Search Result

Results for "

Paclitaxel

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) ADC Linker (1) ADC Payload (9) Amino Acid Derivatives (1) Apoptosis (18) Aurora Kinase (2) AUTACs (1) Autophagy (8) Bacterial (3) BCRP (1) Biochemical Assay Reagents (2) Calcium Channel (3) Caspase (1) COX (2) Cytochrome P450 (3) Dihydrofolate reductase (DHFR) (3) Drug Derivative (4) Drug Intermediate (3) Drug Metabolite (2) Drug-Linker Conjugates for ADC (2) Endogenous Metabolite (5) Ephrin Receptor (1) Epoxide Hydrolase (1) Ferroptosis (2) Fluorescent Dye (8) Fungal (2) Glucocorticoid Receptor (3) Glutathione Peroxidase (1) HIF/HIF Prolyl-Hydroxylase (2) Histamine Receptor (1) ICMT (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Interleukin Related (2) Isotope-Labeled Compounds (10) JAK (1) JNK (1) Kinesin (1) LDLR (1) MAP3K (1) MicroRNA (1) Microtubule/Tubulin (29) Mitosis (2) MMP (2) NAMPT (1) NEKs (1) NF-κB (2) NO Synthase (1) NOD-like Receptor (NLR) (1) Notch (1) P-glycoprotein (18) p38 MAPK (2) Parasite (1) Peptide-Drug Conjugates (PDCs) (2) PERK (1) Pim (1) PROTAC Linkers (3) Ras (1) Reactive Oxygen Species (ROS) (1) Reference Standards (9) Sigma Receptor (1) STAT (3) TNF Receptor (1) Transglutaminase (1) Transmembrane Glycoprotein (1) VEGFR (2) Wnt (3) YB-1 (1)
By Research Areas:	Cancer (100) Cardiovascular Disease (2) Endocrinology (3) Infection (5) Inflammation/Immunology (8) Neurological Disease (10)

By Targets:

5-HT Receptor (1)

ADC Linker (1)

ADC Payload (9)

Amino Acid Derivatives (1)

Apoptosis (18)

Aurora Kinase (2)

AUTACs (1)

Autophagy (8)

Bacterial (3)

BCRP (1)

Biochemical Assay Reagents (2)

Calcium Channel (3)

Caspase (1)

COX (2)

Cytochrome P450 (3)

Dihydrofolate reductase (DHFR) (3)

Drug Derivative (4)

Drug Intermediate (3)

Drug Metabolite (2)

Drug-Linker Conjugates for ADC (2)

Endogenous Metabolite (5)

Ephrin Receptor (1)

Epoxide Hydrolase (1)

Ferroptosis (2)

Fluorescent Dye (8)

Fungal (2)

Glucocorticoid Receptor (3)

Glutathione Peroxidase (1)

HIF/HIF Prolyl-Hydroxylase (2)

Histamine Receptor (1)

ICMT (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Interleukin Related (2)

Isotope-Labeled Compounds (10)

JAK (1)

JNK (1)

Kinesin (1)

LDLR (1)

MAP3K (1)

MicroRNA (1)

Microtubule/Tubulin (29)

Mitosis (2)

MMP (2)

NAMPT (1)

NEKs (1)

NF-κB (2)

NO Synthase (1)

NOD-like Receptor (NLR) (1)

Notch (1)

P-glycoprotein (18)

p38 MAPK (2)

Parasite (1)

Peptide-Drug Conjugates (PDCs) (2)

PERK (1)

Pim (1)

PROTAC Linkers (3)

Ras (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (9)

Sigma Receptor (1)

STAT (3)

TNF Receptor (1)

Transglutaminase (1)

Transmembrane Glycoprotein (1)

VEGFR (2)

Wnt (3)

YB-1 (1)

By Research Areas:

Cancer (100)

Cardiovascular Disease (2)

Endocrinology (3)

Infection (5)

Inflammation/Immunology (8)

Neurological Disease (10)

125

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0015

*Paclitaxel* Maximum Cited Publications 274 Publications Verification	Microtubule/Tubulin ADC Payload Apoptosis Autophagy	Cardiovascular Disease Cancer
Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy .

HY-P4073

ANG1005 GRN1005; Paclitaxel trevatide	Peptide-Drug Conjugates (PDCs) LDLR	Cancer
ANG1005 (Paclitaxel trevatide) is a brain-penetrating peptide-drug conjugate. ANG1005, a taxane derivative, consists of three paclitaxel (HY-B0015) molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via low density lipoprotein receptor-related protein (LRP1) transport system .

HY-B0015R

Paclitaxel (Standard)	Reference Standards Microtubule/Tubulin ADC Payload Apoptosis Autophagy	Cancer
Paclitaxel (Standard) is the analytical standard of Paclitaxel. This product is intended for research and analytical applications. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy .

HY-B0015S

Paclitaxel-d5	Isotope-Labeled Compounds Microtubule/Tubulin ADC Payload	Cancer
Paclitaxel-d₅ is a deuterium-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization .

HY-B0015S1

Paclitaxel-d5 (benzoyloxy)	Isotope-Labeled Compounds Microtubule/Tubulin ADC Payload Apoptosis Autophagy	Cancer
Paclitaxel-d₅ (benzoyloxy) is the deuterium labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy .

HY-164165

Paclitaxel-2′-succinate NHS ester	Microtubule/Tubulin Drug Derivative	Cancer
Paclitaxel-2′-succinate NHS ester is a paclitaxel derivative with a succinic acid linker, in which the carboxyl group is activated by the NHS ester. The NHS ester group is highly reactive toward amino or hydroxyl groups and can be used to conjugate with other molecules such as peptides, proteins, antibodies, enzymes or polymers. Paclitaxel-2′-succinate NHS ester can be used in the development of nanomedicines and in the study of cancer therapy .

HY-106146

Paclitaxel ceribate Protaxel	Microtubule/Tubulin ADC Payload Apoptosis Autophagy	Cancer
Paclitaxel ceribate is the ester form of paclitaxel, a natural antineoplastic agent that stabilizes tubulin polymerization. Paclitaxel causes mitotic arrest and induces apoptosis, ultimately leading to cell death. Paclitaxel also induces autophagy .

HY-W768912

Paclitaxel-13C6	Isotope-Labeled Compounds Microtubule/Tubulin ADC Payload Apoptosis Autophagy	Cancer
Paclitaxel- ¹³C₆ is the ¹³C-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes?tubulin?polymerization. Paclitaxel can cause both mitotic arrest and?apoptotic?cell death. Paclitaxel also induces?autophagy .

HY-W743943

Paclitaxel succinate-d4	Isotope-Labeled Compounds	Others
Paclitaxel succinate-d₄ is the deuterium labeled Paclitaxel succinate.

HY-139248

Paclitaxel octadecanedioate	Drug Derivative	Cancer
Paclitaxel octadecanedioate (compound PTX-FA18) is comprised of Paclitaxel (HY-B0015) conjugated to 1,18-octadecanedioic acid (HY-W005178). Paclitaxel octadecanedioate mixed with human serum albumin (HAS) is cytotoxic to HT-1080, PANC-1, HT-29 and Hela cells (IC₅₀s = 12, 2.48, 8.62, and 64.42 nM, respectively) .

HY-137776R

Paclitaxel C (Standard) Taxuyunnanine A (Standard)	Drug Derivative Reference Standards	Others
Paclitaxel C (Standard) is the analytical standard of Paclitaxel C. This product is intended for research and analytical applications. Paclitaxel C is a compound that can be found in taxus cutting .

HY-137776

Paclitaxel C Taxuyunnanine A	Drug Derivative	Others
Paclitaxel C is a compound that can be found in taxus cutting .

HY-164272

2'-O-TBDMS-Paclitaxel	Microtubule/Tubulin	Cancer
2'-O-TBDMS-Paclitaxel is a paclitaxel (HY-B0015) derivative which 2'-OH group is protected as a tert-butyldimethylsilyl (TBDMS) ether .

HY-D2422B

Cy5-Paclitaxel	Fluorescent Dye Microtubule/Tubulin	Cancer
Cy5-Paclitaxel is a CY5 (HY-D0821) labeled Paclitaxel (HY-B0015) conjugate. Cy5 is a Cyanine dye (with a long wavelength about 662nm) that can be used for molecular labeling and microscopy imaging. Paclitaxel stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy .

HY-125348

6α-Hydroxy paclitaxel	Drug Metabolite	Cancer
6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on *organic anion–transporting polypeptides 1B1/SLCO1B1* (OATP1B1)** with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer .

HY-D2422A

Cy5.5-Paclitaxel	Fluorescent Dye	Others
Cy5.5-Paclitaxel is a Cy5.5 (HY-D0821) labeled Paclitaxel (HY-B0015).

HY-P99974

Nab-Paclitaxel 1 Publications Verification Nanoparticle albumin-bound Paclitaxel; Nanoparticle albumin-bound ABI-007	Microtubule/Tubulin Apoptosis Autophagy	Cancer
Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel (HY-B0015). Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel, in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug. Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability. Nab-Paclitaxel displays less toxicity and greater antitumor activity. Nab-Paclitaxel is more readily available for tumor cell uptake in three rhabdomyosarcoma, seven neuroblastoma cell lines, and one ostersarcoma cell line Nab-Paclitaxel can be studied in cancer research for example breast cancer and solid tumors. (The product specifications below only indicate the effective content of Paditaxel, the actual albumin quality depends on the batch; the ratio of each ingredient in this product is Paditaxel: albumin -1:7~1:11) .

HY-141147

7-O-(Amino-PEG4)-paclitaxel	Drug-Linker Conjugates for ADC	Cancer
7-O-(Amino-PEG4)-paclitaxel is a PEG-class Drug-linker conjugates for ADC, containing a paclitaxel moiety and a amino group. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. 7-O-(Amino-PEG4)-paclitaxel can be used in the synthesis of Antibody-Drug Conjugates (ADCs) .

HY-125348S

*6α-Hydroxy Paclitaxel-d5*	Isotope-Labeled Compounds	Cancer
6α-Hydroxy Paclitaxel-d₅ is the deuterium labeled 6α-Hydroxy paclitaxel. 6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion-transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer .

HY-144149S

*3'-p-Hydroxy paclitaxel-d5*	Isotope-Labeled Compounds	Others
3'-p-Hydroxy paclitaxel-d₅ is the deuterium labeled 3'-p-Hydroxy paclitaxel .

HY-138056

7-Acetyl paclitaxel	Microtubule/Tubulin	Others
7-Acetyl paclitaxel is a microtubule depolymerization inhibitor which inhibits calcium-induced microtubule depolymerization. 7-Acetyl paclitaxel reduces the growth of J774.2 macrophages (IC₅₀ ~ 60 nM) and increases the levels of nitric oxide (NO) and TNF in isolated mouse peritoneal macrophages .

HY-W744002

2'-O-Methyl-d3 Paclitaxel	Isotope-Labeled Compounds	Others
2'-O-Methyl-d₃ Paclitaxel is the deuterium labeled 2'-O-Methyl Paclitaxel (HY-W741186).

HY-W740480

*3'-p-Hydroxy paclitaxel-d5-1*	Isotope-Labeled Compounds	Others
3'-p-Hydroxy paclitaxel-d₅-1 is the deuterium labeled 3'-p-Hydroxy paclitaxel.

HY-141148

7-O-(Cbz-N-amido-PEG4)-paclitaxel	Drug-Linker Conjugates for ADC	Cancer
7-O-(Cbz-N-amido-PEG4)-paclitaxel is a PEG-class Drug-linker conjugates for ADC, containing a paclitaxel moiety and a amino group. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. 7-O-(Cbz-N-amido-PEG4)-paclitaxel can be used in the synthesis of Antibody-Drug Conjugates (ADCs) .

HY-20584

10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyltaxol; 10-DeacetylPaclitaxel 7-Xyloside; 10-Deacetyltaxol 7-Xyloside	Microtubule/Tubulin ADC Payload	Cancer
10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel (a microtubule stabilizing agent; enhances tubulin polymerization) derivative with improved pharmacological features.

HY-77572R

*7-Epi 10-desacetyl paclitaxel* (Standard)** 7-epi-10-deacetyltaxol (Standard); 10-Deacetyl-7-epiPaclitaxel (Standard)	ADC Payload Reference Standards	Cancer
7-Epi 10-desacetyl paclitaxel (Standard) is the analytical standard of 7-Epi 10-desacetyl paclitaxel. This product is intended for research and analytical applications. 7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC50 of 85 μM .

HY-144561S

*6α,3'-p-Dihydroxy paclitaxel-d5*	Isotope-Labeled Compounds	Others
6α,3'-p-Dihydroxy paclitaxel-d₅ is the deuterium labeled 6α,3′-p-Dihydroxypaclitaxel (HY-N11628).

HY-13646C

Encequidar mesylate hydrochloride HM30181 mesylate hydrochloride; HM30181A mesylate hydrochloride	P-glycoprotein	Cancer
Encequidar (HM30181) mesylate hydrochloride is a potent and selective inhibitor of P-glycoprotein (MDR1). Encequidar mesylate hydrochloride improves anti-tumor efficacy of Paclitaxel (HY-B0015) in mouse tumor models .

HY-77572

7-Epi 10-desacetyl paclitaxel 7-epi-10-deacetyltaxol; 10-Deacetyl-7-epiPaclitaxel	ADC Payload	Cancer
7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC₅₀ of 85 μM .

HY-162161

Flutax-2	Fluorescent Dye	Cancer
Flutax-2 is an active fluorescent derivative of Paclitaxel, binds to αβ-tubulin dimer polymerized. Flutax-2 can be used for imaging microtubules in live cells, isolated cytoskeletons and parasite (Ex/Em=496/526 nm) .

HY-132866

YS-370	P-glycoprotein	Cancer
YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein (P-gp). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity .

HY-12929

NSC756093 SU093	Pim	Cancer
NSC756093 is a potent inhibitor of the GBP1:PIM1 interaction. NSC756093 can potentially revert resistance to paclitaxel. NSC756093 can be used for ovarian cancer research .

HY-N7776

7-Xylosyl-10-Deacetyltaxol B 7-xylosyl-10-DeacetylPaclitaxel B	Others	Cancer
7-Xylosyl-10-Deacetyltaxol B (7-xylosyl-10-Deacetylpaclitaxel B) is a paclitaxel derivative derived from T. cuspidate. 7-Xylosyl-10-Deacetyltaxol B has anti-tumor activity and inhibits the growth of S180 sarcoma .

HY-N7777

7-Xylosyl-10-Deacetyltaxol C 7-Xylosyl-10-DeacetylPaclitaxel C	Others	Cancer
7-Xylosyl-10-Deacetyltaxol C (7-Xylosyl-10-Deacetylpaclitaxel C) is a paclitaxel derivative derived from T. cuspidate. 7-Xylosyl-10-Deacetyltaxol C has anti-tumor activity and inhibits the growth of S180 sarcoma .

HY-W019939

Hydroxy-PEG10-Boc	ADC Linker	Cancer
Hydroxy-PEG10-Boc is extacted from patent CN108707228 (example 0024) . Hydroxy-PEG10-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG10-Boc can be conjugated to Paclitaxel (HY-B0015) or docetaxel (HY-B0011) .

HY-175206

P-gp-IN-30	P-glycoprotein	Cancer
P-gp-IN-30 (Compound 13) is a P-glycoprotein (P-gp) inhibitor by targeting YB-1. P-gp-IN-30 significantly enhances sensitivity to Paclitaxel by reducing total YB-1 and nucleus YB-1 protein expression, inhibiting the expression and function of downstream P-gp, further suppressing the efflux rate of Paclitaxel. P-gp-IN-30 potently inhibits tumor growth in A549/Taxol xenografts mice model with combination of Paclitaxel (HY-B0015). P-gp-IN-30 can be used for non-small cell lung cancer (NSCLC) research .

HY-150231

SU056 2 Publications Verification	YB-1	Cancer
SU056 is a YB-1 inhibitor. SU056 induces cell-cycle arrest, apoptosis, and inhibits cell migration in ovarian cancer cells. SU056 interacts with YB-1 and inhibits and its associated downstream proteins and pathways. SU056 can enhance the cytotoxic effects of Paclitaxel (HY-B0015) .

HY-150565

P-gp inhibitor 5	P-glycoprotein	Cancer
P-gp inhibitor 5 is a potent P-glycoprotein (P-gp) inhibitor. P-gp inhibitor 5 has antiproliferative activity against certain cancer cell lines. P-gp inhibitor 5 is effective in reversing the multidrug resistance (MDR) phenotype in ABCB1/Flp-In ^TM-293 and KBvin cells by restoring their sensitivity to Vincristine (HY-N0488A) and Paclitaxel (HY-B0015) .

HY-174425

CYP1B1-IN-9	Cytochrome P450	Cancer
CYP1B1-IN-9 is a highly selective and competitive CYP1B1 Inhibitor with IC₅₀ values of 1.48 nM, > 100 μM, and > 80 μM for CYP1B1, CYP1A1, and CYP1A2, respectively. CYP1B1-IN-9 significantly inhibits the migration and invasion of A549/T cells. CYP1B1-IN-9 has the ability to resensitize Paclitaxel (HY-B0015)-resistant cells, and good metabolic stability and safety, and shows favorable pharmacokinetic parameters. CYP1B1-IN-9 can be used for the study of tumor-drug resistance .

HY-144393

P-gp/BCRP-IN-1	BCRP	Cancer
P-gp/BCRP-IN-1 (compound 19) is a potential, relatively safe, orally active and efficient efflux transporter (P-gp and BCRP) inhibitor. P-gp/BCRP-IN-1 exerts resistance reversal by inhibiting the efflux function of P-gp and BCRP. P-gp/BCRP-IN-1 can overcome the resistance and improve the oral bioavailability of PTX (Paclitaxel) .

HY-N7256

Dihydrocephalomannine	Microtubule/Tubulin	Cancer
Dihydrocephalomannine (compound 1b), an analogue of Paclitaxel, shows reduced cytotoxicity and tubulin binding compared to Paclitaxel .

HY-77574

7-xylosyltaxol 7-XylosylPaclitaxel; Taxol-7-xyloside	Microtubule/Tubulin	Cancer
7-xylosyltaxol(Taxol-7-xyloside) is a taxol (Paclitaxel) derivative; Paclitaxel binds to tubulin and inhibits the disassembly of microtubules.

HY-N0227

7-epi-Taxol 3 Publications Verification 7-epi-Paclitaxel	Microtubule/Tubulin	Cancer
7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.

HY-N0227R

7-epi-Taxol (Standard) 7-epi-Paclitaxel (Standard)	Reference Standards Microtubule/Tubulin	Cancer
7-epi-Taxol (Standard) is the analytical standard of 7-epi-Taxol. This product is intended for research and analytical applications. 7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.

HY-157529

IR820-PTX	Microtubule/Tubulin Fluorescent Dye	Cancer
IR820-PTX, an IR-820 (HY-136886)-Paclitaxel (HY-B0015) conjugate, is an amphipathic small molecule prodrug. IR820-PTX effectively inhibits tumor growth via combined photothermal therapy (PTT) and chemotherapy .

HY-158435

P-gp inhibitor 23	P-glycoprotein Cytochrome P450	Cancer
P-gp inhibitor 23 (compound 14F) is a potent inhibitor of P-gp and CYP3A4, with the EC₅₀ and IC₅₀ of 28 nM and 223 nM, respectively .

HY-173522

KIF2C-IN-1	Kinesin	Cancer
KIF2C-IN-1 (Compound 7S9) is a selective and potent small-molecule KIF2C inhibitor. KIF2C-IN-1 stabilizes the KIF2C-tubulin interaction, blocking the depolymerization of polyglutamylated microtubules. KIF2C-IN-1 enhances the cytotoxicity of Paclitaxel (HY-B0015) in paclitaxel-resistant triple-negative breast cancer (TNBC) cells and significantly reduces tumor growth combined with Paclitaxel in mouse models .

HY-13503

Epothilone A Epo A	Microtubule/Tubulin Apoptosis	Cancer
Epothilone A is a competitive inhibitor of the binding of [ ³H] paclitaxel to tubulin polymers, with a K_i of 0.6-1.4 μM.

HY-131010

Flutax-2 (5/6-mixture)	Fluorescent Dye Microtubule/Tubulin	Cancer
Flutax-2 (5/6-mixture) is an active fluorescent derivative of paclitaxel. Flutax-2 (5/6-mixture) binds to a polymerized α,β tubulin dimer. Excitation/emission wavelength: 496/524 nm. Paclitaxel, a diterpenoid secondary metabolite produced by Taxus species, can be used for the research of a variety of cancers .

HY-77434

9-Dihydro-13-acetylbaccatin III 9-DHAB III; 13-Acetyl-9-dihydrobaccatin III	Drug Intermediate	Cancer
9-Dihydro-13-acetylbaccatin III (9-DHAB III) is an intermediate for the preparation of paclitaxel analogs.

Cat. No.	Product Name

HY-L115

Plant-Sourced Natural Product Library

2,948 compounds

Natural products are characterized by enormous scaffold diversity and structural complexity, because of which, natural products do show a wide range of biological activities. Medicinal plants have been the major source of medicines over many centuries. About a quarter of all Food and Drug Administration (FDA) and/or the European Medical Agency (EMA) approved drugs are plant based, with well-known drugs such as Paclitaxel and Aspirin having been isolated from plants.

MCE provides a unique collection of 2,948 plant-sourced natural products. MCE Plant-Sourced Natural Product Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

HY-L173

Anti-Ovarian Cancer Compound Library

2,391 compounds

Ovarian cancer is the most common cause of death in female genital malignancies, with the highest mortality rate in female genital malignancies. It is characterized by difficulty in detection in the early stage of the disease, high recurrence rate and poor prognosis. In fact, ovarian cancer includes many pathologic types. It is usually divided into epithelial ovarian cancer, malignant germ cell tumors and sex cord stromal tumors, of which epithelial ovarian cancer is the most dominant form. Clinical treatment of ovarian cancer prioritizes surgery combined with paclitaxel chemotherapy. However, due to the spread and drug resistance of tumor cells, the recurrence of ovarian cancer is high. In this case, combined with traditional methods, the development of new therapeutic agents can help to improve the treatment effect of ovarian cancer.

MCE designs a unique collection of 2,391 compounds with definite or potential anti-ovarian cancer activity, which mainly targeting the main targets of ovarian cancer such as PARP, ATM/ATR, VEGFR and HIF/HIF Prolyl-Hydroxylase, etc. It is an essential tool for development and research of anti-ovarian compounds.

Cat. No.	Product Name	Type

HY-131010

Flutax-2 (5/6-mixture)	Dyes
Flutax-2 (5/6-mixture) is an active fluorescent derivative of paclitaxel. Flutax-2 (5/6-mixture) binds to a polymerized α,β tubulin dimer. Excitation/emission wavelength: 496/524 nm. Paclitaxel, a diterpenoid secondary metabolite produced by Taxus species, can be used for the research of a variety of cancers .

HY-D2422B

Cy5-Paclitaxel	Fluorescent Dyes/Probes
Cy5-Paclitaxel is a CY5 (HY-D0821) labeled Paclitaxel (HY-B0015) conjugate. Cy5 is a Cyanine dye (with a long wavelength about 662nm) that can be used for molecular labeling and microscopy imaging. Paclitaxel stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy .

HY-D2422A

Cy5.5-Paclitaxel	Fluorescent Dyes/Probes
Cy5.5-Paclitaxel is a Cy5.5 (HY-D0821) labeled Paclitaxel (HY-B0015).

HY-D2436

PTX-PEG-Cy3

Fluorescent Dyes/Probes

PTX-PEG-Cy3 (Paclitaxel-PEG-Cy3) is a Cy3 (HY-D0822) labeled PTX-PEG conjugate. The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. PTX stabilizes tubulin polymerization. PTX can cause both mitotic arrest and apoptotic cell death. PTX also induces autophagy .

Cat. No.	Product Name	Type

HY-140696D

m-PEG-OH (MW 10000)

mPEG-Hydroxy (MW 10000); Polyethylene glycol monomethyl ether (MW 10000)

Drug Delivery

m-PEG-OH (MW 10000) can be used as a macroinitiator to participate in the synthesis of amphiphilic block copolymers. Amphiphilic block copolymers can be used to prepare nanoscale micelles to deliver active drugs. Paclitaxel (HY-B0015), a hydrophobic anticancer agent encapsulated in micelles, has stronger activity in killing cancer cells than free Paclitaxel. And it preferentially accumulates in tumor tissue with only limited distribution in healthy organs.

HY-140696E

m-PEG-OH (MW 1000)

mPEG-Hydroxy (MW 1000); Polyethylene glycol monomethyl ether (MW 1000)

Drug Delivery

m-PEG-OH (MW 1000) can be used as a macroinitiator to participate in the synthesis of amphiphilic block copolymers. Amphiphilic block copolymers can be used to prepare nanoscale micelles to deliver active drugs. Paclitaxel (HY-B0015), a hydrophobic anticancer agent encapsulated in micelles, has stronger cancer-killing activity than free Paclitaxel. And it accumulates preferentially in tumor tissues and has only limited distribution in healthy organs.

HY-401424

Cremophor EL-36

Polyoxyethylene(36) Castor Oil; PEG-36 Castor Oil

Biochemical Assay Reagents

Cremophor EL-36 is a nonionic surfactant, mainly used as a solubilizing carrier for poorly soluble Paclitaxel (HY-B0015). The functions of Cremophor EL-36 include: 1) affecting pharmacokinetics by encapsulating drugs in micelles, changing drug distribution and clearance; 2) activating the complement system and inducing allergic reactions; 3) binding to lipoproteins and interfering with lipid metabolism. Cremophor EL-36 increases drug solubility through micellization, while mediating toxicity through complement activation and lipoprotein interactions .

HY-140696C

m-PEG-OH (MW 20000)

mPEG-Hydroxy (MW 20000); Polyethylene glycol monomethyl ether (MW 20000)

Drug Delivery

m-PEG-OH (MW 20000) can be used as a macroinitiator to participate in the synthesis of amphiphilic block copolymers. Nanoscale micelles can be prepared by using amphiphilic block copolymers to deliver active drugs. Paclitaxel (HY-B0015), a hydrophobic anticancer agent encapsulated in micelles, has stronger activity in killing cancer cells than free Paclitaxel. And it preferentially accumulates in tumor tissue with only limited distribution in healthy organs.

HY-107629

Flutax 1	Indicators
Flutax 1 is a fluorescent Paclitaxel (HY-B0015) derivative, which can be used for microtubule staining (Ex/Em = 495 nm/520 nm) .

Cat. No.	Product Name	Target	Research Area

HY-P4073

ANG1005 GRN1005; Paclitaxel trevatide	Peptide-Drug Conjugates (PDCs) LDLR	Cancer
ANG1005 (Paclitaxel trevatide) is a brain-penetrating peptide-drug conjugate. ANG1005, a taxane derivative, consists of three paclitaxel (HY-B0015) molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via low density lipoprotein receptor-related protein (LRP1) transport system .

HY-P10794

LH2 peptide	Peptides	Cancer
LH2 peptide is a pH-responsive cell-penetrating peptide dimer with the amino acid sequence LHHLCHLLHHLCHLAG. It can increase its uptake in tumor cells under weakly acidic conditions (such as the tumor microenvironment) through the protonation of histidine residues (pK_a approximately 6). When conjugated with the anticancer drug Paclitaxel (HY-B0015), the PTX-LH2 conjugate showed superior tumor suppression effects compared to paclitaxel alone in a subcutaneous breast tumor model. The LH2 peptide holds potential as a drug delivery vehicle in cancer research .

HY-P10844

ANK peptide	Amino Acid Derivatives	Cancer
ANK peptide is a novel peptide designed based on the conserved residues of single ankyrin motif. ANK peptide is a synuclein-γ (SNCG) inhibitor that binds to SNCG and competes with SNCG-BubR1 interaction to enhance the sensitivity of breast cancer cells to antimicrotubule drugs such as nocodazole and paclitaxel. ANK peptide can be used in the study of cancer .

HY-P11018

(123B9)2-L2-PTX	Peptide-Drug Conjugates (PDCs) Ephrin Receptor	Cancer
(123B9)2-L2-PTX is an EphA2-agonistic peptide-drug conjugate (PDC). (123B9)2-L2-PTX consists of a dimeric 123B9 (HY-P10579) and Paclitaxel (HY-B0015). (123B9)2-L2-PTX significantly reduces circulating tumor cells and inhibits lung tumor metastasis in breast-cancer-Metastasis mice model. (123B9)2-L2-PTX can be used for cancers research, such as melanomas and ovarian and breast cancers .

Cat. No.	Product Name	Target	Research Area

HY-P99974

Nab-Paclitaxel 1 Publications Verification Nanoparticle albumin-bound Paclitaxel; Nanoparticle albumin-bound ABI-007	Microtubule/Tubulin Apoptosis Autophagy	Cancer
Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel (HY-B0015). Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel, in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug. Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability. Nab-Paclitaxel displays less toxicity and greater antitumor activity. Nab-Paclitaxel is more readily available for tumor cell uptake in three rhabdomyosarcoma, seven neuroblastoma cell lines, and one ostersarcoma cell line Nab-Paclitaxel can be studied in cancer research for example breast cancer and solid tumors. (The product specifications below only indicate the effective content of Paditaxel, the actual albumin quality depends on the batch; the ratio of each ingredient in this product is Paditaxel: albumin -1:7~1:11) .

HY-P99377

Navicixizumab OMP-305B83; Anti-DLL4 Reference Antibody (navicixizumab)	Notch	Cancer
Navicixizumab (OMP-305B83) is a bispecific anti-VEGF and anti-DLL4 inhibitory antibody. Navicixizumab can combine with Paclitaxel (HY-B0015) for cancer research. Navicixizumab can be used in the research of ovarian, primary peritoneal, or fallopian tube cancer .

HY-P99279

Bavituximab Anti-Human Phosphatidylserine Recombinant Antibody	Inhibitory Antibodies	Cancer
Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) is a phosphatidylserine (PS)-targeting monoclonal antibody, suppresses tumor growth by targeting tumor vasculature and reactivating antitumor immunity. Bavituximab plus Paclitaxel (HY-B0015) and Carboplatin (HY-17393), have enhanced inhibition on non-small-cell lung cancer .

HY-P991619

CNTO-860 TF8-5G9	Transmembrane Glycoprotein	Cancer
CNTO-860 is a humanized anti-tissue factor monoclonal antibody. CNTO-860 can improve tumor control when combined with Paclitaxel (HY-B0015) in colon cancer model and significantly increase tumor-free survival .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0015

*Paclitaxel* Maximum Cited Publications 274 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Cancer	Microtubule/Tubulin ADC Payload Apoptosis Autophagy
Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy .

HY-B0015R

Paclitaxel (Standard)	Structural Classification Terpenoids Taxaceae Diterpenoids Plants Taxus chinensis (Pilger) Rehd.	Reference Standards Microtubule/Tubulin ADC Payload Apoptosis Autophagy
Paclitaxel (Standard) is the analytical standard of Paclitaxel. This product is intended for research and analytical applications. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy .

HY-20584

10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyltaxol; 10-DeacetylPaclitaxel 7-Xyloside; 10-Deacetyltaxol 7-Xyloside	Classification of Application Fields Terpenoids Source classification Taxaceae Diterpenoids Plants Disease Research Fields Cancer Taxus chinensis (Pilger) Rehd.	Microtubule/Tubulin ADC Payload
10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel (a microtubule stabilizing agent; enhances tubulin polymerization) derivative with improved pharmacological features.

HY-77572

7-Epi 10-desacetyl paclitaxel 7-epi-10-deacetyltaxol; 10-Deacetyl-7-epiPaclitaxel	Structural Classification Microorganisms Classification of Application Fields Terpenoids Taxaceae Source classification Diterpenoids Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Cancer	ADC Payload
7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC₅₀ of 85 μM .

HY-N7256

Dihydrocephalomannine	Other Terpenoids Structural Classification Classification of Application Fields Terpenoids Source classification Plants Cephalotaxaceae Disease Research Fields Cancer Cephalotaxus fortunei Hooker	Microtubule/Tubulin
Dihydrocephalomannine (compound 1b), an analogue of Paclitaxel, shows reduced cytotoxicity and tubulin binding compared to Paclitaxel .

HY-N0227

7-epi-Taxol 3 Publications Verification 7-epi-Paclitaxel	Structural Classification Classification of Application Fields Terpenoids Taxaceae Source classification Diterpenoids Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Cancer	Microtubule/Tubulin
7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.

HY-77572R

*7-Epi 10-desacetyl paclitaxel* (Standard)** 7-epi-10-deacetyltaxol (Standard); 10-Deacetyl-7-epiPaclitaxel (Standard)	Structural Classification Microorganisms Terpenoids Taxaceae Source classification Diterpenoids Plants Taxus chinensis (Pilger) Rehd.	ADC Payload Reference Standards
7-Epi 10-desacetyl paclitaxel (Standard) is the analytical standard of 7-Epi 10-desacetyl paclitaxel. This product is intended for research and analytical applications. 7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC50 of 85 μM .

HY-N7776

7-Xylosyl-10-Deacetyltaxol B 7-xylosyl-10-DeacetylPaclitaxel B	Structural Classification Taxus cuspidata Siebold & Zucc. Terpenoids Source classification Taxaceae Diterpenoids Plants	Others
7-Xylosyl-10-Deacetyltaxol B (7-xylosyl-10-Deacetylpaclitaxel B) is a paclitaxel derivative derived from T. cuspidate. 7-Xylosyl-10-Deacetyltaxol B has anti-tumor activity and inhibits the growth of S180 sarcoma .

HY-N7777

7-Xylosyl-10-Deacetyltaxol C 7-Xylosyl-10-DeacetylPaclitaxel C	Structural Classification Classification of Application Fields Taxus cuspidata Siebold & Zucc. Terpenoids Taxaceae Plants Disease Research Fields Cancer	Others
7-Xylosyl-10-Deacetyltaxol C (7-Xylosyl-10-Deacetylpaclitaxel C) is a paclitaxel derivative derived from T. cuspidate. 7-Xylosyl-10-Deacetyltaxol C has anti-tumor activity and inhibits the growth of S180 sarcoma .

HY-77574

7-xylosyltaxol 7-XylosylPaclitaxel; Taxol-7-xyloside	Classification of Application Fields Terpenoids Source classification Taxaceae Diterpenoids Plants Disease Research Fields Cancer Taxus chinensis (Pilger) Rehd.	Microtubule/Tubulin
7-xylosyltaxol(Taxol-7-xyloside) is a taxol (Paclitaxel) derivative; Paclitaxel binds to tubulin and inhibits the disassembly of microtubules.

HY-N0227R

7-epi-Taxol (Standard) 7-epi-Paclitaxel (Standard)	Structural Classification Terpenoids Taxaceae Source classification Diterpenoids Plants Taxus chinensis (Pilger) Rehd.	Reference Standards Microtubule/Tubulin
7-epi-Taxol (Standard) is the analytical standard of 7-epi-Taxol. This product is intended for research and analytical applications. 7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.

HY-13503

Epothilone A Epo A	Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Cancer	Microtubule/Tubulin Apoptosis
Epothilone A is a competitive inhibitor of the binding of [ ³H] paclitaxel to tubulin polymers, with a K_i of 0.6-1.4 μM.

HY-77434

9-Dihydro-13-acetylbaccatin III 9-DHAB III; 13-Acetyl-9-dihydrobaccatin III	Structural Classification Classification of Application Fields Terpenoids Taxaceae Source classification Diterpenoids Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Cancer	Drug Intermediate
9-Dihydro-13-acetylbaccatin III (9-DHAB III) is an intermediate for the preparation of paclitaxel analogs.

HY-W035709

Hydrocinchonine Dihydrocinchonine	Structural Classification Alkaloids Other Alkaloids Source classification Rubiaceae Neolamarckia cadamba (Roxb.) Bosser Plants	Apoptosis
Hydrocinchonine (Dihydrocinchonine) is a multidrug resistance (MDR)-reversal agent. Hydrocinchonine exerts synergistic apoptotic effect with Paclitaxel in MES-SA/DX5 cells .

HY-126370

Geranylgeranyl pyrophosphate	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Geranylgeranyl pyrophosphate is a metabolite involved in protein geranylgeranylation. Geranylgeranyl pyrophosphate is the common precursor of diterpenoids, for example, Paclitaxel. Geranylgeranyl pyrophosphate can be used for cancer research .

HY-126370A

Geranylgeranyl pyrophosphate triammonium	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Geranylgeranyl pyrophosphate triammonium is a metabolite involved in protein geranylgeranylation. Geranylgeranyl pyrophosphate triammonium is the common precursor of diterpenoids, for example, Paclitaxel. Geranylgeranyl pyrophosphate triammonium can be used for cancer research .

HY-13503R

Epothilone A (Standard) Epo A (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification Disease Research Anticancer	Reference Standards Microtubule/Tubulin Apoptosis
Epothilone A (Standard) is the analytical standard of Epothilone A. This product is intended for research and analytical applications. Epothilone A is a competitive inhibitor of the binding of [3H] paclitaxel to tubulin polymers, with a Ki of 0.6-1.4 μM.

HY-77554

Cephalomannine	Structural Classification Classification of Application Fields Terpenoids Taxaceae Source classification Diterpenoids Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Cancer	Microtubule/Tubulin HIF/HIF Prolyl-Hydroxylase
Cephalomannine is a Paclitaxel (HY-B0015) alkaloidal analog that can be isolated from most Cephalotaxus species. Cephalomannine is an orally active anti-tumor agent and can be used as a chemotherapy agent for cancer research .

HY-16565

10-Deacetylbaccatin III	Structural Classification Classification of Application Fields Terpenoids Taxaceae Source classification Diterpenoids Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Cancer	Biochemical Assay Reagents Drug Intermediate Parasite
10-Deacetylbaccatin-III is an intermediate in the preparation process of paclitaxel. 10-Deacetylbaccatin III can be isolated from the dried needles and small branches of the European yew tree (Taxus baccata). 10-Deacetylbaccatin III exhibits antileishmanial activity .

HY-77554R

Cephalomannine (Standard)	Structural Classification Terpenoids Taxaceae Source classification Diterpenoids Plants Taxus chinensis (Pilger) Rehd.	Microtubule/Tubulin HIF/HIF Prolyl-Hydroxylase Reference Standards
Cephalomannine (Standard) is the analytical standard of Cephalomannine. This product is intended for research and analytical applications. Cephalomannine is a Paclitaxel (HY-B0015) alkaloidal analog that can be isolated from most Cephalotaxus species. Cephalomannine is an orally active anti-tumor agent and can be used as a chemotherapy agent for cancer research .

HY-N15297

Isotenulin	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Helenium arizonicum S.F.Blake	P-glycoprotein
Isotenulin inhibits the efflux function of P-glycoprotein by stimulation of P-glycoprotein ATPase, thereby overcoming the multidrug resistance (MDR) of cancer cells. Isotenulin exhibits cytotoxicity in multidrug-resistant cancer cell KB-vin and sensitive cancer cell HeLaS3. Isotenulin exhibits synergistic effect with Paclitaxel (HY-B0015), Vinblastine (HY-13780) and Doxorubicin (HY-15142) .

HY-110252

Salvinorin B	Structural Classification Terpenoids Labiatae Encelia stenophylla Greene Source classification Diterpenoids Plants	Endogenous Metabolite
Salvinorin B is a salvinorin, and its analog Salvinorin A is a selective full agonist of κ-opioid receptor (KOPr). Salvinorin A derivative β-tetrahydropyran Salvinorin B also has KOPr agonist activity, activates downstream signaling pathways by binding to KOPr, inhibits pain transmission and reduces inflammatory response, and has central penetrability. Salvinorin B can be used for the study of neuropathic pain (such as paclitaxel-induced pain) and inflammatory diseases[1][2].

HY-119833

Rubone	Structural Classification Chalcones Flavonoids Leguminosae Source classification Plants Brachypterum robustum (Roxburgh ex Candolle) Dalzell & Gibson	MicroRNA
Rubone, a chalcone analog, is a modulator of miR-34a. Rubone upregulates miR-34a expression in a p53 dependent manner, downregulates the downstream target Bcl-2 and Cyclin D1 expression, and suppresses hepatocellular carcinoma (HCC) growth in vivo. Rubone enhances the anticancer effect of Paclitaxel (PTX; HY-B0015) in PTX-resistant prostate cancer cell lines by reversing the expression of miR-34a downstream targets .

HY-N0256

Hederagenin 5 Publications Verification	Triterpenes Structural Classification Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae Cancer	COX NF-κB
Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin also has preventive potential against alcoholic liver injury .

HY-N0256R

Hederagenin (Standard)	Triterpenes Structural Classification Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Terpenoids Source classification Plants Araliaceae	Reference Standards COX NF-κB
Hederagenin (Standard) is the analytical standard of Hederagenin. This product is intended for research and analytical applications. Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin also has preventive potential against alcoholic liver injury .

HY-113327R

1,3,7-Trimethyluric acid (Standard)	Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Drug Metabolite Reference Standards Endogenous Metabolite
Hederagenin (Standard) is the analytical standard of Hederagenin. This product is intended for research and analytical applications. Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin also has preventive potential against alcoholic liver injury .

Cat. No.	Product Name	Chemical Structure

HY-B0015S

Paclitaxel-d5
Paclitaxel-d₅ is a deuterium-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization .

HY-B0015S1

Paclitaxel-d5 (benzoyloxy)
Paclitaxel-d₅ (benzoyloxy) is the deuterium labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy .

HY-125348S

6α-Hydroxy Paclitaxel-d5

6α-Hydroxy Paclitaxel-d₅ is the deuterium labeled 6α-Hydroxy paclitaxel. 6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion-transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer .

HY-W768912

Paclitaxel-13C6
Paclitaxel- ¹³C₆ is the ¹³C-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes?tubulin?polymerization. Paclitaxel can cause both mitotic arrest and?apoptotic?cell death. Paclitaxel also induces?autophagy .

HY-W743943

Paclitaxel succinate-d4
Paclitaxel succinate-d₄ is the deuterium labeled Paclitaxel succinate.

HY-144149S

*3'-p-Hydroxy paclitaxel-d5*
3'-p-Hydroxy paclitaxel-d₅ is the deuterium labeled 3'-p-Hydroxy paclitaxel .

HY-W744002

2'-O-Methyl-d3 Paclitaxel
2'-O-Methyl-d₃ Paclitaxel is the deuterium labeled 2'-O-Methyl Paclitaxel (HY-W741186).

HY-W740480

*3'-p-Hydroxy paclitaxel-d5-1*
3'-p-Hydroxy paclitaxel-d₅-1 is the deuterium labeled 3'-p-Hydroxy paclitaxel.

HY-144561S

*6α,3'-p-Dihydroxy paclitaxel-d5*
6α,3'-p-Dihydroxy paclitaxel-d₅ is the deuterium labeled 6α,3′-p-Dihydroxypaclitaxel (HY-N11628).

HY-W777281

Fluocinolone acetonide-13C3

Fluocinolone acetonide- ¹³C₃ is the ¹³C-labeled Fluocinolone (Acetonide) (HY-B0415). Fluocinolone is a glucocorticoid glucocorticoid receptor agonist. Fluocinolone is effective in preventing both lipid accumulation and inflammation. Fluocinolone can promote the proliferation of DPCs and has the potential role in repairing injured pulp tissues. Fluocinolone can be used to study the prevention of chemotherapy-induced peripheral neuropathy caused by Paclitaxel (HY-B0015) .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Paclitaxel

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Natural
Products