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Results for "

TCO

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (80) Biochemical Assay Reagents (22) Drug-Linker Conjugates for ADC (2) Epigenetic Reader Domain (3) ERK (1) Fluorescent Dye (42) GPR139 (1) Liposome (1) Microtubule/Tubulin (1) Molecular Glues (1) PROTAC Linkers (79) PROTACs (1) Radionuclide-Drug Conjugates (RDCs) (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (155) Metabolic Disease (1) Neurological Disease (1)
Click Chemistry:	ADC Synthesis (69) TCO (103) Labeling and Fluorescence Imaging (28) DBCO (8) PROTAC Synthesis (43) Azide (1) Tetrazine (94)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

231

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

198

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-141187

**TCO-PEG3-TCO**	PROTAC Linkers	Cancer
TCO-PEG3-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-140731

TCO-PEG-TCO (MW 5000)	PROTAC Linkers	Cancer
TCO-PEG-TCO (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG-TCO (MW 5000) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-141175

TCO-PNB ester	Biochemical Assay Reagents	Others
TCO-PNB ester is an amine-reactive building block used for modification of amine-containing molecule. TCO-PNB ester contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group .

HY-141165

TCO-NHS ester	PROTAC Linkers	Cancer
TCO-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-151696

TCO-PEG3-maleimide	ADC Linker	Others
TCO-PEG3-maleimide (TCO-PEG3-NEM) is a click chemistry reagent. TCO-PEG3-maleimide efficiently binds TCO (trans-cyclooctene) moiety to thiol-containing molecules (such as antibodies, cysteine-containing peptides) .

HY-151698

TCO-NHS Ester (axial)	ADC Linker	Others
TCO-NHS Ester axial is a click chemistry reagent that can be used as a building block in amine reactions. TCO-NHS Ester axial contains TCO groups, which can undergo inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-133478

**TCO-PEG11-TCO**	PROTAC Linkers	Cancer
TCO-PEG11-TCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG11-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-W190914

**Tco-PEG2-Tco**	Biochemical Assay Reagents	Others
TCO-PEG2-TCO is a homebifunctional reagent containing TCO moiety at both ends of the molecule. TCO group specifically and efficiently reacts with tetrazine. The hydrophilic PEG linker increases the solubility of compounds in aqueous media.

HY-141188

**TCO-PEG4-TCO**	PROTAC Linkers	Cancer
TCO-PEG4-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141189

**TCO-PEG8-TCO**	PROTAC Linkers	Cancer
TCO-PEG8-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-156391

TCO4-PEG2-Maleimide	PROTAC Linkers	Cancer
TCO4-PEG2-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG2-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.

HY-156392

TCO4-PEG7-Maleimide	PROTAC Linkers	Cancer
TCO4-PEG7-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG7-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.

HY-W872575

TCO4-PEG3-Maleimide	PROTAC Linkers	Cancer
TCO4-PEG3-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG3-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.

HY-136039

TCO-SS-amine	ADC Linker	Cancer
TCO-SS-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-SS-amine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-140015

TCO-PEG3-acid	PROTAC Linkers	Cancer
TCO-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . TCO-PEG3-acid is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-156488

TCO-PEG7-Maleimide	Biochemical Assay Reagents	Others
TCO-PEG7-Maleimide contains TCO groups, and can undergo specific "click" reactions with tetrazine groups.

HY-W800817

TCO-PEG4-maleimide	Biochemical Assay Reagents	Others
TCO-PEG4-maleimide is a click chemistry building block containing a TCO moiety and a maleimide group. The maleimide group will react with a thiol group to form a covalent bond. TCO moiety is very reactive with tetrazine (3rd generation click chemistry).

HY-W800750

TCO-PEG2-acid	Biochemical Assay Reagents	Others
TCO-PEG2-acid is a click chemistry linker containing a TCO (trans-cycloctene) and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators such as EDC. TCO reagent is highly reactive with tetrazine in an inverse electron demand Diels Alder (IEDDA) reaction followed by a retro-DA reaction. The hydrophilic PEG spacer increases solubility in aqueous media.

HY-133475

TCO-PEG5-maleimide	PROTAC Linkers	Cancer
TCO-PEG5-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG5-maleimide is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-141171

TCO-PEG24-NHS ester	PROTAC Linkers	Cancer
TCO-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG24-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-141167A

TCO-PEG4-NHS ester	PROTAC Linkers	Cancer
TCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-133474

TCO-PEG3-oxyamine	PROTAC Linkers	Cancer
TCO-PEG3-oxyamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG3-oxyamine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-133476

TCO-PEG3-alcohol	PROTAC Linkers	Cancer
TCO-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG3-alcohol is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-140310

TCO-PEG4-DBCO	ADC Linker PROTAC Linkers	Cancer
TCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. TCO-PEG4-DBCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-141186

TCO-OH	PROTAC Linkers	Cancer
TCO-OH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-141176

TCO-amine	PROTAC Linkers	Cancer
TCO-amine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-202399

TCO-PEG2-NHS ester	PROTAC Linkers	Others
TCO-PEG2-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG2-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups .

HY-171559

TCO-PEG5-NHS ester	PROTAC Linkers	Others
TCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG5-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups .

HY-136077

TCO-PEG3-aldehyde	ADC Linker	Cancer
TCO-PEG3-aldehyde is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG3-aldehyde is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-136050

TCO-PEG3-Biotin	ADC Linker	Cancer
TCO-PEG3-Biotin is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG3-Biotin is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-154802

TCO-GK-PEG4-NHS ester	ADC Linker Radionuclide-Drug Conjugates (RDCs)	Cancer
TCO-GK-PEG4-NHS ester is an ADC Linker, and can be used for synthesis of ^[18F]AlF-NOTA-Tz-TCO-GK-2Rs15d. ^[18F]AlF-NOTA-Tz-TCO-GK-2Rs15d binds with high affinity and immunoreactivity to HER2 . TCO-GK-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-148057

TCO-PEG4-VC-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
TCO-PEG4-VC-PAB-MMAE is a agent-linker conjugate for ADC. TCO-PEG4-VC-PAB-MMAE contains a cleavable ADC linker (TCO-PEG4-VC-PA) and a potent tubulin inhibitor MMAE (HY-15162) . TCO-PEG4-VC-PAB-MMAE is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-141170

TCO-PEG12-NHS ester	ADC Linker PROTAC Linkers	Cancer
TCO-PEG12-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG12-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-141159

TCO-PEG4-acid	PROTAC Linkers	Cancer
TCO-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141160

TCO-PEG6-acid	PROTAC Linkers	Cancer
TCO-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141161

TCO-PEG8-acid	PROTAC Linkers	Cancer
TCO-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141164

TCO-PEG36-acid	PROTAC Linkers	Cancer
TCO-PEG36-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-141162

TCO-PEG12-acid	PROTAC Linkers	Cancer
TCO-PEG12-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141163

TCO-PEG24-acid	PROTAC Linkers	Cancer
TCO-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-162991

TCO-PAL-PARP	Fluorescent Dye	Others
TCO-PAL-PARP is a PARP PAL probe modified with a trans-cyclooctene group, which can be utilized in live cells .

HY-RS16317

TCO Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TCO Human Pre-designed siRNA Set A contains three designed siRNAs for TCO gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TCO Human Pre-designed siRNA Set A TCO Human Pre-designed siRNA Set A

HY-130934

TCO-PEG1-Val-Cit-OH	ADC Linker	Cancer
TCO-PEG1-Val-Cit-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG1-Val-Cit-OH is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-151769

TCO-PEG2-Sulfo-NHS ester-EDC Urea	ADC Linker	Others
TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent containing an azide group. TCO-PEG2-Sulfo-NHS ester is a PEG linker containing a TCO moiety and a sulfo-NHS ester moiety. The sulfo group makes this molecule soluble in waqueous buffer. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety. Reagent grade, for research use only . TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-141168

TCO-PEG6-NHS ester	PROTAC Linkers	Cancer
TCO-PEG6-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141178

TCO-PEG3-amine	PROTAC Linkers	Cancer
TCO-PEG3-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141174

TCO-PEG12-TFP ester	PROTAC Linkers	Cancer
TCO-PEG12-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-141181

TCO-PEG8-amine	PROTAC Linkers	Cancer
TCO-PEG8-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141166

TCO-PEG3-NHS ester	PROTAC Linkers	Cancer
TCO-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141183

TCO-PEG4-biotin	PROTAC Linkers	Cancer
TCO-PEG4-biotin is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141184

TCO-PEG9-maleimide	PROTAC Linkers	Cancer
TCO-PEG9-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

Cat. No.	Product Name	Type

HY-156304

Coumarin-C2-TCO	Fluorescent Dyes/Probes
Coumarin-C2-TCO is a dye derivative of Coumarin (HY-N0709). Coumarin-C2-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.

HY-D1071

DBCO-PEG12-TCO

Dyes

DBCO-PEG12-TCO cantains a TCO and a DBCO moiety. TCO group can specifically react with terrahydrazine. DBCO-PEG12-TCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. DBCO-PEG12-TCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-151759

Sulfo-Cy5-TCO	Dyes
Sulfo-Cy5-TCO is a click chemistry reagent containing a *TCO* group. Sulfo-Cy5-TCO is water soluble dye, which is highly reactive with tetrazines and methyltetrazines with the fastest bioconjugation speed .

HY-D2248

ICG-TCO	Fluorescent Dyes/Probes
ICG-TCO is a fluorescent dye coupled by Indocyanine Green (ICG) and TCO. ICG-TCO can be used for detection and visualization of tetrazine-containing molecules.

HY-156303

Coumarin-PEG2-TCO	Fluorescent Dyes/Probes
Coumarin-PEG2-TCO is a dye derivative of Coumarin (HY-N0709) containing 2 PEG units. Coumarin-PEG2-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.

HY-156306

Coumarin-PEG3-TCO	Fluorescent Dyes/Probes
Coumarin-PEG3-TCO is a dye derivative of Coumarin (HY-N0709) containing 3 PEG units. Coumarin-PEG3-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.

HY-D2142

Cy5-PEG2-TCO	Fluorescent Dyes/Probes
Cy5-PEG2-TCO is a fluorescent dye that reacts with tetrazines. Cy5-PEG2-TCO contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.

HY-155324

Cy3-PEG7-TCO	Fluorescent Dyes/Probes
Cy3-PEG7-TCO is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 7 PEG units. Cy3-PEG7-TCO can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.

HY-155323

Cy3-PEG3-TCO	Fluorescent Dyes/Probes
Cy3-PEG3-TCO is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 3 PEG units. Cy3-PEG3-TCO can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.

HY-155322

Cy3-PEG2-TCO	Fluorescent Dyes/Probes
Cy3-PEG2-TCO is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 2 PEG units. Cy3-PEG2-TCO can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.

HY-D2144

Cy5-PEG7-TCO	Fluorescent Dyes/Probes
Cy5-PEG7-TCO is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 7 PEG units. Cy5-PEG7-TCO utilizes its own TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.

HY-D2143

Cy5-PEG3-TCO	Fluorescent Dyes/Probes
Cy5-PEG3-TCO is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 3 PEG units. Cy5-PEG3-TCO utilizes its own TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.

HY-D2147

*Cy5-PEG7-TCO4*	Fluorescent Dyes/Probes
Cy5-PEG7-TCO4 is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 7 PEG units. Cy5-PEG7-TCO4 utilizes its own TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.

HY-155325

*Cy3-PEG2-TCO4*	Fluorescent Dyes/Probes
Cy3-PEG2-TCO4 is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 2 PEG units. Cy3-PEG2-TCO4 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.

HY-D2146

*Cy5-PEG3-TCO4*	Fluorescent Dyes/Probes
Cy5-PEG3-TCO4 is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 3 PEG units. Cy5-PEG3-TCO4 utilizes its own TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.

HY-155326

*Cy3-PEG3-TCO4*	Fluorescent Dyes/Probes
Cy3-PEG3-TCO4 is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 3 PEG units. Cy3-PEG3-TCO4 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.

HY-D2145

*Cy5-PEG2-TCO4*	Fluorescent Dyes/Probes
Cy5-PEG2-TCO4 is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 2 PEG units. Cy5-PEG2-TCO4 utilizes its own TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.

HY-D1867

Sulfo-Cy3-PEG2-TCO disodium

Fluorescent Dyes/Probes

Sulfo-Cy3-PEG2-TCO disodium is a derivative of Cy3 (Cyanine3) (HY-D0822) dye containing sulfonate and TCO groups. The TCO groups of Sulfo-Cy3-PEG2-TCO disodium react with tetrazine functional groups in highly specific click chemistry to form covalent bonds. Thus, Sulfo-Cy3-PEG2-TCO disodium can be covalently bound to some biomolecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.

HY-D2219

Sulfo-Cy7 tetrazine	Fluorescent Dyes/Probes
Sulfo-Cy7 tetrazine is a near-infrared water-soluble fluorophore. Sulfo-Cy7 tetrazine contains the methyltetrazine group for rapid, efficient, and metal-free conjugation to cycloolefin in a reaction called TCO linkage .

HY-D2744

BP Fluor 488 TCO

Fluorescent Dyes/Probes

BP Fluor 488 TCO reacts with tetrazines to produce a stable, covalent linkage, also referred to as the inverse-electron demand Diels-Alder cycloaddition reaction. This reaction is extremely fast (k > 800 M-1 s-1), selective, biocompatible, and does not require Cu-catalyst or elevated temperatures. Such excellent reaction rate constants are unparalleled by any other bioorthogonal reaction pair described to date.

HY-151712

Sulfo-Cy5-Methyltetrazine	Fluorescent Dyes/Probes
Sulfo-Cy5-Methyltetrazine is a click chemistry reagent containing a methyltetrazine group. Sulfo-Cy5-Methyltetrazine acts as a fluorophore linker for trans-cyclooctene-based labeling. Sulfo-Cy5-Methyltetrazine shows good stability at physiological pH and is also highly reactive towards cyclooctene.

HY-W800838

BP Fluor 488 Tetrazine

Fluorescent Dyes/Probes

BP Fluor 488 Tetrazine is a bright, green-fluorescent probe used for detection TCO-tagged biopolymers. BP Fluor 488 Tetrazine demonstrates exceptionally fast cycloaddition kinetics (up to 30 000 M-1 s-1) with trans-cyclooctenes (TCO) as the dienophile, the fastest kinetics ever reported for any bioorthogonal reaction. In applications such as in vivo cancer imaging or pre?targeted cell labeling studies where rapid reaction kinetics is a must BP Fluor 488 Tetrazine probe would of great value.

HY-D1646

BDP TR methyltetrazine	Fluorescent Dyes/Probes
BDP TR methyltetrazine is a BDP dye linker containing a methyltetrazine group. BDP TR methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-D1870

Sulfo-Cy3-PEG3-biotin potassium

Dyes

Sulfo-Cy3-PEG3-biotin potassium is a biotin-modified derivative of Cy3 (Cyanine3) (HY-D0822) dye containing a TCO group. The TCO group of Sulfo-Cy3-PEG3-biotin potassium reacts with the tetrazine functional group in highly specific click chemistry to form a covalent bond. Thus, Sulfo-Cy3-PEG3-biotin potassium can be covalently bound to some biomolecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples. And because it is labeled with biotin, it is often used in affinity chromatography experiments, such as immunoprecipitation.

HY-D2243

Cy3.5 tetrazine	Fluorescent Dyes/Probes
Cy3.5 tetrazineis a Tetrazine modified Cy3.5 fluorescent dye. SiR-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .

HY-156309

Coumarin-PEG8-tetrazine	Fluorescent Dyes/Probes
Coumarin-PEG8-tetrazine is a dye derivative of Coumarin (HY-N0709) containing 8 PEG units. Coumarin-PEG8-tetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-D2117

TAMRA-PEG4-Me-Tet	Fluorescent Dyes/Probes
TAMRA-PEG4-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG8-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-D2116

TAMRA-PEG8-Me-Tet	Fluorescent Dyes/Probes
TAMRA-PEG8-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 8 PEG units. TAMRA-PEG8-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-D2118

TAMRA-PEG3-Me-Tet	Fluorescent Dyes/Probes
TAMRA-PEG3-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-D2148

AF 430 tetrazine	Fluorescent Dyes/Probes
AF 430 tetrazine is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 425 nm and an emission wavelength of 542 nm. AF 430 tetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. To achieve specific coupling of dye labels and biomolecules .

HY-D2134

Cy5-PEG3-Tetrazin	Fluorescent Dyes/Probes
Cy5-PEG3-Tetrazin is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 3 PEG units. Cy5-PEG3-Tetrazin contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-D2159

Cy5-PEG8-Tetrazin	Fluorescent Dyes/Probes
Cy5-PEG8-Tetrazin is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 7 PEG units. Cy5-PEG8-Tetrazin contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-D1482A

Sulfo Cy5-tetrazine sodium	Fluorescent Dyes/Probes
Sulfo Cy5-tetrazine sodium is a tetrazine-coupled Cy5 (HY-D0821) derivative dye with fluorescence properties similar to CY5 (Ex/Em=633/647 nm). Sulfo-Cy5-tetrazine sodium is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .

HY-D1482

Sulfo-Cy5-tetrazine	Fluorescent Dyes/Probes
Sulfo Cy5-tetrazine is a tetrazine-coupled Cy5 (HY-D0821) derivative dye with fluorescence properties similar to CY5 (Ex/Em=633/647 nm). Sulfo-Cy5-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .

HY-D1598

Sulfo-CY3 tetrazine potassium

Fluorescent Dyes/Probes

Sulfo-CY3 tetrazine potassium is a sulfo-Cyanine3 derivative that contains methyltetrazine moiety (Ex=548 nm, Em=563 nm). Sulfo-CY3 tetrazine potassium can be used for the labeling of metabolically engineered cell-surface glycoconjugates . Sulfo-CY3 tetrazine (potassium) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-D2489

Cy5-tetrazine	Fluorescent Dyes/Probes
Cy5-tetrazine is a fluorescent dye. Cy5-tetrazine is a CY5 (HY-D0821) derivative contains a tetrazine moiety. Cyanine5.5 tetrazine can be used for in vivo imaging and low background applications. Cy5-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .

HY-D1557

Cyanine5.5 tetrazine

Fluorescent Dyes/Probes

Cyanine5.5 tetrazine is a far-infrared luminescent dye. Cyanine5.5 tetrazine is a Cyanine5.5 (HY-D0925A) derivative contains a tetrazine moiety. Cyanine5.5 tetrazine can be used for in vivo imaging and low background applications. Cyanine5.5 tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-138659

Janelia Fluor® 646, Tetrazine

JF646, Tetrazine

Fluorescent Dyes/Probes

Janelia Fluor 646, Tetrazine (JF646, Tetrazine) a red fluorescent dye that contains a tetrazine group. JF646, Tetrazine can be used in cellular imaging . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. Janelia Fluor? 646, Tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

Cat. No.	Product Name	Type

HY-166981

*DSPE-PEG-TCO* (MW 2000)**	Drug Delivery
DSPE-PEG-TCO (MW 2000) is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG-TCO (MW 2000) can be used in drug delivery research .

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