Search Result

Results for "

dioxygenases

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Indoleamine 2,3-Dioxygenase (IDO) (46) Apoptosis (7) ATP Synthase (3) Aurora Kinase (4) Bacterial (5) Biochemical Assay Reagents (3) Collagen (1) Cytochrome P450 (1) Drug Derivative (2) Endogenous Metabolite (17) Estrogen Receptor/ERR (1) Fat Mass and Obesity-associated Protein (FTO) (1) Herbicide (2) Histone Demethylase (8) HPPD (10) Isotope-Labeled Compounds (3) mAChR (4) Methionine Adenosyltransferase (MAT) (1) Molecular Glues (1) mTOR (3) Neurokinin Receptor (1) NF-κB (1) Parasite (4) Phosphodiesterase (PDE) (1) PROTACs (3) Reactive Oxygen Species (ROS) (11) Reference Standards (9) Sirtuin (1) Virus Protease (4)
By Research Areas:	Cancer (57) Cardiovascular Disease (2) Infection (12) Inflammation/Immunology (17) Metabolic Disease (12) Neurological Disease (12)

By Targets:

Indoleamine 2,3-Dioxygenase (IDO) (46)

Apoptosis (7)

ATP Synthase (3)

Aurora Kinase (4)

Bacterial (5)

Biochemical Assay Reagents (3)

Collagen (1)

Cytochrome P450 (1)

Drug Derivative (2)

Endogenous Metabolite (17)

Estrogen Receptor/ERR (1)

Fat Mass and Obesity-associated Protein (FTO) (1)

Herbicide (2)

Histone Demethylase (8)

HPPD (10)

Isotope-Labeled Compounds (3)

mAChR (4)

Methionine Adenosyltransferase (MAT) (1)

Molecular Glues (1)

mTOR (3)

Neurokinin Receptor (1)

NF-κB (1)

Parasite (4)

Phosphodiesterase (PDE) (1)

PROTACs (3)

Reactive Oxygen Species (ROS) (11)

Reference Standards (9)

Sirtuin (1)

Virus Protease (4)

By Research Areas:

Cancer (57)

Cardiovascular Disease (2)

Infection (12)

Inflammation/Immunology (17)

Metabolic Disease (12)

Neurological Disease (12)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Indoleamine 2,3-Dioxygenase (IDO)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-133597

4-Chlorocatechol	Drug Derivative	Others
4-Chlorocatechol is a major degradation product of 4-chloro-2-aminophenol (4C2AP). 4-Chlorocatechol is also a substrate for catechol 1,2-dioxygenases and chlorocatechol dioxygenase .

HY-113038B

α-Hydroxyglutaric acid 2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid	Histone Demethylase Endogenous Metabolite	Cancer
α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-113038A

α-Hydroxyglutaric acid disodium 2-Hydroxyglutarate disodium; 2-Hydroxyglutaric acid disodium; 2-Hydroxypentanedioic acid disodium	Histone Demethylase Endogenous Metabolite	Cancer
α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-P2976

Lipoxygenase, general LOX	Endogenous Metabolite	Others
Lipoxygenase, general (LOX) is a dioxygenase, is often used in biochemical studies. Lipoxygenase, general catalyzes the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid .

HY-144900

Topramezone	Reactive Oxygen Species (ROS)	Others
Topramezone is a potent 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor. Topramezone is a herbicide, used for the post-emergence control of broadleaf and grass weeds in corn .

HY-128355

IDO/TDO-IN-1	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and *tryptophan 2,3-dioxygenase* (TDO) inhibitor with IC₅₀**s of 9.7 and 47 nM, respectively .

HY-33298

LM10	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
LM10 is a potent inhibitor of tryptophan 2,3-dioxygenase (TDO). Tryptophan 2,3-dioxygenase (TDO) is an unrelated hepatic enzyme that also degrades tryptophan along the kynurenine pathway. LM10 has the potential for the research of cancer diseases .

HY-15683

IDO5L 3 Publications Verification	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO5L is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC₅₀ of 67 nM.

HY-133597R

4-Chlorocatechol (Standard)	Drug Derivative	Others
4-Chlorocatechol (Standard) is the analytical standard of 4-Chlorocatechol. This product is intended for research and analytical applications. 4-Chlorocatechol is a major degradation product of 4-chloro-2-aminophenol (4C2AP). 4-Chlorocatechol is also a substrate for catechol 1,2-dioxygenases and chlorocatechol dioxygenase .

HY-144900R

Topramezone (Standard)	Reference Standards Reactive Oxygen Species (ROS)	Others
Topramezone (Standard) is the analytical standard of Topramezone. This product is intended for research and analytical applications. Topramezone is a potent 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor. Topramezone is a herbicide, used for the post-emergence control of broadleaf and grass weeds in corn .

HY-W016584

4,5-Dichlorocatechol	Others	Infection
4,5-Dichlorocatechol is a substrate of the broad-spectrum chlorocatechol 1,2-dioxygenase of pseudomonas chlororaphis RW71. The K_i values for 4,5-dichlorocatechol is 30 nM for the dioxygenase of the Chlorobenzoate-degrading strain Pseudomonas putida AC27 and 4 nM for the dioxygenase of Acidovorax sp. strain PS14 .

HY-16987

IDO-IN-3	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC₅₀ of 290 nM.

HY-79531

IDO-IN-1	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC₅₀ of 59 nM.

HY-D0033

Roxyl-9	Indoleamine 2,3-Dioxygenase (IDO)	Others
Roxyl-9 is a IDO1 (Indoleamine 2,3-dioxygenase 1) inhibitor .

HY-145346

NLG802	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
NLG802 is a proagent of indoximod, an orally active *indoleamine 2,3-dioxygenase* (IDO)** inhibitor.

HY-151425

TDO-IN-1	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
TDO-IN-1 is an orally active and selective inhibitor of tryptophan 2,3-dioxygenase (TDO), shows excellent selectivity over *indoleamine-2,3-dioxygenase* (IDO), with an IC₅₀ value of 0.62 μM (IDO). TDO-IN-1 reverse the local immune tolerance of tumor tissue to inhibit tumor growth in vivo .

HY-133609

3,5-Dichlorocatechol	Biochemical Assay Reagents	Infection
3,5-Dichlorocatechol is a substrate of the broad-spectrum chlorocatechol 1,2-dioxygenase of pseudomonas chlororaphis RW71 .

HY-P2915

Protocatechuate 3,4-dioxygenase	Biochemical Assay Reagents	Others
Protocatechuate 3,4-dioxygenase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-133612

3,6-Dichlorocatechol	Biochemical Assay Reagents	Infection
3,6-Dichlorocatechol is a substrate of the broad-spectrum chlorocatechol 1,2-dioxygenase of pseudomonas chlororaphis RW71 .

HY-115122

IDO-IN-12	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-12 is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO 2017181849 A1.

HY-151886

NU223612	PROTACs Indoleamine 2,3-Dioxygenase (IDO)	Neurological Disease Cancer
NU223612 is a potent PROTAC (PROTACs) that degrades *indoleamine 2,3-dioxygenase* 1 (IDO1) (Indoleamine 2,3-Dioxygenase (IDO)) with a K_d of 640 nM. NU223612 potently degrades the IDO1 protein through CRBN**-mediated proteasomal degradation. NU223612 is bound to CRBN with an affinity of 290 nM. NU223612 can cross the blood-brain barrier (BBB) .

HY-15683R

IDO5L (Standard)	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO5L (Standard) is the analytical standard of IDO5L. This product is intended for research and analytical applications. IDO5L is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 67 nM.

HY-18770B

Navoximod 10+ Cited Publications GDC-0919; NLG-919	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Navoximod (GDC-0919; NLG-?919) is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with K_i/EC₅₀ of 7 nM/75 nM.

HY-148383

DP00477	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
DP00477 is a potent *IDO1 (indoleamine 2,3-dioxygenase* 1) inhibitor with an IC₅₀** value of 7.0 µM. DP00477 has the potential for the research of cancer .

HY-129749

IDO-IN-13	Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology
IDO-IN-13 is a potent *indoleamine 2,3-dioxygenase* 1 (IDO1) inhibitor with an EC₅₀** of 17 nM, extracted from patent WO2019040102A1, example 43 .

HY-139204

BMS-986242 1 Publications Verification	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
BMS-986242 is an orally active, potent and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor. BMS-986242 can be used for the research of cancer .

HY-177086

IDO1/TDO-IN-9	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1/TDO-IN-9 (Compound 66) is a potent dual inhibitor targeting indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) with IC₅₀s of <1 μM. IDO1/TDO-IN-9 inhibits the activity of IDO1 and TDO, blocking tryptophan degradation to kynurenine, restoring immune activity in the tumor microenvironment, and suppressing tumor growth. IDO1/TDO-IN-9 is promising for research of cancers .

HY-18770A

IDO-IN-6 NLG-1486	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-6 (NLG-1486) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, Compound 1486, has an IC₅₀ of <1 μM.

HY-18769

BMS-978587 1 Publications Verification IDO-IN-4	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
BMS-978587 (IDO-IN-4) is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor, extracted from patent WO2014150677A1, Compound example 1 enantiomer 1.

HY-N0707

(S)-Indoximod 1-Methyl-L-tryptophan; (S)-NLG-8189	Indoleamine 2,3-Dioxygenase (IDO)	Neurological Disease Cancer
(S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of *indoleamine 2,3-dioxygenase* (IDO) (K_i**: 19 μM). (S)-Indoximod can be used for the research of cancer and neurological disease .

HY-18770

IDO-IN-5 NLG-1489	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-5 (NLG-1489) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1489, has an IC₅₀ of 1-10 μM.

HY-100687

GNF-PF-3777 8-Nitrotryptanthrin	Indoleamine 2,3-Dioxygenase (IDO)	Neurological Disease
GNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with K_i of 0.97 μM.

HY-18770C

IDO-IN-8 NLG-1487	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-8 (NLG-1487) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1487, has an IC₅₀ of 1-10 μM.

HY-W012814S1

4-Methylcatechol-d8	Endogenous Metabolite	Others
4-Methylcatechol-d₈ is the deuterium labeled 4-Methylcatechol . 4-Methylcatechol, a metabolite of p-toluate, is a substrate as well as a suicide inhibitor of Catechol 2,3-Dioxygenase .

HY-N12125

Entadamide A	Others	Infection
Entadamide A (compound 1) is a tryptophan derivative. Entadamide A prevents tryptophan depletion by inhibiting indoleamine 2, 3-dioxygenase (IDO), thereby inhibiting HIV replication. Entadamide A can be used in drug and neuropsychiatric studies of redesivir [1].

HY-W012814S

4-Methylcatechol-d3	Endogenous Metabolite	Others
4-Methylcatechol-d₃ is the deuterium labeled 4-Methylcatechol . 4-Methylcatechol, a metabolite of p-toluate, is a substrate as well as a suicide inhibitor of Catechol 2,3-Dioxygenase .

HY-P4149

Imsamotide IDO194-214	Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology Cancer
Imsamotide (IDO194-214) is a *Indoleamine 2,3-Dioxygenase* (IDO)** peptide with sequences of DTLLKALLEIASCLEKALQVF, the IDO194-214. Imsamotide is also an immunological agent for active immunization, as well as an antineoplastic agent .

HY-135767

Bicyclopyrone	HPPD	Metabolic Disease
Bicyclopyrone is an inhibitor of *4-hydroxyphenylpyruvate dioxygenase* (Hpd)** .

HY-16724

Indoximod 5+ Cited Publications 1-Methyl-D-tryptophan; NLG-8189	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Indoximod (1-Methyl-D-tryptophan) is an orally active indoleamine 2,3-dioxygenase (IDO) pathway inhibitor. Indoximod acts as a Trp mimetic in regulating mTOR. Indoximod is an immunometabolic adjuvant used for the research of cancer .

HY-N2463

Kushenol E 1 Publications Verification	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive *indoleamine 2,3-dioxygenase* 1 (IDO1) inhibitor with an IC₅₀ of 7.7 µM and a K_i** of 9.5 µM, has anti-tumor activity .

HY-151093

IDO2-IN-1 2 Publications Verification	Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology
IDO2-IN-1 is an orally active and potent *Indoleamine 2,3-dioxygenase* 2 (IDO2) inhibitor with an IC₅₀** value of 112 nM. IDO2-IN-1 can be used for inflammatory autoimmunity research .

HY-N0707S

(S)-Indoximod-d3 1-Methyl-L-tryptophan-d₃; (S)-NLG-8189-d₃	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
(S)-Indoximod-d₃ is the deuterium labeled (S)-Indoximod. (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer .

HY-W025799

N-Benzylideneaniline N-Benzalaniline; N-Phenylbenzylimine	Histone Demethylase	Cancer
N-Benzylideneaniline is an inhibitor of xylinostilbene-α,β-dioxygenase (LSD) .

HY-110387

IDO-IN-9	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC₅₀s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell), extracted from patent WO 2016041489 A1, compound 6.

HY-111234

IDO-IN-11	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC₅₀s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell), extracted from patent WO 2016041489 A1, compound 13.

HY-108681

680C91 1 Publications Verification	Collagen	Neurological Disease Inflammation/Immunology Cancer
680C91 is an orally active, selective tryptophan 2,3-dioxygenase (TDO) inhibitor with a K_i of 51 nM. TDO is the key enzyme of tryptophan catabolism. 680C91 can be used for the research of cancer immunotherapy and Alzheimer’s Disease .

HY-107368

Sulcotrione	Reactive Oxygen Species (ROS)	Others
Sulcotrione is a β-triketone herbicide which can inhibit hydroxyphenylpyruvate dioxygenase (HPPD).

HY-101560

Linrodostat 5 Publications Verification BMS-986205; ONO-7701	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Linrodostat (BMS-986205) is a selective and irreversible *indoleamine 2,3-dioxygenase* 1 (IDO1) inhibitor with an IC₅₀ value of 1.1 nM in IDO1**-HEK293 cells. Linrodostat is well tolerated with potent pharmacodynamic activity in advanced cancers .

HY-161348

AT-0174	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
AT-0174 is an orally active dual inhibitor of IDO1/TDO2 (tryptophan 2,3-dioxygenase-2) with IC₅₀ values of 0.17 and 0.25 μM, respectively. AT-0174 has antitumor activity .

HY-101560A

Linrodostat mesylate BMS-986205 mesylate; ONO-7701 mesylate	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Linrodostat (BMS-986205) mesylate is a selective irreversible inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), which effectively inhibits IDO1-HEK293 mesylate cells with an IC₅₀ value of 1.1 nM. Linrodostat mesylate demonstrates good pharmacological activity in advanced cancer .

Cat. No.	Product Name	Target	Research Area

HY-P4149

Imsamotide IDO194-214	Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology Cancer
Imsamotide (IDO194-214) is a *Indoleamine 2,3-Dioxygenase* (IDO)** peptide with sequences of DTLLKALLEIASCLEKALQVF, the IDO194-214. Imsamotide is also an immunological agent for active immunization, as well as an antineoplastic agent .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113038B

α-Hydroxyglutaric acid 2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid	Structural Classification Immune System Disorder Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer	Histone Demethylase Endogenous Metabolite
α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-113038A

α-Hydroxyglutaric acid disodium 2-Hydroxyglutarate disodium; 2-Hydroxyglutaric acid disodium; 2-Hydroxypentanedioic acid disodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Histone Demethylase Endogenous Metabolite
α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-133609

3,5-Dichlorocatechol	Microorganisms Source classification	Biochemical Assay Reagents
3,5-Dichlorocatechol is a substrate of the broad-spectrum chlorocatechol 1,2-dioxygenase of pseudomonas chlororaphis RW71 .

HY-N0707

(S)-Indoximod 1-Methyl-L-tryptophan; (S)-NLG-8189	Structural Classification Classification of Application Fields Leguminosae Ketones, Aldehydes, Acids Source classification Abrus precatorius Linn. Plants Disease Research Fields Cancer	Indoleamine 2,3-Dioxygenase (IDO)
(S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of *indoleamine 2,3-dioxygenase* (IDO) (K_i**: 19 μM). (S)-Indoximod can be used for the research of cancer and neurological disease .

HY-N12125

Entadamide A	Structural Classification Natural Products Petasites formosanus Kitam. Leguminosae Source classification Plants	Others
Entadamide A (compound 1) is a tryptophan derivative. Entadamide A prevents tryptophan depletion by inhibiting indoleamine 2, 3-dioxygenase (IDO), thereby inhibiting HIV replication. Entadamide A can be used in drug and neuropsychiatric studies of redesivir [1].

HY-N2463

Kushenol E 1 Publications Verification	Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Moghania philippinensis (Merr. Et Rolfe) L. Plants Disease Research Fields Cancer	Indoleamine 2,3-Dioxygenase (IDO)
Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive *indoleamine 2,3-dioxygenase* 1 (IDO1) inhibitor with an IC₅₀ of 7.7 µM and a K_i** of 9.5 µM, has anti-tumor activity .

HY-114991

Leptospermone	Leptospermum scoparium J. R. Forst. et G. Forst. Structural Classification Natural Products Source classification Myrtaceae Plants	HPPD
Leptospermone is a competitive, reversible inhibitor for p-Hydroxyphenylpyruvate dioxygenase (HPPD), with an IC₅₀ of 12.1 μM. Leptospermone exhibits herbicidal activity for its bleaching effect .

HY-W012814

4-Methylcatechol	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Other Diseases Phenols Polyphenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis Reactive Oxygen Species (ROS)
4-Methylcatechol is an intermediate in the degradation of some alkylbenzenes and an orally active suicide inhibitor of catechol 2,3-dioxygenase (C23O). 4-Methylcatechol induces apoptosis in melanoma cells through oxidative stress, but some studies have also shown that 4-Methylcatechol is carcinogenic. In addition, 4-Methylcatechol has antiplatelet and blood pressure-lowering activities. 4-Methylcatechol can also inhibit protein oxidation in beef but does not disulfide formation .

HY-116620

Benzomalvin C	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Neurokinin Receptor
Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/mL in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC₅₀ value of 130 μM for recombinant IDO. It is isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.

HY-113038AR

α-Hydroxyglutaric acid disodium (Standard) 2-Hydroxyglutarate disodium (Standard); 2-Hydroxyglutaric acid disodium (Standard); 2-Hydroxypentanedioic acid disodium (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Histone Demethylase Endogenous Metabolite
Ophiopogonin D (Standard) is the analytical standard of Ophiopogonin D. This product is intended for research and analytical applications. Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside . Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years .

HY-N0110

Palmatine chloride Maximum Cited Publications 6 Publications Verification	Structural Classification Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Cancer	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite
Palmatine chloride is an orally active and irreversible *indoleamine 2,3-dioxygenase* 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀** of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-N0110B

Palmatine hydroxide Maximum Cited Publications 6 Publications Verification	Alkaloids Phellodendron amurense Rupr. Other Alkaloids Source classification Rutaceae Plants	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite
Palmatine hydroxide is an orally active and irreversible *indoleamine 2,3-dioxygenase* 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine hydroxide can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀** of 96 μM. Palmatine hydroxide shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-N0110A

Palmatine	Alkaloids Structural Classification Phellodendron amurense Rupr. Classification of Application Fields Source classification Rutaceae Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite
Palmatine is an orally active and irreversible *indoleamine 2,3-dioxygenase* 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀** of 96 μM. Palmatine shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-W010040

4-Hydroxyphenylpyruvic acid 1 Publications Verification	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Phenols Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite
4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine. 4-Hydroxyphenylpyruvic acid is a substrate of 4-hydroxyphenylpyruvic acid dioxygenase. 4-Hydroxyphenylpyruvic acid can be used in the study of HPD-related diseases, such as type III tyrosinemia and hawkinsinuria .

HY-W012814R

4-Methylcatechol (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Source classification Phenols Polyphenols Endogenous metabolite	Reference Standards Endogenous Metabolite Apoptosis Reactive Oxygen Species (ROS)
4-Methylcatechol (Standard) is the analytical standard of 4-Methylcatechol. This product is intended for research and analytical applications. 4-Methylcatechol is an intermediate in the degradation of some alkylbenzenes and an orally active suicide inhibitor of catechol 2,3-dioxygenase (C23O). 4-Methylcatechol induces apoptosis in melanoma cells through oxidative stress, but some studies have also shown that 4-Methylcatechol is carcinogenic. In addition, 4-Methylcatechol has antiplatelet and blood pressure-lowering activities. 4-Methylcatechol can also inhibit protein oxidation in beef but does not disulfide formation[1][2][3][4][5][6].

HY-N0110R

Palmatine chloride (Standard)	Structural Classification Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Source classification Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Apoptosis Virus Protease Indoleamine 2,3-Dioxygenase (IDO) Parasite Bacterial Aurora Kinase mAChR Reference Standards
Palmatine (chloride) (Standard) is the analytical standard of Palmatine (chloride). This product is intended for research and analytical applications. Palmatine chloride is an orally active and irreversible *indoleamine 2,3-dioxygenase* 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀** of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-N12196

Terretonin	Structural Classification Other Monoterpenes Microorganisms Terpenoids Source classification	Cytochrome P450
Terretonin is a fungal terpenoid isolated from Aspergillus terreus. The complete biosynthetic pathway of terretonin includes: cytochrome P450 Trt6 catalyzes the oxidation of terrenoid to obtain an unstable intermediate; then it is catalyzed by isomerase Trt14 and processed by non-heme iron-dependent dioxygenase Trt7 to complete the biosynthesis of terretonin .

HY-W010040R

4-Hydroxyphenylpyruvic acid (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Source classification Disease markers Phenols Endocrine diseases Nervous System Disorder Endogenous metabolite	Reference Standards Endogenous Metabolite
4-Hydroxyphenylpyruvic acid (Standard) is the analytical standard of 4-Hydroxyphenylpyruvic acid (HY-W010040). This product is intended for research and analytical applications. 4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine. 4-Hydroxyphenylpyruvic acid is a substrate of 4-hydroxyphenylpyruvic acid dioxygenase. 4-Hydroxyphenylpyruvic acid can be used in the study of HPD-related diseases, such as type III tyrosinemia and hawkinsinuria .

HY-113038

D-α-Hydroxyglutaric acid 3 Publications Verification (R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid	Classification of Application Fields Neurological Disease Anti-aging Source classification Endocrine diseases Endogenous metabolite Immune System Disorder Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Disease Research Fields Inflammation/Immunology Cancer	Reactive Oxygen Species (ROS) ATP Synthase mTOR Endogenous Metabolite
D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid increases *reactive oxygen* species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR** signaling .

HY-100542

D-α-Hydroxyglutaric acid disodium 3 Publications Verification Disodium (R)-2-hydroxyglutarate	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Reactive Oxygen Species (ROS) ATP Synthase mTOR Endogenous Metabolite
D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases *reactive oxygen* species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR** signaling .

HY-100542R

D-α-Hydroxyglutaric acid disodium (Standard) Disodium (R)-2-hydroxyglutarate (Standard)	Structural Classification Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Reactive Oxygen Species (ROS) ATP Synthase mTOR Endogenous Metabolite
D-α-Hydroxyglutaric acid (disodium) (Standard) is the analytical standard of D-α-Hydroxyglutaric acid (disodium). This product is intended for research and analytical applications. D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling .

Cat. No.	Product Name	Chemical Structure

HY-N0707S

(S)-Indoximod-d3
(S)-Indoximod-d₃ is the deuterium labeled (S)-Indoximod. (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer .

HY-113038AS

α-Hydroxyglutaric acid-13C5 disodium
α-Hydroxyglutaric acid- ¹³C₅ (sodium) is the ¹³C labeled α-Hydroxyglutaric acid sodium . α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-113038AS1

α-Hydroxyglutaric acid-d4 disodium

α-Hydroxyglutaric acid-d₄ (disodium) is the deuterium labeled α-Hydroxyglutaric acid disodium . α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-W654003

D-α-Hydroxyglutaric acid-d5 disodium

D-α-Hydroxyglutaric acid-d₅ disodium (Disodium (R)-2-hydroxyglutarate-d₅) is the deuterium labeled D-α-Hydroxyglutaric acid disodium (HY-100542). D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling .

HY-W012814S1

4-Methylcatechol-d8
4-Methylcatechol-d₈ is the deuterium labeled 4-Methylcatechol . 4-Methylcatechol, a metabolite of p-toluate, is a substrate as well as a suicide inhibitor of Catechol 2,3-Dioxygenase .

HY-W012814S

4-Methylcatechol-d3
4-Methylcatechol-d₃ is the deuterium labeled 4-Methylcatechol . 4-Methylcatechol, a metabolite of p-toluate, is a substrate as well as a suicide inhibitor of Catechol 2,3-Dioxygenase .

HY-W745979

Sulcotrione-d7
Sulcotrione-d₇ is the deuterium labeled Sulcotrione (HY-107368). Sulcotrione is a β-triketone herbicide which can inhibit hydroxyphenylpyruvate dioxygenase (HPPD).

HY-B0607S

Nitisinone-d3
Nitisinone-d₃ (NTBC-d₃) is deuterium labeled Nitisinone. Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC₅₀ of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism .

HY-W777526

Nitisinone-13C6
Nitisinone- ¹³C₆ is a ¹³C-labeled Nitisinone (HY-B0607). Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC₅₀ of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism .

HY-W704805

Sodium 2-hydroxypentanedioate-2,3,3-d3

Sodium 2-hydroxypentanedioate-2,3,3-d₃ is the deuterium labeled α-Hydroxyglutaric acid disodium (HY-113038A). α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

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