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SMARCA2 degrader

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) DNA/RNA Synthesis (1) Drug Intermediate (1) E1/E2/E3 Enzyme (1) E3 Ligase Ligand-Linker Conjugates (25) Epigenetic Reader Domain (57) Ligands for E3 Ligase (9) Ligands for Target Protein for PROTAC (15) Molecular Glues (2) Pregnane X Receptor (PXR) (2) PROTAC Linkers (16) PROTACs (80) SWI/SNF Complex (9) Target Protein Ligand-Linker Conjugates (4)
By Research Areas:	Cancer (147)
Click Chemistry:	Azide (15)

154

Inhibitors & Agonists

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-162745

SMARCA2 degrader-20	PROTACs	Cancer
SMARCA2 degrader-20 is a PROTAC *SMARCA2* degrader with a DC₅₀ less than 100 nM in A549 cells .

HY-162245

*PROTAC SMARCA2* degrader-3**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-3 is a PROTAC degrader of the SWI/SNF ATPase subunits, *SMARCA2. PROTAC SMARCA2* degrader-3 has anticancer effects (WO2023244764A1; Compound 153) .

HY-168257

*PROTAC SMARCA2* degrader-30**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-30 (example 85) is a PROTAC SMARCA2 degrader with a DC₅₀ less than 100 nM in H1299 cells .

HY-161882

*PROTAC SMARCA2* degrader-8**	PROTACs	Cancer
PROTAC SMARCA2 degrader-8 (compound 1) is a potent *SMARCA2* degrader with a DC₅₀ of 28nM in A375 cells .

HY-176871

*PROTAC SMARCA2* degrader-35**	SWI/SNF Complex PROTACs DNA/RNA Synthesis	Cancer
PROTAC SMARCA2 degrader-35 (Compound 43) is a selective *SMARCA2* PROTAC degrader with a DC₅₀ < 0.1 μM for SMARCA2. PROTAC SMARCA2 degrader-35 has anticancer activity and regulates cancer cell proliferation and growth through cell cycle arrest and DNA replication inhibition in SMARCA4-deleted cancer cells . Pink: SMARCA2 ligand (HY-178414); Blue: E3 ligase ligand; Black: linker

HY-169278

*PROTAC SMARCA2* degrader-26**	Epigenetic Reader Domain PROTACs	Cancer
PROTAC SMARCA2 degrader-26 (compound 45) is a potent *SMARCA2* PROTAC degrader. PROTAC SMARCA2 degrader-26 induces SMARCA2 and SMARCA4 degradation in VCaP cells with the percent degradation of 94% and 57% for SMARCA2 and SMARCA4, respectively. PROTAC SMARCA2 degrader-26 shows antiproliferative activity .

HY-169271

*PROTAC SMARCA2* degrader-20**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-20 (Compound I-40) is a PROTAC SMARCA2 degrader. PROTAC SMARCA2 degrader-20 has the potential for the research of cancer .

HY-169270

*PROTAC SMARCA2* degrader-19**	Epigenetic Reader Domain PROTACs	Cancer
PROTAC SMARCA2 degrader-19 (Compound 46) is a PROTAC degrader for *SMARCA2, that degrades* *SMARCA2* in cell A549 and MV411 with a DC₅₀ < 100 nM. PROTAC SMARCA2 degrader-19 degrades *SMARCA4* in cell MV411 with a DC₅₀ > 1000 nM .

HY-169269

*PROTAC SMARCA2* degrader-18**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-18 (Example144) is a PROTAC SMARCA2 degrader. PROTAC SMARCA2 degrader-18 has the potential for the research of non-small cell lung cancer (NSCLC) .

HY-169274

*PROTAC SMARCA2* degrader-23**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-23 (Example 1) is a potent and selective PROTAC SMARCA2 degrader，with a DC₅₀ of <100 nM. PROTAC SMARCA2 degrader-23 has the potential for the research of cancer .

HY-169273

*PROTAC SMARCA2* degrader-22**	PROTACs SWI/SNF Complex	Cancer
PROTAC SMARCA2 degrader-22 (Compound 5) is a PROTAC degrader for *SMARCA2* with a degradation efficacy of 94% at 100 nM. PROTAC SMARCA2 degrader-22 inhibits the proliferation of cell A549 with an EC₅₀ < 250 nM .

HY-175867

*PROTAC SMARCA2* degrader-34**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-34 (compound 52) is a selective SMARCA2 PROTAC degrader (DC50 in HeLa cell: < 0.1 μM for *SMARCA2, > 1 μM for SMARCA4). PROTAC SMARCA2* degrader-34 can be used for study of cancer. (Pink: SMARCA2 ligand (HY-178414) ; Blue: E3 ligand (HY-168055) ; Black: linker) .

HY-168229

*PROTAC SMARCA2* degrader-27**	PROTACs SWI/SNF Complex	Cancer
PROTAC SMARCA2 degrader-27 (compound 4) is a PROTAC SMARCA2 degrader. PROTAC SMARCA2 degrader-27 has the potential to be used in cancer research (Pink: SMARCA2 ligand (HY-168230); Blue: VHL ligand (HY-168232); Black: linker (HY-168231)) .

HY-169275

*PROTAC SMARCA2* degrader-24**	PROTACs SWI/SNF Complex	Cancer
PROTAC SMARCA2 degrader-24 (Compound 34) is a PROTAC degrader for *SMARCA2* with a DC₅₀ < 0.1 µM in HeLa. PROTAC SMARCA2 degrader-24 degrades *SMARCA4* with a DC₅₀ > 10 μM in HeLa .

HY-168246

*PROTAC SMARCA2* degrader-29**	Epigenetic Reader Domain PROTACs	Cancer
PROTAC SMARCA2 degrader-29 (Example 87) is a PROTAC *SMARCA2* (BRM) degrader, with DC₅₀ of 10-100 nM (BRM) and > 1 μM (BRG1, also known as SMARCA2) respectively .

HY-153424

*PROTAC SMARCA2* degrader-1**	Target Protein Ligand-Linker Conjugates	Cancer
PROTAC SMARCA2 degrader-1 (compound ex7) is a BRM2 (SMARCA2) degrader (DC₅₀<0.1 μM). PROTAC SMARCA2 degrader-1 is also an E3 ubiquitin ligase binding linker useful in research of cancers. PROTAC SMARCA2 degrader-1 is a target protein ligand-linker conjugate .

HY-163874

*PROTAC SMARCA2* degrader-12**	PROTACs	Cancer
SMARCA2 degrader-13 (compound I-406) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-163866

*PROTAC SMARCA2* degrader-14**	PROTACs	Cancer
SMARCA2 degrader-3 (compound I-323) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-163867

*PROTAC SMARCA2* degrader-15**	PROTACs	Cancer
SMARCA2 degrader-4 (compound I-332) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-163865

*PROTAC SMARCA2* degrader-13**	PROTACs	Cancer
SMARCA2 degrader-2 (compound I-322) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-168234

*PROTAC SMARCA2* degrader-31**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2-degrader-36 (compound 38) is a *SMARCA2* degrader and can reach the the degradation rate of 99 % at the 100 nM in H929 cells. PROTAC SMARCA2-degrader-36 shows anti-proliferative activity and can be used for study of cancer(Structure Note: PINK SMARCA2 ligand HY-44012; Blue, VHL ligand (HY-112078); Black, linker HY-W014125) .

HY-159462

*PROTAC SMARCA2* degrader-10**	PROTACs	Cancer
PROTAC SMARCA2 degrader-10 (compound I-507) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-162747

*PROTAC SMARCA2* degrader-17**	PROTACs	Cancer
PROTAC SMARCA2 degrader-17 (compound I-290) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-162742

*PROTAC SMARCA2* degrader-16**	PROTACs	Cancer
PROTAC SMARCA2 degrader-16 (compound I-278) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159450

*PROTAC SMARCA2* degrader-6**	PROTACs	Cancer
PROTAC SMARCA2 degrader-6 (compound I-427) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-162746

*PROTAC SMARCA2* degrader-9**	PROTACs	Cancer
PROTAC SMARCA2 degrader-9 (compound I-285) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-169272

*PROTAC SMARCA2* degrader-21**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-21 (Compound I-5) is a PROTAC degrader for *SMARCA, that degrades* *SMARCA2* with a DC₅₀ of 10-50 nM in A549 cell, and degrades *SMARCA2* and *SMARCA4* in MV411 with DC₅₀ of <1 nM and >100 nM, respectively .

HY-153425

*PROTAC SMARCA2* degrader-2**	PROTACs	Cancer
PROTAC SMARCA2 degrader-2 is a potent and selective SMARCA2/4 PROTAC degrader with an IC₅₀ of <0.1 μΜ in HeLa HiBiT assay. PROTAC SMARCA2 degrader-2 is extracted from patent WO2023287787A1 and has the potential for SMARCA4-related or deficient cancer research .

HY-159449

*PROTAC SMARCA2* degrader-5**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-5 (Compound I-425) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2. PROTAC SMARCA2* degrader-5 degrades *SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* with DC₅₀ of 100-500 nM . (Pink: Ligand for target protein (HY-159531); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-170343

*PROTAC SMARCA2* degrader-32**	PROTACs SWI/SNF Complex	Cancer
PROTAC SMARCA2 degrader-32 (Compound 27) is the degrader for *SMARCA2* with a DC₅₀ of 1.3 nM. PROTAC SMARCA2 degrader-32 inhibits the proliferation of lung cancer cell NCI-H838 with a GI₅₀ of 34 nM . (Pink: ligand for target protein SMARCA2 ligand-11 (HY-170349); Black: linker (HY-W895794); Blue: ligand for E3 ligase VHL (HY-170348))

HY-168236

*PROTAC SMARCA2* degrader-28**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-28 (Compound 158) is a PROTAC degrader for *SMARCA2, that degrades* SMARCA2 with a DC₅₀ of 3 nM in HiBiT A549 cells. (Pink: Ligand for target protein (HY-168237); Black: Linker (HY-168238); Blue: Ligand for E3 ligase (HY-W087383))

HY-159451

*PROTAC SMARCA2* degrader-7**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-7 (Compound I-428) is a PROTAC degrader for SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A (SMARCA) *SMARCA2. PROTAC SMARCA2* degrader-7 degrades *SMARCA2* and *SMARCA4* in MV411 with DC₅₀ of <100 and 100-500 nM. (Pink: Ligand for target protein (HY-159542); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-169276

*PROTAC SMARCA2* degrader-25**	PROTACs	Cancer
PROTAC SMARCA2 degrader-25 (example 86) is a potent PROTAC SMARCA2 degrader with the DC₅₀ of ＜0.01 μM (Pink: ligand for target protein (HY-169487); Black: linker (HY-W052601); Blue: E3 ligase ligand (HY-W087383)) .

HY-175756

SMARCA2/4 degrader-1	Epigenetic Reader Domain Molecular Glues	Cancer
SMARCA2/4 degrader-1 (Compound 1) is a *SMARCA2/4* molecular glue degrader with a DC₅₀ of 2.2  nM for SMARCA4. SMARCA2/4 degrader-1 covalently recruits both CUL4 ^DCAF16 and CRL1 ^FBXO22 to degrade SMARCA2/4 .

HY-173333

*PROTAC SMARCA2/4 degrader-38*	PROTACs Epigenetic Reader Domain Apoptosis	Cancer
PROTAC SMARCA2/4 degrader-38 is a degrader *SMARCA2/4* PROTAC (DC₅₀: 3.0 nM and 4.0 nM respectively). PROTAC SMARCA2/4 degrader-38 promotes the ubiquitination and degradation of SMARCA2/4. PROTAC SMARCA2/4 degrader-38 blocks the G0/G1 cell cycle and induces apoptosis. PROTAC SMARCA2/4 degrader-38 can be used in acute myeloid leukemia (AML) research. (Pink: SMARCA2/4 ligand; Blue: VHL ligand (HY-112078); Black: linker; Target Protein Ligand-Linker Conjugates (HY-173343)) .

HY-159457

*PROTAC SMARCA2/4-degrader-6*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-6 (compound I-438) is a *SMARCA2/4* degrader. PROTAC SMARCA2/4-degrader-6 has the potential for the research of cancer. (Pink: SMARCA2/4 ligand, (HY-159545); Black: linker (HY-W006635); Blue: VHL ligand (HY-112078)) .

HY-163875

*PROTAC SMARCA2/4-degrader-22*	PROTACs	Cancer
SMARCA2 degrader-14 (compound I-408) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-163876

*PROTAC SMARCA2/4-degrader-23*	PROTACs	Cancer
SMARCA2 degrader-15 (compound I-409) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-163872

*PROTAC SMARCA2/4-degrader-10*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-10 (compound I-399) is a potent *SMARCA2* degrader with an DC₅₀ value of ＜100 nM. PROTAC SMARCA2/4-degrader-10 has the potential for the research of cancer (Blue:SMARCA2/4 ligand, (HY-159542); Black: linker (HY-W088435); Pink:VHL ligand (HY-125845)) .

HY-159458

*PROTAC SMARCA2/4-degrader-7*	PROTACs	Cancer
SMARCA2/4-degrader-7 (compound I-439) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159459

*PROTAC SMARCA2/4-degrader-32*	PROTACs	Cancer
PROTAC SMARCA2/4-degrader-32 (compound I-446) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-163869

*PROTAC SMARCA2/4-degrader-16*	PROTACs	Cancer
PROTAC SMARCA2/4-degrader-16 (compound I-337) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159452

*PROTAC SMARCA2/4-degrader-1*	PROTACs	Cancer
SMARCA2/4-degrader-1 (compound I-430) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159453

*PROTAC SMARCA2/4-degrader-2*	PROTACs	Cancer
SMARCA2/4-degrader-2 (compound I-431) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-162741

*PROTAC SMARCA2/4-degrader-33*	PROTACs	Cancer
PROTAC SMARCA2/4-degrader-33 (compound I-277) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-169861

*PROTAC SMARCA2/4 degrader-37*	PROTACs Epigenetic Reader Domain	Others
PROTAC SMARCA2/4 degrader-37 (Example 4) is a PROTAC-based *SMARCA2/4* degrader, with an IC₅₀ of ≤0.1 μM (Pink: SMARCA2/4 lignad (HY-172446); Black: CRBN ligand (HY-41547); Linker (HY-N2407)) .

HY-163871

*PROTAC SMARCA2/4-degrader-18*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-18 (Compound I-348) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-18* degrades *SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-159531); Black: Linker (HY-76547); Blue: Ligand for E3 Ligase (HY-125845))

HY-163870

*PROTAC SMARCA2/4-degrader-17*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-17 (Compound I-345) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-17* degrades *SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-W053507); Blue: Ligand for E3 Ligase (HY-125845))

HY-162743

*PROTAC SMARCA2/4-degrader-29*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-29 (Compound I-279) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-29* degrades *SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: ligand for target protein (HY-163926); Black: linker (HY-159682); Blue: ligand for E3 ligase (HY-W382038)) .

HY-162744

*PROTAC SMARCA2/4-degrader-31*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-31 (Compound I-280) is a degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-31* degrades *SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for target protein (HY-163926); Black: Linker (HY-159682); Blue: Ligand for E3 ligase (HY-W382038)) .

Cat. No.	Product Name		Classification

HY-159462

*PROTAC SMARCA2* degrader-10**		Azide
PROTAC SMARCA2 degrader-10 (compound I-507) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159450

*PROTAC SMARCA2* degrader-6**		Azide
PROTAC SMARCA2 degrader-6 (compound I-427) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159449

*PROTAC SMARCA2* degrader-5**		Azide
PROTAC SMARCA2 degrader-5 (Compound I-425) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2. PROTAC SMARCA2* degrader-5 degrades *SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* with DC₅₀ of 100-500 nM . (Pink: Ligand for target protein (HY-159531); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159451

*PROTAC SMARCA2* degrader-7**		Azide
PROTAC SMARCA2 degrader-7 (Compound I-428) is a PROTAC degrader for SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A (SMARCA) *SMARCA2. PROTAC SMARCA2* degrader-7 degrades *SMARCA2* and *SMARCA4* in MV411 with DC₅₀ of <100 and 100-500 nM. (Pink: Ligand for target protein (HY-159542); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159457

*PROTAC SMARCA2/4-degrader-6*		Azide
PROTAC SMARCA2/4-degrader-6 (compound I-438) is a *SMARCA2/4* degrader. PROTAC SMARCA2/4-degrader-6 has the potential for the research of cancer. (Pink: SMARCA2/4 ligand, (HY-159545); Black: linker (HY-W006635); Blue: VHL ligand (HY-112078)) .

HY-159458

*PROTAC SMARCA2/4-degrader-7*		Azide
SMARCA2/4-degrader-7 (compound I-439) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159459

*PROTAC SMARCA2/4-degrader-32*		Azide
PROTAC SMARCA2/4-degrader-32 (compound I-446) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159452

*PROTAC SMARCA2/4-degrader-1*		Azide
SMARCA2/4-degrader-1 (compound I-430) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159453

*PROTAC SMARCA2/4-degrader-2*		Azide
SMARCA2/4-degrader-2 (compound I-431) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159461

*PROTAC SMARCA2/4-degrader-9*		Azide
PROTAC SMARCA2/4-degrader-9 (Compound I-503) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2* degrader-9 degrades *SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM . (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159455

*PROTAC SMARCA2/4-degrader-4*		Azide
PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-4* degrades *SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for target protein (HY-159472); Black: Linker (HY-159478); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159456

*PROTAC SMARCA2/4-degrader-5*		Azide
PROTAC SMARCA2/4-degrader-5 (Compound I-437) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-5* degrades *SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ of 100-500 nM. (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-159557); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159460

*PROTAC SMARCA2/4-degrader-8*		Azide
PROTAC SMARCA2/4-degrader-8 (Compound I-502) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2. PROTAC SMARCA2/4-degrader-8* degrades *SMARCA2* with DC₅₀ <100 nM in A549 and in MV411, degrades *SMARCA4* with DC₅₀<100 nM in MV411(Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W063924); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159454

*PROTAC SMARCA2/4-degrader-3*		Azide
SMARCA2/4-degrader-3 (compound I-433) is a PROTAC *SMARCA2/4*-degrader based on VH032-NH2, with a degradation potency (DC₅₀) <100 nM in MV4-11 cells .

HY-163926

SMARCA2/4-IN-2		Azide
SMARCA2/4-IN-2 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-IN-2 can be used for synthesis PROTAC SMARCA2/4-degrader-5 (HY-159456) .

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