Search Result

Pathways Recommended:	TGF-beta/Smad

Results for "

beta adrenoceptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	β-catenin (6) 5-HT Receptor (19) Adenosine Receptor (1) Adrenergic Receptor (187) Akt (8) Angiotensin Receptor (2) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (2) Apoptosis (16) Bacterial (1) Bcl-2 Family (1) Calcium Channel (1) Caspase (1) Dopamine Receptor (2) Drug Derivative (1) Drug Metabolite (4) GABA Receptor (2) Imidazoline Receptor (3) Influenza Virus (2) Isotope-Labeled Compounds (33) mAChR (10) Monoamine Oxidase (3) Ornithine decarboxylase (ODC) (1) Phosphodiesterase (PDE) (4) PI3K (2) Potassium Channel (1) Reactive Oxygen Species (ROS) (1) Reference Standards (28) Renin (3) Wnt (6)
By Research Areas:	Cancer (42) Cardiovascular Disease (81) Endocrinology (98) Infection (11) Inflammation/Immunology (49) Metabolic Disease (15) Neurological Disease (53)
Click Chemistry:	Alkynes (1)

204

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Amyloid-β TGF-β Receptor Beta-secretase β-glucuronidase 3β-HSD TGF-beta/Smad 17β-HSD β-catenin 11β-HSD Beta-lactamase Dopamine β-hydroxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12463

Carmoterol hydrochloride	Adrenergic Receptor	Inflammation/Immunology
Carmoterol hydrochloride is a highly potent, selective and long-acting *β2-adrenoceptor* agonist with the pEC₅₀ of 10.19. Carmoterol has 53 times higher affinity for the β2-adrenoceptors than for the β1-adrenoceptors. Carmoterol hydrochloride can be used for the research of asthma and chronic obstructive pulmonary disease (COPD) .

HY-101355A

CGP 20712 dihydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology
CGP 20712 dihydrochloride is a highly selective *β1-adrenoceptor* antagonist with an IC₅₀ of 0.7 nM. CGP 20712 dihydrochloride exhibits ~10,000-fold selectivity over β2-adrenoceptors .

HY-101355B

CGP 20712 A CGP 20712 mesylate	Adrenergic Receptor	Cardiovascular Disease
CGP 20712 A (CGP 20712 mesylate) is a highly selective *β1-adrenoceptor* antagonist with an IC₅₀ of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors .

HY-107327

Carazolol (±)-Carazolol; DL-Carazolol; Suacron	Adrenergic Receptor	Cardiovascular Disease
Carazolol is a **β₁/β₂ adrenoceptor antagonist of high potency used in the research of hypertension. Carazolol is also a potent, selective β₃-adrenoceptor** agonist .

HY-103207

Amibegron hydrochloride SR 58611A	Adrenergic Receptor	Neurological Disease Endocrinology
Amibegron hydrochloride is a selective *β3-adrenoceptor* agonist, with an EC₅₀ of 3.5 nM for *β-adrenoceptor* in rat colon; Amibegron hydrochloride has anxiolytic and antidepressant activity.

HY-107155

β-Blocker B-24/76	Adrenergic Receptor Ornithine decarboxylase (ODC)	Cardiovascular Disease
β-Blocker B-24/76 is a **beta adrenoceptor blocker. β-Blocker B-24/76 exhibits beta 1-adrenoceptor** blocking and beta *2-adrenoceptor* stimulating properties. β-Blocker B-24/76 can suppress the increased ornithine decarboxylase activity in hypertrophied hearts. β-Blocker B-24/76 can be used for the research of cardiovascular disease .

HY-12463A

Carmoterol	Adrenergic Receptor	Inflammation/Immunology
Carmoterol is a highly potent, selective and long-acting *β2-adrenoceptor* agonist with the pEC₅₀ of 10.19. Carmoterol has 53 times higher affinity for the β2-adrenoceptors than for the β1-adrenoceptors . Carmoterol can be used for the research of asthma and chronic obstructive pulmonary disease (COPD) .

HY-U00183

Epanolol Visacor; ICI141292	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Epanolol (Visacor; ICI141292) is a potent *β-adrenoceptor* partial agonist with a greater affinity for β1- than β2-adrenoceptors.

HY-U00206

D2343	Adrenergic Receptor	Endocrinology
D2343 is a *β2-adrenoceptor* agonist and also is an α1- adrenoceptor inhibitor.

HY-111479

Amibegron SR-58611	Adrenergic Receptor	Neurological Disease Endocrinology
Amibegron is a selective *β3-adrenoceptor* agonist, with an EC₅₀ of 3.5 nM for *β-adrenoceptor* in rat colon; Amibegron has anxiolytic and antidepressant activity.

HY-136435

Mapenterol hydrochloride	Adrenergic Receptor	Endocrinology
Mapenterol hydrochloride is a type of *β2-adrenoceptor* agonist .

HY-135487

Sibenadet AR-C68397AA free base; AR-C68397XX	Dopamine Receptor Adrenergic Receptor	Neurological Disease
Sibenadet (AR-C68397AA free base) is a dual dopamine D₂/β₂-adrenoceptor agonist with selective β₂-adrenoceptor agonism. Sibenadet inhibits capsaicin-induced plasma protein extravasation in rat trachea. Sibenadet suppresses edema from sensory nerve fiber activation by activating β₂-adrenoceptor. Sibenadet is promising for research of chronic obstructive pulmonary disease (COPD) .

HY-W517264

Carazolol hydrochloride BM 51052 hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Carazolol (BM 51052) hydrochloride is a highly potent antagonist of **β₁/β₂ adrenoceptor. Carazolol hydrochloride is also a potent, selective β₃-adrenoceptor** agonist. Carazolol hydrochloride can be used in the research of hypertension .

HY-14773

Mirabegron 5 Publications Verification YM178	Adrenergic Receptor	Neurological Disease Endocrinology Cancer
Mirabegron is a selective *β₃-adrenoceptor* agonist with EC₅₀ of 22.4 nM.

HY-U00066

Cicloprolol hydrochloride	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Cicloprolol is a partial β 1-adrenoceptor agonist .

HY-B0010

Formoterol fumarate 4 Publications Verification (±)Formoterol fumarate	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Formoterol fumarate (Formoterol) is a potent, selective and long-acting β2-adrenoceptor agonist.

HY-14301

Olodaterol 1 Publications Verification BI1744	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Olodaterol (BI1744) is a selective, long acting *β₂-adrenoceptor* (β₂-AR) agonist (EC₅₀=0.1 nM and pK_i= 9.14 for human β₂-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis .

HY-14301A

Olodaterol hydrochloride 1 Publications Verification BI1744 hydrochloride	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Olodaterol (BI1744) hydrochloride is a selective, long acting *β₂-adrenoceptor* (β₂-AR) agonist (EC₅₀=0.1 nM and pK_i= 9.14 for human β₂-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis .

HY-19942A

TD-5471 hydrochloride	Adrenergic Receptor	Metabolic Disease Endocrinology
TD-5471 hydrochloride is a potent and selective full agonist of the human *β₂-adrenoceptor*.

HY-12980

Batefenterol GSK961081; TD-5959	Adrenergic Receptor mAChR	Inflammation/Immunology Endocrinology
Batefenterol (GSK961081;TD-5959) is a novel muscarinic receptor antagonist and *β₂-adrenoceptor* agonist; displays high affinity for hM2, hM3 muscarinic and hβ₂-adrenoceptor with K_i values of 1.4, 1.3 and 3.7 nM, respectively.

HY-101355AR

CGP 20712 dihydrochloride (Standard)	Adrenergic Receptor Reference Standards	Neurological Disease Endocrinology
CGP 20712 (dihydrochloride) (Standard) is the analytical standard of CGP 20712 (dihydrochloride). This product is intended for research and analytical applications. CGP 20712 dihydrochloride is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 dihydrochloride exhibits ~10,000-fold selectivity over β2-adrenoceptors .

HY-107327R

Carazolol (Standard) (±)-Carazolol (Standard); DL-Carazolol (Standard); Suacron (Standard)	Reference Standards Adrenergic Receptor	Cardiovascular Disease
Carazolol (Standard) is the analytical standard of Carazolol. This product is intended for research and analytical applications. Carazolol is a **β₁/β₂ adrenoceptor antagonist of high potency used in the research of hypertension. Carazolol is also a potent, selective β₃-adrenoceptor** agonist .

HY-19942

TD-5471	Adrenergic Receptor	Metabolic Disease Endocrinology
TD-5471 is a potent and selective full agonist of the human *β₂-adrenoceptor* .

HY-101355BR

CGP 20712 A (Standard) CGP 20712 mesylate (Standard)	Reference Standards Adrenergic Receptor	Cardiovascular Disease
CGP 20712 A (Standard) is the analytical standard of CGP 20712 A. This product is intended for research and analytical applications. CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors .

HY-107327S

Carazolol-d7 (±)-Carazolol-d₇; DL-Carazolol-d₇; Suacron-d₇	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease
Carazolol-d₇ is the deuterium labeled Carazolol (HY-107327). Carazolol is a highly potent antagonist of **β₁/β₂ adrenoceptor. Carazolol is also a potent, selective β₃-adrenoceptor** agonist. Carazolol can be used in the research of hypertension .

HY-107327S1

Carazolol-d7 hydrochloride	Adrenergic Receptor Isotope-Labeled Compounds	Cardiovascular Disease
Carazolol-d₇ (hydrochloride) is the deuterium labeled Carazolol hydrochloride (HY-W517264). Carazolol hydrochloride is a highly potent antagonist of **β₁/β₂ adrenoceptor. Carazolol hydrochloride is also a potent, selective β₃-adrenoceptor** agonist. Carazolol hydrochloride can be used in the research of hypertension .

HY-W777156

Carazolol-d6 hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease
Carazolol-d₆ (hydrochloride) is deuterium labeled Carazolol hydrochloride (HY-W517264). Carazolol hydrochloride is a highly potent antagonist of **β₁/β₂ adrenoceptor. Carazolol hydrochloride is also a potent, selective β₃-adrenoceptor** agonist. Carazolol hydrochloride can be used in the research of hypertension .

HY-14301AR

Olodaterol hydrochloride (Standard) BI1744 hydrochloride (Standard)	Reference Standards Adrenergic Receptor	Inflammation/Immunology Endocrinology
Olodaterol (hydrochloride) (Standard) is the analytical standard of Olodaterol (hydrochloride). This product is intended for research and analytical applications. Olodaterol (BI1744) hydrochloride is a selective, long acting *β₂-adrenoceptor* (β₂-AR) agonist (EC₅₀=0.1 nM and pK_i= 9.14 for human β₂-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis .

HY-136435S1

Mapenterol-d6 hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor	Endocrinology
Mapenterol-d₆ (hydrochloride) is the deuterium labeled Mapenterol hydrochloride. Mapenterol hydrochloride is a type of β2-adrenoceptor agonist .

HY-119868

Butaxamine Butoxamin	Adrenergic Receptor	Metabolic Disease
Butaxamine (Butoxamin) is a potent, selective and orally active *β2-adrenoceptor* antagonist. Butaxamine shows antiosteoporotic activity .

HY-100704A

(Rac)-Procaterol hydrochloride	Adrenergic Receptor	Inflammation/Immunology
(Rac)-Procaterol hydrochloride is a selective, orally active agonist at *β2-adrenoceptor*. (Rac)-Procaterol hydrochloride is used as a bronchodilator .

HY-B0010B

Formoterol-1 1 Publications Verification (±)Formoterol	Adrenergic Receptor	Inflammation/Immunology
Formoterol ((±)Formoterol) is an orally active β2-selective agonist. Formoterol potently relaxes the peripheral airways through stimulating the beta 2-adrenoceptors selectively as is the case in the central airways and that it significantly inhibits IgE-mediated slow reactive substance of anaphylaxis (SRS-A) release through beta-adrenoceptor stimulation .

HY-12980R

Batefenterol (Standard)	Adrenergic Receptor mAChR	Inflammation/Immunology Endocrinology
Batefenterol (Standard) is the analytical standard of Batefenterol. This product is intended for research and analytical applications. Batefenterol (GSK961081;TD-5959) is a novel muscarinic receptor antagonist and β2-adrenoceptor agonist; displays high affinity for hM2, hM3 muscarinic and hβ2-adrenoceptor with Ki values of 1.4, 1.3 and 3.7 nM, respectively.

HY-137909

Formoterol O-β-D-glucuronide	Adrenergic Receptor	Inflammation/Immunology
Formoterol O-β-D-glucuronide is a metabolite of Formoterol (HY-B0010). Formoterol is a potent, selective and long-acting β2-adrenoceptor agonist .

HY-W744625

Olodaterol-d3 hydrochloride BI1744-d₃ hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor	Endocrinology
Olodaterol-d₃ hydrochloride (BI1744-d₃ hydrochloride) is the deuterium labeled Olodaterol hydrochloride (HY-14301A). Olodaterol (BI1744) hydrochloride is a selective, long acting β2-adrenoceptor (β2-AR) agonist (EC₅₀=0.1 nM and pKi= 9.14 for human β2-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis .

HY-10998

Salmefamol AH 3923	Adrenergic Receptor	Inflammation/Immunology
Salmefamol (AH3923) is an orally active *β2-adrenoceptor* agonist. Salmefamol (AH3923) can be used in the study for asthma .

HY-118770

Nafetolol K 5407 free base	Adrenergic Receptor	Cardiovascular Disease
Nafetolol (K 5407), specifically effective on cardiac (β1)-adrenoceptors, is an orally active β blocking agent, with a t_1/2 of ~ 2 h in dogs .

HY-B0010S

Formoterol-d6 (±)Formoterol-d₆	Isotope-Labeled Compounds Adrenergic Receptor	Inflammation/Immunology Endocrinology
Formoterol-d₆ is the deuterium labeled Formoterol. Formoterol ((±)Formoterol) is a potent, selective and long-acting β2-adrenoceptor agonist .

HY-124950A

(+)-Picumeterol (+)-GR114297A	Adrenergic Receptor	Metabolic Disease
(+)-Picumeterol is a configurations of Picumeterol (HY-124950). Picumeterol is a potent and selective *β₂-adrenoceptor* agonist with bronchodilator and anti-bronchoconstrictor effects .

HY-167866

Ersentilide	Adrenergic Receptor Potassium Channel	Cardiovascular Disease
Ersentilide, a benzamide derivative, is a is a *β1-adrenoceptor* antagonist and Ikr blocker. Ersentilide is effective in several intact animal models of arrhythmia .

HY-14773S

(Rac)-Mirabegron-d5 (Rac)-YM178-d₅	Isotope-Labeled Compounds Adenosine Receptor	Metabolic Disease
(Rac)-Mirabegron-d₅ is a deuterium labeled (Rac)-Mirabegron. (Rac)-Mirabegron is the racemate of Mirabegron. Mirabegron is a selective β3-adrenoceptor agonist .

HY-17503

Metoprolol 10+ Cited Publications	Adrenergic Receptor Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol is an orally active, selective *β1-adrenoceptor* antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-14773R

Mirabegron (Standard) YM178 (Standard)	Reference Standards Adrenergic Receptor	Neurological Disease Endocrinology
Mirabegron (Standard) is the analytical standard of Mirabegron. This product is intended for research and analytical applications. Mirabegron is a selective *β₃-adrenoceptor* agonist with EC₅₀ of 22.4 nM.

HY-129660

LK 204-545	Adrenergic Receptor	Cardiovascular Disease
LK 204-545 is a potent and highly selective *β₁-adrenoceptor* antagonist. LK 204-545 is promising for research of cardiovascular diseases .

HY-17503D

Metoprolol Hydrochloride	Adrenergic Receptor Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Metoprolol Hydrochloride is an orally active and selective *β1-adrenoceptor* antagonist. Metoprolol Hydrochloride exhibits anti-inflammatory, antitumor, and anti-angiogenic properties .

HY-117024

Abediterol napadisylate AZD0548 napadisylate; LAS100977 napadisylate	Adrenergic Receptor	Inflammation/Immunology
Abediterol napadisylate is an inhaled long-acting *β2-adrenoceptor* agonist (LABA) and can be used for the research of asthma and chronic obstructive pulmonary disease (COPD) .

HY-169340

SAR-150640	Adrenergic Receptor	Inflammation/Immunology
SAR-150640, a selective *β₃-adrenoceptor* agonist, prevents the increase in MMP activity and production observed after LPS stimulation or in cases of chorioamnionitis .

HY-14304

Zinterol MJ 9184	Adrenergic Receptor	Cardiovascular Disease
Zinterol (MJ 9184) is a potent and selective *β2-adrenoceptor* agonist . Zinterol increases I_Ca in a concentration-dependent manner with an EC₅₀ of 2.2 nM .

HY-17498B

Atenolol hydrochloride (RS)-Atenolol hydrochloride; Tenormin hydrochloride; ICI 66082 hydrochloride	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Endocrinology Cancer
Atenolol hydrochloride is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol hydrochloride can be used for the research of hypertension and angina pectoris .

HY-111144

Abediterol AZD0548; LAS100977	Adrenergic Receptor	Inflammation/Immunology
Abediterol (LAS100977) is an inhaled long-acting *β2-adrenoceptor* agonist (LABA) and can be used for the research of asthma and chronic obstructive pulmonary disease (COPD) .

Cat. No.	Product Name	Target	Research Area

HY-P1376

G-Protein antagonist peptide	mAChR Adrenergic Receptor	Endocrinology
G-Protein antagonist peptide is the substance P-related peptide that inhibits binding of G proteins to their receptors. G-Protein antagonist peptide competitively and reversibly inhibits M2 muscarinic receptor activation of G_i or G_o and inhibits G_s activation by β-adrenoceptors.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-17503

Metoprolol Maximum Cited Publications 15 Publications Verification	Classification of Application Fields Disease Research Fields Endocrinology	Adrenergic Receptor Apoptosis
Metoprolol is an orally active, selective *β1-adrenoceptor* antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-136409R

N-Decanoyl-L-homoserine lactone (Standard) C10-HSL (Standard)	Microorganisms Source classification	Reference Standards Bacterial Reactive Oxygen Species (ROS)
Formoterol (hemifumarate hydrate) (Standard) is the analytical standard of Formoterol (hemifumarate hydrate). This product is intended for research and analytical applications. Formoterol hemifumarate hydrate is a selective, long-acting beta 2-adrenoceptor agonist. Formoterol is a bronchodilator used for the research of the asthma and chronic obstructive pulmonary disease (COPD). Formoterol hemifumarate hydrate induces mitochondrial biogenesis and promotes cognitive recovery after traumatic brain injury .

HY-N7142

DL-Norepinephrine hydrochloride 2 Publications Verification	Neurological Disease Classification of Application Fields Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology	Adrenergic Receptor
DL-Norepinephrine hydrochloride is a synthetic phenylethylamine. DL-Norepinephrine hydrochloride is a neurotransmitter targets α1 and β1 adrenoceptors. DL-Norepinephrine hydrochloride mimics the sympathomimetic actions of the endogenous norepinephrine．DL-Norepinephrine hydrochloride has an increasing effect on subendocardial oxygen tension .

HY-17501

Bambuterol (±)-Bambuterol; KWD-2183	Classification of Application Fields Disease Research Fields Endocrinology	Adrenergic Receptor
Bambuterol ((±)-Bambuterol; KWD-2183) is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a proagent of terbutaline.

HY-N8268R

Nordeoxycholic acid (Standard) 3α,12α-Dihydroxynorcholanic acid (Standard)	Animals Source classification	Drug Metabolite Reference Standards
Reproterol (hydrochloride) (Standard) is the analytical standard of Reproterol (hydrochloride). This product is intended for research and analytical applications. Reproterol hydrochloride is a dual-acting beta2-adrenoceptor agonist and phosphodiesterase inhibitor. Reproterol hydrochloride is more potent than albuterol and feterol in stimulating cAMP production in human monocytes, demonstrating its potential in enhancing airway function. Furthermore, Reproterol significantly inhibited the production of LTB4, indicating its anti-inflammatory properties. Reproterol hydrochloride may have inhibitory effects in respiratory diseases such as asthma and COPD .

HY-101392R

Harmane (Standard)	Alkaloids other families Source classification Plants	Reference Standards Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor
Harmane (Standard) is the analytical standard of Harmane. This product is intended for research and analytical applications. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over *α2-adrenoceptor* (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for human MAO A/B, respectively). Harmane exhibits comutagenic effect .

Cat. No.	Compare	Product Name	Species	Source

HY-P702206

	ADRB2 Protein, Human (G16R, E27Q, Cell-Free, His, SUMO) beta-2 adrenergic receptor; beta-2 adrenoreceptor; beta-2 adrenoceptor	Human	E. coli Cell-free
	ADRB2 protein is an important member of the β-adrenergic receptor family and mediates catecholamine-induced adenylyl cyclase activation through G protein action. It has 30 times greater affinity for epinephrine and plays a crucial role in cellular responses to sympathetic nervous system stimulation. ADRB2 Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived ADRB2 protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag with mutatant of G16R, E27Q.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-107327S

Carazolol-d7
Carazolol-d₇ is the deuterium labeled Carazolol (HY-107327). Carazolol is a highly potent antagonist of **β₁/β₂ adrenoceptor. Carazolol is also a potent, selective β₃-adrenoceptor** agonist. Carazolol can be used in the research of hypertension .

HY-W744625

Olodaterol-d3 hydrochloride
Olodaterol-d₃ hydrochloride (BI1744-d₃ hydrochloride) is the deuterium labeled Olodaterol hydrochloride (HY-14301A). Olodaterol (BI1744) hydrochloride is a selective, long acting β2-adrenoceptor (β2-AR) agonist (EC₅₀=0.1 nM and pKi= 9.14 for human β2-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis .

HY-17503AS

Metoprolol-d7 hydrochloride
Metoprolol-d₇ (hydrochloride) is the deuterium labeled Metoprolol. Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-107327S1

Carazolol-d7 hydrochloride
Carazolol-d₇ (hydrochloride) is the deuterium labeled Carazolol hydrochloride (HY-W517264). Carazolol hydrochloride is a highly potent antagonist of **β₁/β₂ adrenoceptor. Carazolol hydrochloride is also a potent, selective β₃-adrenoceptor** agonist. Carazolol hydrochloride can be used in the research of hypertension .

HY-W777156

Carazolol-d6 hydrochloride
Carazolol-d₆ (hydrochloride) is deuterium labeled Carazolol hydrochloride (HY-W517264). Carazolol hydrochloride is a highly potent antagonist of **β₁/β₂ adrenoceptor. Carazolol hydrochloride is also a potent, selective β₃-adrenoceptor** agonist. Carazolol hydrochloride can be used in the research of hypertension .

HY-136435S1

Mapenterol-d6 hydrochloride
Mapenterol-d₆ (hydrochloride) is the deuterium labeled Mapenterol hydrochloride. Mapenterol hydrochloride is a type of β2-adrenoceptor agonist .

HY-B0010S

Formoterol-d6
Formoterol-d₆ is the deuterium labeled Formoterol. Formoterol ((±)Formoterol) is a potent, selective and long-acting β2-adrenoceptor agonist .

HY-14773S

(Rac)-Mirabegron-d5
(Rac)-Mirabegron-d₅ is a deuterium labeled (Rac)-Mirabegron. (Rac)-Mirabegron is the racemate of Mirabegron. Mirabegron is a selective β3-adrenoceptor agonist .

HY-14773S1

Mirabegron-d8
Mirabegron-d₈ (YM178-d₈) is deuterium labeled Mirabegron. Mirabegron is a selective *β₃-adrenoceptor* agonist with EC₅₀ of 22.4 nM.

HY-14773S3

Mirabegron-d5
Mirabegron-d₅ (YM178-d₅) is deuterium labeled Mirabegron. Mirabegron is a selective *β₃-adrenoceptor* agonist with EC₅₀ of 22.4 nM.

HY-17503S3

Metoprolol-d5
Metoprolol-d₅ is the deuterium labeled Metoprolol . Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-17498S

Atenolol-d7
Atenolol-d₇ is the deuterium labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM atβ1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .

HY-17503BS

Metoprolol-d6 tartrate
Metoprolol-d₆ (tartrate) is the deuterium labeled Metoprolol tartrate. Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-17498S1

Atenolol-d6
Atenolol-d₆ ((RS)-Atenolol-d₆) is deuterium labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .

HY-135119

Salmeterol-d3
Salmeterol-d₃ is a deuterium labeled Salmeterol. Salmeterol is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively .

HY-17503AS1

Metoprolol-d6 succinate
Metoprolol-d₆ (succinate) is deuterium labeled Metoprolol (succinate). Metoprolol succinate is an orally active, selective *β1-adrenoceptor* antagonist. Metoprolol succinate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-17498S3

Atenolol-13C6
Atenolol- ¹³C₆ ((RS)-Atenolol- ¹³C₆) is ¹³C labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .

HY-14302S1

Salmeterol-d5
Salmeterol-d5 is a deuterated labeled Salmeterol . Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively .

HY-W759997

Reproterol-d3
Reproterol-d₃ is the deuterium labeled Reproterol (HY-135490). Reproterol is a dual acting β2-adrenoceptor agonist and PDE inhibitor. The theophylline constituent of Reproterol inhibits phosphodiesterase activity induced by adenylyl cyclase. Reproterol has the potential for asthma research .

HY-17453S

Salmeterol-d3 xinafoate
Salmeterol-d₃ (xinafoate) is the deuterium labeled Salmeterol xinafoate. Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively .

HY-17453S1

Salmeterol-13C6 xinafoate
Salmeterol- ¹³C₆ (xinafoate) is the ¹³C₆ labeled Salmeterol (xinafoate). Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively.

HY-157502S

Buctopamine-d9
Buctopamine-d9 is the deuterium labeled Buctopamine. Buctopamine is a β2 adrenoceptor agonist .

HY-14300S2

Vilanterol-d12
Vilanterol-d₁₂ (GW642444-d₁₂) is deuterium labeled Vilanterol. Vilanterol (GW642444) is a long-acting *β₂-adrenoceptor* (β₂-AR) agonist with 24 h activity. The pEC₅₀s for β₂-AR,β₁-AR and β₃-AR is 10.37±0.05, 6.98±0.03 and 7.36±0.03, respectively.

HY-B1810S

Tulobuterol-d9 hydrochloride
Tulobuterol-d₉ (hydrochloride) is the deuterium labeled Tulobuterol. Tulobuterol (C-78 free base) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength .

HY-116790BSA

(±)-Penbutolol-d9 hydrochloride
(±)-Penbutolol-d₉ (hydrochloride) is a deuterium labeled (±)-Penbutolol hydrochloride. (+)-Penbutolol hydrochloride is a β-adrenoceptor antagonist, with an IC₅₀ of 0.74 μM .

HY-B0976AS

Fenoterol-d6 hydrobromide
Fenoterol-d₆ (hydrobromide) (Th-1165a-d₆) is the deuterium labeled Fenoterol hydrobromide. Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research .

HY-100635S

Diacetolol-d7
Diacetolol-d₇ is a deuterium labeled Diacetolol. Diacetolol is the major metabolite of Acebutolol. Diacetolol is a β-adrenoceptor blocking and anti-arrhythmic agent .

HY-17501S

Bambuterol-d9 hydrochloride
Bambuterol-d₉ (hydrochloride) is the deuterium labeled Bambuterol. Bambuterol ((±)-Bambuterol) hydrochloride is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a prodrug of terbutaline.

HY-15746S1

(rac)-Dobutamine-d6 hydrochloride
(rac)-Dobutamine-d₆ (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion .

HY-15746S

(rac)-Dobutamine-d4 hydrochloride
(rac)-Dobutamine-d₄ (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion .

HY-N7142S

DL-Norepinephrine-d6 hydrochloride
DL-Norepinephrine-d₆ (hydrochloride) is the deuterium labeled DL-Norepinephrine hydrochloride. DL-Norepinephrine hydrochloride is a synthetic phenylethylamine that mimics the sympathomimetic actions of the endogenous norepinephrine．DL-Norepinephrine hydrochloride is a neurotransmitter targets α1 and β1 adrenoceptors, has an increasing effect on subendocardial oxygen tension .

HY-N7142S1

DL-Norepinephrine-d3 hydrochloride
DL-Norepinephrine-d₃ (hydrochloride) is the deuterium labeled DL-Norepinephrine hydrochloride . DL-Norepinephrine hydrochloride is a synthetic phenylethylamine that mimics the sympathomimetic actions of the endogenous norepinephrine．DL-Norepinephrine hydrochloride is a neurotransmitter targets α1 and β1 adrenoceptors, has an increasing effect on subendocardial oxygen tension .

HY-W742404

Bopindolol-d9

Bopindolol-d₉ ((±)-Bopindolol-d₉) is the deuterium labeled Bopindolol (HY-B1562). Bopindolol ((±)-Bopindolol) is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol is a proagent of Pindolol (HY-B0982). Bopindolol can be used for essential and renovascular hypertension research.

HY-101392S

Harmane-d1

Harmane-d is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over α2-adrenoceptor (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for human MAO A/B, respectively) .

HY-101392S1

Harmane-d2

Harmane-d₂ is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over α2-adrenoceptor (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for human MAO A/B, respectively) .

HY-N7142S3

DL-Norepinephrine-d6
DL-Norepinephrine-d₆ is the deuterium labeled DL-Norepinephrine (HY-N7142). DL-Norepinephrine is a synthetic phenylethylamine. DL-Norepinephrine is a neurotransmitter targets α1 and β1 adrenoceptors. DL-Norepinephrine mimics the sympathomimetic actions of the endogenous norepinephrine. DL-Norepinephrine has an increasing effect on subendocardial oxygen tension .

HY-17380S

(S)-Timolol-d9 maleate

(S)-Timolol-d₉ (maleate) is deuterium labeled (S)-Timolol (Maleate). (S)-Timolol Maleate (L-714,465 Maleate) is a non-cardioselective hydrophilic β-adrenoceptor blocker. (S)-Timolol Maleate is widely used as standard medication for intraocular pressure (glaucoma) by preventing the production of aqueous humor. (S)-Timolol Maleate can be used for hypertension, angina pectoris and myocardial infarction .

HY-17494S

(Rac)-Timolol-d5 maleate

rac Timolol-d₅ (maleate) is a labelled racemic (S)-Timolol maleate. (S)-Timolol Maleate (L-714,465 Maleate) is a non-cardioselective hydrophilic β-adrenoceptor blocker. (S)-Timolol Maleate is widely used as standard medication for intraocular pressure (glaucoma) by preventing the production of aqueous humor. (S)-Timolol Maleate can be used for hypertension, angina pectoris and myocardial infarction .

HY-B0194S

Tizanidine-d4

Tizanidine-d₄ is the deuterium labeled Tizanidine (HY-B0194). Tizanidine, a skeletal muscle relaxant, is an orally effective central α₂-adrenoceptor agonist (IC₅₀ = 6.9 nmol). Tizanidine primarily exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons. Tizanidine has anti-injury activity and can inhibit gastrointestinal (GI) transport. Tizanidine can inhibit the proliferation, migration, and invasion of lung cancer cells and induce cell apoptosis by upregulating Nischarin and inhibiting the AKT and Wnt3a/β-catenin signaling pathways. Tizanidine can be used to treat spasticity caused by diseases such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI).

HY-B0194AS

Tizanidine-d4 hydrochloride

Tizanidine-d₄ hydrochloride is deuterium labeled Tizanidine hydrochloride (HY-B0194A). Tizanidine hydrochloride, a skeletal muscle relaxant, is an orally effective central α₂-adrenoceptor agonist (IC₅₀ = 6.9 nmol). Tizanidine hydrochloride primarily exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons. Tizanidine hydrochloride has anti-injury activity and can inhibit gastrointestinal (GI) transport. Tizanidine hydrochloride can inhibit the proliferation, migration, and invasion of lung cancer cells and induce cell apoptosis by upregulating Nischarin and inhibiting the AKT and Wnt3a/β-catenin signaling pathways. Tizanidine hydrochloride can be used to treat spasticity caused by diseases such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI).

Cat. No.	Product Name		Classification

HY-101721

Ko-3290		Alkynes
Ko-3290 is an antagonist of *β-adrenoceptor*, with cardioselectivity and antilipolytic effects in animals. Ko-3290 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks