-SC13 is a potent DNA fragmentation endonuclease 1 *(FEN1)* inhibitor with antitumor activity. FEN1-IN-SC13 interferes with DNA replication and repair in vitro and in cells ^[1].

HY-119993

AR03 BMH-23	DNA/RNA Synthesis	Cancer
AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC₅₀ of 2.1 µM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells ^[1].

HY-136731

APE1-IN-1	DNA/RNA Synthesis	Cancer
APE1-IN-1 is a potent and blood-brain barrier (BBB) penetrant apurinic/apyrimidinic (AP) endonuclease 1 (APE1) inhibitor with an IC₅₀ value of 2 μM. APE1-IN-1 can potentiate the cytotoxicity of the alkylating agents Methylmethane sulfonate and Temozolomide (HY-17364) to cancer cells ^[1].

HY-151883

APE1-IN-2	Apoptosis MDM-2/p53	Cancer
APE1-IN-2 (compound AP1) is a Pt(IV) proagent, targeting a critical BER protein, apurinic/apyrimidinic endonuclease 1 (APE1). APE1-IN-2 shows anticancer activity. APE1-IN-2 induces intracellular accumulation of platinum and activates DNA damage response and apoptosis signals ^[1].

HY-W014622

CRT0044876 2 Publications Verification	DNA/RNA Synthesis	Cancer
CRT0044876 is a potent and selective apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor (IC₅₀=~3 μM). CRT0044876 inhibits the AP endonuclease, 3′-phosphodiesterase and 3′-phosphatase activities of APE1, and is a specific inhibitor of the exonuclease III family of enzymes to which APE1 belongs. CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds ^[1].

HY-19357

Erenapurstat 3 Publications Verification E3330; APX-3330	DNA/RNA Synthesis NF-κB AP-1 HIF/HIF Prolyl-Hydroxylase VEGFR Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease Cancer
Erenapursta (E3330) is a direct, orally active and selective inhibitor of **Ape-1 (apurinic/apyrimidinic endonuclease 1)/Ref-1 (redox factor-1) redox. Erenapursta is able to impair tumor growth and blocks the activity of NF-κB, AP-1, and HIF-1α** in pancreatic cancer. Erenapursta shows anticancer activities ^[1] .

HY-123834

FEN1-IN-1 Maximum Cited Publications 6 Publications Verification	FLAP ATM/ATR	Cancer
FEN1-IN-1 (compound 1) is a small molecule flap endonuclease 1 (FEN1) inhibitor with antitumor activity. FEN1-IN-1 binds to the active site of *FEN1* and partly achieves inhibition by the co-ordination of Mg ²⁺ ions. FEN1-IN-1 initiaties a DNA damage response and activates the ATM checkpoint signalling pathway, the phosphorylation of histone H2AX and the ubiquitination of FANCD2 in mammalian cells. FEN1-IN-1 is promising for research of cancers ^[1].

Species:	Human (2)
Tag:	His (1) Tag Free (1) Myc (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P70348

	*Flap endonuclease 1/FEN-1 Protein, Human* rHuFlap endonuclease 1/FEN-1; Flap endonuclease 1; FEN-1; DNase IV; Flap Structure-Specific endonuclease 1; Maturation Factor 1; MF1; hFEN-1; FEN1; RAD2	Human	E. coli
	Flap endonuclease 1 (FEN-1) is a structure-specific nuclease crucial for DNA replication and repair. In replication, it cleaves 5'-overhanging flaps, guiding DNA polymerase and creating a nick for ligation. FEN-1 is integral to the long patch base excision repair pathway, preventing genomic instability. It exhibits 5'-3' exonuclease and RNase H activities, playing roles in rDNA and mitochondrial DNA replication and repair. Flap endonuclease 1/FEN-1 Protein, Human is the recombinant human-derived Flap endonuclease 1/FEN-1 protein, expressed by E. coli , with tag free.

HY-P700010

	*Flap endonuclease 1/FEN-1 Protein, Human (His, Myc)* rHuFlap endonuclease 1/FEN-1; Flap endonuclease 1; FEN-1; DNase IV; Flap Structure-Specific endonuclease 1; Maturation Factor 1; MF1; hFEN-1; FEN1; RAD2	Human	E. coli
	Flap endonuclease 1 (FEN-1) is a structure-specific nuclease crucial for DNA replication and repair. In replication, it cleaves 5'-overhanging flaps, guiding DNA polymerase and creating a nick for ligation. FEN-1 is integral to the long patch base excision repair pathway, preventing genomic instability. It exhibits 5'-3' exonuclease and RNase H activities, playing roles in rDNA and mitochondrial DNA replication and repair. Flap endonuclease 1/FEN-1 Protein, Human (His, Myc) is the recombinant human-derived Flap endonuclease 1/FEN-1 protein, expressed by E. coli , with N-10*His, C-Myc labeled tag.

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HY-P80669

	FEN1 Antibody (YA765) FEN1; RAD2; Flap endonuclease 1; FEN-1; DNase IV; Flap structure-specific endonuclease 1; Maturation factor 1; MF1; hFEN-1	WB, IP	Human, Mouse, Rat
	FEN1 Antibody (YA765) is a non-conjugated and Mouse origined monoclonal antibody about 43 kDa, targeting to FEN1 (1E7). It can be used for WB,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P82375

	APE1 Antibody (YA2120) APEX1; APE; APE1; APEX; APX; HAP1; REF1; DNA-(apurinic or apyrimidinic site) lyase; APEX nuclease; APEN; Apurinic-apyrimidinic endonuclease 1; AP endonuclease 1; APE-1; REF-1; Redox factor-1	WB	Human, Mouse, Rat
	APE1 Antibody (YA2120) is a non-conjugated IgG antibody, targeting APE1, with a predicted molecular weight of 36 kDa (observed band size: 36 kDa). APE1 Antibody (YA2120) can be used for WB experiment in human, mouse, rat background.

HY-P85602

	FEN-1 Antibody (YA5294) DNase IV; FEN-1; FEN1; FEN1_HUMAN; Flap endonuclease 1; Flap structure specific endonuclease 1; Flap structure-specific endonuclease 1; hFEN-1; hFEN1; Maturation factor 1; MF1; Rad2.	WB, ICC	Human, Mouse, Rat, Monkey, Hamster
	FEN-1 Antibody (YA5294) is a mouse-derived and non-conjugated monoclonal antibody, targeting to FEN-1. It can be applicated for WB, ICC assays, in the background of human, mouse, rat, monkey, hamster.

HY-P85603

	FEN-1 Antibody (YA5295) DNase IV; FEN-1; FEN1; FEN1_HUMAN; Flap endonuclease 1; Flap structure specific endonuclease 1; Flap structure-specific endonuclease 1; hFEN-1; hFEN1; Maturation factor 1; MF1; Rad2.	WB, IP	Human, Mouse, Rat
	FEN-1 Antibody (YA5295) is a mouse-derived and non-conjugated monoclonal antibody, targeting to FEN-1. It can be applicated for WB, IP assays, in the background of human, mouse, rat.

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