1-Bromo-2-methyl-3-nitrobenzene

Cat. No.: HY-W014159 Purity: 99.50%: Data Sheet
COA

SDS
Handling Instructions
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1-Bromo-2-methyl-3-nitrobenzene is an organic synthesis intermediate. 1-Bromo-2-methyl-3-nitrobenzene participates in chemical reactions such as electrophilic substitution and coupling through the bromine atom and nitro group in the molecule, and acts as a synthetic precursor. 1-Bromo-2-methyl-3-nitrobenzene can construct complex molecular structures by relying on the leaving property of bromine and the electron-withdrawing property of nitro group, and can be used in the synthesis of benzimidazole VISTA inhibitors in medicinal chemistry.

For research use only. We do not sell to patients.

1-Bromo-2-methyl-3-nitrobenzene Chemical Structure

CAS No. : 55289-35-5

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10 g	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

Molecular Weight

216.03

Formula

C₇H₆BrNO₂

CAS No.

55289-35-5

Appearance

Solid

Color

Light yellow to light brown

SMILES

O=[N+](C1=C(C)C(Br)=CC=C1)[O-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (462.89 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6289 mL	23.1445 mL	46.2890 mL
5 mM	0.9258 mL	4.6289 mL	9.2578 mL
10 mM	0.4629 mL	2.3145 mL	4.6289 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.84%

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Data Sheet (274 KB) SDS (393 KB)

COA (251 KB) HNMR (95 KB) GC (209 KB)

Handling Instructions (2659 KB)

References

[1]. Wang T, et al. Novel Benzimidazoles as Potent Small-Molecule Inhibitors and Degraders of V-Domain Ig Suppressor of T-Cell Activation (VISTA). J Med Chem. 2023 Sep 14;66(17):11881-11892. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.6289 mL	23.1445 mL	46.2890 mL	115.7225 mL
	5 mM	0.9258 mL	4.6289 mL	9.2578 mL	23.1445 mL
	10 mM	0.4629 mL	2.3145 mL	4.6289 mL	11.5723 mL
	15 mM	0.3086 mL	1.5430 mL	3.0859 mL	7.7148 mL
	20 mM	0.2314 mL	1.1572 mL	2.3145 mL	5.7861 mL
	25 mM	0.1852 mL	0.9258 mL	1.8516 mL	4.6289 mL
	30 mM	0.1543 mL	0.7715 mL	1.5430 mL	3.8574 mL
	40 mM	0.1157 mL	0.5786 mL	1.1572 mL	2.8931 mL
	50 mM	0.0926 mL	0.4629 mL	0.9258 mL	2.3145 mL
	60 mM	0.0771 mL	0.3857 mL	0.7715 mL	1.9287 mL
	80 mM	0.0579 mL	0.2893 mL	0.5786 mL	1.4465 mL
	100 mM	0.0463 mL	0.2314 mL	0.4629 mL	1.1572 mL