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dissociation constant

" in MedChemExpress (MCE) Product Catalog:

39

Inhibitors & Agonists

1

Fluorescent Dye

4

Biochemical Assay Reagents

8

Peptides

6

Natural
Products

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-23430A
    TES sodium

    		Biochemical Assay Reagents Others
    TES sodium is an excellent hydrogen ion buffer. TES sodium has characteristics such as an appropriate dissociation constant, a low metal-binding constant, and high water solubility. TES sodium can be used in the research of mammalian cell culture, viruses, and so on .
    TES sodium
  • HY-23430
    TES

    		Biochemical Assay Reagents Others
    TES is an excellent hydrogen ion buffer. TES has characteristics such as an appropriate dissociation constant, a low metal-binding constant, and high water solubility. TES can be used in the research of mammalian cell culture, viruses, and so on .
    TES
  • HY-15294
    CZC24832

    		PI3K Inflammation/Immunology Cancer
    CZC24832 is a highly selective and potent PI3Kγ inhibitor (IC50=27 nM) with apparent dissociation constants (Kd app) of 19 nM.
    CZC24832
  • HY-W015752
    5-Methoxyresorcinol

    		Drug Intermediate Others
    5-Methoxyresorcinol is a model molecule of the A ring of flavonoids, specifically simulating the chemical behavior of the resorcinol-type A ring found in catechins. 5-Methoxyresorcinol exhibits extremely low reactivity of tocopherol. 5-Methoxyresorcinol hardly inhibits cholesteryl ester transfer protein (CETP) .
    5-Methoxyresorcinol
  • HY-121251
    BI-167107
    1 Publications Verification

    		 Adrenergic Receptor Neurological Disease Endocrinology Cancer
    BI-167107 is a high affinity, full agonist that binds to the β2 adrenergic receptor (β2AR) with a dissociation constant Kd of 84 pM .
    BI-167107
  • HY-W341997
    9-Octadecynoic acid

    		PPAR Metabolic Disease
    9-Octadecynoic acid is a DNA binding agent with a dissociation constant of 1.8 mM. 9-Octadecynoic acid is also an agonist for peroxisome proliferator-activated receptor γ (PPARγ) .
    9-Octadecynoic acid
  • HY-116138
    RG-14467

    		EGFR Others
    RG-14467 is an epidermal growth factor receptor tyrosine kinase inhibitor with activity that inhibits enzyme activity. RG-14467 has similar inhibition kinetics to Lavendustin-A, with a dissociation constant of 3.4μM for the initial rapidly formed complex and an overall dissociation constant estimated to be less than or equal to 30nM, and is a partially competitive inhibitor for ATP.
    RG-14467
  • HY-157820
    Galectin-4-IN-2

    		Galectin Others
    Galectin-4-IN-2 (compound 12) is an inhibitor of galectin 4C with a galectin dissociation constant of 1.6 mM .
    Galectin-4-IN-2
  • HY-138143
    N-(p-Tosyl)-GPR-pNA acetate

    Chromozym-TH

    		 Fluorescent Dye Others
    N-(p-Tosyl)-GPR-pNA acetate (Chromozym-TH) is a chromogenic substrate targeting the synthetic peptides Hirunorm IV and Hirunorm V and can be used to detect the dissociation constants (KI) of both peptides. Hirunorm IV and Hirunorm V are reversible inhibitors of amidolytic thrombin activity. By varying the peptide concentration at a fixed concentration of the chromogenic substrate N-(p-Tosyl)-GPR-pNA acetate, the dissociation constants determined were 0.134 nM (Hirunorm IV) and 0.245 nM (Hirunorm V) .
    N-(p-Tosyl)-GPR-pNA acetate
  • HY-23430S
    TES-d15

    		Isotope-Labeled Compounds Biochemical Assay Reagents Others
    TES-d15 is the deuterium labeled TES (HY-23430). TES is an excellent hydrogen ion buffer. TES has characteristics such as an appropriate dissociation constant, a low metal-binding constant, and high water solubility. TES can be used in the research of mammalian cell culture, viruses, and so on .
    TES-d15
  • HY-B1920A
    Josamycin hydrochloride

    EN-141 hydrochloride

    		 Antibiotic Bacterial Infection
    Josamycin (EN-141) hydrochloride is an orally active macrolide antibiotic exhibiting antimicrobial activity against a wide spectrum of pathogens, such as bacteria. The dissociation constant Kd from ribosome for Josamycin hydrochloride is 5.5 nM .
    Josamycin hydrochloride
  • HY-B1920
    Josamycin

    EN-141

    		 Bacterial Antibiotic Infection
    Josamycin (EN-141) is an orally active macrolide antibiotic exhibiting antimicrobial activity against a wide spectrum of pathogens, such as bacteria. The dissociation constant Kd from ribosome for Josamycin is 5.5 nM .
    Josamycin
  • HY-162960
    pan-KRAS degrader 1

    		Ras Cancer
    pan-KRAS degrader 1 (Compound 1) is a panKRAS degrader with a surface plasmon resonance (SPR) dissociation constant Ki value of 25 nM for KRAS G12V .pan-KRAS degrader 1 has antitumor activity .
    pan-KRAS degrader 1
  • HY-153967
    BLU0588
    1 Publications Verification

    		 PKA Cancer
    BLU0588 is an orally active, potent and selective PRKACA (protein kinase cAMP-activated catalytic subunit alpha) kinase inhibitor, with an IC50 of 1 nM and dissociation constant (Kd) of 4 nM. BLU0588 can be used for fibrolamellar carcinoma (FLC) research .
    BLU0588
  • HY-N2319
    Dihydroergocristine mesylate

    DHEC mesylate

    		 Amyloid-β Neurological Disease
    Dihydroergocristine mesylate (DHEC mesylate) is a inhibitor of γ-secretase (GSI), reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (Kd) of 25.7 nM and 9.8 μM, respectively .
    Dihydroergocristine mesylate
  • HY-P2355
    BOC-FlFlF

    BOC2; Boc-Phe-dLeu-Phe-dLeu-Phe

    		 Formyl Peptide Receptor (FPR) Inflammation/Immunology
    BOC-FlFlF (Boc-Phe-dLeu-Phe-dLeu-Phe) is a selective FPR1 antagonist. Boc-FlFlF has an apparent dissociation constant (KD) of 230 nM as determined by the intracellular calcium mobilization assay. Boc-FlFlF can be used for the study of inflammation .
    BOC-FlFlF
  • HY-P2355A
    BOC-FlFlF TFA

    BOC2 TFA; Boc-Phe-dLeu-Phe-dLeu-Phe TFA

    		 Formyl Peptide Receptor (FPR) Inflammation/Immunology
    BOC-FlFlF (TFA) (Boc-Phe-dLeu-Phe-dLeu-Phe (TFA)) is a selective FPR1 antagonist. BOC-FlFlF has an apparent dissociation constant (KD) of 230 nM as determined by the intracellular calcium mobilization assay. BOC-FlFlF can be used for the study of inflammation .
    BOC-FlFlF TFA
  • HY-N13361
    Elodeoidileon A

    		RAR/RXR Neurological Disease
    Elodeoidileon A is an agonist for RXRα, that interacts with RXRα-LBD protein with a dissociation constant Kd of 5.85 μM. Elodeoidileon A promotes the expression of ATP-binding cassette transporter A1 (ABCA1). Elodeoidileon A reveals the potential in Alzheimer's disease research .
    Elodeoidileon A
  • HY-B1920R
    Josamycin (Standard)

    EN-141 (Standard)

    		 Reference Standards Bacterial Antibiotic Infection
    Josamycin (Standard) is the analytical standard of Josamycin. This product is intended for research and analytical applications. Josamycin (EN-141) is an orally active macrolide antibiotic exhibiting antimicrobial activity against a wide spectrum of pathogens, such as bacteria. The dissociation constant Kd from ribosome for Josamycin is 5.5 nM .
    Josamycin (Standard)
  • HY-157659
    WDR5-MLL1 antagonist 1

    		WDR5 Others
    WDR5-MLL1 antagonist 1 (compound 47) is a compound optimized through protein crystal structure guidance. It has stronger antagonistic activity against WDR5-MLL interaction with a dissociation constant (Kd) of 0.3μM.
    WDR5-MLL1 antagonist 1
  • HY-P3717
    Targefrin

    		Ephrin Receptor Cancer
    Targefrin is a potent EphA2-targeting agent, acts as an antagonist. Targefrin binds EphA2-LBD with 21 nM dissociation constant and an IC50 value of 10.8 nM. Targefrin induces cellular receptor internalization and degradation in several pancreatic cancer cell lines .
    Targefrin
  • HY-113646
    Shield-2

    		FKBP Others
    Shield-2 is an efficient stabilizing ligand binding to the FKBP (F36V) protein with a dissociation constant of 29 nM. Shield-2 binds tightly to the FKBP mutants destabilizing domains and prevents degradation, thus providing small molecule regulation over intracellular protein levels .
    Shield-2
  • HY-D0861
    EGTA
    Maximum Cited Publications
    18 Publications Verification

    		 Biochemical Assay Reagents Inflammation/Immunology
    EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca 2+ over Mg 2+ (Mg 2+ Kd 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages .
    EGTA
  • HY-D0861A
    EGTA tetrasodium
    Maximum Cited Publications
    18 Publications Verification

    		 Biochemical Assay Reagents Inflammation/Immunology
    EGTA tetrasodium is a specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca 2+ over Mg 2+ (Mg 2+ Kd 1-10 mM). EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages .
    EGTA tetrasodium
  • HY-N2319R
    Dihydroergocristine mesylate (Standard)

    DHEC mesylate (Standard)

    		 Reference Standards Amyloid-β Neurological Disease
    Dihydroergocristine (mesylate) (Standard) is the analytical standard of Dihydroergocristine (mesylate). This product is intended for research and analytical applications. Dihydroergocristine mesylate (DHEC mesylate) is a inhibitor of γ-secretase (GSI), reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (Kd) of 25.7 nM and 9.8 μM, respectively .
    Dihydroergocristine mesylate (Standard)
  • HY-175861
    NSC20116

    		Drug Derivative E1/E2/E3 Enzyme Cancer
    NSC20116 is a uracil derivative that specifically targets the Set-and-Ring (SRA) domain of the oncogene UHRF1. NSC20116 binds to the 5-methylcytosine (5mC) (HY-W008091) recognition pocket of UHRF1 SRA domain, with a dissociation constant (Kd) of 362 nM. NSC20116 can be used for the study of cancer .
    NSC20116
  • HY-113045
    Aquacobalamin

    		Endogenous Metabolite Metabolic Disease
    Aquacobalamin is one of the major forms of vitamin B12 isolated from mammalian cells. Aquacobalamin accelerates the oxidation of azo-dye Orange II (HY-N1442) by HSO5 - in aqueous solutions. Aquacobalamin binds hydrogen peroxide reversibly to form a cobalt(III) hydroperoxo adduct with a 0.25 mM dissociation constant .
    Aquacobalamin
  • HY-156106
    VHL-IN-1

    		Ligands for E3 Ligase HIF/HIF Prolyl-Hydroxylase Cancer
    VHL-IN-1 (compound 30) is a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor (dissociation constant Kd=37 nM) that stabilizes and induces HIF-1α transcriptional activity. VHL-IN-1 has potential as a HIF-1α stabilizer and degrader of proteolytically targeted chimeras (PROTACs) .
    VHL-IN-1
  • HY-156906
    UNC3474

    		MDM-2/p53 Cancer
    UNC3474 is a small molecule ligand, binding with 53BP1. UNC3474 binds the aromatic methyl-lysine binding cage of 53BP1 TT, with a dissociation constant (Kd) of 1.0 ± 0.3 μM. UNC3474 inhibits the recruitment of 53BP1 to DSBs by stabilizing a pre-existing autoinhibited state of 53BP1 in cells .
    UNC3474
  • HY-103414S
    Raclopride-d5 hydrochloride

    		Isotope-Labeled Compounds Dopamine Receptor Neurological Disease
    Raclopride-d5 hydrochloride is the deuterium labeled Raclopride. Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively .
    Raclopride-d5 hydrochloride
  • HY-P11080
    Oncocin

    		Bacterial Infection
    Oncocin is an antibacterial peptide. It belongs to proline-rich antimicrobial peptides (PrAMPs). Oncocin works against Gram-negative bacteria. It has MIC values of 0.125-8 μg/mL for 34 strains and clinical isolates of Enterobacteriaceae and nonfermenters. Oncocin binds to the substrate-binding domain of the chaperone DnaK. The binding has dissociation constants in the micromolar range. This binding causes protein misfolding and aggregation and the bacteria death .
    Oncocin
  • HY-168440
    Aurora-A ligand 1

    		Ligands for Target Protein for PROTAC Aurora Kinase Cancer
    Aurora-A ligand 1 is a high-affinity and specific Aurora-A inhibitor with a dissociation constant (Kd) value of 0.85 nM. Aurora-A ligand 1 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC Aurora-A degraders with antitumor activity. Aurora-A ligand 1 can be used for the synthesis of HLB-0532259 (HY-168439). HLB-0532259 shows anti-tumor activity against neuroblastoma .
    Aurora-A ligand 1
  • HY-P10931F
    RAD21 (356–395), biotin labeled

    		Fluorescent Dye Cancer
    RAD21 (356–395), biotin labeled is biotin-labeled RAD21 (356–395) (HY-P10931). RAD21 (356–395) is a peptide encompassing amino acids 356 to 395 of the RAD21 protein, which can be used to study the interaction mechanism between STAG1 and RAD21. The equilibrium dissociation constant (KD) value for the interaction between RAD21 (356–395) and STAG1 is 127 nM .
    RAD21 (356–395), biotin labeled
  • HY-111007
    CH5015765

    		HSP Cancer
    CH5015765 is an orally available Hsp90 inhibitor bound to the N-terminal ATP binding site, with a dissociation constant of 3.4 nM, CH5015765 exerts antiproliferative activity against human cancer cell lines, with IC50 values of 0.46 μM for HCT116 colorectal cancer cells and 0.57 μM for NCI-N87 gastric cancer cells. CH5015765 can be used for the study of cancer .
    CH5015765
  • HY-W009756
    N-Phenylnaphthalen-1-amine
    2 Publications Verification

    		 Fluorescent Dye Others
    N-Phenyl-1-naphthylamine is a dye that fluoresces strongly when bound to the inner phospholipid bilayer of Gram-negative bacteria. N-Phenyl-1-naphthylamine can be used to measure outer membrane permeability. N-Phenylnaphthalen-1-amine is a fluorescence probe for odorant-binding proteins (OBP) with a dissociation constant of 1.67 μM. N-Phenylnaphthalen-1-amine exhibits an excitation wavelength of 337 nM and an emission wavelength of 407 nM .
    N-Phenylnaphthalen-1-amine
  • HY-P10827
    PIC1 PA

    		Complement System Inflammation/Immunology
    PIC1 PA, a 15 amino-acid peptide, is a potent PIC1 analog that inhibits classical pathway mediated complement activation. PIC1 PA functionally disrupts the C1s-C1r-C1r-C1s/MASPs interaction with collagen-like region (CLR) of C1q/MBL, respectively. PIC1 PA specifically binds to the CLR of C1q and bounds to purified C1q with a mean equilibrium dissociation constant (KD) of 33.3 nM .
    PIC1 PA
  • HY-173291
    Tau ligand-1

    		Tau Protein Neurological Disease
    Tau ligand-1 (Compound 75) is a ligand for aggregated tau protein that can penetrate the blood-brain barrier . In tissues from patients with Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and Pick's disease, Tau ligand-1 exhibits high affinity for aggregated tau protein, with equilibrium dissociation constant (KD) values ranging from 1 to 3.8 nM . Tau ligand-1 can serve as a potential positron emission tomography (PET) tracer and holds promise for application in positron emission tomography imaging studies of tau-related diseases in the central nervous system .
    Tau ligand-1
  • HY-175253
    YZ-35

    		STAT Apoptosis Cancer
    YZ-35 is a STAT3 inhibitor, with a Ki value of 0.38 μM. YZ-35 binds directly to STAT3 with high affinity, exhibiting a dissociation constant (Kd) of 190 nM. YZ-35 directly attenuates the dual phosphorylation of STAT3 (Tyr705 and Ser727). YZ-35 suppresses colony formation, cellular migration, and induces apoptosis in breast cancer cell lines (BCSC). YZ-35 selectively suppresses BCSC self-renewal. YZ-35 inhibits tumor growth in the BCSC xenograft models. YZ-35 can be used for the study of breast cancer .
    YZ-35
  • HY-160924
    MS147

    		PROTACs E1/E2/E3 Enzyme Cancer
    MS147 is a VHL-based PROTAC degrader of PRC1 (Polycomb Repressive Complex 1). The dissociation constants (Kd) of MS147 for EED (Embryonic Ectoderm Development) and VHL (Von Hippel-Lindau) are 3.0 μM and 450 nM, respectively. MS147 specifically binds to the EED protein through its EED-binding moiety; EED is a core component of PRC2 (Polycomb Repressive Complex 2) and interacts with the core components of PRC1, BMI1 (B-lymphoma Mo-MLV insertion region 1 homolog) and RING1B (Ring Finger Protein 1B). By this binding, MS147 is able to recruit BMI1 and RING1B near to VHL. Through the degradation of BMI1 and RING1B, MS147 reduces the level of H2AK119ub (histone H2A lysine 119 ubiquitination), affecting the proliferation of cancer cells. (Blue: VHL ligand (HY-125845), Black: linker ; Pink: PRC1 ligand (HY-158771)) .
    MS147

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