TfR1

By Targets:	Amyloid-β (1) Ferroptosis (2) Reactive Oxygen Species (ROS) (1) Small Interfering RNA (siRNA) (2) Transferrin Receptor (8) VDAC (1)
By Research Areas:	Cancer (6) Infection (2) Inflammation/Immunology (2) Neurological Disease (5)
Click Chemistry:	Azide (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-159569

TfR-1-IN-1	Transferrin Receptor Ferroptosis	Cancer
TfR-1-IN-1 (compound C4) is an inhibitor of transferrin receptor 1 (TfR-1) with anticancer activity. TfR-1-IN-1 strongly increases intracellular iron (II) levels as a driving force for the induction of ferroptosis. TfR-1-IN-1 significantly reduces the metabolic activity of ovarian cancer (A2780cis), breast cancer (MDA-MB 231), and leukemia (HL-60) cell lines with IC₅₀ values of 0.51, 0.46, and 0.48 μM, respectively ^[1].

HY-P990129

*Anti-Mouse CD71/TfR1* Antibody (8D3)**	Transferrin Receptor	Infection
Anti-Mouse CD71/TfR1 Antibody (8D3) is a rat-derived anti-mouse CD71/TfR1 IgG2a type antibody inhibitor. Anti-Mouse CD71/TfR1 Antibody (8D3) depletes of CD71+ erythroid cells but does not change percentages of Tregs in neonatal mice. Anti-Mouse CD71/TfR1 Antibody (8D3) enhances neonatal mice defence against infection ^[1] .

HY-P991047

*Anti-CD71/TfR1* Antibody** JR-141 antibody (uncoupled from iduronate 2-sulfatase)	Transferrin Receptor	Neurological Disease Cancer
Anti-CD71/TfR1 Antibody (JR-141 antibody (uncoupled from iduronate 2-sulfatase)) is a humanized anti-human transferrin receptor (CD71; TfR) antibody. Anti-CD71/TfR1 Antibody is the antibody part of the fusion protein Pabinafusp alfa (HY-P99797). The recommend isotype control of Anti-CD71/TfR1 Antibody: Human IgG1 kappa, Isotype Control (HY-P99001) ^[1].

HY-P990130

*Anti-Mouse/Rat CD71/TfR1* Antibody (OX-26)**	Transferrin Receptor	Neurological Disease
Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) is a mouse-derived IgG2a κ type antibody, targeting to mouse/rat *CD71/TfR1. Anti-Mouse/Rat CD71/TfR1* Antibody (OX-26) targets the transferrin receptor and binds to an extracellular domain for the transferrin receptor. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) can be used for the research in drug delivery, especially for drug delivery to the brain ^[1].

HY-P10928

BCY17901 TFA	Transferrin Receptor	Neurological Disease Cancer
BCY17901 TFA is a potent irreversible transferrin receptor 1 (TfR1) inhibitor (K_i=12 nM). BCY17901 TFA inhibits TfR1-mediated endocytosis and iron transport, and suppresses the proliferation of tumor cells dependent on iron metabolism. BCY17901 TFA can be used in the research of solid tumors (such as breast cancer, glioblastoma) and neurodegenerative diseases ^[1].

HY-P9999

Trontinemab RG6102; RO-7126209	Amyloid-β	Neurological Disease
Trontinemab (RG6102) is a brain-penetrant, anti-amyloid, bispecific and humanizedized *IgG1-κ* antibody, targeting to Aβ plaques and transferrin receptor 1 (TFR1). Trontinemab binds to fibrillar Aβ as well as Aβ plaques triggering plaque clearance by engaging immune cells on Alzheimer disease (AD) brain sections. Trontinemab also shows specific affinity to cynomolgus and human *TFR1* ^[1] .

HY-P990856

Anti-CD71 Antibody (OKT-9)	Transferrin Receptor	Cancer
Anti-CD71 Antibody (OKT-9) is a kind of mouse IgG1 κ chimeric antibody, targeting to human CD71. Anti-CD71 Antibody (OKT-9) can recognize CD71 also known as Transferrin receptor protein 1 (TfR1). Anti-CD71 Antibody (OKT-9) can be used for the detections of immunohistochemistry, immunofluorescence and flow cytometry in cancer, such as leukemia and lymphoma ^[1].

HY-P990791

*Anti-Mouse CD71/TfR1* Antibody (R17 217.1.3)**	Transferrin Receptor	Infection Inflammation/Immunology Cancer
Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse *CD71/TfR1. Anti-Mouse CD71/TfR1* Antibody (R17 217.1.3) can deplete CD71 ⁺ cells and inhibit transferrin receptor. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can be used for the researches of cancer, infection, inflammation and immunology, such as lung cancer, lymphocytic choriomeningitis virus (LCMV) infection and Cardiac allograft ^[1] .

HY-P10928A

BCY17901	Transferrin Receptor	Neurological Disease Cancer
BCY17901 is a potent irreversible transferrin receptor 1 (TfR1) inhibitor (K_i=12 nM). BCY17901 inhibits TfR1-mediated endocytosis and iron transport, and suppresses the proliferation of tumor cells dependent on iron metabolism. BCY17901 can be used in the research of solid tumors (such as breast cancer, glioblastoma) and neurodegenerative diseases ^[1].

HY-176212

Ferroptosis-IN-20	Ferroptosis VDAC Reactive Oxygen Species (ROS)	Inflammation/Immunology
Ferroptosis-IN-20 (Compound 34a) is a Ferroptosis inhibitor (EC₅₀: 24.2 nM) targeting voltage-dependent anion channel (VDAC). Ferroptosis-IN-20 inhibits VDAC oligomerization and lipid peroxidation. Ferroptosis-IN-20 reduces content of ROS, attenuates TFR1-mediated iron uptake, inhibits Fe ²⁺ level and restores glutathione (GSH) level. Ferroptosis-IN-20 alleviates Folic acid (HY-16637)-induced acute kidney injury (AKI) ^[1].

HY-RS14431

TFRC Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TFRC Human Pre-designed siRNA Set A contains three designed siRNAs for TFRC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TFRC Human Pre-designed siRNA Set A TFRC Human Pre-designed siRNA Set A

HY-RS16743

Tfrc Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tfrc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tfrc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tfrc Mouse Pre-designed siRNA Set A Tfrc Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

HY-P10928

BCY17901 TFA	Transferrin Receptor	Neurological Disease Cancer
BCY17901 TFA is a potent irreversible transferrin receptor 1 (TfR1) inhibitor (K_i=12 nM). BCY17901 TFA inhibits TfR1-mediated endocytosis and iron transport, and suppresses the proliferation of tumor cells dependent on iron metabolism. BCY17901 TFA can be used in the research of solid tumors (such as breast cancer, glioblastoma) and neurodegenerative diseases ^[1].

HY-P10928A

BCY17901	Transferrin Receptor	Neurological Disease Cancer
BCY17901 is a potent irreversible transferrin receptor 1 (TfR1) inhibitor (K_i=12 nM). BCY17901 inhibits TfR1-mediated endocytosis and iron transport, and suppresses the proliferation of tumor cells dependent on iron metabolism. BCY17901 can be used in the research of solid tumors (such as breast cancer, glioblastoma) and neurodegenerative diseases ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P990129

*Anti-Mouse CD71/TfR1* Antibody (8D3)**	Transferrin Receptor	Infection
Anti-Mouse CD71/TfR1 Antibody (8D3) is a rat-derived anti-mouse CD71/TfR1 IgG2a type antibody inhibitor. Anti-Mouse CD71/TfR1 Antibody (8D3) depletes of CD71+ erythroid cells but does not change percentages of Tregs in neonatal mice. Anti-Mouse CD71/TfR1 Antibody (8D3) enhances neonatal mice defence against infection ^[1] .

HY-P991047

*Anti-CD71/TfR1* Antibody** JR-141 antibody (uncoupled from iduronate 2-sulfatase)	Transferrin Receptor	Neurological Disease Cancer
Anti-CD71/TfR1 Antibody (JR-141 antibody (uncoupled from iduronate 2-sulfatase)) is a humanized anti-human transferrin receptor (CD71; TfR) antibody. Anti-CD71/TfR1 Antibody is the antibody part of the fusion protein Pabinafusp alfa (HY-P99797). The recommend isotype control of Anti-CD71/TfR1 Antibody: Human IgG1 kappa, Isotype Control (HY-P99001) ^[1].

HY-P990130

*Anti-Mouse/Rat CD71/TfR1* Antibody (OX-26)**	Transferrin Receptor	Neurological Disease
Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) is a mouse-derived IgG2a κ type antibody, targeting to mouse/rat *CD71/TfR1. Anti-Mouse/Rat CD71/TfR1* Antibody (OX-26) targets the transferrin receptor and binds to an extracellular domain for the transferrin receptor. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) can be used for the research in drug delivery, especially for drug delivery to the brain ^[1].

HY-P9999

Trontinemab RG6102; RO-7126209	Amyloid-β	Neurological Disease
Trontinemab (RG6102) is a brain-penetrant, anti-amyloid, bispecific and humanizedized *IgG1-κ* antibody, targeting to Aβ plaques and transferrin receptor 1 (TFR1). Trontinemab binds to fibrillar Aβ as well as Aβ plaques triggering plaque clearance by engaging immune cells on Alzheimer disease (AD) brain sections. Trontinemab also shows specific affinity to cynomolgus and human *TFR1* ^[1] .

HY-P990856

Anti-CD71 Antibody (OKT-9)	Transferrin Receptor	Cancer
Anti-CD71 Antibody (OKT-9) is a kind of mouse IgG1 κ chimeric antibody, targeting to human CD71. Anti-CD71 Antibody (OKT-9) can recognize CD71 also known as Transferrin receptor protein 1 (TfR1). Anti-CD71 Antibody (OKT-9) can be used for the detections of immunohistochemistry, immunofluorescence and flow cytometry in cancer, such as leukemia and lymphoma ^[1].

HY-P990791

*Anti-Mouse CD71/TfR1* Antibody (R17 217.1.3)**	Transferrin Receptor	Infection Inflammation/Immunology Cancer
Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse *CD71/TfR1. Anti-Mouse CD71/TfR1* Antibody (R17 217.1.3) can deplete CD71 ⁺ cells and inhibit transferrin receptor. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can be used for the researches of cancer, infection, inflammation and immunology, such as lung cancer, lymphocytic choriomeningitis virus (LCMV) infection and Cardiac allograft ^[1] .

Species:	Human (3) Mouse (6) Rat (2) Cynomolgus (3) Pig (2)
Tag:	His (12) Avi (6) Fc (4)
Source:	HEK293 (16)

Cat. No.	Compare	Product Name	Species	Source

HY-P72455

	TFRC Protein, Mouse (HEK293, His) Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; CD71; TfRc	Mouse	HEK293
	TFRC is a key protein in cellular iron uptake, coordinating receptor-mediated endocytosis of the ligand transferrin into specialized endosomes, where endosomal acidification triggers iron release.TFRC actively regulates T and B cell proliferation through iron uptake.TFRC Protein, Mouse (HEK293, His) is the recombinant mouse-derived TFRC protein, expressed by HEK293 , with N-8*His labeled tag.

HY-P77855

	TFRC Protein, Cynomolgus (HEK293, His) TR; TfR1; CD71; sTfR; T9; p90; TfRC; TfR	Cynomolgus	HEK293
	TFRC is a key protein in cellular iron uptake, coordinating receptor-mediated endocytosis of the ligand transferrin into specialized endosomes, where endosomal acidification triggers iron release. TFRC actively regulates T and B cell proliferation through iron uptake. TFRC Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TFRC protein, expressed by HEK293 , with N-His labeled tag.

HY-P78523

	TFRC Protein, Human (HEK293, His-Avi) TR; TfR1; CD71; sTfR; T9; p90; TfRC; TfR	Human	HEK293
	TFRC protein promotes cellular iron uptake through receptor-mediated endocytosis. TFRC is essential for erythroid and nervous system development and plays a crucial role in iron homeostasis. TFRC Protein, Human (HEK293, His-Avi) is the recombinant human-derived TFRC protein, expressed by HEK293 , with N-His, N-Avi labeled tag.

HY-P700841

	TFRC Protein, Human (Biotinylated, HEK293, His-Avi) TR; TfR1; CD71; sTfR; T9; p90; TfRC; TfR	Human	HEK293
	TFRC protein promotes cellular iron uptake through receptor-mediated endocytosis. TFRC is essential for erythroid and nervous system development and plays a crucial role in iron homeostasis. TFRC Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived TFRC protein, expressed by HEK293 , with C-Avi, N-His labeled tag.

HY-P78904

	TFRC Protein, Cynomolgus (Biotinylated, HEK293, His) CD71; TfRC; TfR; sTfR; TfR1; Trfr; T9; p90	Cynomolgus	HEK293
	TFRC proteins mediate iron uptake by triggering receptor-mediated endocytosis of ligand-occupied transferrin receptors, followed by acidification and iron release. It is essential for red blood cell and nervous system development, and for maintaining iron balance. TFRC Protein, Cynomolgus (Biotinylated, HEK293, His) is the recombinant cynomolgus-derived TFRC protein, expressed by HEK293 , with N-His labeled tag.

HY-P701303

	TFRC Protein, Mouse (Biotinylated, HEK293, His) CD71; TfRC; TfR; sTfR; TfR1; Trfr; T9; p90	Mouse	HEK293
	TFRC is a key protein in cellular iron uptake, coordinating receptor-mediated endocytosis of the ligand transferrin into specialized endosomes, where endosomal acidification triggers iron release.TFRC actively regulates T and B cell proliferation through iron uptake.TFRC Protein, Mouse (Biotinylated, HEK293, His) is the recombinant mouse-derived TFRC protein, expressed by HEK293 , with His labeled tag.

HY-P704917

	TFRC Protein, Mouse (HEK293, Fc) Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; CD71; TfRc	Mouse	HEK293

HY-P705097

	TFRC Protein, Human (Biotinylated, HEK293, Fc-Avi) TR; TfR1; CD71; sTfR; T9; p90; TfRC; TfR	Human	HEK293

HY-P705204

	TFRC Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) CD71; TfRC; TfR; sTfR; TfR1; Trfr; T9; p90	Cynomolgus	HEK293

HY-P705277

	TFRC Protein, Mouse (Biotinylated, HEK293, His-Avi) CD71; TfRC; TfR; sTfR; TfR1; Trfr; T9; p90	Mouse	HEK293

HY-P705163

	TFRC Protein, Rat (Biotinylated, HEK293, His-Avi) Transferrin receptor protein 1; TfRc; TR; TfR; TfR1; Trfr; CD71	Rat	HEK293

HY-P73453

	Transferrin Protein, Mouse (HEK293, His) Serotransferrin; Transferrin; Beta-1 metal-binding globulin; Siderophilin; TF; TRF	Mouse	HEK293
	Transferrin is an important iron-binding transport protein that combines two Fe(3+) ions with an anion, usually bicarbonate.Its main function is to transport iron from the site of absorption to the site of storage and utilization.Transferrin Protein, Mouse (HEK293, His) is the recombinant mouse-derived Transferrin protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P73454

	Transferrin Protein, Rat (HEK293, His) Serotransferrin; Transferrin; Beta-1 metal-binding globulin; Siderophilin; TF; TRF	Rat	HEK293
	Transferrin is an important iron-binding transport protein that combines two Fe(3+) ions with an anion, usually bicarbonate. Its primary function is to transport iron from the site of absorption and heme degradation to the site of storage and utilization. Transferrin Protein, Rat (HEK293, His) is the recombinant rat-derived Transferrin protein, expressed by HEK293 , with C-His labeled tag.

HY-P73581

	Transferrin Protein, Mouse (HEK293, Fc) Serotransferrin; Transferrin; Beta-1 metal-binding globulin; Siderophilin; TF; TRF	Mouse	HEK293
	Transferrin is an important iron-binding transport protein that combines two Fe(3+) ions with an anion, usually bicarbonate.Its main function is to transport iron from the site of absorption to the site of storage and utilization.Transferrin Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Transferrin protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P74494

	Transferrin Protein, Pig (HEK293, His) Serotransferrin; Transferrin; Beta-1 metal-binding globulin; Siderophilin; TF; TRF	Pig	HEK293
	Transferrin is an important iron-binding transport protein that binds two Fe(3+) ions, usually with anions such as bicarbonate. Crucially, it transports iron from the site of absorption and heme degradation to the site of storage and utilization. Transferrin Protein, Pig (HEK293, His) is the recombinant pig-derived Transferrin protein, expressed by HEK293 , with C-His labeled tag.

HY-P74495

	Transferrin Protein, Pig (HEK293, hFc) Serotransferrin; Transferrin; Beta-1 metal-binding globulin; Siderophilin; TF; TRF	Pig	HEK293
	Transferrin is an important iron-binding transport protein that binds two Fe(3+) ions, usually with anions such as bicarbonate. Crucially, it transports iron from the site of absorption and heme degradation to the site of storage and utilization. Transferrin Protein, Pig (HEK293, hFc) is the recombinant pig-derived Transferrin protein, expressed by HEK293 , with C-hFc labeled tag.

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HY-P86512

	Transferrin Receptor Antibody (YA6204) Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; T9; p90; CD antigen CD71; [Cleaved into: Transferrin receptor protein 1, serum form; sTfR; ]	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Transferrin Receptor Antibody (YA6204) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transferrin Receptor. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

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Cat. No.	Product Name		Classification

HY-P10928

BCY17901 TFA		Azide
BCY17901 TFA is a potent irreversible transferrin receptor 1 (TfR1) inhibitor (K_i=12 nM). BCY17901 TFA inhibits TfR1-mediated endocytosis and iron transport, and suppresses the proliferation of tumor cells dependent on iron metabolism. BCY17901 TFA can be used in the research of solid tumors (such as breast cancer, glioblastoma) and neurodegenerative diseases ^[1].

Cat. No.	Product Name		Classification

HY-RS14431

TFRC Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TFRC Human Pre-designed siRNA Set A contains three designed siRNAs for TFRC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16743

Tfrc Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Tfrc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tfrc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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