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SA

" in MedChemExpress (MCE) Product Catalog:

92

Inhibitors & Agonists

2

Fluorescent Dye

15

Biochemical Assay Reagents

3

Peptides

12

Natural
Products

15

Recombinant Proteins

4

Isotope-Labeled Compounds

10

Antibodies

7

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-U00074

    SA-446 racemate

    Angiotensin-converting Enzyme (ACE) Cardiovascular Disease
    Rentiapril racemate (SA-446 racemate) is the racemate of Rentiapril. Rentiapril is an angiotensin converting enzyme (ACE) inhibitor.
    Rentiapril racemate
  • HY-B0432A
    Propafenone hydrochloride
    1 Publications Verification

    SA-79 hydrochloride

    Sodium Channel Cardiovascular Disease
    Propafenone (hydrochloride) (SA-79 (hydrochloride)) is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.
    Propafenone hydrochloride
  • HY-123120

    Thrombin Others
    SA-152 is an organophosphorus inhibitor. SA-152 modulates the fibrinogen coagulation and TAME esterase activity of bovine α-thrombin .
    SA-152
  • HY-155685

    PROTACs VEGFR Ephrin Receptor Apoptosis Cancer
    SA-VA is an intracellular self-assembled PROTAC based on azide and alkyne. SA-VA is able to selectively degrade VEGFR-2 and EphB4 proteins in U87 cells. SA-VA can be converted to PROTAC in situ by click reaction with the help of endogenous copper in tumor tissues. SA-VA promotes apoptosis and blocks cells in S phase .
    SA-VA
  • HY-150260

    Bacterial Infection
    SA09-Cu is a noncompetitive and potent NDM-1 inhibitor with an IC50 of 9.6 nM. SA09-Cu can convert NDM-1 into an inactive state by oxidizing the Zn(II)-thiolate site of the enzyme and avoids to be reduced by intracellular thiols of bacteria. SA09-Cu exhibits excellent inhibition against a series of clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) in restoring the Meropenem (HY-13678) effect, and slows down the development of carbapenem resistance .
    SA09-Cu
  • HY-18080

    FAAH Autophagy Metabolic Disease
    SA 47 is a selective and potent inhibitor of fatty acid amide hydrolase (FAAH) and carbamate .
    SA 47
  • HY-155684

    PROTACs VEGFR PDGFR Ephrin Receptor Cancer
    SA-PA is an intracellular self-assembled PROTAC based on azide and alkyne. SA-PA is able to selectively degrade VEGFR-2, PDGFR-β and EphB4 proteins in U87 cells. SA-PA can be converted to PROTAC in situ by click reaction with the help of endogenous copper in tumor tissues .
    SA-PA
  • HY-U00240

    FAAH Autophagy Neurological Disease
    SA72 is a highly selective fatty acid amide hydrolase (FAAH) inhibitor.
    SA72
  • HY-164308

    LAG-3 Inflammation/Immunology
    SA-15-P inhibits LAG-3/MHCII and LAG-3/FGL1 interactions with IC50 values of 4.21 and 6.52 μM respectively. LAG-3/MHCII interaction is a target for immunotherapies .
    SA-15-P
  • HY-U00184

    Sesden; SA504

    mAChR Cardiovascular Disease
    Timepidium bromide (Sesden; SA504) is an anticholinergic agent.
    Timepidium bromide
  • HY-B0432AR

    SA-79 hydrochloride (Standard)

    Reference Standards Sodium Channel Cardiovascular Disease
    Propafenone (hydrochloride) (Standard) is the analytical standard of Propafenone (hydrochloride). This product is intended for research and analytical applications. Propafenone (hydrochloride) (SA-79 (hydrochloride)) is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.
    Propafenone hydrochloride (Standard)
  • HY-103463

    FAAH MAGL Neurological Disease
    SA57 is a potent, selective FAAH inhibitor with IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH. SA57 also inhibits the 2-arachidonoylglycerol hydrolases MAGL (IC50s of 410 nM and 1.4 μM for mouse and human MAGL) and mouse α/β-hydrolase domain-containing protein 6 (mABHD6; IC50 of 850 nM), but not other brain serine hydrolases .
    SA57
  • HY-B0432
    Propafenone
    1 Publications Verification

    SA-79

    Sodium Channel Adrenergic Receptor Potassium Channel Cardiovascular Disease Cancer
    Propafenone (SA-79), a sodium-channel blocker, acts an antiarrhythmic agent. Propafenone also has high affinity for the β receptor (IC50=32 nM) . Propafenone blocks the transient outward current (Ito) and the sustained delayed rectifier K current (Isus) with IC50 values of 4.9 μm and 8.6 μm, respectively . Propafenone suppresses esophageal cancer proliferation through inducing mitochondrial dysfunction and induce apoptosis .
    Propafenone
  • HY-B0432R

    SA-79 (Standard)

    Reference Standards Sodium Channel Adrenergic Receptor Potassium Channel Cardiovascular Disease Cancer
    Propafenone (Standard) is the analytical standard of Propafenone. This product is intended for research and analytical applications. Propafenone (SA-79), a sodium-channel blocker, acts an antiarrhythmic agent. Propafenone also has high affinity for the β receptor (IC50=32 nM) . Propafenone blocks the transient outward current (Ito) and the sustained delayed rectifier K current (Isus) with IC50 values of 4.9 μm and 8.6 μm, respectively . Propafenone suppresses esophageal cancer proliferation through inducing mitochondrial dysfunction and induce apoptosis .
    Propafenone (Standard)
  • HY-13510
    Cutamesine dihydrochloride
    5 Publications Verification

    SA4503 dihydrochloride; AGY94806 dihydrochloride

    Sigma Receptor Neurological Disease
    Cutamesine (SA4503) dihydrochloride is a potent and selective sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes. Cutamesine dihydrochloride shows >100-fold less affinity for the sigma 2 receptor (IC50 of 1784 nM). Cutamesine dihydrochloride has antidepressant effects .
    Cutamesine dihydrochloride
  • HY-118530
    Bucillamine
    1 Publications Verification

    SA96; Thiobutarit

    VEGFR Cardiovascular Disease Inflammation/Immunology
    Bucillamine (SA96) is an orally active and potent sulfhydryl donor and antioxidant. Bucillamine is also an antirheumatic agent with antiangiogenic properties. Bucillamine can protect against Ischemia/reperfusion (I/R) injury in high-risk organ transplants. Bucillamine inhibits the production of VEGF. Bucillamine can be used for the research of choroidal neovascularization (CNV) and rheumatoid arthritis (RA) .
    Bucillamine
  • HY-14813
    Cutamesine
    5 Publications Verification

    SA4503; AGY 94806

    Sigma Receptor Neurological Disease
    Cutamesine (SA4503) is a potent and selective sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes. Cutamesine shows >100-fold less affinity for the sigma 2 receptor (IC50 of 1784 nM). Cutamesine has antidepressant effects .
    Cutamesine
  • HY-118530R

    SA96 (Standard); Thiobutarit (Standard)

    Reference Standards VEGFR Cardiovascular Disease Inflammation/Immunology
    Bucillamine (Standard) is the analytical standard of Bucillamine. This product is intended for research and analytical applications. Bucillamine (SA96) is an orally active and potent sulfhydryl donor and antioxidant. Bucillamine is also an antirheumatic agent with antiangiogenic properties. Bucillamine can protect against Ischemia/reperfusion (I/R) injury in high-risk organ transplants. Bucillamine inhibits the production of VEGF. Bucillamine can be used for the research of choroidal neovascularization (CNV) and rheumatoid arthritis (RA) .
    Bucillamine (Standard)
  • HY-106446
    Rentiapril
    1 Publications Verification

    SA-446

    Angiotensin-converting Enzyme (ACE) Cardiovascular Disease
    Rentiapril is an orally active angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity .
    Rentiapril
  • HY-106446R

    SA-446 (Standard)

    Reference Standards Angiotensin-converting Enzyme (ACE) Cardiovascular Disease
    Rentiapril (Standard) is the analytical standard of Rentiapril. This product is intended for research and analytical applications. Rentiapril is an orally active angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity .
    Rentiapril (Standard)
  • HY-B0432AS

    SA-79 (D7 hydrochloride)

    Sodium Channel Others
    Propafenone-d7 (hydrochloride) is the deuterium labeled Propafenone, which is a classic anti-arrhythmic agent.
    Propafenone D7 hydrochloride
  • HY-157369

    Biochemical Assay Reagents Others
    Salmonella Arizona Agar is a special medium for Salmonella Arizona. The composition of 1 litre medium is 88.5 g Salmonella Arizona Agar .
    Salmonella Arizona Agar
  • HY-15790H

    (S)-A 3309; (S)-AZD 7806

    Apical Sodium-Dependent Bile Acid Transporter TNF Receptor Interleukin Related Metabolic Disease Inflammation/Immunology
    (S)-Elobixibat is the S enantiomer of Elobixibat (HY-15790). (S)-Elobixibat is an orally effective Apical Sodium-Dependent Bile (IBAT) inhibitor. (S)-Elobixibat decreases LDL cholesterol, increases serum GLP-1, promotes colon motility, and has the potential to treat metabolic syndrome. (S)-Elobixibat can be used to study constipation, dyslipidemia, non-alcoholic hepatitis, and liver tumors .
    (S)-Elobixibat
  • HY-124779A

    (S)-GEA 654 hydrochloride; (S)-A03 hydrochloride

    Serotonin Transporter Neurological Disease
    (S)-Alaproclate ((S)-A03) hydrochloride is a potent selective serotonin reuptake inhibitor (SSRI), which is used as an antidepressant agent. (S)-Alaproclate (hydrochloride) also produces a potent block of N-methyl-d-aspartate (NMDA) receptor currents in hippocampal neurons (IC50=1.1 μM) with a potent blocker of K + currents .
    (S)-Alaproclate hydrochloride
  • HY-113658

    Endogenous Metabolite Others
    ts-SA is a carbonic anhydrase (CA) inhibitor with activity against seven human CA homologues. ts-SA can bind to the Zn(II) ion in the enzyme active site in a deprotonated form. The organic skeleton of ts-SA extends in the enzyme cavity and participates in multiple interactions with amino acid residues and water molecules. Due to its structural differences, the inhibitory performance of ts-SA is significantly better than that of another pyridine derivative. ts-SA exhibits low nanomolar inhibitory activity and is a multi-target CA inhibitor .
    ts-SA
  • HY-129356

    Antibiotic ADC Payload DNA Alkylator/Crosslinker Apoptosis Cancer
    Seco-Duocarmycin SA is a DNA alkylator. Seco-Duocarmycin SA is an antitumor antibiotic (IC50 = 10 pM). Seco-Duocarmycin SA can induce a concentration-dependent increase in apoptotic cell death. Seco-Duocarmycin SA can lead to significant cell cycle arrest in S and G2/M phases. Seco-Duocarmycin SA acts as an ADC cytotoxin for antibody-drug conjugates .
    Seco-Duocarmycin SA
  • HY-129356A

    Antibiotic ADC Payload DNA Alkylator/Crosslinker Apoptosis Cancer
    (S)-Seco-Duocarmycin SA is the S-enantiomer of Seco-Duocarmycin SA (HY-129356). Seco-Duocarmycin SA is a DNA alkylating agent. Seco-Duocarmycin SA is an antitumor antibiotic (IC50 = 10 pM). Seco-Duocarmycin SA can induce a concentration-dependent increase in apoptotic cell death. Seco-Duocarmycin SA can lead to significant cell cycle arrest in S and G2/M phases. Seco-Duocarmycin SA acts as an ADC cytotoxin for antibody-drug conjugates .
    (S)-Seco-Duocarmycin SA
  • HY-12456

    Antibiotic ADC Payload DNA Alkylator/Crosslinker Necroptosis Apoptosis Cancer
    Duocarmycin SA is an orally active antitumor antibiotic with an IC50 of 10 pM . Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro .
    Duocarmycin SA
  • HY-171177

    Phosphatase Neurological Disease Cancer
    P5SA-2 is a selective allosteric activator of PPP5C. P5SA-2 exerts its effects by modulating the phosphatase domain of PPP5C and can increase PPP5C activity by 3.2-fold at 100 μM with an apparent affinity constant of 7.8 μM. P5SA-2 can be used in cancer and Alzheimer's disease research .
    P5SA-2
  • HY-108462
    ML-SA1
    3 Publications Verification

    Dengue Virus TRP Channel Flavivirus Infection
    ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral .
    ML-SA1
  • HY-D0893

    Fluorescent Dye Others
    NSP-SA-NHS is an acridinium ester that can be used for chemiluminescent immunoassay. A rapid and sensitive chemiluminescent immunoassay of Bisphenol A (BPA) with NSP-SA-NHS-labeled has been developed .
    NSP-SA-NHS
  • HY-152182
    ML-SA5
    2 Publications Verification

    TRP Channel Cancer
    ML-SA5 is a potent TRPML1 cation channel agonist that activates the entire endosomal TRPML1 (ML1) current in DMD myocytes with an EC50 of 285 nM and is more potent than ML-SA1. ML-SA5 has anticancer activity and can inhibit tumour growth .
    ML-SA5
  • HY-170490

    Photosensitizer Apoptosis Cancer
    TTQ-SA is a near-infrared (NIR) spiro-AIEgen (aggregation-induced emission luminogen), that converts near-infrared light (NIR) into thermal energy, causing thermal damage and death of tumor cells. TTQ-SA exhibits cellular uptake and targeting ability in cancer cell MF-7. TTQ-SA silences the expression of survivin gene with combination of DNAzyme, enhances the sensitivity of tumor cells to photothermal therapy .
    TTQ-SA
  • HY-400706

    Antibiotic Cancer
    Duocarmycin SA intermediate-2 is an intermediate in the synthesis of the antibiotic Duocarmycin SA (HY-12456). Duocarmycin SA intermediate-2 induces sequence-selective alkylation of double-stranded DNA and has synergistic, tumor suppressor cytotoxicity with proton irradiation .
    Duocarmycin SA intermediate-2
  • HY-400705

    Antibiotic Cancer
    Duocarmycin SA intermediate-1 is an intermediate in the synthesis of the antibiotic Duocarmycin SA (HY-12456). Duocarmycin SA intermediate-1 induces sequence-selective alkylation of double-stranded DNA and has synergistic, tumor-suppressive cytotoxicity with proton irradiation .
    Duocarmycin SA intermediate-1
  • HY-D2363

    FAP Radionuclide-Drug Conjugates (RDCs) Prolyl Endopeptidase (PREP) Cancer
    DOTA.SA.FAPi TFA inhibits fibroblast activation protein (FAP) with an IC50 of 0.9 nM. DOTA.SA.FAPi TFA targets protease PREP with an IC50 of 5.4 μM. DOTA.SA.FAPi TFA can be used a PET tracer, when labeled with 68Ga, and used for research about cancer . DOTA.SA.FAPi (TFA) can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
    DOTA.SA.FAPi TFA
  • HY-164364B

    FAP Cancer
    DOTAGA.(SA.FAPi)2 analogue TFA is a DOTAGA.(SA.FAPi)2 TFA (HY-164364A) analogue, in which the ligand and the chelator are identical to those of DOTAGA.(SA.FAPi)2 TFA. DOTAGA.(SA.FAPi)2 TFA is a potent dimeric fibroblast-activation protein inhibitor (FAPi) .
    DOTAGA.(SA.FAPi)2 analogue TFA
  • HY-164364A

    FAP Cancer
    DOTAGA.(SA.FAPi)2 TFA is a potent dimeric fibroblast-activation protein inhibitor (FAPi). DOTAGA.(SA.FAPi)2 TFA has the potential for cancer diagnosis research .
    DOTAGA.(SA.FAPi)2 TFA
  • HY-B0432B
    (S)-Propafenone
    1 Publications Verification

    (S)-SA-79

    Sodium Channel Cardiovascular Disease
    (S)-Propafenone ((S)-SA-79) is the S-enantiomer of Propafenone. (S)-Propafenone ((S)-SA-79) exerts beta-blocking action and the sodium channel-dependent antiarrhythmic class 1 activity .
    (S)-Propafenone
  • HY-120892

    Flu-SA

    Biochemical Assay Reagents Others
    Fluprostenol serinol amide (Flu-SA) is used for proteomics research.
    Fluprostenol serinol amide
  • HY-139742
    ADTL-SA1215
    1 Publications Verification

    Sirtuin Cancer
    ADTL-SA1215 is a first-in-class specific small-molecule activator of SIRT3 that modulates autophagy in triple negative breast cancer.
    ADTL-SA1215
  • HY-171562

    Biochemical Assay Reagents Metabolic Disease
    Cholesterol-SA-PEG-Azide (MW 2000) is a lipid that can be used for drug delivery. Cholesterol-SA-PEG-Azide (MW 2000) contains Cholesterol (HY-N0322), Succinic acid (HY-N0420), PEG units and an azide group. Cholesterol-SA-PEG-Azide (MW 2000) contains an azide group that can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an alkyne group .
    Cholesterol-SA-PEG-Azide (MW 2000)
  • HY-120467

    Bimatoprost serinol amide

    Prostaglandin Receptor Endocrinology
    Bima SA (Bimatoprost serinol amide) is a Prostaglandin analog and has the potential for the research of glaucoma .
    Bima SA
  • HY-126684

    Drug-Linker Conjugates for ADC Cancer
    Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA is a agent-linker conjugate for ADC by using the antitumor antibiotic, Duocarmycin SA, linked via Mal-PEG4-VC-PAB-DMEA-Seco.
    Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA
  • HY-159767A

    Radionuclide-Drug Conjugates (RDCs) Cancer
    (S)-DOTAGA.(SA.FAPi)2 is a precursor for radiopharmaceutical labeling, which can be combined with radionuclides to create radionuclide drug conjugates (RDCs). RDCs have the capability to specifically target biomolecules and can be used in medical imaging .
    (S)-DOTAGA.(SA.FAPi)2
  • HY-171685

    Antibody-Drug Conjugates (ADCs) CCR DNA Alkylator/Crosslinker ADC Payload Antibiotic Apoptosis Cancer
    Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA is an antibody-drug conjugate (ADC) consisting of the humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab (HY-P99188) conjugated with the linker MC-Vc-PAB-DMEA-PEG2 and the DNA alkylator Duocarmycin SA (HY-12456). Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA can be used in cancer research .
    Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA
  • HY-D0871

    N-Cyclohexyltaurine

    Biochemical Assay Reagents Others Cancer
    CHES (N-Cyclohexyltaurine) is a zwitterionic buffer. CHES can bind to hemagglutinin (HA) emulating with sialic acid (SA) and receptor binding site (RBS)-targeting broadly neutralizing antibodies .
    CHES
  • HY-N1836

    3-Hydroxy-3-acetonyloxindole

    TMV Infection
    3-Acetonyl-3-hydroxyoxindole (AHO) is a potent systemic acquired resistance (SAR) inducer in plants. 3-Acetonyl-3-hydroxyoxindole induces resistance in tobacco plants against infection with tobacco mosaic virus (TMV) and the fungal pathogen Erysiphe cichoracearum. 3-Acetonyl-3-hydroxyoxindole increases the level of pathogenesis-related gene 1 (PR-1) expression, salicylic acid (SA) accumulation and phenylalanine ammonia-lyase activity .
    3-Acetonyl-3-hydroxyoxindole
  • HY-B0432AS2

    Isotope-Labeled Compounds Sodium Channel Cardiovascular Disease
    Propafenone-d5 (hydrochloride) is the deuterium labeled Propafenone hydrochloride. Propafenone (SA-79) hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias[1].
    Propafenone-d5 hydrochloride
  • HY-B0432AS3

    Isotope-Labeled Compounds Sodium Channel Cardiovascular Disease
    Propafenone-d5 Ethyl (hydrochloride) is the deuterium labeled Propafenone hydrochloride. Propafenone (SA-79)hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias .
    Propafenone-d5 hydrochloride(Ethyl)

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