Raclopride-d₅ hydrochloride

Cat. No.: HY-103414S Purity: 99.82%: Data Sheet
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Raclopride-d₅ hydrochloride is the deuterium labeled Raclopride. Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (K_is) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively.

For research use only. We do not sell to patients.

Raclopride-d<sub>5</sub> hydrochloride Chemical Structure

Raclopride-d₅ hydrochloride Chemical Structure

CAS No. : 1217623-85-2

Size	Stock	Quantity
1 mg	Get quote 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Other Forms of Raclopride-d₅ hydrochloride:

Raclopride In-stock

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•Related Small Molecules:

•Related Proteins:

View All Dopamine Receptor Isoform Specific Products:

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Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

D₃ Receptor

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

352.27

Formula

C₁₅H₁₆D₅Cl₃N₂O₃

CAS No.

1217623-85-2

Unlabeled CAS

98527-32-3

Appearance

Solid

Color

White to off-white

SMILES

C(NC[C@H]1N(C(C([2H])([2H])[2H])([2H])[2H])CCC1)(=O)C2=C(OC)C(Cl)=CC(Cl)=C2O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (283.87 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8387 mL	14.1937 mL	28.3873 mL
5 mM	0.5677 mL	2.8387 mL	5.6775 mL
10 mM	0.2839 mL	1.4194 mL	2.8387 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.82%

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Data Sheet (273 KB) SDS (251 KB)

COA (250 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Seeman P, et al. Dopamine receptor pharmacology. Trends Pharmacol Sci. 1994 Jul;15(7):264-70. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8387 mL	14.1937 mL	28.3873 mL	70.9683 mL
	5 mM	0.5677 mL	2.8387 mL	5.6775 mL	14.1937 mL
	10 mM	0.2839 mL	1.4194 mL	2.8387 mL	7.0968 mL
	15 mM	0.1892 mL	0.9462 mL	1.8925 mL	4.7312 mL
	20 mM	0.1419 mL	0.7097 mL	1.4194 mL	3.5484 mL
	25 mM	0.1135 mL	0.5677 mL	1.1355 mL	2.8387 mL
	30 mM	0.0946 mL	0.4731 mL	0.9462 mL	2.3656 mL
	40 mM	0.0710 mL	0.3548 mL	0.7097 mL	1.7742 mL
	50 mM	0.0568 mL	0.2839 mL	0.5677 mL	1.4194 mL
	60 mM	0.0473 mL	0.2366 mL	0.4731 mL	1.1828 mL
	80 mM	0.0355 mL	0.1774 mL	0.3548 mL	0.8871 mL
	100 mM	0.0284 mL	0.1419 mL	0.2839 mL	0.7097 mL