2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Indoleamine 2,3-Dioxygenase (IDO) Quinone Reductase Reactive Oxygen Species (ROS)
  4. Pronqodine A

Pronqodine A is an Indoleamine 2,3-Dioxygenase (IDO) inhibitor, with an IC50 of 131.5 nM. Pronqodine A inhibits bradykinin-induced release of PGE2, 6-keto-prostaglandin F1α, PGD2 and induces the production of reactive oxygen species (ROS) in human synovial sarcoma SW982 cells. Pronqodine A is a good substrate for human quinone reductase NQO1. Pronqodine A can be used for the study of inflammation.

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Pronqodine A

Pronqodine A Chemical Structure

CAS No. : 1424195-39-0

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Pronqodine A Related Antibodies

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Description

Pronqodine A is an Indoleamine 2,3-Dioxygenase (IDO) inhibitor, with an IC50 of 131.5 nM. Pronqodine A inhibits bradykinin-induced release of PGE2, 6-keto-prostaglandin F1α, PGD2 and induces the production of reactive oxygen species (ROS) in human synovial sarcoma SW982 cells. Pronqodine A is a good substrate for human quinone reductase NQO1. Pronqodine A can be used for the study of inflammation[1][2].

In Vitro

Pronqodine A (1-1000 nM) inhibits bradykinin-induced release of PGE2, 6-keto-prostaglandin F1α, and PGD2 in human synovial sarcoma SW982 cells[1].
Pronqodine A (300 nM, 30 min) induces intracellular ROS production in SW982 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pronqodine A Related Antibodies
Molecular Weight

194.21

Formula

C8H6N2O2S
CAS No.
SMILES

O=C1C=C(C(C2=C1SN=C2)=O)NC
Structure Classification
Initial Source

Streptomyces strain
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Pronqodine A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pronqodine A1424195-39-0Indoleamine 2,3-Dioxygenase (IDO)Quinone ReductaseReactive Oxygen Species (ROS)rhNQO1Indoleamine 2,3-DioxygenaseSW982 cellsinflammationInhibitorinhibitorinhibit

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