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Isoforms Recommended: Cathepsin L
Results for "

cathepsin-L

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

3

Peptides

5

Recombinant Proteins

1

Antibodies

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P2923
    Cathepsin L

    		Biochemical Assay Reagents Others
    Cathepsin L is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Cathepsin L
  • HY-115733
    Cathepsin L-IN-2

    (Rac)-Z-Phe-Phe-FMK

    		 Cathepsin Cancer
    Cathepsin L-IN-2 ((Rac)-Z-Phe-Phe-FMK) is an isomer of the Cathepsin L inhibitor Z-Phe-Phe-FMK (HY-141867), with an IC50 of 15 μM for cathepsin L. Z-Phe-Phe-FMK irreversibly blocks the proteolytic function of cathepsins by covalently binding to the cysteine residues in the active center of the enzyme. Cathepsin L-IN-2 and Z-Phe-Phe-FMK can be used to study neurodegenerative diseases (such as GRN-related frontotemporal dementia) and cancer invasion and metastasis.
    Cathepsin L-IN-2
  • HY-141867
    Z-FF-FMK

    Z-Phe-Phe-FMK

    		 Cathepsin Neurological Disease
    Z-FF-FMK is a selective cathepsin-L inhibitor. Z-FF-FMK can prevent β-amyloid to induce apoptotic changes such as activation of caspase-3, cleavage of the DNA repair enzyme, poly-ADP ribose polymerase, and DNA fragmentation .
    Z-FF-FMK
  • HY-128140
    Z-FY-CHO
    5 Publications Verification

    Z-Phe-Tyr-CHO

    		 Cathepsin Neurological Disease Metabolic Disease
    Z-FY-CHO (Z-Phe-Tyr-CHO) is a potent and specific cathepsin L (CTSL) inhibitor .
    Z-FY-CHO
  • HY-169171
    Cathepsin L-IN-5

    		Cathepsin Infection
    Cathepsin L-IN-5 (D6-3) is a potent Cathepsin L (CatL) inhibitor with an IC50 of 0.27 nM. Cathepsin L-IN-5 effectively blocks the CatL function and substantially hinders the entry of the SARS-CoV-2 pseudovirus to cells by inhibiting the cleavage of the spike protein. Cathepsin L-IN-5 can be utilized in SARS-CoV-2 research .
    Cathepsin L-IN-5
  • HY-P10118
    Cathepsin L-IN-3

    		Cathepsin Others
    Cathepsin L-IN-3 is a tripeptide-sized cathepsin L inhibitor.
    Cathepsin L-IN-3
  • HY-152204
    Cathepsin L/S-IN-1

    		Cathepsin Cancer
    Cathepsin L/S-IN-1 is a dual inhibitor of Cathepsin L and Cathepsin S with IC50s of 4.10 μM and 1.79 μM, respectively. Cathepsin L/S-IN-1 shows a significant antimetastatic and invasive effects on pancreatic cancer BxPC-3 and PANC-1 cells .
    Cathepsin L/S-IN-1
  • HY-137392
    Cathepsin L-IN-4

    1-Naphthalenesulfonyl-Ile-Trp-CHO

    		 Cathepsin Others
    Cathepsin L-IN-4 is an inhibitor of cathepsin L with IC50 at nanomolar concentrations .
    Cathepsin L-IN-4
  • HY-163389
    Mpro/Cathepsin L-IN-1

    		SARS-CoV Cathepsin Infection
    Mpro/Cathepsin L-IN-1 (Compound 4d) is a SARS-CoV-2 M pro/hCatL inhibitor, with Kis of 5.54 μM and 0.701 μM respectively .
    Mpro/Cathepsin L-IN-1
  • HY-170772
    Dual Cathepsin L/JAK-IN-1

    		p38 MAPK STAT Interleukin Related Cathepsin JAK Inflammation/Immunology
    Dual Cathepsin L/JAK-IN-1 (Compound A8) is a dual inhibitor of Cathepsin L (CTSL) and JAK, with IC50 values of 0.68 μM, 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for CTSL, JAK1/2/3, and TYK2, respectively. Dual Cathepsin L/JAK-IN-1 effectively blocks the activation of the MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. Dual Cathepsin L/JAK-IN-1 can be used in research on acute lung injury (ALI) .
    Dual Cathepsin L/JAK-IN-1

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