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Results for "

cholesterol-lowering

" in MedChemExpress (MCE) Product Catalog:

38

Inhibitors & Agonists

1

Biochemical Assay Reagents

3

Peptides

13

Natural
Products

3

Isotope-Labeled Compounds

2

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-128749
    D-Glucaric acid potassium

    Potassium D-glucarate

    		 Endogenous Metabolite Apoptosis Metabolic Disease Inflammation/Immunology Cancer
    D-Glucaric acid potassium (Potassium D-glucarate) is an orally active end product of the D-glucuronic acid pathway in mammals. D-Glucaric acid potassium is present in a variety of fruits and vegetables. D-Glucaric acid potassium has cholesterol-lowering and anti-tumor activities. D-Glucaric acid potassium can inhibit tumor cell proliferation and inflammation, and induce apoptosis .
    D-Glucaric acid potassium
  • HY-N6811
    1-Octacosanol

    		Insecticide Infection Cardiovascular Disease
    1-Octacosanol is a straight-chain aliphatic 28-carbon fatty alcohol and a major component of the cholesterol-lowering agent Policosanol. 1-Octacosanol exhibits various activities such as anti-fatigue, anti-angiogenic, cholesterol-lowering, and insecticidal effects .
    1-Octacosanol
  • HY-B0893
    3-Pyridinemethanol

    Nicotinyl alcohol; Pyridine-3-carbinol

    		 CETP Metabolic Disease
    3-Pyridinemethanol (Nicotinyl alcohol), a pyridine derivative, is a cholesterol-lowering agent .
    3-Pyridinemethanol
  • HY-B0723S
    Ospemifene-d4

    FC-1271a-d4

    		 Isotope-Labeled Compounds Estrogen Receptor/ERR Cancer
    Ospemifene-d4 is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active estrogen receptor modulator for the prevention of osteoporosis with IC50 values of 827 nM and 1633 nM for estrogen receptor α (ERα) and ERβ, respectively. Ospemifene has bone-sparing, antitumor, and cholesterol-lowering effects .
    Ospemifene-d4
  • HY-100253
    TA-7552

    		Acyltransferase Cardiovascular Disease
    TA-7552 is a potent cholesterol-lowering agent.
    TA-7552
  • HY-153451
    PCSK9-IN-15

    		PCSK9 Metabolic Disease
    PCSK9-IN-15 (compound 5) is a potent inhibitor of proprotein convertase subtilisin/kexin 9 (PCSK9, KD <200 nM). PCSK9 is involved in cholesterol metabolism and regulates levels of low-density lipoprotein cholesterol (LDL-C) in the blood. PCSK9- in -15 can be used to study cholesterol-lowering and dyslipidemia .
    PCSK9-IN-15
  • HY-16166
    Dalvastatin

    RG-12561

    		 HMG-CoA Reductase (HMGCR) Inflammation/Immunology
    Dalvastatin (RG-12561) inhibitor of HMG-CoA reductase and cholesterol-lowering synthesis .
    Dalvastatin
  • HY-116241
    L-157012

    		HMG-CoA Reductase (HMGCR) Metabolic Disease
    L-157012 is a HMG-CoA reductase (HMGCR) inhibitor. L-157012 is also a cholesterol-lowering agent .
    L-157012
  • HY-117760
    Spirolaxine

    		Bacterial Endogenous Metabolite Infection
    Spirolaxine is a plant growth inhibitor and possess significant anti-Helicobacter pylori activity. Spirolaxine exhibits cholesterol-lowering activity .
    Spirolaxine
  • HY-16109
    BMS-188494

    		CETP Metabolic Disease
    BMS-188494 is a cholesterol-lowering agent that degrades into a monoester form, BMS-188494, and a free acid form, BMS-187745 .
    BMS-188494
  • HY-N0131S1
    Stigmasterol-d5-1

    Stigmasterin-d5-1

    		 Isotope-Labeled Compounds MMP Endogenous Metabolite Inflammation/Immunology
    Stigmasterol-d5-1 is deuterium labeled Stigmasterol. Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases .
    Stigmasterol-d5-1
  • HY-B0589H
    Atorvastatin strontium

    		HMG-CoA Reductase (HMGCR) Autophagy Cardiovascular Disease
    Strontium atorvastatin is a cholesterol-lowering drug with activity in ameliorating cardiovascular disease-related events. Strontium atorvastatin exerts its biological activity by inhibiting HMG-CoA reductase in liver tissue. Strontium atorvastatin is also used to suppress dyslipidemia .
    Atorvastatin strontium
  • HY-N8425
    Octacosanoic acid

    Montanic acid

    		 Endogenous Metabolite Metabolic Disease
    Octacosanoic acid is a very long-chain saturated fatty acid. It is the major component of D-003, a mixture of very long-chain aliphatic acids purified from sugar cane wax that has antiplatelet and cholesterol-lowering activities in animal models .
    Octacosanoic acid
  • HY-124064
    TMP-153

    		Acyltransferase Metabolic Disease
    TMP-153 is an orally active inhibitor of ACAT with an IC50 value of approximately 5-10 nM against hepatic and intestinal ACAT in varicose animals. TMP-153 exhibits cholesterol-lowering effects and can be utilized in the research of atherosclerosis .
    TMP-153
  • HY-N0131R
    Stigmasterol (Standard)

    Stigmasterin (Standard)

    		 MMP Endogenous Metabolite Inflammation/Immunology
    Stigmasterol (Standard) is the analytical standard of Stigmasterol (HY-N0131). This product is intended for research and analytical applications. Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases.
    Stigmasterol (Standard)
  • HY-101529
    Imanixil

    HOE-402(free base)

    		 LDLR Cardiovascular Disease
    Imanixil (HOE-402 free base) is an inducer of the LDL receptor (LDLR). Imanixil (HOE-402 free base) is also a potent cholesterol-lowering compound, which inhibits very low density-lipoprotein (VLDL) production, and consequently attenuates atherosclerosis development .
    Imanixil
  • HY-NP026
    Spirulina C-phycocyanin

    C-phycocyaninfromporphyratenera

    		 SOD Integrin Inflammation/Immunology
    Spirulina C-phycocyanin, a component of the light-harvesting phycobilisome complex in photosystem II, is a highly dominant chromoprotein in Spirulina. Spirulina C-phycocyanin can be detected by Raman spectral measurement. Spirulina C-phycocyanin has antioxidant, anti-inflammatory, antiplatelet, liver-protective and cholesterol-lowering effects .
    Spirulina C-phycocyanin
  • HY-W008226
    Phloracetophenone

    2,4,6-trihydroxyacetophenone; 1-(2,4,6-Trihydroxyphenyl)ethanone

    		 Cytochrome P450 Bacterial Antibiotic Infection Metabolic Disease
    Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity . Phloracetophenone stimulats bile secretion mediated through Mrp2 .
    Phloracetophenone
  • HY-N8425R
    Octacosanoic acid (Standard)

    		Endogenous Metabolite Metabolic Disease
    Octacosanoic acid (Standard) is the analytical standard of Octacosanoic acid. This product is intended for research and analytical applications. Octacosanoic acid is a very long-chain saturated fatty acid. It is the major component of D-003, a mixture of very long-chain aliphatic acids purified from sugar cane wax that has antiplatelet and cholesterol-lowering activities in animal models .
    Octacosanoic acid (Standard)
  • HY-161941
    MeIm

    		LDLR PCSK9 Cardiovascular Disease
    MeIm (compound 7) is a high-affinity PCSK9 targeting peptide mimetic with cholesterol-lowering activity. MeIm increases cellular uptake of LDL (EC50=6.04 μM) by inhibiting the binding of PCSK9 to LDLR (IC50=11.2 μM). MeIm can be used in the study of cardiovascular diseases .
    MeIm
  • HY-128749A
    D-Glucaric acid tetrahydrate

    Calcium D-glucarate tetrahydrate

    		 Endogenous Metabolite Apoptosis Metabolic Disease Inflammation/Immunology Cancer
    D-Glucaric acid tetrahydrate (Calcium D-glucarate tetrahydrate) is an orally active end product of the D-glucuronic acid pathway in mammals. D-Glucaric acid tetrahydrate is present in a variety of fruits and vegetables. D-Glucaric acid tetrahydrate has cholesterol-lowering and anti-tumor activities. D-Glucaric acid tetrahydrate can inhibit tumor cell proliferation and inflammation, and induce apoptosis .
    D-Glucaric acid tetrahydrate
  • HY-117459
    E-3030 free acid

    		PPAR Metabolic Disease
    E-3030 free acid is a potent dual activator of peroxisome proliferator-activated receptor (PPAR) alpha and PPARgamma, exhibiting significant antidiabetic and lipid-modulating effects. E-3030 decreases blood glucose, triglyceride, non-esterified fatty acids, and insulin levels, while increasing blood adiponectin levels. E-3030 improves glucose tolerance and shows remarkable triglyceride- and non-high-density lipoprotein cholesterol-lowering effects in animal models.
    E-3030 free acid
  • HY-B2097
    Incadronate disodium

    YM 175; Bisphonal

    		 Farnesyl Transferase Metabolic Disease
    Incadronate disodium (YM 175) is a bisphosphonate with strong inhibitory activity on bone resorption. Incadronate disodium indirectly stimulates renal 25-hydroxyvitamin D-1-hydroxylase by increasing circulating parathyroid hormone. Incadronate disodium, a cholesterol-lowering agent, is a potent inhibitor of rat liver microsomal squalene synthase (Ki=57 nM). Incadronate disodium inhibits sterol biosynthesis in mouse macrophage J774 cells (IC50=64 μM). Incadronate disodium has the potential for malignant tumors research .
    Incadronate disodium
  • HY-128749AR
    D-Glucaric acid tetrahydrate (Standard)

    Calcium D-glucarate tetrahydrate (Standard)

    		 Endogenous Metabolite Apoptosis Metabolic Disease Inflammation/Immunology Cancer
    D-Glucaric acid tetrahydrate (Standard) (Calcium D-glucarate tetrahydrate (Standard)) is the analytical standard of D-Glucaric acid tetrahydrate (HY-128749A). This product is intended for research and analytical applications. D-Glucaric acid tetrahydrate (Calcium D-glucarate tetrahydrate) is an orally active end product of the D-glucuronic acid pathway in mammals. D-Glucaric acid tetrahydrate is present in a variety of fruits and vegetables. D-Glucaric acid tetrahydrate has cholesterol-lowering and anti-tumor activities. D-Glucaric acid tetrahydrate can inhibit tumor cell proliferation and inflammation, and induce apoptosis .
    D-Glucaric acid tetrahydrate (Standard)
  • HY-N1459
    Campesterol
    3 Publications Verification

    		 Endogenous Metabolite Cancer
    Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.
    Campesterol
  • HY-100288
    RP 73163 Racemate

    		Acyltransferase Metabolic Disease
    RP 73163 Racemate is the racemate of RP 73163. RP 73163 is a potent ACAT inhibitor, with cholesterol lowering activity.
    RP 73163 Racemate
  • HY-P10906
    Talovirtide

    		Biochemical Assay Reagents Others
    Talovirtide is a peptide containing L-valyl .
    Talovirtide
  • HY-P10872
    P315V3

    		SARS-CoV Infection
    P315V3 is an pan inhibitor for coronavirus, that inhibits SARS-CoV-2 prototypePT, Delta, BA.1 and BA.4 strain with IC50s of 10.9, 8.9, 8.6, and 2.7 nM. P315V3 exhibits cytotoxicity in Vero cell with CC50 of 4.3 μM. P315V3 exhibits anti-infectious efficacy in mouse models .
    P315V3
  • HY-N1459R
    Campesterol (Standard)

    (24R)-5-Ergosten-3β-ol (Standard)

    		 Endogenous Metabolite Cancer
    Campesterol (Standard) is the analytical standard of Campesterol. This product is intended for research and analytical applications. Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.
    Campesterol (Standard)
  • HY-19264
    264W94

    		Apical Sodium-Dependent Bile Acid Transporter Metabolic Disease
    264W94 is a potent ileal bile acid transporter (IBAT) inhibitor and a new cholesterol lowering agent. 264W94 has CYP7A1 induction, and antilipemic action .
    264W94
  • HY-N1459S
    (24Rac)-Campesterol-d7

    (24Rac)-5-Ergosten-3β-ol-d7

    		 Endogenous Metabolite Cancer
    Campesterol-d7 ((24R)-5-Ergosten-3β-ol-d7) is the deuterium labeled Campesterol. Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.
    (24Rac)-Campesterol-d7
  • HY-19513
    MB-07344

    		Thyroid Hormone Receptor Metabolic Disease Endocrinology
    MB-07344 is a potent thyroid hormone receptor (TR)-β agonist with a Ki of 2.17 nM. MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin (HY-B0589) in rabbits, dogs and monkeys .
    MB-07344
  • HY-19513A
    MB-07344 sodium

    		Thyroid Hormone Receptor Metabolic Disease Endocrinology
    MB-07344 sodium is a potent thyroid hormone receptor (TR)-β agonist with a Ki of 2.17 nM. MB-07344 sodium has additive cholesterol lowering activity in combination with Atorvastatin (HY-B0589) in rabbits, dogs and monkeys .
    MB-07344 sodium
  • HY-N0322B
    Cholesterol (Excipient)

    		Liposome Endogenous Metabolite Others
    Cholesterol Excipient is a component of the cell membrane and a precursor of some hormones, vitamin D and bile acid, with oral activity. Cholesterol Excipient is a drug delivery carrier based on the lipid environment of the cell membrane. Due to its amphiphilicity, good biocompatibility and biodegradability, it can be used as an excipient in drug preparations. Cholesterol Excipient can self-assemble into delivery systems such as micelles, nanoparticles, and liposomes, and achieve controlled drug release by regulating membrane fluidity or responding to the microenvironment. It has the characteristics of high drug loading efficiency and good biocompatibility. Cholesterol Excipient is mainly used for research in the fields of targeted delivery of anticancer, antibacterial, antiviral drugs and treatment of skin diseases.
    Cholesterol itself is also an endogenous regulator involved in the cleavage of amyloid precursor protein (APP) mediated by β-secretase and intestinal absorption, as well as an endogenous estrogen-related receptor α (ERRα) agonist. Cholesterol affects the subcellular localization of APP processing enzymes by regulating the cell membrane lipid environment, which can promote the production of β-amyloid protein and its adsorption and removal by probiotics. It is used to study the pathogenesis of Alzheimer's disease (AD) and the cholesterol-lowering function of probiotics[1][2][3][4][5].
    Cholesterol (Excipient)
  • HY-P2424
    Cholecystokinin-J

    CCK-J

    		 Calcium Channel Others
    Cholecystokinin-J (CCK-J), a cholecystokinin, stimulates Ca 2+ release .
    Cholecystokinin-J
  • HY-N0322BR
    Cholesterol (Excipient) (Standard)

    		Reference Standards Liposome Endogenous Metabolite Others
    Cholesterol (Excipient) (Standard) is the analytical standard of Cholesterol (Excipient) (HY-N0322B). This product is intended for research and analytical applications. Cholesterol Excipient is a component of the cell membrane and a precursor of some hormones, vitamin D and bile acid, with oral activity. Cholesterol Excipient is a drug delivery carrier based on the lipid environment of the cell membrane. Due to its amphiphilicity, good biocompatibility and biodegradability, it can be used as an excipient in drug preparations. Cholesterol Excipient can self-assemble into delivery systems such as micelles, nanoparticles, and liposomes, and achieve controlled drug release by regulating membrane fluidity or responding to the microenvironment. It has the characteristics of high drug loading efficiency and good biocompatibility. Cholesterol Excipient is mainly used for research in the fields of targeted delivery of anticancer, antibacterial, antiviral drugs and treatment of skin diseases.
    Cholesterol itself is also an endogenous regulator involved in the cleavage of amyloid precursor protein (APP) mediated by β-secretase and intestinal absorption, as well as an endogenous estrogen-related receptor α (ERRα) agonist. Cholesterol affects the subcellular localization of APP processing enzymes by regulating the cell membrane lipid environment, which can promote the production of β-amyloid protein and its adsorption and removal by probiotics. It is used to study the pathogenesis of Alzheimer's disease (AD) and the cholesterol-lowering function of probiotics[1][2][3][4][5].
    Cholesterol (Excipient) (Standard)
  • HY-N0527
    Pentagalloylglucose
    10+ Cited Publications

    Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose

    		 JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species Neurological Disease Inflammation/Immunology Cancer
    Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities .
    Pentagalloylglucose
  • HY-N0527R
    Pentagalloylglucose (Standard)

    		JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species Neurological Disease Inflammation/Immunology Cancer
    Pentagalloylglucose (Standard) is the analytical standard of Pentagalloylglucose. This product is intended for research and analytical applications. Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities .
    Pentagalloylglucose (Standard)

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