Search Result

Isoforms Recommended:	SIRT6

Results for "

SIRT6

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (4) Autophagy (1) c-Myc (1) Cytochrome P450 (1) ERK (2) HBV (1) HDAC (1) Histone Demethylase (1) Interleukin Related (1) mTOR (1) NF-κB (1) P2X Receptor (1) p38 MAPK (1) PROTACs (1) Reactive Oxygen Species (ROS) (1) Ribosomal S6 Kinase (RSK) (1) Sirtuin (15) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (10) Endocrinology (1) Infection (1) Inflammation/Immunology (4) Metabolic Disease (4) Neurological Disease (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148712

SIRT6 activator 12q	Apoptosis Sirtuin	Cancer
SIRT6 activator 12q is potent, selective and orally active *SIRT6* activator with IC₅₀ values of 171.20, >200, >200, >200, 0.58 μM for SIRT1, SIRT2, SIRT3, SIRT5, SIRT6, respectively. SIRT6 activator 12q inhibits cell growth and migration. SIRT6 activator 12q induces Apoptosis and cell cycle arrest at G2 phase. SIRT6 activator 12q shows anticancer activity .

HY-103721

SIRT6-IN-2	Sirtuin	Cancer
SIRT6-IN-2 (Compound 5) is a selective *SIRT6* inhibitor (IC₅₀: 34 μM). SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects .

HY-156027

SIRT6-IN-3	Sirtuin HDAC Akt mTOR Ribosomal S6 Kinase (RSK) ERK	Neurological Disease Inflammation/Immunology Endocrinology Cancer
SIRT6-IN-3 (compound 8a) is a selective inhibitor of *SIRT6* (IC₅₀=7.49 μM). SIRT6-IN-3 inhibits pancreatic ductal adenocarcinoma (PDAC) cells proliferation and induces apoptosis. SIRT6-IN-3 increases the sensitivity of cancer cells to gemcitabine (HY-17026) via blocking the DNA damage repair pathway. SIRT6-IN-3 is used in pancreatic cancer research .

HY-169159

SIRT6 activator 2	Sirtuin	Metabolic Disease
SIRT6 activator 2 (compound 31) is a sirtuin 6 activator with anti-lipid accumulation properties. SIRT6 activator 2 significantly downregulates LXR, SREBP-1c, and their target genes associated with lipogenesis, and can be used for research related to lipid metabolism-related diseases .

HY-RS12950

SIRT6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Sirtuin	Others
SIRT6 Human Pre-designed siRNA Set A contains three designed siRNAs for SIRT6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SIRT6 Human Pre-designed siRNA Set A SIRT6 Human Pre-designed siRNA Set A

HY-RS12952

Sirt6 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sirt6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sirt6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sirt6 Rat Pre-designed siRNA Set A Sirt6 Rat Pre-designed siRNA Set A

HY-RS12951

Sirt6 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Sirtuin	Others
Sirt6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sirt6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sirt6 Mouse Pre-designed siRNA Set A Sirt6 Mouse Pre-designed siRNA Set A

HY-170402

SIRT6-IN-4	Sirtuin Apoptosis	Cancer
SIRT6-IN-4 (Compound 10d) is a selective inhibitor for *SIRT6* with an IC₅₀ of 5.68 μM. SIRT6-IN-4 inhibits the proliferation of MCF-7 with an IC₅₀ of 8.30 μM. SIRT6-IN-4 arrests the cell cycle at G2/M phase, inhibits thecell migration and invasion of MCF-7, and induces apoptosis. SIRT6-IN-4 exhibits antitumor efficacy in mouse models .

HY-169846

CL5D	Sirtuin	Metabolic Disease
CL5D is an activator of protein deacetylase *SIRT6. CL5D can significantly enhance the deacetylation activity of SIRT6* and improve its catalytic efficiency. CL5D regulates SIRT6 activity by promoting conformational changes, especially dependent on the role of Arg-65 residue. CL5D can be used to study the activation mechanism of SIRT6 and its function in metabolism, DNA repair and aging .

HY-177084

Forvisirvat SP-624	Sirtuin	Neurological Disease
Forvisirvat (SP-624) is an orally active, brain-penetrant and selective sirtuin 6 (SIRT6) activator. Forvisirvat activates the deacetylase activity of SIRT6, enhancing DNA repair and mitochondrial health, and exhibits antidepressant activity in animal models. Forvisirvat is promising for research of major depressive disorder .

HY-107454

OSS_128167 25+ Cited Publications	Sirtuin HBV	Infection Metabolic Disease Inflammation/Immunology Cancer
OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC₅₀s of 89 μM, 1578 μM and 751 μM for *SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV* activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects .

HY-153104

CrBKA	Sirtuin	Cancer
CrBKA is a fluorogenic small-molecule substrate of *SIRT6* with weak activity .

HY-156757

MDL-811	Sirtuin Interleukin Related Cytochrome P450	Neurological Disease Inflammation/Immunology Cancer
MDL-811 is a selective allosteric activator of *SIRT6* with an EC₅₀ of 5.7 μM. MDL-811 possesses anti-inflammatory, antitumor, and neuroprotective activities. MDL-811 can be used for the research of diseases such as colorectal cancer and ischemic stroke .

HY-115453

UBCS039 10+ Cited Publications	Sirtuin Autophagy	Cancer
UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC₅₀ of 38 μM .

HY-123194

SIRT2/6-IN-1	Histone Demethylase Sirtuin	Metabolic Disease
SIRT2/6-IN-1 (Compound 5) is a *SIRT6/SIRT2* inhibitor, with IC₅₀s of 106 μM and 114 μM. SIRT2/6-IN-1 increases H3K9 acetylation, increases glucose uptake and reduces TNF-α secretion in cells .

HY-N5025

Bullatine A	P2X Receptor Apoptosis ERK p38 MAPK c-Myc NF-κB Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology Cancer
Bullatine A, a diterpenoid alkaloid, is a potent P2X7 antagonist. Bullatine A possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A inhibits ATP-induced BV-2 cell death/apoptosis and P2X receptor-mediated inflammatory responses. Bullatine A suppresses glioma cell growth by targeting *SIRT6. Bullatine A specifically attenuates pain hypersensitivity in rats. Bullatine A attenuates LPS (HY-D1056)-induced systemic inflammatory response by inhibiting the ROS/JNK/NF-κB* pathway in mice. Bullatine A improves despair behavior in Chronic chronic social defeat stress (CSDS) mice. Bullatine A can be used for the study of inflammation, glioblastoma (GBM) and depression .

HY-168574

SZU-B6	PROTACs Sirtuin Apoptosis	Cancer
SZU-B6 is a PROTAC degrader for *SIRT6* with DC₅₀ of 45 nM and 154 nM in cell SK-HEP-1 and Huh-7. SZU-B6 inhibits the proliferation of cell SK-HEP-1 with an IC₅₀ of 1.51 μM, inhibits the colony formation of SK-HEP-1 and Huh-7, induces apoptosis and arrests the cell cycle at G2/M phase in SK-HEP-1. SZU-B6 exhibits antitumor efficacy in mouse model. (Pink: ligand for target protein (HY-16605); Black: linker (HY-W012935); BLue: ligand for E3 ligase (HY-W453548)

Bullatine A	Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Ranunculaceae Source classification Aconitum carmichaeli Debx. Plants Inflammation/Immunology Disease Research Fields	P2X Receptor Apoptosis ERK p38 MAPK c-Myc NF-κB Reactive Oxygen Species (ROS)
Bullatine A, a diterpenoid alkaloid, is a potent P2X7 antagonist. Bullatine A possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A inhibits ATP-induced BV-2 cell death/apoptosis and P2X receptor-mediated inflammatory responses. Bullatine A suppresses glioma cell growth by targeting *SIRT6. Bullatine A specifically attenuates pain hypersensitivity in rats. Bullatine A attenuates LPS (HY-D1056)-induced systemic inflammatory response by inhibiting the ROS/JNK/NF-κB* pathway in mice. Bullatine A improves despair behavior in Chronic chronic social defeat stress (CSDS) mice. Bullatine A can be used for the study of inflammation, glioblastoma (GBM) and depression .

Species:	Human (2)
Tag:	His (1) GST (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P703626

	Sirt6 Protein, Human (His) SIR2L6	Human	E. coli
	Sirt6 Protein, Human (His) is the recombinant human-derived Sirt6, expressed by E. coli , with His labeled tag. ,

HY-P702952

	SIRT6 Protein, Human (GST) SIR2L6	Human	E. coli
	SIRT6 Protein, Human (GST) is the recombinant human-derived SIRT6, expressed by E. coli , with GST labeled tag. ,

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80322

	SIRT6 Antibody (YA078) 1 Publications Verification	WB, ICC/IF, IHC-P, FC	Human, Mouse
	SIRT6 Antibody (YA078) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SIRT6.

HY-P85522

	SIRT6 Antibody (YA5214) 2810449N18Rik; AI043036; Mono ADP ribosyltransferase SIRTuin 6; NAD-dependent protein deacetylase SIRTuin-6; Regulatory protein SIR2 homolog 6; Regulatory protein SIR2 homolog; SIR2 like 6; SIR2 like protein 6; Sir2 related protein type 6; SIR2-like protein 6; SIR2	WB, ICC/IF, IP	Human, Mouse, Rat, Monkey
	SIRT6 Antibody (YA5214) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SIRT6.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

SIRT6 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SIRT6 Human Pre-designed siRNA Set A contains three designed siRNAs for SIRT6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sirt6 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Sirt6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sirt6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sirt6 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Sirt6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sirt6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks