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Results for "

TfR1

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Peptides

5

Inhibitory Antibodies

11

Recombinant Proteins

1

Antibodies

1

Click Chemistry

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-159569

    Transferrin Receptor Ferroptosis Cancer
    TfR-1-IN-1 (compound C4) is an inhibitor of transferrin receptor 1 (TfR-1) with anticancer activity. TfR-1-IN-1 strongly increases intracellular iron (II) levels as a driving force for the induction of ferroptosis. TfR-1-IN-1 significantly reduces the metabolic activity of ovarian cancer (A2780cis), breast cancer (MDA-MB 231), and leukemia (HL-60) cell lines with IC50 values ​​of 0.51, 0.46, and 0.48 μM, respectively [1].
    TfR-1-IN-1
  • HY-P991047

    JR-141 antibody (uncoupled from iduronate 2-sulfatase)

    Transferrin Receptor Neurological Disease Cancer
    Anti-CD71/TfR1 Antibody (JR-141 antibody (uncoupled from iduronate 2-sulfatase)) is a humanized anti-human transferrin receptor (CD71; TfR) antibody. Anti-CD71/TfR1 Antibody is the antibody part of the fusion protein Pabinafusp alfa (HY-P99797). The recommend isotype control of Anti-CD71/TfR1 Antibody: Human IgG1 kappa, Isotype Control (HY-P99001) [1].
    Anti-CD71/TfR1 Antibody
  • HY-P990129

    Transferrin Receptor Others
    Anti-Mouse CD71/TfR1 Antibody (8D3) is a rat-derived IgG2a type antibody inhibitor, targeting to mouse CD71/TfR1.
    Anti-Mouse CD71/TfR1 Antibody (8D3)
  • HY-P10928

    Transferrin Receptor Neurological Disease Cancer
    BCY17901 TFA is a potent irreversible transferrin receptor 1 (TfR1) inhibitor (Ki=12 nM). BCY17901 TFA inhibits TfR1-mediated endocytosis and iron transport, suppressing the proliferation of tumor cells dependent on iron metabolism. BCY17901 TFA is promising for research of solid tumors, such as breast cancer, glioblastoma and neurodegenerative diseases [1].
    BCY17901 TFA
  • HY-P9999

    RG6102; RO-7126209

    Amyloid-β Neurological Disease
    Trontinemab (RG6102) is a brain-penetrant, anti-amyloid, bispecific and humanizedized IgG1-κ antibody, targeting to plaques and transferrin receptor 1 (TFR1). Trontinemab binds to fibrillar as well as plaques triggering plaque clearance by engaging immune cells on Alzheimer disease (AD) brain sections. Trontinemab also shows specific affinity to cynomolgus and human TFR1 [1] .
    Trontinemab
  • HY-RS14431

    T9; TR; TfR; p90; CD71; TfR1; TRFR; IMD46

    Small Interfering RNA (siRNA) Others

    TFRC Human Pre-designed siRNA Set A contains three designed siRNAs for TFRC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TFRC Human Pre-designed siRNA Set A
    TFRC Human Pre-designed siRNA Set A
  • HY-RS16743

    TR; TfR; p90; CD71; TfR1; Trfr; Mtvr1; 2610028K12Rik; E430033M20Rik

    Small Interfering RNA (siRNA) Others

    Tfrc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tfrc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Tfrc Mouse Pre-designed siRNA Set A
    Tfrc Mouse Pre-designed siRNA Set A
  • HY-176212

    Ferroptosis VDAC Reactive Oxygen Species (ROS) Inflammation/Immunology
    Ferroptosis-IN-20 (Compound 34a) is a Ferroptosis inhibitor (EC50: 24.2 nM) targeting voltage-dependent anion channel (VDAC). Ferroptosis-IN-20 inhibits VDAC oligomerization and lipid peroxidation. Ferroptosis-IN-20 reduces content of ROS, attenuates TFR1-mediated iron uptake, inhibits Fe 2+ level and restores glutathione (GSH) level. Ferroptosis-IN-20 alleviates Folic acid (HY-16637)-induced acute kidney injury (AKI) [1].
    Ferroptosis-IN-20

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