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Results for "

TOP2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (2) Small Interfering RNA (siRNA) (6) Topoisomerase (6)
By Research Areas:	Cancer (5) Cardiovascular Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (2) siRNAs (6)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS14894

TOP2A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TOP2A Human Pre-designed siRNA Set A contains three designed siRNAs for TOP2A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TOP2A Human Pre-designed siRNA Set A TOP2A Human Pre-designed siRNA Set A

HY-164143

T638	Topoisomerase	Cancer
T638 is a topoisomerase II (TOP2) inhibitor. T638 inhibits *TOP2A* activity with a IC₅₀ of 0.7 uM. T638 strongly inhibits cancer cell growth .

HY-160005

LMP517 NSC 781517	Topoisomerase DNA/RNA Synthesis	Cancer
LMP517 (NSC 781517) is a potent and non-camptothecin Topoisomerase I and II (TOP1 and *TOP2) dual inhibitor. LMP517 can induce TOP1 and TOP2* cleavage complexes (TOP1ccs and TOP2ccs). LMP517 can induce cancer cells DNA damage and γH2AX production. LMP517 can be used for the research of cancer, such as small cell lung cancer ^[2].

HY-122594

BNS-22	Topoisomerase	Cancer
BNS-22 is a DNA topoisomerase II (TOP2) catalytic inhibitor with the IC₅₀ values of 2.8 μM and 0.42 μM for human TOP2α and TOP2β, respectively. BNS-22 induces abnormal division and has anti-proliferative activity .

HY-RS14895

Top2a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Top2a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Top2a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Top2a Mouse Pre-designed siRNA Set A Top2a Mouse Pre-designed siRNA Set A

HY-RS20119

Top2b Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Top2b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Top2b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Top2b Mouse Pre-designed siRNA Set A Top2b Mouse Pre-designed siRNA Set A

HY-RS14896

Top2a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Top2a Rat Pre-designed siRNA Set A contains three designed siRNAs for Top2a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Top2a Rat Pre-designed siRNA Set A Top2a Rat Pre-designed siRNA Set A

HY-RS14897

TOP2B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TOP2B Human Pre-designed siRNA Set A contains three designed siRNAs for TOP2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TOP2B Human Pre-designed siRNA Set A TOP2B Human Pre-designed siRNA Set A

HY-RS26623

Top2b Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Top2b Rat Pre-designed siRNA Set A contains three designed siRNAs for Top2b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Top2b Rat Pre-designed siRNA Set A Top2b Rat Pre-designed siRNA Set A

HY-13550

Ametantrone NSC 196473; NSC 290813	DNA/RNA Synthesis	Cancer
Ametantrone (NSC 196473) is an antitumor agent that intercalates into DNA and induces topoisomerase II (TOP2)-mediated DNA break .

HY-123393

PNU-142586	Topoisomerase	Others
PNU-142586 is the major metabolite of Linezolid (HY-10394). PNU-142586 can inhibit the activity of DNA topoisomerase 2-α (TOP2A) and DNA topoisomerase 2-β (TOP2B). PNU-142586 interferes with DNA replication and transcription by blocking the binding of DNA to TOP2 and inhibiting ATP hydrolysis. PNU-142586 can be used to study Linezolid-induced hematotoxicity and its molecular mechanism .

HY-174374

Topobexin	Topoisomerase	Cardiovascular Disease
Topobexin (Topobexin 9) is a highly selective inhibitor for *TOP2B. Topobexin selectively inhibits TOP2B in vitro and immobilizes TOP2*B on DNA. Topobexin demonstrates significant protection of cardiomyocytes against DAU-induced damage. Topobexin prevents anthracycline-induced cardiotoxicity and DAU-induced decrease in LV systolic function in vivo with rabbit model .

HY-111630

PluriSIn #2 2 Publications Verification	Topoisomerase	Cancer
PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs) .

Cat. No.	Compare	Product Name	Species	Source

HY-P704742

	TOP2A Protein, Human TOP2A; DNA TOPoisomerase 2-alpha; TOP2; DNA TOPoisomerase II; alpha isozyme	Human	E. coli
	TOP2A Protein, Human is the recombinant human-derived TOP2A protein, expressed by E. coli, with tag free tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80980

	Topoisomerase II alpha Antibody (YA3544) DNA TOPoisomerase II; DNA TOPoisomerase II-alpha; TOP2; TP2A; alpha isozyme, TOPoisomerase II alpha	WB, IHC-P, IP	Human, Mouse, Rat
	Topoisomerase II alpha Antibody (YA3544) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Topoisomerase II alpha.

HY-P85929

	Topoisomerase II alpha Antibody (YA5621) alpha isozyme; ATP hydrolyzing DNA TOPoisomerase II alfa; DNA gyrase; DNA TOPoisomerase; ATP hydrolyzing; DNA TOPoisomerase 2 alpha; DNA TOPoisomerase 2-alpha; DNA TOPoisomerase II 170 kD; DNA TOPoisomerase II alpha isozyme; DNA TOPoisomerase II; DNA TOPoisomerase2; TOP 2A; TOP2; TOP2A; TOP2A_HUMAN; TOPoisomerase DNA II alpha 170 kDa; TP2A	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
	Topoisomerase II alpha Antibody (YA5621) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Topoisomerase II alpha.

HY-P84062

	Topoisomerase II alpha Antibody (YA3759) TOP2; TP2A	WB, ICC/IF, FC, ELISA	Human, Rat
	Topoisomerase II alpha Antibody (YA3759) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Topoisomerase II alpha.

HY-P87126

	TopBP1 Antibody (YA6819) DNA TOPoisomerase 2 binding protein 1 antibody; DNA TOPoisomerase 2-binding protein 1 antibody; DNA TOPoisomerase II binding protein 1 antibody; DNA TOPoisomerase II binding protein antibody; DNA TOPoisomerase II-beta-binding protein 1 antibody; DNA TOPoisomerase II-binding protein 1 antibody; DNA TOPoisomerase IIbeta binding protein 1 antibody; Hypothetical protein KIAA0259 [Fragment] antibody; KIAA0259 antibody; TOP2BP1 antibody; DNA TOPoisomerase 2 binding protein 1 antibody; DNA TOPoisomerase 2-binding protein 1 antibody; DNA TOPoisomerase II binding protein 1 antibody; DNA TOPoisomerase II binding protein antibody; DNA TOPoisomerase II-beta-binding protein 1 antibody; DNA TOPoisomerase II-binding protein 1 antibody; DNA TOPoisomerase IIbeta binding protein 1 antibody; Hypothetical protein KIAA0259 [Fragment] antibody; KIAA0259 antibody; TOP2BP1 antibody; TOPB1_HUMAN antibody; TOPBP 1 antibody; TOPBP1 antibody; TOPoisomerase (DNA) II binding protein 1 antibody; TOPoisomerase II binding protein 1 antibody;	WB, IHC-P	Human
	TopBP1 Antibody (YA6819) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TopBP1.