Search Result
Results for "
dispiro[4,2,5,2]pentadecane-6,10,14-trien moiety
" in MedChemExpress (MCE) Product Catalog:
6
Biochemical Assay Reagents
2
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-N7926
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Parasite
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Inflammation/Immunology
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Pentadecane is a floral volatile antimalarial agent that can inhibit the growth of parasites such as Leishmania and avoid infection of macrophages. The IC50s of Pentadecane against promastigotes and amastigotes are 65.3 μM and 60.5 μM, respectively. Pentadecane also has anti-inflammatory, analgesic, and antipyretic activities .
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- HY-N7926S
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- HY-N7926R
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Parasite
Reference Standards
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Inflammation/Immunology
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Pentadecane (Standard) is the analytical standard of Pentadecane. This product is intended for research and analytical applications. Pentadecane is a floral volatile antimalarial agent that can inhibit the growth of parasites such as Leishmania and avoid infection of macrophages. The IC50s of Pentadecane against promastigotes and amastigotes are 65.3 μM and 60.5 μM, respectively. Pentadecane also has anti-inflammatory, analgesic, and antipyretic activities .
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- HY-N11076
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Others
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Cardiovascular Disease
Cancer
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12E,14-Trien-19-oic acid is a diterpenoid. 12E,14-Trien-19-oic acid can be isolated from Bhutanese medicinal plant, shug chher. 12E,14-Trien-19-oic acid can be used for the research of platelet aggregation .
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- HY-N8776
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Others
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Others
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11-Hydroxybisabola-1,3,5-trien-9-one is a Sesquiterpenoids product that can be isolated from the leaves of Alpinia intermedia .
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- HY-N1223
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Others
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Others
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Stigmasta-4,22,25-trien-3-one, (22E)- is a Steroids product that can be isolated from the herbs of Callicarpa giraldiana .
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- HY-N1498
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Others
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Others
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15,18-Dihydroxyabieta-8,11,13-trien-7-one is a compound isolated from the aerial part of Abies recurvata .
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- HY-N1608
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Others
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Others
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18-Norabieta-8,11,13-trien-4α-ol (Compound 4) is a natural product that can be isolated from the resins of Populus euphratica .
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- HY-N13195
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5 alpha Reductase
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Others
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(15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one shows a 5a-reductase inhibitory activity with an IC50 value of 41.9 μM. (15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one inhibits the growth of the ventral prostate induced by testosterone in rat. (15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one is promising for research of benign prostatic hyperplasia (BPH) as well as other 5α-dihydrotestosterone (DHT)-related disorders, such as acne and male pattern baldness .
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- HY-N11644
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Others
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Cancer
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Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid, also known as ganoderic acid 24. Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid shows high cytotoxicity against cancer cells, such as human lung cancer cells CH27, melanoma cells M21, and oral cancer cells HSC-3 .
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- HY-N1607
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Others
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Others
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18-Nor-4,15-dihydroxyabieta-8,11,13-trien-7-one is a compound isolated from the buds of Pinus banksiana Lamb .
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- HY-43723
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- HY-N9533
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Others
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Others
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16R-Hydroxy-3-oxolanosta7,9(11),24-trien-21-oic acid is a lanostanoid that can be found in the Sri Lankan basidiomycete Ganoderma applanatum .
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- HY-107450
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- HY-107442
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Epigenetic Reader Domain
Ligands for Target Protein for PROTAC
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Cancer
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PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136) . PROTAC BRD4-binding moiety 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-107451
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- HY-143270
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- HY-N7175
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9,11-Dehydroergosterol peroxide; 9(11)-DHEP
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Apoptosis
Endogenous Metabolite
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Cancer
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5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide), an important steroid from medicinal mushroom, exerts antitumor activity in several tumor types. 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol inhibits HT29 cell growth by inducing CDKN1A expression, thus causing cell cycle arrest and apoptosis .
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- HY-N10947
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Others
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Others
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Lanosta-7,9(11),24-trien-3β,15α-dihydrcxy-26-oic acid (compound 2) is a nature product that could be isolated from the Chinese medicinal fungus Ganoderma lucidurn .
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- HY-N11650
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Bacterial
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Infection
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(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid (compound 15) is an antitubercular agent with MIC value of 12.5 μg/mL for Mycobacterium tuberculosis H37Ra. (22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid shows cytotoxicity with IC50 value of 32 μM for Vero cells .
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- HY-107444
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- HY-107445
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- HY-107445A
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- HY-N13704
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Others
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Others
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(19S,23E)-5β,19-Epoxy-19-methoxycucurbita-6,23,25-trien-3β-ol is an active compound.
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- HY-W653776
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Drug Intermediate
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Others
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(6a,11β)-11,20-Dihydroxy-6-methyl-3-oxopregna-1,4,17(20)-trien-21-al is a Methylprednisolon (HY-B0260) impurity.
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- HY-107452
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PROTAC FKBP12-binding moiety 1
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Ligands for Target Protein for PROTAC
FKBP
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Cancer
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SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) is a synthetic ligand for FKBP (SLF). SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) can be used in the synthesis of PROTACs .
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- HY-N13492
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Others
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Others
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(19R,23E)-5β,19-Epoxy-19-methoxycucurbita-6,23,25-trien-3β-ol is a Triterpene product that can be isolated from Momordica charantia .
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- HY-111852
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- HY-N8127
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Others
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Others
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(1(10)E,2R*,4R*)-2-Methoxy-8,12-epoxygermacra-1(10),7,11-trien-6-one (compound 6) is a sesquiterpene .
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- HY-44103
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PROTAC BRD4-binding moiety 4
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Ligands for Target Protein for PROTAC
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Cancer
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Desmethyl-QCA276 (PROTAC BRD4-binding moiety 4), the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM . Desmethyl-QCA276 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-111857
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BMS-354825 carbaldehyde; PROTAC ABL binding moiety 4
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Ligands for Target Protein for PROTAC
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Cancer
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Dasatinib carbaldehyde (BMS-354825 carbaldehyde), the Dasatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .
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- HY-165842
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(11Z,14Z,17Z)-Eicosa-11,14,17-trien-1-ol
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Biochemical Assay Reagents
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Metabolic Disease
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11(Z),?14(Z),?17(Z)-?Eicosatrien?ol ((11Z,14Z,17Z)-Eicosa-11,14,17-trien-1-ol) is an ester product.
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- HY-111855
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- HY-114420
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- HY-111849
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CGP-57148B carbaldehyde; STI571 carbaldehyde; PROTAC ABL binding moiety 1
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Ligands for Target Protein for PROTAC
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Cancer
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Imatinib carbaldehyde (CGP-57148B carbaldehyde), the Imatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .
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- HY-123350
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Antibiotic
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Infection
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Saroaspidin B, a dimer of a phloroglucinol moiety, is an antibiotic compound .
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- HY-107453
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PROTAC Sirt2-binding moiety 1
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Ligands for Target Protein for PROTAC
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Cancer
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SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2 . SirReal1-O-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-P1348
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[Gly8,36,Glu22]-GLP-1 (7-37)
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GCGR
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Cardiovascular Disease
Metabolic Disease
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GLP-1 moiety from Dulaglutide is a 31-amino acid fragment of Dulaglutide. GLP-1 moiety from Dulaglutide is a glucagon-like peptide 1 receptor (GLP-1) agonist. Dulaglitude can be used in researches of diabetes and myocardial injury .
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- HY-107448
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Protac cdk9-binding moiety 1
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Drug Intermediate
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Others
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1H-Pyrazole-1-carboxylic acid, 3-amino-5-cyclobutyl-, 1,1-dimethylethyl ester (Protac cdk9-binding moiety 1) is a drug intermediate for synthesis of various active compounds.
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- HY-156047
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Endogenous Metabolite
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Others
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Oasomycin B, a member of the desertomycin family, is a polyketide. Oasomycin B can be isolated from Streptomyces sp. Oasomycin B, lacking the positively charged amino moiety, has no significant antibacterial activity and fails to induce Orsellinic acid (HY-N3126) production in A. nidulans .
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- HY-173549
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CPPA-Triphenylphosphonium
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Drug Intermediate
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Cancer
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CPPA-TPP (CPPA-Triphenylphosphonium) is a compound conjugated to the mitochondria-targeting moiety triphenylphosphonium (TPP). CPPA-TPP can be used in the synthesis of nanoparticles that release Camptothecin (HY-16560) in a reactive oxygen species dependent manner, leading to cancer cell death .
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- HY-148154
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Drug Derivative
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Others
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Poly(oxy-1,2-ethanediyl)-propoxy-amide-C6 (n=450) is an active compound. Poly(oxy-1,2-ethanediyl)-propoxy-amide-C6 is a small molecule moiety for pegylation modification in Avacincaptad pegol (HY-147080) .
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- HY-111850
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PROTAC IAP binding moiety 1
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Ligands for E3 Ligase
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Cancer
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Bestatin-amido-Me, the Bestatin-based IAP ligand, binds to ABL inhibitor via a linker to form SNIPER .
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- HY-D2489
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Fluorescent Dye
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Others
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Cy5-tetrazine is a fluorescent dye. Cy5-tetrazine is a CY5 (HY-D0821) derivative contains a tetrazine moiety. Cyanine5.5 tetrazine can be used for in vivo imaging and low background applications. Cy5-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .
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- HY-N3796
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Echinuline
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NF-κB
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Inflammation/Immunology
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Echinulin (Echinuline) is a cyclic dipeptide carrying a triprenylated indole moiety. Echinulin contributes to the activation of T cell subsets, which leads to NF-κB activation.Echinulin exerts its immune roles by the NF-κB pathway.Echinulin has the potential to serve as a immunotherapeutic agent .
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- HY-125908
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- HY-111853
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PROTAC IAP binding moiety 2
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Ligands for E3 Ligase
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Cancer
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MV-1-NH-Me, the MV-1 based IAP ligand, binds to ABL inhibitor via a linker to form SNIPER .
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- HY-176822
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Epigenetic Reader Domain
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Others
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SGC-BRDVIII-NC (Compound 35) is a negative control compound of SMARCA2/4 and PB1 bromodomain (BRD) inhibitor. SGC-BRDVIII-NC completely abolishes protein-ligand binding capacity with the methylation of the phenolic hydroxyl moiety. SGC-BRDVIII-NC can be used for adipogenesis research .
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- HY-148153
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Drug Derivative
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Inflammation/Immunology
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C6-Amide-(PEG)n-CH3 (n=310) is an active compound. C6-Amide-(PEG)n-CH3 is a small molecule moiety for PEGylation in Egaptivon pegol (HY-147079) that can be used for the research of platelet dysfunction disorders .
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- HY-W717038
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Isotope-Labeled Compounds
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Others
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Di-(tert-butyl-dimethylsilyl) curcumin-d6 is the deuterium labeled (1E,4Z,6E)-1,7-Bis(4-((tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-one (HY-W703940).
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- HY-107443
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Molibresib carboxylic acid; GSK525762A carboxylic acid; PROTAC BRD4-binding moiety 2
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Ligands for Target Protein for PROTAC
Epigenetic Reader Domain
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Cancer
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I-BET762 carboxylic acid (Molibresib carboxylic acid) is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid (Molibresib carboxylic acid) is a BRD4 inhibitor with a pIC50 of 5.1 .
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- HY-107443A
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(R)-Molibresib carboxylic acid; (R)-GSK525762A carboxylic acid; (R)-PROTAC BRD4-binding moiety 2
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Ligands for Target Protein for PROTAC
Epigenetic Reader Domain
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Cancer
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(R)-I-BET762 carboxylic acid, the R-enantiomer of I-BET762 carboxylic acid (HY-107443). I-BET762 carboxylic acid is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid is a BRD4 inhibitor with a pIC50 value of 5.1 .
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- HY-151679
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ADC Linker
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Others
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Fmoc-L-Lys(4-N3-Z)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Lys(4-N3-Z)-OH acts as Lysine building-block for SPPS containing an Azide moiety as a bioorthogonal ligation handle, an infrared probe and a photo-affinity reagent. It can be decaged by trans-cyclooctenols via a strain-promoted 1,3-dipolar cycloaddition . Fmoc-L-Lys(4-N3-Z)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-126664
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- HY-W441002
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Liposome
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Others
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DSPE-succinic acid is a phophalipid capped with a carboxylic acid moiety. The carboxylic acid moiety is reactive with amine to from a stable amide linkage. DSPE-succinic acid can be used to prepare nanoparticles or liposomes for agent nanocarrier to deliver therapeutics .
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- HY-151754
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ADC Linker
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Others
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DACN(Tos2,6-OH) is a click chemistry reagent containing an Azide. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. The reactivity of an alkyne heavily depends on the electronic and steric characteristics of the substituents as well as structural strain. In comparison to nonbent acyclic alkynes, cyclononyne alkynes show remarkably high reactivity. Such strain-promoted azide-alkyne cycloadditions (SPAAC) using cycloalkynes have served for reliable molecular conjugation in a broad range of fields. The nitrogens are used as connection points for a variety of functional units. In comparison to cyclooctynes, DACNs possess high thermal and chemical stability along with comparable click reactivity . DACN(Tos2,6-OH) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-B1422
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Aminacrine
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Bacterial
HIV
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Infection
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9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
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- HY-P1193
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Neurokinin Receptor
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Neurological Disease
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GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist . GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats .
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- HY-163925
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Radionuclide-Drug Conjugates (RDCs)
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Cancer
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Lu-AAZTA-NI-PSMA-093 enhances tumor uptake and retention by combining a hypoxia-sensitive nitroimidazole (NI) moiety with a targeting moiety to PSMA. Lu-AAZTA-NI-PSMA-093 can be used in prostate cancer .
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- HY-146010
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Carbonic Anhydrase
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Cancer
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Carbonic anhydrase inhibitor 13 (compound 7) is a potent carbonic anhydrase (CA) inhibitor, which features 3-methylthiazolo[3,2-a]benzimidazole moiety (as a tail) connected to the zinc anchoring benzenesulfonamide moiety via ureido linker .
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- HY-159132
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Carbonic Anhydrase
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Cancer
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CAIX/CAXII-IN-2 (compound 23) is a CAIX/CAXII inhibitor, with Ki values of 8.9 nM and 5.3 nM for CAIX/CAXII, respectively. CAIX/CAXII-IN-2 can be used in cancer research .
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- HY-W800817
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Biochemical Assay Reagents
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Others
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TCO-PEG4-maleimide is a click chemistry building block containing a TCO moiety and a maleimide group. The maleimide group will react with a thiol group to form a covalent bond. TCO moiety is very reactive with tetrazine (3rd generation click chemistry).
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- HY-157716
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- HY-133718
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(S)-Acarviosin
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Amylases
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Others
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Acarviosin, a pseudodisaccharide moiety, is a part of the potent inhibitor of α-amylase .
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- HY-B1422R
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Aminacrine (Standard)
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Reference Standards
Bacterial
HIV
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Infection
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9-Aminoacridine (Standard) is the analytical standard of 9-Aminoacridine. This product is intended for research and analytical applications. 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
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- HY-129281
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- HY-D1554
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Fluorescent Dye
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Others
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Cyanine5 tetrazine, a fluorophore, is a molecule that contains a cyano5 fluorophore and a tetrazine moiety .
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- HY-16138
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CG-200745
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HDAC
MDM-2/p53
Apoptosis
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Cancer
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Ivaltinostat (CG-200745) is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat inhibits deacetylation of histone H3 and tubulin. Ivaltinostat induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. Ivaltinostat enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine (HY-16138) and 5-Fluorouracil (5-FU; HY-90006). Ivaltinostat induces apoptosis and has anti-tumour effects .
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- HY-146970
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Antibiotic
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Cancer
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Lankacyclinone C is a lankacidin C congener lacking the δ-lactone moiety, with antitumor activity .
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- HY-117422
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11-Oxo-prosta-5Z,12E,14Z-trien-1-oic acid
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PPAR
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Cancer
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CAY10410 (11-Oxo-prosta-5Z), a 15d-PGJ2 analog, is a potent PPARγ agonist. CAY10410 has the ability to activate PPARγ in human B cells without killing B lymphocytes .
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- HY-16138A
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CG-200745 formic
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HDAC
MDM-2/p53
Apoptosis
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Inflammation/Immunology
Endocrinology
Cancer
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Ivaltinostat (CG-200745) formic is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat formic inhibits deacetylation of histone H3 and tubulin. Ivaltinostat formic induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. Ivaltinostat formic enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine (HY-16138) and 5-Fluorouracil (5-FU; HY-90006). Ivaltinostat formic induces apoptosis and has anti-tumour effects .
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- HY-W102590
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Biochemical Assay Reagents
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Others
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DOTMP is a bifunctional chelator. Bifunctional chelating agents are used to stably link the radiometal to the carrier moiety of the radiopharmaceutical .
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- HY-E70124A
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- HY-E70124C
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- HY-157592
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- HY-107824
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Endogenous Metabolite
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Others
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D-Melibiose is a disaccharide which is composed of one galactose and one glucose moiety in an alpha (1-6) glycosidic linkage.
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- HY-119697
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(+)-Setosusin
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Endogenous Metabolite
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Others
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Setosusin ((+)-Setosusin) is a fungal meroditerpenoid featuring a unique spiro-fused 3(2H)-furanone moiety .
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- HY-N2990
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3β,16α-Dihydroxylanosta-7,9(11),24-trien-21-oic acid
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Others
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Inflammation/Immunology
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16α-Hydroxydehydrotrametenolic acid is a triterpene Acid in fermented mycelia of edible fungus Poria cocos .
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- HY-W004649
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Biochemical Assay Reagents
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Others
|
|
Tris-BOC-cyclen is a bifunctional chelator. Bifunctional chelating agentscan be used to stably link the radiometal to the carrier moiety of the radiopharmaceutical .
|
-
- HY-W402032
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Bis-Cbz-cyclen is a bifunctional chelator. Bifunctional chelating agents are used to stably link the radiometal to the carrier moiety of the radiopharmaceutical .
|
-
- HY-100217
-
|
|
Amino Acid Derivatives
|
Others
|
|
DL-3-Indolylglycine is an unnatural amino acid that is very similar to Tryptophan, with the indole moiety directly attached to the α-position.
|
-
- HY-N14218
-
-
- HY-W800655
-
|
|
PROTAC Linkers
|
Cancer
|
|
Thalidomide-O-PEG4-Acid is a PROTAC linker that can react with Amine containing moiety in the presence of Activator EDC or HATU.
|
-
- HY-157258
-
|
|
Others
|
Inflammation/Immunology
|
|
Trimethoprim pentanoic acid is hapten. Trimethoprim pentanoic acid shows IC50 of 0.15 ng/mL when exposed diaminopyrimidine moiety to the immune system .
|
-
- HY-160983
-
|
|
DNA/RNA Synthesis
|
Cancer
|
|
PHYLPA-8 is an inhibitor for DNA polymerase-α, which exhibits weak inhibitory activity for the stereochemistry of the fatty acid moiety and the cyclic phosphate .
|
-
- HY-174447
-
|
|
PARP
|
Cancer
|
|
ADP-ribose/PARP-IN-1 (Compound Ex.16) is a conjugated compound. ADP-ribose/PARP-IN-1 contains disease targeting moieties, PARP inhibitor moieties, cleavable linkers, chelators. ADP-ribose/PARP-IN-1 targets specific targets through the disease targeting moiety and selectively delivers PARP inhibitors to tumor cells. The cleavable linker of ADP-ribose/PARP-IN-1 releases the PARP inhibitor under appropriate conditions, inhibiting PARP to prevent DNA damage repair, while the radionuclide carried by the chelator exerts a killing effect. ADP-ribose/PARP-IN-1 can be used in the research of prostate cancer .
|
-
- HY-N11464
-
|
|
Others
|
Others
|
|
Kuwanon O is a flavonoid derivative with a fused dihydrochalcone partial moiety, that can be isolated from the root bark of Morus lhou (set.) Koidz .
|
-
- HY-151769
-
|
|
ADC Linker
|
Others
|
|
TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent containing an azide group. TCO-PEG2-Sulfo-NHS ester is a PEG linker containing a TCO moiety and a sulfo-NHS ester moiety. The sulfo group makes this molecule soluble in waqueous buffer. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety. Reagent grade, for research use only . TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-N15960
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Photoclick cholesterol II is a sterol lipid Cholesterol (HY-N0322) analog that contains a clickable terminal alkyne moiety and a photoactivatable diaziridine group.
|
-
- HY-111606
-
-
- HY-101859
-
NucPE1
4 Publications Verification
Nuclear Peroxy Emerald 1
|
Reactive Oxygen Species (ROS)
|
Others
|
|
NucPE1 (Nuclear Peroxy Emerald 1) is a nuclear-localized fluorescent hydrogen peroxide that is specifically localized to cellular nuclei without appended targeting moieties.
|
-
- HY-167644
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Cefoxazole is a β-lactam antibiotic containing an isoxazole moiety and exhibits antibacterial activity. Cefoxazole can be used in studies related to infectious diseases .
|
-
- HY-100503
-
|
|
ADC Payload
|
Cancer
|
|
Maytansinoid DM4 is a thiol-containing maytansine derivative with highly potent cytotoxicity. Maytansinoid DM4 can be used as a cytotoxic moiety of ADC .
|
-
- HY-114657
-
|
|
Neprilysin
|
Others
|
|
Benproperine is a new neprilysin B inhibitor composed of N-acyl-L-prolyl-L-valine, whose N-acyl moiety is α-isobutylsuccinic acid β-hydroxamic acid.
|
-
- HY-119526
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Bismaleimide is a compound used to prepare aerogels with excellent heat resistance. By optimizing its use as a bridging moiety and the polarity of the solvent, aerogels with good properties can be produced.
|
-
- HY-D1556
-
|
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyfluorescein) ammonium
|
Fluorescent Dye
|
Others
|
|
DOPE-CF is a pH-sensitive fluorescent membrane labelled probe with a fluorescein moiety that is a weak acid and a conjugated base that is highly fluorescent and can be attached to phospholipid ethanolamine lipids .
|
-
- HY-123271
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Ro 23-9424 is a broad-spectrum cephalosporin composed of a cephalosporin and a quinolone moiety. Ro 23-9424 shows antimicrobial activity in vivo and in vitro .
|
-
- HY-W800714
-
|
|
Biochemical Assay Reagents
|
Others
|
|
SPDP-Gly-Gly-methoxy is a linker with SPDP and methyl ester moiety. The SPDP is an amine and thiol reactive crosslinker. It is also membrane permeable, allowing it to participate in intracellular crosslinking reactions.
|
-
- HY-N9332
-
|
|
Others
|
Others
|
|
Kalopanax saponin G is an ester glycoside of oleanolic acid possessing no sugar moiety at the C-3 hydroxyl group. Kalopanax saponin G is isolated from the bark of Kalopanax pictus .
|
-
-
-
HY-L0118V
-
|
|
942 compounds
|
|
A unique set of molecules containing mild electrophilic moieties that covalently interact with amino acid residues in the target protein. The diversity of our compounds for covalent drug discovery ranges from natural product-like scaffolds to macrocycles, creating multiple opportunities in hit generation for a selected target.
|
| Cat. No. |
Product Name |
Type |
-
- HY-B1422
-
|
Aminacrine
|
Fluorescent Dyes/Probes
|
|
9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
|
-
- HY-101859
-
NucPE1
4 Publications Verification
Nuclear Peroxy Emerald 1
|
Fluorescent Dyes/Probes
|
|
NucPE1 (Nuclear Peroxy Emerald 1) is a nuclear-localized fluorescent hydrogen peroxide that is specifically localized to cellular nuclei without appended targeting moieties.
|
-
- HY-D2489
-
|
|
Fluorescent Dyes/Probes
|
|
Cy5-tetrazine is a fluorescent dye. Cy5-tetrazine is a CY5 (HY-D0821) derivative contains a tetrazine moiety. Cyanine5.5 tetrazine can be used for in vivo imaging and low background applications. Cy5-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .
|
-
- HY-B1422R
-
|
Aminacrine (Standard)
|
Fluorescent Dyes/Probes
|
|
9-Aminoacridine (Standard) is the analytical standard of 9-Aminoacridine. This product is intended for research and analytical applications. 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
|
-
- HY-D1556
-
|
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyfluorescein) ammonium
|
Fluorescent Dyes/Probes
|
|
DOPE-CF is a pH-sensitive fluorescent membrane labelled probe with a fluorescein moiety that is a weak acid and a conjugated base that is highly fluorescent and can be attached to phospholipid ethanolamine lipids .
|
| Cat. No. |
Product Name |
Type |
-
- HY-W441002
-
|
|
Drug Delivery
|
|
DSPE-succinic acid is a phophalipid capped with a carboxylic acid moiety. The carboxylic acid moiety is reactive with amine to from a stable amide linkage. DSPE-succinic acid can be used to prepare nanoparticles or liposomes for agent nanocarrier to deliver therapeutics .
|
-
- HY-W102590
-
|
|
Chelators
|
|
DOTMP is a bifunctional chelator. Bifunctional chelating agents are used to stably link the radiometal to the carrier moiety of the radiopharmaceutical .
|
-
- HY-157716
-
|
|
Cell Assay Reagents
|
|
08:0 PI ammonium is a glycerophospholipid with a head group carrying a cyclohexanol moiety.
|
-
- HY-E70180
-
|
EC:3.2.1.22; GLA
|
Enzyme Substrates
|
|
alpha-Galactosidase A is a lysosomal exoglycosidase and hydrolyses the terminal α-galactosyl moieties of glycoconjugates .
|
-
- HY-W004649
-
|
|
Chelators
|
|
Tris-BOC-cyclen is a bifunctional chelator. Bifunctional chelating agentscan be used to stably link the radiometal to the carrier moiety of the radiopharmaceutical .
|
-
- HY-W402032
-
|
|
Chelators
|
|
Bis-Cbz-cyclen is a bifunctional chelator. Bifunctional chelating agents are used to stably link the radiometal to the carrier moiety of the radiopharmaceutical .
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P1348
-
|
[Gly8,36,Glu22]-GLP-1 (7-37)
|
GCGR
|
Cardiovascular Disease
Metabolic Disease
|
|
GLP-1 moiety from Dulaglutide is a 31-amino acid fragment of Dulaglutide. GLP-1 moiety from Dulaglutide is a glucagon-like peptide 1 receptor (GLP-1) agonist. Dulaglitude can be used in researches of diabetes and myocardial injury .
|
-
- HY-P1193
-
|
|
Neurokinin Receptor
|
Neurological Disease
|
|
GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist . GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-N7926
-
-
-
- HY-N7926R
-
|
|
Natural Products
Kaempferia galanga L.
Source classification
Plants
Zingiberaceae
|
Parasite
Reference Standards
|
|
Pentadecane (Standard) is the analytical standard of Pentadecane. This product is intended for research and analytical applications. Pentadecane is a floral volatile antimalarial agent that can inhibit the growth of parasites such as Leishmania and avoid infection of macrophages. The IC50s of Pentadecane against promastigotes and amastigotes are 65.3 μM and 60.5 μM, respectively. Pentadecane also has anti-inflammatory, analgesic, and antipyretic activities .
|
-
-
- HY-N11076
-
-
-
- HY-N8776
-
-
-
- HY-N1223
-
-
-
- HY-N1608
-
-
-
- HY-N13195
-
|
|
Triterpenes
Microorganisms
Terpenoids
Source classification
|
5 alpha Reductase
|
|
(15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one shows a 5a-reductase inhibitory activity with an IC50 value of 41.9 μM. (15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one inhibits the growth of the ventral prostate induced by testosterone in rat. (15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one is promising for research of benign prostatic hyperplasia (BPH) as well as other 5α-dihydrotestosterone (DHT)-related disorders, such as acne and male pattern baldness .
|
-
-
- HY-N11644
-
|
|
Triterpenes
Microorganisms
Terpenoids
Source classification
|
Others
|
|
Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid, also known as ganoderic acid 24. Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid shows high cytotoxicity against cancer cells, such as human lung cancer cells CH27, melanoma cells M21, and oral cancer cells HSC-3 .
|
-
-
- HY-N9533
-
-
-
- HY-N7175
-
|
9,11-Dehydroergosterol peroxide; 9(11)-DHEP
|
Classification of Application Fields
Source classification
Solanum lyratum Thunberg
Solanaceae
Plants
Disease Research Fields
Steroids
Cancer
|
Apoptosis
Endogenous Metabolite
|
|
5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide), an important steroid from medicinal mushroom, exerts antitumor activity in several tumor types. 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol inhibits HT29 cell growth by inducing CDKN1A expression, thus causing cell cycle arrest and apoptosis .
|
-
-
- HY-N10947
-
-
-
- HY-N11650
-
|
|
Triterpenes
Microorganisms
Terpenoids
Source classification
|
Bacterial
|
|
(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid (compound 15) is an antitubercular agent with MIC value of 12.5 μg/mL for Mycobacterium tuberculosis H37Ra. (22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid shows cytotoxicity with IC50 value of 32 μM for Vero cells .
|
-
-
- HY-N13704
-
-
-
- HY-N13492
-
-
-
- HY-N8127
-
-
-
- HY-123350
-
-
-
- HY-156047
-
|
|
Natural Products
Microorganisms
Source classification
|
Endogenous Metabolite
|
|
Oasomycin B, a member of the desertomycin family, is a polyketide. Oasomycin B can be isolated from Streptomyces sp. Oasomycin B, lacking the positively charged amino moiety, has no significant antibacterial activity and fails to induce Orsellinic acid (HY-N3126) production in A. nidulans .
|
-
-
- HY-N3796
-
-
-
- HY-107824
-
-
-
- HY-119697
-
-
-
- HY-N2990
-
-
-
- HY-N14218
-
-
-
- HY-N11464
-
-
-
- HY-N15960
-
|
|
Lipid
|
Biochemical Assay Reagents
|
|
Photoclick cholesterol II is a sterol lipid Cholesterol (HY-N0322) analog that contains a clickable terminal alkyne moiety and a photoactivatable diaziridine group.
|
-
-
- HY-N9332
-
-
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-N7926S
-
|
|
|
Pentadecane-d32 is the deuterium labeled Pentadecane .
|
-
-
- HY-W717038
-
|
|
|
Di-(tert-butyl-dimethylsilyl) curcumin-d6 is the deuterium labeled (1E,4Z,6E)-1,7-Bis(4-((tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-one (HY-W703940).
|
-
| Cat. No. |
Compare |
Product Name |
Application |
Reactivity |
Compare Products
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| Products |
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| Cat. No. |
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| Host |
|
| Reactivity |
|
| Application |
|
Dilution
Ratio |
|
| Molecular Weight |
|
| Conjugation |
|
| Clonality |
|
| Immunogen |
|
| Appearance |
|
| Isotype |
|
| Gene ID |
|
| SwissProt ID |
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| Purity |
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| Formulation |
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| Free Sample |
Yes
No
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| Size |
* This product has been "discontinued".
Optimized version of product available:
|
| Cat. No. |
Product Name |
|
Classification |
-
- HY-107442
-
|
|
|
Alkynes
|
|
PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136) . PROTAC BRD4-binding moiety 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-107453
-
|
PROTAC Sirt2-binding moiety 1
|
|
Alkynes
|
|
SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2 . SirReal1-O-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-151679
-
|
|
|
Azide
|
|
Fmoc-L-Lys(4-N3-Z)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Lys(4-N3-Z)-OH acts as Lysine building-block for SPPS containing an Azide moiety as a bioorthogonal ligation handle, an infrared probe and a photo-affinity reagent. It can be decaged by trans-cyclooctenols via a strain-promoted 1,3-dipolar cycloaddition . Fmoc-L-Lys(4-N3-Z)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-159132
-
|
|
|
Azide
|
|
CAIX/CAXII-IN-2 (compound 23) is a CAIX/CAXII inhibitor, with Ki values of 8.9 nM and 5.3 nM for CAIX/CAXII, respectively. CAIX/CAXII-IN-2 can be used in cancer research .
|
-
- HY-151769
-
|
|
|
TCO
Labeling and Fluorescence Imaging
|
|
TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent containing an azide group. TCO-PEG2-Sulfo-NHS ester is a PEG linker containing a TCO moiety and a sulfo-NHS ester moiety. The sulfo group makes this molecule soluble in waqueous buffer. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety. Reagent grade, for research use only . TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
| Cat. No. |
Product Name |
|
Classification |
-
- HY-W441002
-
|
|
|
Phospholipids
|
|
DSPE-succinic acid is a phophalipid capped with a carboxylic acid moiety. The carboxylic acid moiety is reactive with amine to from a stable amide linkage. DSPE-succinic acid can be used to prepare nanoparticles or liposomes for agent nanocarrier to deliver therapeutics .
|
-
- HY-157716
-
|
|
|
Phospholipids
|
|
08:0 PI ammonium is a glycerophospholipid with a head group carrying a cyclohexanol moiety.
|
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