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Suzuki

" in MedChemExpress (MCE) Product Catalog:

36

Inhibitors & Agonists

2

Fluorescent Dye

21

Biochemical Assay Reagents

1

Isotope-Labeled Compounds

1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-Y0747
    Iodobenzene

    1-Iodobenzene

    		 Biochemical Assay Reagents Others
    Iodobenzene can undergo Ullmann coupling reaction on copper catalyst to generate biphenyl. Iodobenzene can undergo Suzuki reaction with phenylboronic acid to generate biphenyl .
    Iodobenzene
  • HY-W019633
    Benzothiazole-5-boronic acid pinacol ester

    		Biochemical Assay Reagents Others
    Benzothiazole-5-boronic acid pinacol ester is a compound that can be used in the boronate part of Suzuki coupling reactions .
    Benzothiazole-5-boronic acid pinacol ester
  • HY-32928
    4-Cyanobenzeneboronic acid

    		Biochemical Assay Reagents Others
    4-Cyanobenzeneboronic acid is a Boronic acid derivative. 4-Cyanobenzeneboronic acid can be used in Suzuki-Miyaura cross-coupling reactions .
    4-Cyanobenzeneboronic acid
  • HY-W001987
    4,6-Dichloropyrimidin-5-amine

    		Biochemical Assay Reagents Others
    Organic ligands can be prepared through Suzuki cross-coupling reaction between 4,6-Dichloropyrimidin-5-amine and dimethyl(5-pinyl)isophthalate .
    4,6-Dichloropyrimidin-5-amine
  • HY-W004698
    (2-Methoxypyrimidin-5-yl)boronic acid

    		Drug Intermediate Others
    (2-Methoxypyrimidin-5-yl)boronic acid is a drug intermediate that can serve as a key reactant in the Suzuki-Miyaura coupling reaction, and is used for the synthesis of isoquinoline ketone derivatives with anti-tumor activity .
    (2-Methoxypyrimidin-5-yl)boronic acid
  • HY-Y0747S
    Iodobenzene-d5

    1-Iodobenzene-d5

    		 Isotope-Labeled Compounds Others
    Iodobenzene-d5 is the deuterium labeled 1-Iodobenzene. Iodobenzene can undergo Ullmann coupling reaction on copper catalyst to generate biphenyl. Iodobenzene can undergo Suzuki reaction with phenylboronic acid to generate biphenyl .
    Iodobenzene-d5
  • HY-W244282
    Thalidomide-pinacolborane

    		Ligands for E3 Ligase Cancer
    Thalidomide-pinacolborane is a Thalidomide analogue featuring a boronic pinacol ester, otherwise known as a Bpin group, and they are most frequently used in Suzuki reactions. This molecule is an activator for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction.
    Thalidomide-pinacolborane
  • HY-77642
    4-(Methylsulfonyl)phenylboronic acid

    		Biochemical Assay Reagents Drug Intermediate Metabolic Disease
    4-(Methylsulfonyl)phenylboronic acid is an intermediate. 4-(Methylsulfonyl)phenylboronic acid can be used to synthesize GPR119 agonists via Suzuki coupling reaction. 4-(Methylsulfonyl)phenylboronic acid can be used in the research of type 2 diabetes .
    4-(Methylsulfonyl)phenylboronic acid
  • HY-W002849
    Cyjohnphos

    2-(Dicyclohexylphosphino)biphenyl

    		 Biochemical Assay Reagents Others
    Cyjohnphos is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Cyjohnphos can be used in combination with a nickel catalyst for the Suzuki-Miyaura arylation of tertiary benzylic acetates with aryl boroxines to produce diaryl and triaryl quaternary stereocenters .
    Cyjohnphos
  • HY-Y0747S1
    Iodobenzene-d2

    1-Iodobenzene-d2

    		 Isotope-Labeled Compounds Others
    Iodobenzene-d2 is the deuterium labeled 1-Iodobenzene. Iodobenzene can undergo Ullmann coupling reaction on copper catalyst to generate biphenyl. Iodobenzene can undergo Suzuki reaction with phenylboronic acid to generate biphenyl .
    Iodobenzene-d2
  • HY-W002570
    2-Naphthylboronic acid

    		Biochemical Assay Reagents Others
    2-Naphthylboronic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. 2-Naphthylboronic acid can undergo silylation reaction. 2-Naphthylboronic acid also readily undergo Suzuki-Miyaura cross-coupling .
    2-Naphthylboronic acid
  • HY-D2261
    BODIPY-cholesterol conjugate-1

    		Fluorescent Dye Metabolic Disease
    BODIPY-cholesterol conjugate-1 (compound 5) is a BODIPY-cholesterol conjugate. BODIPY-cholesterol conjugate-1 is a useful probe for simultaneous visualization of intracellular cholesterol pools and for monitoring cholesterol efflux from cells to extracellular acceptors . (λex 541 nm, λem 615 nm).
    BODIPY-cholesterol conjugate-1
  • HY-D2262
    BODIPY-cholesterol conjugate-2

    		Fluorescent Dye Metabolic Disease
    BODIPY-cholesterol conjugate-2 (compound 6) is a BODIPY-cholesterol conjugate. BODIPY-cholesterol conjugate-2 is a useful probe for simultaneous visualization of intracellular cholesterol pools and for monitoring cholesterol efflux from cells to extracellular acceptors. (λex=589 nm, λem=638 nm) .
    BODIPY-cholesterol conjugate-2
  • HY-W002801
    2-Benzyloxyphenylboronic acid

    		Biochemical Assay Reagents Others
    2-Benzyloxyphenylboronic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. 2-Benzyloxyphenylboronic acid is also a substrate used in asymmetric Suzuki coupling reactions. 2-Benzyloxyphenylboronic acid can be utilized in the synthesis of other active compounds .
    2-Benzyloxyphenylboronic acid
  • HY-W003601
    2-Bromo-4-fluoropyridine

    		Biochemical Assay Reagents Others
    2-Bromo-4-fluoropyridine is a synthetic halogenated heterocyclic organic compound and a key intermediate in the pharmaceutical and agrochemical industries. 2-Bromo-4-fluoropyridine can be used to synthesize bioactive molecules through cross-coupling reactions, such as Suzuki coupling or Buchwald-Hartwig amination.
    2-Bromo-4-fluoropyridine
  • HY-32748
    2-Bromo-5-fluoropyridine

    		Biochemical Assay Reagents Drug Intermediate Others
    2-Bromo-5-fluoropyridine is an intermediate. 2-Bromo-5-fluoropyridine can undergo Suzuki coupling reaction with Boronic acid (HY-41551). 2-Bromo-5-fluoropyridine can be used in the synthesis of GSK1292263A (a GPR119 receptor agonist) .
    2-Bromo-5-fluoropyridine
  • HY-W005558
    6-Aminopyridine-3-boronic acid

    		Biochemical Assay Reagents Others
    6-Aminopyridine-3-boronic acid is a boronic acid derivative. Boronic acid derivatives are widely used in organic synthesis for carbon-carbon bond formation. In Suzuki coupling, aryl halides and boronic acid aryl or vinyl esters or boronic acid are coupled using Pd(PPh3)4. It can be used as a pharmaceutical intermediate [1] .
    6-Aminopyridine-3-boronic acid
  • HY-75129
    Pyridin-3-ylboronic acid

    		Biochemical Assay Reagents Others
    Pyridin-3-ylboronic acid is an organic compound. Pyridin-3-ylboronic acid is a key reagent in the Suzuki-Miyaura cross-coupling reaction. Pyridin-3-ylboronic acid is used in organic synthesis to construct oligopyridine compounds, and then as an α-helix mimetic to study protein-protein interactions .
    Pyridin-3-ylboronic acid
  • HY-134811
    KRAS G12D inhibitor 1

    		Ras Cancer
    KRAS G12D inhibitor 1 (Example 243) is a KRAS G12D inhibitor, with an IC50 of 0.4 nM. KRAS G12D inhibitor 1 exhibits an IC50 of 0.8 nM for KRAS G12D-mediated ERK phosphorylation. KRAS G12D inhibitor 1 can be used for the study of cancers with KRAS G12D mutations, such as pancreatic ductal adenocarcinoma and colorectal cancer .
    KRAS G12D inhibitor 1
  • HY-W003129
    2-Bromo-4-chloropyridine

    		Biochemical Assay Reagents Drug Intermediate Infection
    2-Bromo-4-chloropyridine is an intermediate. 2-Bromo-4-chloropyridine undergoes Suzuki coupling reaction with 4-tert-butylphenylboronic acid (HY-W007389). 2-Bromo-4-chloropyridine facilitates the construction of compounds with broad-spectrum antibacterial activity .
    2-Bromo-4-chloropyridine
  • HY-101974
    Biotin-PEG3-Bromide

    		Biochemical Assay Reagents Others
    Biotin-PEG3-Bromide is a short PEG linker featuring a biotin group and a bromide. The bromide is a halogen which is easily displaced by nucleophiles such as alcohols or amines. Alternatively, bromide can be applied in a number of cross-coupling reactions such as in a Suzuki reaction. Biotin is useful for affinity-based applications such as pull-down assays or for ligating with streptavidin proteins.
    Biotin-PEG3-Bromide
  • HY-75637
    3-Amino-5-methylpyrazole

    		Drug Intermediate Others
    5-Methyl-1H-pyrazol-3-amine is a pyrazole heterocyclic compound and can be used as a key intermediate for the synthesis of pyrazolylamide derivatives.
    3-Amino-5-methylpyrazole
  • HY-21623
    Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct

    		Biochemical Assay Reagents Others
    Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct is a catalyst. Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct stabilizes intermediates and reduces activation energy in coupling reactions. Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct can be used in Suzuki-Miyaura coupling reactions .
    Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct
  • HY-42045
    Pyrimidine-5-boronic acid pinacol ester

    		Biochemical Assay Reagents Others
    Pyrimidine-5-boronic acid pinacol ester is a derivative of Boronic acid. Boronic acid is an intermediate commonly used in organic synthesis reactions and can be used as a key reagent in the Suzuki-Miyaura reaction. It generates organic free radicals through oxygen-mediated oxidation and exhibits potential mutagenic activity. Boronic acid is mainly used in research in the fields of drug synthesis and catalytic reactions. At the same time, it should be noted that it may be a genotoxic impurity (GTIs) .
    Pyrimidine-5-boronic acid pinacol ester
  • HY-32959
    N-Boc-2-pyrroleboronic acid

    		Biochemical Assay Reagents Others
    N-Boc-2-pyrroleboronic acid is an organic synthesis intermediate used primarily in the synthesis of chiral pharmaceutical molecules and biologically active molecules. The boronic acid on the pyrrole ring can participate in Suzuki coupling reactions. The boronic acid can be oxidized to a hydroxyl group under the action of nitrogen oxides, and after tautomerization, it can be further transformed into 2-oxo-2,5-dihydro-1-pyrrolecarboxylic acid tert-butyl ester .
    N-Boc-2-pyrroleboronic acid
  • HY-114362
    DL-alpha-Tocopherol methoxypolyethylene glycol succinate

    TPGS-750-M

    		 Biochemical Assay Reagents Others
    DL-alpha-Tocopherol methoxypolyethylene glycol succinate (TPGS-750-M) is an amphiphile, acts as a surfactant. DL-alpha-Tocopherol methoxypolyethylene glycol succinate has a positive effect on Suzuki-Miyaura cross coupling. DL-alpha-Tocopherol methoxypolyethylene glycol succinate increases the styrene titer. DL-alpha-Tocopherol methoxypolyethylene glycol succinate is used in the stability test of NPYM-modified drugs in biological fluids .
    DL-alpha-Tocopherol methoxypolyethylene glycol succinate
  • HY-W001222
    3-Furanboronic acid

    		Biochemical Assay Reagents Others
    3-Furanboronic acid is a biochemical reagent. 3-Furanboronic acid can be smoothly coupled with a variety of active and inactive 2-chloropyridines, 2-chloroquinolines, and 2-chloropyrimidine .
    3-Furanboronic acid
  • HY-W002734
    (3-Hydroxyphenyl)boronic acid

    3-Hydroxybenzeneboronic acid

    		 Drug Intermediate Endocrinology
    (3-Hydroxyphenyl)boronic acid (3-Hydroxybenzeneboronic acid) is a drug intermediate that can be used for the synthesis of 17β-hydroxysteroid dehydrogenase type 1 inhibitors .
    (3-Hydroxyphenyl)boronic acid
  • HY-W002463
    3-Chlorophenyl boronic acid

    		Biochemical Assay Reagents Others
    3-Chlorophenylboronic acid is employed as a reactant involved in 1,4-conjugate addition reactions with ethenesulfonamides to form arylethanesulfonamides, Suzuki-Miyaura reactions with dibromotrifluoromethylbenzene, cross-coupling reactions with diazoesters3 or potassium cyanate. 3-Chlorophenylboronic acid is involved in the synthesis of biarylketones and phthalides and synthesis of inhibitors including PDE4 inhibitors among others. 3-Chlorophenyl boronic acid can affect cell migration. 3-Chlorophenyl boronic acid can be used to study wound healing .
    3-Chlorophenyl boronic acid
  • HY-W020985
    Bis[1,2-bis(diphenylphosphino)ethane]palladium(0)

    Pd(DIPHOS)2

    		 Biochemical Assay Reagents Others
    Bis[1,2-bis(diphenylphosphino)ethane]palladium(0), often abbreviated as Pd(PPh3)2 or Pd(dppf), is an organometallic compound. This compound is widely used as a catalyst for organic chemical reactions, especially cross-coupling reactions such as Suzuki-Miyaura reaction and Heck reaction, and its high catalytic activity, selectivity and stability make it a versatile tool for the synthesis of complex organic compounds , in addition, the potential application of Pd(PPh3)2 in the production of electronic materials and in medical and biochemical research has also been investigated.
    Bis[1,2-bis(diphenylphosphino)ethane]palladium(0)
  • HY-171854
    SB-583355

    		G2A (GPR132) Neurological Disease Inflammation/Immunology
    SB-583355 (Compound 56) is a potent G2A antagonist. SB-583355 can be prepared by a Suzuki reaction between 4-methoxyphenyl boronic acid and 3-bromo-4-hydroxybenzoic acid following the conditions followed by an amide coupling reaction. SB-583355 blocks the activation of G2A mediated either by 9-HOPE or T-10148 in human G2A expressing CHO-K1 cells. SB-583355 can be studied in research for inflammation, myeloid leukemia, and neuropathic pain .
    SB-583355
  • HY-175553
    VEGFR-2-IN-72

    		VEGFR Apoptosis Cancer
    VEGFR-2-IN-72 is a selective VEGFR-2 inhibitor with an IC50 of 22.2 nM. VEGFR-2-IN-72 exhibits anticancer activity against HepG2 and Hep3B human HCC cell lines with IC50s of 15.7 and 2.4 μM. VEGFR-2-IN-72 can cause a mild blockage of the cell cycle and induce cell aopoptosis. VEGFR-2-IN-72 can used for the study of hepatocellular carcinoma (HCC) .
    VEGFR-2-IN-72
  • HY-40190
    5-Bromo-2,3-dihydro-1H-inden-1-one

    		Biochemical Assay Reagents Drug Intermediate Metabolic Disease
    5-Bromo-2,3-dihydro-1H-inden-1-one is a bromoindanone compound. 5-Bromo-2,3-dihydro-1H-inden-1-one acts as a key intermediate in organic synthesis, participating in reactions such as Suzuki coupling and Buchwald amination. 5-Bromo-2,3-dihydro-1H-inden-1-one can be used in the research of obesity-related metabolic diseases .
    5-Bromo-2,3-dihydro-1H-inden-1-one
  • HY-146489
    Anti-infective agent 3

    		Bacterial Parasite Infection
    Anti-infective agent 3 (compound 3l) shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC50 values of 0.47 and 0.13 μM, respectively. Anti-infective agent 3 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 4 μg/mL .
    Anti-infective agent 3
  • HY-146488
    Anti-infective agent 2

    		Parasite Bacterial Infection
    Anti-infective agent 2 (compound 3k) shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC50 values of 0.07 and 2.20 μM, respectively. Anti-infective agent 2 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 32 μg/mL .
    Anti-infective agent 2
  • HY-146487
    Anti-infective agent 1

    		Bacterial Parasite Infection
    Anti-infective agent 1 (compound 3a) is a potent and selective antiprotozoal and antimycobacterial agent. Anti-infective agent 1 shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC50 values of 10.95 and 0.06 μM, respectively. Anti-infective agent 1 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 8 μg/mL .
    Anti-infective agent 1

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