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anti-leukemia activities

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (1) Antibiotic (1) Apoptosis (11) Autophagy (3) Bacterial (2) Biochemical Assay Reagents (1) c-Myc (1) Calmodulin (1) Caspase (1) Deubiquitinase (2) DNA Methyltransferase (2) DNA/RNA Synthesis (2) Endogenous Metabolite (2) Epigenetic Reader Domain (5) FLT3 (1) HDAC (2) HIF/HIF Prolyl-Hydroxylase (1) Mitochondrial Metabolism (1) Parasite (1) PROTACs (1) Reference Standards (2) RET (1) SARS-CoV (2)
By Research Areas:	Cancer (20) Infection (5) Inflammation/Immunology (2)

By Targets:

Amino Acid Derivatives (1)

Antibiotic (1)

Apoptosis (11)

Autophagy (3)

Bacterial (2)

Biochemical Assay Reagents (1)

c-Myc (1)

Calmodulin (1)

Caspase (1)

Deubiquitinase (2)

DNA Methyltransferase (2)

DNA/RNA Synthesis (2)

Endogenous Metabolite (2)

Epigenetic Reader Domain (5)

FLT3 (1)

HDAC (2)

HIF/HIF Prolyl-Hydroxylase (1)

Mitochondrial Metabolism (1)

Parasite (1)

PROTACs (1)

Reference Standards (2)

RET (1)

SARS-CoV (2)

By Research Areas:

Cancer (20)

Infection (5)

Inflammation/Immunology (2)

Inhibitors & Agonists

Peptides

Natural
Products

Targets Recommended: BMI1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W011156

Mpa(Trt)	Amino Acid Derivatives	Others
Mpa(Trt) is a 3-mercaptopropionic acid derivative containing a trityl protecting group (Trt) and can be used to synthesize compounds with anti-leukemia activity .

HY-114162A

VTP50469 fumarate 5+ Cited Publications	Epigenetic Reader Domain Apoptosis	Cancer
VTP50469 fumarate is a potent, highly selective and orally active Menin-MLL interaction inhibitor with a K_i of 104 pM. VTP50469 fumarate has potently anti-leukemia activity .

HY-114162

VTP50469 5+ Cited Publications	Epigenetic Reader Domain Apoptosis	Cancer
VTP50469 is a potent, highly selective and orally active Menin-MLL interaction inhibitor with a K_i of 104 pM. VTP50469 has potently anti-leukemia activity .

HY-N0840

Bruceantin 1 Publications Verification (-)-Bruceantin; NCI165563; NSC165563	c-Myc Caspase Mitochondrial Metabolism Apoptosis Parasite	Infection Cancer
Bruceantin ((-)-Bruceantin) is a quassinoid found in B. javanica. Bruceantin activates caspase signaling pathway, causes the mitochondrial dysfunction, inhibits cell proliferation, induces cell differentiation and apoptosis. Bruceantin exhibits anti-leukemia and antiprotozoal activities .

HY-114162R

VTP50469 (Standard)	Reference Standards Epigenetic Reader Domain Apoptosis	Cancer
VTP50469 (Standard) is the analytical standard of VTP50469. This product is intended for research and analytical applications. VTP50469 is a potent, highly selective and orally active Menin-MLL interaction inhibitor with a K_i of 104 pM. VTP50469 has potently anti-leukemia activity .

HY-120997

E6 Berbamine Berbamine p-nitrobenzoate	Calmodulin	Cancer
E6 Berbamine (Berbamine p-nitrobenzoate) is a potent calmodulin (CaM) antagonist. E6 Berbamine inhibits the activity of calmodulin (CaM)-dependent myosin light chain kinase (MLCK), with a K_i of 0.95 μM . E6 Berbamine also shows anti-leukemia activities, with an IC₅₀ of 2.13 μM in K562 cells .

HY-N14720

Demethylolivomycin A	Antibiotic Bacterial	Infection Cancer
Demethylolivomycin A is an antitumor antibiotic. Demethylolivomycin A has anti-Gram-positive bacteria and anti-leukemia P388 activity .

HY-N1112

Uncargenin C	Others	Cancer
Uncargenin C is a triterpenoid, which can be isolated from Uncaria rhychophyllo Miq. Jacks. The intermediate of Uncargenin C has anti-leukemia activity, but not itself .

HY-168860

Antituberculosis agent-13	Bacterial	Infection Cancer
Antituberculosis agent-13 (Compound 11) inhibits Mycobacterium tuberculosis, that inhibits Mtb wildtype and mutated strains with IC₅₀ of 4-62.5 nM. Antituberculosis agent-13 exhibits anti-leukemia activity that inhibits MOLM-13 with IC₅₀ of 3.8 μM .

HY-149805

Anticancer agent 110	Apoptosis	Cancer
Anticancer agent 110 is an anticancer agent with in vitro anticancer activity and excellent anti-leukemia potency. Anticancer agent 110 is highly cytotoxic to K-562 lineage chronic myelogenous leukemia cells at nanomolar concentrations. Anticancer agent 110 causes DNA damage and leads to apoptosis .

HY-158341

IOX5	HIF/HIF Prolyl-Hydroxylase Apoptosis	Cancer
IOX5 is a selective prolyl hydroxylase (PHD) inhibitor with an IC₅₀ of 0.19 μM for PHD2. IOX5 stabilizes HIF-1α in acute myeloid leukemia (AML) cells, inhibits cell proliferation and induces apoptosis. IOX5 has anti-leukemia activity .

HY-124069

M-525	Epigenetic Reader Domain	Cancer
M-525 is a first-in-class, highly potent, irreversible and covalent menin-MLL protein-protein interaction inhibitor. M-525 binds to menin with an IC₅₀ of 3 nM and achieves low nanomolar potencies in cell growth inhibition and in suppression of MLL regulated gene expression in MLL leukemia cells. Anti-leukemia activity .

HY-13765

6-Thioguanine Maximum Cited Publications 11 Publications Verification Thioguanine; 2-Amino-6-purinethiol	SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite	Infection Inflammation/Immunology Cancer
6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

HY-161516

HDAC6-IN-42	HDAC	Cancer
HDAC6-IN-42 (compound 2b) is an HDAC6 inhibitor (IC₅₀=0.009 μM). HDAC6-IN-42 shows significant anti-leukemia activity and synergistic effect with Decitabine (HY-A0004). HDAC6-IN-42 can be used for the AML research .

HY-30272

Monobenzone 1 Publications Verification	Biochemical Assay Reagents Apoptosis DNA/RNA Synthesis	Cancer
Monobenzone is a potent skin depigmenting agent. Monobenzone induces depigmentation and exhibits good potential for vitiligo research. Monobenzone is a potent inhibitor of RNR (Ribonucleotide reductase) enzyme activity by targeting RRM2 (a regulatory small subunit M2 of RNR) protein, and thus has significant anti-leukemia efficacy in vitro and in vivo. Monobenzone inhibits acute myeloid leukemia (AML) cells proliferation and DNA synthesis, induces cell cycle arrest, and Apoptosis .

HY-13765R

6-Thioguanine (Standard) Thioguanine (Standard); 2-Amino-6-purinethiol (Standard)	Reference Standards SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite	Infection Inflammation/Immunology Cancer
6-Thioguanine (Standard) is the analytical standard of 6-Thioguanine. This product is intended for research and analytical applications. 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

HY-149539

PLM-101	FLT3 RET	Cancer
PLM-101 is an orally available anticancer agent targeting FLT3 and RET with inhibitory activity against acute myeloid leukemia cells. PLM-101 inhibits RET, thereby inducing autophagic degradation of FLT3; and it inhibits the PI3K and Ras/ERK pathways, resulting in anti-leukemia activity. PLM-101 has anti-tumor efficacy in a mouse MV4-11 flank xenograft model (dose: 3, 10 mg/kg; po) and an allogeneic xenograft mouse model (dose: 40 mg/kg; po) .

HY-178155

AP232	DNA/RNA Synthesis Autophagy	Cancer
AP232 is a selective U2AF1-UHM Inhibitor with an IC₅₀ of 7.96 μM. AP232 exhibits 2.8-24-fold selectivity against other UHM-containing proteins. AP232 exerts anti-leukemia activity and shows higher activities in cell lines carrying splicing factor mutations. AP232 can induce leukemia cells G2/M and G1 arrest, impair lysosome acidification, and inhibit autophagy. AP232 can be used for the research of cancer, such as Leukemia .

HY-168936

DP-15	PROTACs Epigenetic Reader Domain Apoptosis	Cancer
DP-15 is the degrader for GSPT1 and BRD4 with DC₅₀s of 5.25 nM and 0.48 nM. DP-15 exhibits anti-proliferative activity of AML cells and NHL cells with an IC₅₀ of nanomolar levels, arrests the cell cycle at G1 phase, and induces apoptosis in MOLM13. DP-15 exhibits anti-leukemia activity in MOLM-13 xenograft mouse models . (Pink: ligand for target protein JQ-1 carboxylic acid (HY-78695); Black: linker (HY-W262798); Blue: ligand for E3 ligase Cereblon Thalidomide-5-OH (HY-23095))

HY-141844

HDAC/BET-IN-1	HDAC	Cancer
HDAC/BET-IN-1 displays submicromolar inhibitory activity against HDAC1 and 6 (IC₅₀ = 0.163 μM and 0.067 μM), and BRD4 (K_i = 0.076 μM), and possess potent antileukemia activity.

HY-162462

Antitumor agent-151	Apoptosis	Cancer
Antitumor agent-151 (7k) is a significant HsClpP agonist and an antileukemia drug candidate. Antitumor agent-151 (7k) exhibits remarkably enhanced proteolytic activity of HsClpP (EC₅₀ = 0.79 μM) and antitumor activity in vitro (IC₅₀ = 0.038 μM). Antitumor agent-151 (7k) induces apoptosis .

Cat. No.	Product Name	Target	Research Area

HY-W011156

Mpa(Trt)	Amino Acid Derivatives	Others
Mpa(Trt) is a 3-mercaptopropionic acid derivative containing a trityl protecting group (Trt) and can be used to synthesize compounds with anti-leukemia activity .

Bruceantin 1 Publications Verification (-)-Bruceantin; NCI165563; NSC165563	Simaroubaceae Classification of Application Fields Brucea antidysenterica J.F.Mill. Terpenoids Source classification Diterpenoids Plants Disease Research Fields Brucea javanica (L.) Merr. Cancer	c-Myc Caspase Mitochondrial Metabolism Apoptosis Parasite
Bruceantin ((-)-Bruceantin) is a quassinoid found in B. javanica. Bruceantin activates caspase signaling pathway, causes the mitochondrial dysfunction, inhibits cell proliferation, induces cell differentiation and apoptosis. Bruceantin exhibits anti-leukemia and antiprotozoal activities .

6-Thioguanine 10+ Cited Publications Thioguanine; 2-Amino-6-purinethiol	Infection Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite
6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

6-Thioguanine (Standard) Thioguanine (Standard); 2-Amino-6-purinethiol (Standard)	Natural Products Source classification Endogenous metabolite	Reference Standards SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite
6-Thioguanine (Standard) is the analytical standard of 6-Thioguanine. This product is intended for research and analytical applications. 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

Demethylolivomycin A	Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Demethylolivomycin A is an antitumor antibiotic. Demethylolivomycin A has anti-Gram-positive bacteria and anti-leukemia P388 activity .

Uncargenin C	Triterpenes Staphyleaceae Terpenoids Source classification Plants Turpinia arguta (Lindl.) Seem.	Others
Uncargenin C is a triterpenoid, which can be isolated from Uncaria rhychophyllo Miq. Jacks. The intermediate of Uncargenin C has anti-leukemia activity, but not itself .

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