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Results for "

Sec61

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

1

Peptides

1

Natural
Products

2

Antibodies

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-139615
    Sec61-IN-1

    		Sec61 Cancer
    Sec61-IN-1 (compound A317) is a potent sec61 inhibitor that effectively targets glioma cells and enhances T cell cytotoxic effects[1][2].
    Sec61-IN-1
  • HY-139616
    Sec61-IN-2

    		Others Others
    Sec61-IN-2 (A347) is a protein secretion inhibitor (extracted from patent WO2020176863) .
    Sec61-IN-2
  • HY-139617
    Sec61-IN-3

    		Others Others
    Sec61-IN-2 (A3) is a protein secretion inhibitor (extracted from patent WO2020176863) .
    Sec61-IN-3
  • HY-156355
    Sec61-IN-5

    		Others Cancer
    Sec61-IN-5 (Compound 16c) is a Sec61 inhibitor. Sec61 shows cytotoxicity in A549 cells (IC50: 0.27 nM). Sec61-IN-5 inhibits Sec61-dependent secretory function (IC50: 0.08 nM) .
    Sec61-IN-5
  • HY-156349
    Sec61-IN-4

    		Apoptosis Others
    Sec61-IN-4 (Compound 16b) is a Sec61 inhibitor (IC50: 0.04 nM in U87-MG cells) .
    Sec61-IN-4
  • HY-RS12621
    SEC61A1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SEC61A1 Human Pre-designed siRNA Set A contains three designed siRNAs for SEC61A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SEC61A1 Human Pre-designed siRNA Set A
    SEC61A1 Human Pre-designed siRNA Set A
  • HY-RS12623
    SEC61G Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SEC61G Human Pre-designed siRNA Set A contains three designed siRNAs for SEC61G gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SEC61G Human Pre-designed siRNA Set A
    SEC61G Human Pre-designed siRNA Set A
  • HY-RS12622
    SEC61B Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SEC61B Human Pre-designed siRNA Set A contains three designed siRNAs for SEC61B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SEC61B Human Pre-designed siRNA Set A
    SEC61B Human Pre-designed siRNA Set A
  • HY-176763
    KZR-261

    		Sec61 Apoptosis Caspase Cancer
    KZR-261 is a Sec61 inhibitor. KZR-261 directly binds to the Sec61 channel to potently inhibit the biogenesis of a subset of Sec61 client proteins. KZR-261 has a broad antitumor activity (such as colorectal pancreas and prostate cancer), along with the activation of an endoplasmic reticulum stress response, with minimal adverse effects on normal cells. KZR-261 significantly induces apoptosis of H929 cells. KZR-261 potently inhibits tumor growth in multiple xenograft tumor mice models with good tolerance .
    KZR-261
  • HY-N10661
    Ipomoeassin F

    Ipom-F

    		 SARS-CoV Infection Cancer
    Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .
    Ipomoeassin F
  • HY-110078
    Eeyarestatin I
    5+ Cited Publications

    		 p97 Apoptosis Cancer
    Eeyarestatin I, a potent endoplasmic reticulum-associated protein degradation (ERAD) inhibitor, is a potent protein translocation inhibitor. Eeyarestatin I inhibits Sec61 translocon. Eeyarestatin I targets the p97-associated deubiquitinating process (PAD) and inhibits atx3-dependent deubiquitination. Eeyarestatin I interferes at a step prior to proteasomal degradation. Eeyarestatin I induces cell death via the proapoptotic protein NOXA and has anticancer effects .
    Eeyarestatin I
  • HY-134809
    Cyclotriazadisulfonamide

    CADA

    		 HIV Infection Inflammation/Immunology
    Cyclotriazadisulfonamide (CADA) is a specific CD4-targeted HIV entry inhibitors. Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of human CD4 (huCD4) into the ER lumen in a signal peptide (SP)-dependent way. Cyclotriazadisulfonamide is also a Sec61 translocon inhibitor .
    Cyclotriazadisulfonamide

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