VISTA

By Targets:	VISTA (7) ADC Payload (2) Autophagy (2) Biochemical Assay Reagents (1) Glucocorticoid Receptor (2) IFNAR (1) PD-1/PD-L1 (5) Reference Standards (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (11) Inflammation/Immunology (6)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Targets Recommended: VISTA

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-157937

VISTA-IN-3	IFNAR	Cancer
VISTA-IN-3 (Compound A4) is a potent *VISTA* small molecule inhibitor with a K_D value of 0.49 μM. VISTA-IN-3 can induce the release of IFN-γ cytokines. VISTA-IN-3 synergistically enhances anti-cancer activity with PD-L1 antibody .

HY-155971

VISTA-IN-2	Autophagy	Inflammation/Immunology Cancer
VISTA-IN-2 (Compound 1) is an inhibitor of V-domain Ig suppressor of T-cell activation (VISTA). VISTA-IN-2 induces VISTA degradation in cells through an autophagic mechanism. VISTA-IN-2 rescues VISTA-mediated immunosuppression, and enhances antitumor activity of immune cells. VISTA-IN-2 also activates the antitumor immunity and inhibits tumor growth in a CT26 mouse model .

HY-13570C

Betamethasone disodium phosphate Betamethasone 21-phosphate disodium salt; VISTA-Methasone	Glucocorticoid Receptor	Others
Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt) is a kind of corticosteroid, which is commonly used in the intralesional research of keloids .

HY-147179

INX-SM-56	ADC Payload	Inflammation/Immunology
INX-SM-56 is a cytotoxin that can be used for the synthesis of anti-VISTA antibody agent conjugate. VISTA: V-region Immunoglobulin-containing Suppressor of T cell Activation .

HY-147311

NSC622608	PD-1/PD-L1	Inflammation/Immunology
NSC622608 is a V-domain Ig suppressor of T-cell activation (VISTA) ligand with an IC₅₀ value of 4.8 μM .

HY-13570CR

Betamethasone disodium phosphate (Standard) Betamethasone 21-phosphate disodium salt (Standard); VISTA-Methasone (Standard)	Glucocorticoid Receptor Reference Standards	Others
Betamethasone disodium phosphate (Standard) is the analytical standard of Betamethasone disodium phosphate. This product is intended for research and analytical applications. Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt) is a kind of corticosteroid, which is commonly used in the intralesional research of keloids .

HY-172396

*PD-L1/VISTA-IN-2*	PD-1/PD-L1 VISTA	Cancer
PD-L1/VISTA-IN-2 (Compound S8) is an orally active bifunctional PD-L1/VISTA inhibitor with an IC₅₀ of 1.4 μM for PD-L1 and a K_D of 2.1 μM for *VISTA. PD-L1/VISTA*-IN-2 can activate the tumor immune microenvironment and exert anti-cancer effects .

HY-P991447

*Anti-VSIR/VISTA* Antibody (SG7)**	VISTA	Cancer
Anti-VSIR/VISTA Antibody (SG7) is a human monoclonal antibody (mAb) targeting *VISTA/B7-H5. Anti-VSIR/VISTA* Antibody (SG7) inhibits VISTA function and prevents PSGL-1 and VSIG3 from binding to VISTA. Anti-VSIR/VISTA Antibody (SG7) has anti-tumor activity in the mouse B16F10 melanoma model. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-170793

*PD-L1/VISTA-IN-1*	PD-1/PD-L1 VISTA	Cancer
PD-L1/VISTA-IN-1 (Compound P17) is an orally active dual-target inhibitor of PD-L1 and *VISTA. PD-L1/VISTA-IN-1 can block the PD-1/PD-L1* interaction (IC₅₀: 0.1492 μM) and the *VISTA* pathway (K_D: 0.2723 μM), thereby reactivating T cells. PD-L1/VISTA-IN-1 has anti-tumor activity .

HY-Q25865

MG-V-53	VISTA	Cancer
MG-V-53 is a potent small molecule V domain T-cell activating immunoglobulin suppressor (VISTA) inhibitor with IC₅₀ value of 121 nM. MG-V-53 has antitumor activity .

HY-169853

M351-0056	VISTA	Inflammation/Immunology
M351-0056 is the agonist for the immune checkpoint protein *VISTA, that reduces the secretion of VISTA-induced cytokines, promotes the T-cell proliferation induced by VISTA*, and exhibits immunomodulatory activity. M351-0056 ameliorates Imiquimod (HY-B0180)-induced psoriatic dermatitis in mouse models .

HY-147119

INX-SM-6	ADC Payload	Inflammation/Immunology
INX-SM-6 can be used for targeted delivery of anti-inflammatory agent. INX-SM-6 inhibits LPS-induced IL-1β production in human PBMCS .

HY-101093

CA-170 1 Publications Verification	PD-1/PD-L1	Inflammation/Immunology Cancer
CA-170 is an orally delivered dual inhibitor of *VISTA* and PD-L1. CA-170 exhibits potent rescue of proliferation and effector functions of T cells inhibited by PD-L1/L2 and VISTA with selectivity over other immune checkpoint proteins as well as a broad panel of receptors and enzymes .

HY-P99040

Onvatilimab JNJ-61610588; CI-8993; VSTB112	VISTA	Cancer
Onvatilimab (JNJ-61610588) is a human IgG1κ anti-VISTA (V-domain Ig Suppressor of T-cell Activation) monoclonal antibody. Onvatilimab can be used in colorectal cancer research .

HY-159894

Autophagy-lysosome activator-1	Autophagy	Cancer
Autophagy-lysosome activator-1 (Compound F1) is a Autophagy-lysosome activator. Autophagy-lysosome activator-1 effectively induces PD-L1 or VISTA degradation in tumor cells .

HY-P991421

W0180	VISTA	Cancer
W0180 is a human IgG1 monoclonal antibody (mAb) targeting *VISTA/B7-H5*. W0180 has the potential to activate T cells. W0180 can be used in solid tumors research .

HY-169190

PD-1/PD-L1-IN-53	PD-1/PD-L1	Cancer
PD-1/PD-L1-IN-53 (compound B3) is an inhibitor targeting PD-1/PD-L1 and *VISTA* signaling pathways. PD-1/PD-L1-IN-53 can be used in anti-cancer research .

HY-RS18981

Vsir Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Vsir Mouse Pre-designed siRNA Set A contains three designed siRNAs for Vsir gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vsir Mouse Pre-designed siRNA Set A Vsir Mouse Pre-designed siRNA Set A

HY-W014159

1-Bromo-2-methyl-3-nitrobenzene	Biochemical Assay Reagents	Others
1-Bromo-2-methyl-3-nitrobenzene is an organic synthesis intermediate. 1-Bromo-2-methyl-3-nitrobenzene participates in chemical reactions such as electrophilic substitution and coupling through the bromine atom and nitro group in the molecule, and acts as a synthetic precursor. 1-Bromo-2-methyl-3-nitrobenzene can construct complex molecular structures by relying on the leaving property of bromine and the electron-withdrawing property of nitro group, and can be used in the synthesis of benzimidazole VISTA inhibitors in medicinal chemistry .

HY-RS15711

VSIR Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
VSIR Human Pre-designed siRNA Set A contains three designed siRNAs for VSIR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

VSIR Human Pre-designed siRNA Set A VSIR Human Pre-designed siRNA Set A

Cat. No.	Product Name	Type

HY-W014159

1-Bromo-2-methyl-3-nitrobenzene	Biochemical Assay Reagents
1-Bromo-2-methyl-3-nitrobenzene is an organic synthesis intermediate. 1-Bromo-2-methyl-3-nitrobenzene participates in chemical reactions such as electrophilic substitution and coupling through the bromine atom and nitro group in the molecule, and acts as a synthetic precursor. 1-Bromo-2-methyl-3-nitrobenzene can construct complex molecular structures by relying on the leaving property of bromine and the electron-withdrawing property of nitro group, and can be used in the synthesis of benzimidazole VISTA inhibitors in medicinal chemistry .

1-Bromo-2-methyl-3-nitrobenzene

Biochemical Assay Reagents

1-Bromo-2-methyl-3-nitrobenzene is an organic synthesis intermediate. 1-Bromo-2-methyl-3-nitrobenzene participates in chemical reactions such as electrophilic substitution and coupling through the bromine atom and nitro group in the molecule, and acts as a synthetic precursor. 1-Bromo-2-methyl-3-nitrobenzene can construct complex molecular structures by relying on the leaving property of bromine and the electron-withdrawing property of nitro group, and can be used in the synthesis of benzimidazole VISTA inhibitors in medicinal chemistry .

Cat. No.	Product Name	Target	Research Area

HY-P990145

*Anti-Mouse VISTA* Antibody (13F3)**	Inhibitory Antibodies	Others
Anti-Mouse VISTA Antibody (13F3) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse VISTA.

HY-P99040

Onvatilimab JNJ-61610588; CI-8993; VSTB112	VISTA	Cancer
Onvatilimab (JNJ-61610588) is a human IgG1κ anti-VISTA (V-domain Ig Suppressor of T-cell Activation) monoclonal antibody. Onvatilimab can be used in colorectal cancer research .

HY-P991447

*Anti-VSIR/VISTA* Antibody (SG7)**	VISTA	Cancer
Anti-VSIR/VISTA Antibody (SG7) is a human monoclonal antibody (mAb) targeting *VISTA/B7-H5. Anti-VSIR/VISTA* Antibody (SG7) inhibits VISTA function and prevents PSGL-1 and VSIG3 from binding to VISTA. Anti-VSIR/VISTA Antibody (SG7) has anti-tumor activity in the mouse B16F10 melanoma model. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991421

W0180	VISTA	Cancer
W0180 is a human IgG1 monoclonal antibody (mAb) targeting *VISTA/B7-H5*. W0180 has the potential to activate T cells. W0180 can be used in solid tumors research .

Recombinant Proteins Recommended:

VISTA

Species:	Human (5) Rhesus Macaque (2) Mouse (2) Rat (1) Cynomolgus (2)
Tag:	His (5) Avi (2) Fc (7)
Source:	HEK293 (12)

Cat. No.	Compare	Product Name	Species	Source

HY-P70983

	VISTA/B7-H5 Protein, Human (HEK293, His) VISTA; B7-H5; Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1	Human	HEK293
	VISTA/B7-H5 protein, an immunoregulatory receptor, inhibits T-cell response and may regulate embryonic stem cell differentiation by inhibiting BMP4 signaling. It also stimulates MMP14-mediated MMP2 activation, suggesting a role in matrix metalloproteinase processes. These roles highlight the significance of VISTA/B7-H5 in immune regulation, embryonic development, and extracellular matrix dynamics. VISTA/B7-H5 Protein, Human (HEK293, His) is the recombinant human-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72428

	VISTA/B7-H5 Protein, Mouse (159a.a, HEK293, His) V-type immunoglobulin domain-containing suppressor of T-cell activation; Vsir; Dies1; PD-1H; VISTA	Mouse	HEK293
	VISTA/B7-H5 Protein is a type I transmembrane protein expressed primarily in white blood cells that inhibits T cell function. VISTA/B7-H5 Protein promotes embryonic stem cell differentiation by inhibiting BMP4 signaling and stimulates MMP14 mediated MMP2 activation. VISTA/B7-H5 Protein is highly expressed in tumors. VISTA/B7-H5 Protein, Mouse (159a.a, HEK293, His) is the recombinant mouse-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P73546

	VISTA/B7-H5 Protein, Rat (HEK293, Fc) Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1	Rat	HEK293
	VISTA/B7-H5 protein, an immunoregulatory receptor, inhibits T-cell response and may regulate embryonic stem cell differentiation by inhibiting BMP4 signaling. It also stimulates MMP14-mediated MMP2 activation, suggesting a role in matrix metalloproteinase processes. These roles highlight the significance of VISTA/B7-H5 in immune regulation, embryonic development, and extracellular matrix dynamics. VISTA/B7-H5 Protein, Rat (HEK293, Fc) is the recombinant rat-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P73547

	VISTA/B7-H5 Protein, Mouse (HEK293, Fc) Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1	Mouse	HEK293
	VISTA/B7-H5 Protein is a type I transmembrane protein expressed primarily in white blood cells that inhibits T cell function. VISTA/B7-H5 Protein promotes embryonic stem cell differentiation by inhibiting BMP4 signaling and stimulates MMP14 mediated MMP2 activation. VISTA/B7-H5 Protein is highly expressed in tumors. VISTA/B7-H5 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P73544

	VISTA/B7-H5 Protein, Rhesus Macaque (HEK293, His) Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1	Rhesus Macaque	HEK293
	VISTA/B7-H5 protein is an immune regulatory receptor that can inhibit the activation of T cells and regulate immune responses as a ligand and receptor. VISTA/B7-H5 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77879

	VISTA/B7-H5 Protein, Human (HEK293, Fc) B7H5; B7-H5; VISTA; VSIR ; PD1H; PD-1H; 4632428N05Rik; C10orf54; Dies1; Gi24; PP2135; SISP1	Human	HEK293
	VISTA/B7-H5 protein, an immunoregulatory receptor, inhibits T-cell response and may regulate embryonic stem cell differentiation by inhibiting BMP4 signaling. It also stimulates MMP14-mediated MMP2 activation, suggesting a role in matrix metalloproteinase processes. These roles highlight the significance of VISTA/B7-H5 in immune regulation, embryonic development, and extracellular matrix dynamics. VISTA/B7-H5 Protein, Human (HEK293, Fc) is the recombinant human-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P78929

	VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, Fc-Avi) B7-H5; SISP1; Gi24; VISTA	Human	HEK293
	VISTA/B7-H5 protein, an immunoregulatory receptor, inhibits T-cell response and may regulate embryonic stem cell differentiation by inhibiting BMP4 signaling. It also stimulates MMP14-mediated MMP2 activation, suggesting a role in matrix metalloproteinase processes. These roles highlight the significance of VISTA/B7-H5 in immune regulation, embryonic development, and extracellular matrix dynamics. VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 162 a.a., with molecular weight of 55-66 kDa.

HY-P73545

	VISTA/B7-H5 Protein, Rhesus Macaque (HEK293, Fc) Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1	Rhesus Macaque	HEK293
	VISTA/B7-H5 protein is an immune regulatory receptor that can inhibit the activation of T cells and regulate immune responses as a ligand and receptor. VISTA/B7-H5 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P70962

	VISTA/B7-H5 Protein, Cynomolgus (HEK293, His) Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1	Cynomolgus	HEK293
	VISTA/B7-H5 Protein is a B7 family member that maintains T cell and myeloid quiescence and is a promising target for combination cancer immunotherapy. VISTA not only acts as a ligand expressed on antigenpresenting cells, but also functions as a receptor on T cells. VISTA inhibits T cell activation, proliferation, and cytokine production. VISTA/B7-H5 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P73482

	VISTA/B7-H5 Protein, Cynomolgus (HEK293, Fc) Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1	Cynomolgus	HEK293
	VISTA/B7-H5 Protein is a B7 family member that maintains T cell and myeloid quiescence and is a promising target for combination cancer immunotherapy. VISTA not only acts as a ligand expressed on antigenpresenting cells, but also functions as a receptor on T cells. VISTA inhibits T cell activation, proliferation, and cytokine production. VISTA/B7-H5 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P78936

	VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, His-Avi) Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1	Human	HEK293
	VISTA/B7-H5 protein, an immunoregulatory receptor, inhibits T-cell response and may regulate embryonic stem cell differentiation by inhibiting BMP4 signaling. It also stimulates MMP14-mediated MMP2 activation, suggesting a role in matrix metalloproteinase processes. These roles highlight the significance of VISTA/B7-H5 in immune regulation, embryonic development, and extracellular matrix dynamics. VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P704262

	CD38 Protein, Human (HEK293, mFc) VISTA; B7-H5; Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). CD38 Protein, Human (HEK293, mFc) is the recombinant human-derived CD38 protein, expressed by HEK293, with C-mFc labeled tag.

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HY-P81531

	VISTA Antibody (YA1276) VSIR; PP2135, UNQ730/PRO1412; C10orf54, SISP1; VISTA; V-type immunoglobulin domain-containing suppressor of T-cell activation; Platelet receptor Gi24; Stress-induced secreted protein-1; V-set domain-containing immunoregulatory receptor; V-set immunoregulatory receptor	IHC-P	Human
	VISTA Antibody (YA1276) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1276), targeting VISTA. VISTA Antibody (YA1276) can be used for IHC-P experiment in human background.

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Cat. No.	Product Name		Classification

HY-RS18981

Vsir Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Vsir Mouse Pre-designed siRNA Set A contains three designed siRNAs for Vsir gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS15711

VSIR Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
VSIR Human Pre-designed siRNA Set A contains three designed siRNAs for VSIR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Inhibitors & Agonists

Biochemical Assay Reagents

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides