OPG

By Targets:	Apoptosis (1) Isotope-Labeled Compounds (1) PPAR (1) RANKL/RANK (4) Reference Standards (1) Small Interfering RNA (siRNA) (3) Toll-like Receptor (TLR) (2) Wnt (2) β-catenin (2)
By Research Areas:	Cancer (3) Inflammation/Immunology (5) Metabolic Disease (3) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6973R

Boldine (Standard) 1 Publications Verification	Reference Standards RANKL/RANK	Inflammation/Immunology
Boldine (Standard) is the analytical standard of Boldine. This product is intended for research and analytical applications. Boldine is an aporphine isoquinoline alkaloid extracted from the root of Litsea cubeba and also possesses these properties, including antioxidant, anti-inflammatory and cytoprotective effects. Boldine suppresses osteoclastogenesis, improves bone destruction by down-regulating the *OPG/RANKL/RANK* signal pathway and may be a potential therapeutic agent for rheumatoid arthritis .

HY-B0012

Pamidronic acid 1 Publications Verification	RANKL/RANK Toll-like Receptor (TLR) Wnt β-catenin	Metabolic Disease Inflammation/Immunology Cancer
Pamidronic acid, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronic acid significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of *OPG* in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronic acid can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma .

HY-N6973

Boldine 1 Publications Verification	RANKL/RANK Apoptosis	Inflammation/Immunology Cancer
Boldine is an apomorphine isoquinoline alkaloid extracted from the root of the pheasant pepper (Litsea cubeba). Boldine is an oral effective antioxidant, anti-inflammatory, antitumor agent, and can inhibit osteoclast formation. Boldine induces apoptosis of human bladder cancer cells by regulating ERK, AKT and GSK-3β. Boldine ameliorates bone destruction by down-regulating the *OPG/RANKL/RANK* signaling pathway. It can be used in rheumatoid arthritis research .

HY-168336

E0924G	PPAR	Metabolic Disease
E0924G is an orally active activator for PPARδ with EC₅₀ of 2.82 μM. E0924G promotes the upregulation of osteoprotegerin (OPG) with an EC₅₀ of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibites F-actin ring formation in RAW264.7 macrophages. E0924G regulates the bone density and bone loss in ovariectomized (OVX) and age-related osteoporosis models .

HY-RS24031

Tnfrsf11b Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tnfrsf11b Rat Pre-designed siRNA Set A contains three designed siRNAs for Tnfrsf11b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tnfrsf11b Rat Pre-designed siRNA Set A Tnfrsf11b Rat Pre-designed siRNA Set A

HY-N9346

Phlorigidoside C	Others	Inflammation/Immunology
Phlorigidoside C, a natural iridoid glucoside, possesses anti-rheumatoid arthritis effect .

HY-RS17571

Tnfrsf11b Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tnfrsf11b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tnfrsf11b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tnfrsf11b Mouse Pre-designed siRNA Set A Tnfrsf11b Mouse Pre-designed siRNA Set A

HY-176305S

Neurofilament, U-15N	Isotope-Labeled Compounds	Neurological Disease
Neurofilament, U- ¹⁵N is the ¹⁵N-labeled Neurofilament.

HY-RS14802

TNFRSF11B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TNFRSF11B Human Pre-designed siRNA Set A contains three designed siRNAs for TNFRSF11B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TNFRSF11B Human Pre-designed siRNA Set A TNFRSF11B Human Pre-designed siRNA Set A

HY-B0012R

Pamidronic acid (Standard)	RANKL/RANK Toll-like Receptor (TLR) Wnt β-catenin	Metabolic Disease Inflammation/Immunology Cancer
Pamidronic acid (Standard) is the analytical standard of Pamidronic acid. This product is intended for research and analytical applications. Pamidronic acid, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronic acid significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of OPG in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronic acid can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6973R

Boldine (Standard) 1 Publications Verification	Structural Classification Alkaloids Classification of Application Fields Source classification Phenols Plants Lauraceae Inflammation/Immunology Disease Research Fields Litsea cubeba (Lour.) Pers.	Reference Standards RANKL/RANK
Boldine (Standard) is the analytical standard of Boldine. This product is intended for research and analytical applications. Boldine is an aporphine isoquinoline alkaloid extracted from the root of Litsea cubeba and also possesses these properties, including antioxidant, anti-inflammatory and cytoprotective effects. Boldine suppresses osteoclastogenesis, improves bone destruction by down-regulating the *OPG/RANKL/RANK* signal pathway and may be a potential therapeutic agent for rheumatoid arthritis .

HY-N6973

Boldine 1 Publications Verification	Alkaloids Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Lauraceae Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Litsea cubeba (Lour.) Pers.	RANKL/RANK Apoptosis
Boldine is an apomorphine isoquinoline alkaloid extracted from the root of the pheasant pepper (Litsea cubeba). Boldine is an oral effective antioxidant, anti-inflammatory, antitumor agent, and can inhibit osteoclast formation. Boldine induces apoptosis of human bladder cancer cells by regulating ERK, AKT and GSK-3β. Boldine ameliorates bone destruction by down-regulating the *OPG/RANKL/RANK* signaling pathway. It can be used in rheumatoid arthritis research .

HY-N9346

Phlorigidoside C	Structural Classification Iridoids Classification of Application Fields Terpenoids Labiatae Source classification Phaseolus lunatus L. Plants Inflammation/Immunology Disease Research Fields Saccharides Monosaccharides	Others
Phlorigidoside C, a natural iridoid glucoside, possesses anti-rheumatoid arthritis effect .

Species:	Human (4) Virus (2) Rhesus Macaque (1) Mouse (1)
Tag:	His (5) Avi (1) Fc (3) Flag (1)
Source:	HEK293 (7) CHO (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P73332

	*TNFRSF11B/OPG* Protein, Human (HEK293, His, solution)** OPG; Tumor necrosis factor receptor superfamily member 11B; TNFRSF11B; OCIF	Human	HEK293
	Osteoprotegerin (OPG), a TNF receptor superfamily, is expressed in many tissues including heart, kidney, liver, spleen, and bone marrow. Osteoprotegerin has osteoprotective effect and is critical in bone remodeling. Osteoprotegerin can bind to RANKL and inhibit the binding between TNFSF11 and RANKL, thereby neutralizing the RANKL function in osteoclastogenesis. OPG is also involved in multiple biological processes of cancers. TNFRSF11B/OPG Protein, Human (HEK293, His, solution) is a recombinant human TNFRSF11B/OPG (E22-L401) with C-terminal His tag, which is produced in HEK293 cell.

HY-P70805

	*TNFRSF11B/OPG* Protein, Human (HEK293, His)** Tumor Necrosis Factor Receptor Superfamily Member 11B; Osteoclastogenesis Inhibitory Factor; Osteoprotegerin; TNFRSF11B; OCIF; OPG	Human	HEK293
	Osteoprotegerin (OPG), a TNF receptor superfamily, is expressed in many tissues including heart, kidney, liver, spleen, and bone marrow. Osteoprotegerin has osteoprotective effect and is critical in bone remodeling. Osteoprotegerin can bind to RANKL and inhibit the binding between TNFSF11 and RANKL, thereby neutralizing the RANKL function in osteoclastogenesis. OPG is also involved in multiple biological processes of cancers. TNFRSF11B/OPG Protein, Human (HEK293, His) is a recombinant human TNFRSF11B/OPG (E22-L401) with C-terminal 6*His tag, which is produced in HEK293 cell.

HY-P71017

	*TNFRSF11B/OPG* Protein, Mouse (HEK293, His)** 1 Publications Verification Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin; Tnfrsf11b; Ocif; OPG	Mouse	HEK293
	Osteoprotegerin (OPG), a TNF receptor superfamily, is expressed in many tissues including heart, kidney, liver, spleen, and bone marrow. Osteoprotegerin has osteoprotective effect and is critical in bone remodeling. Osteoprotegerin can bind to RANKL and inhibit the binding between TNFSF11 and RANKL, thereby neutralizing the RANKL function in osteoclastogenesis. OPG is also involved in multiple biological processes of cancers. TNFRSF11B/OPG Protein, Mouse (HEK293, His) is a recombinant mouse TNFRSF11B/OPG (E22-L401) with C-terminal 10*His tag, which is produced in HEK293 cell.

HY-P74661

	*TNFRSF11B/OPG* Protein, Rhesus Macaque (HEK293, hFc)** OCIF; OPG; OPGtumor necrosis factor receptor superfamily member 11B	Rhesus Macaque	HEK293
	Osteoprotegerin (OPG), a TNF receptor superfamily, is expressed in many tissues including heart, kidney, liver, spleen, and bone marrow. Osteoprotegerin has osteoprotective effect and is critical in bone remodeling. Osteoprotegerin can bind to RANKL and inhibit the binding between TNFSF11 and RANKL, thereby neutralizing the RANKL function in osteoclastogenesis. OPG is also involved in multiple biological processes of cancers. TNFRSF11B/OPG Protein, Rhesus Macaque (HEK293, hFc) is a recombinant Rhesus Macaque TNFRSF11B/OPG (M28-L428) with C-terminal hFc tag, which is produced in HEK293 cell.

HY-P7053

	*TNFRSF11B/OPG* Protein, Human (CHO, Fc)** rHuOPG; Tumor necrosis factor receptor superfamily member 11B; TNFRSF11B; OCIF	Human	CHO
	Osteoprotegerin (OPG), a TNF receptor superfamily, is expressed in many tissues including heart, kidney, liver, spleen, and bone marrow. Osteoprotegerin has osteoprotective effect and is critical in bone remodeling. Osteoprotegerin can bind to RANKL and inhibit the binding between TNFSF11 and RANKL, thereby neutralizing the RANKL function in osteoclastogenesis. OPG is also involved in multiple biological processes of cancers. TNFRSF11B/OPG Protein, Human (CHO, Fc) is a recombinant human TNFRSF11B/OPG (E22-L201) with C-terminal hFc tag, which is produced in CHO cell.

HY-P700432

	*TNFRSF11B/OPG* Protein, Human (HEK293, hFc-Flag)** Tumor Necrosis Factor Receptor Superfamily Member 11B; Osteoclastogenesis Inhibitory Factor; Osteoprotegerin; TNFRSF11B; OCIF; OPG	Human	HEK293
	TNFRSF11B/OPG acts as a decoy receptor for TNFSF11/RANKL, neutralizing its osteoclastic effects and promoting osteoclast apoptosis in vitro. It regulates the TNFSF11/TNFRSF11B ratio and is critical for bone homeostasis. TNFRSF11B/OPG Protein, Human (HEK293, hFc-Flag) is the recombinant human-derived TNFRSF11B/OPG protein, expressed by HEK293 , with C-hFc, C-Flag labeled tag.

HY-P703789

	A30 Protein, Monkeypox virus (HEK293, His) Envelope protein OPG155; Protein A30; OPG155	Virus	HEK293
	A30 Protein, Monkeypox virus (HEK293, His) is the recombinant virus-derived A30 protein, expressed by HEK293, with N-His tag.

HY-P705143

	E8L Protein, Monkeypox virus (Biotinylated, HEK293, His-Avi) Cell surface-binding protein OPG105; OPG105; Carbonic anhydrase homolog; OPG105; E8L; (strain Zaire-96-I-16	Virus	HEK293

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Products	In-stock - + Add to Cart
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Species
Source
Tag
Accession
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HY-176305S

Neurofilament, U-15N
Neurofilament, U- ¹⁵N is the ¹⁵N-labeled Neurofilament.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81123

	Osteoprotegerin Antibody (YA3535) MGC29565 antibody; OCIF antibody; OPG antibody; Osteoclastogenesis inhibitory factor antibody; Osteoprotegerin antibody; PDB5 antibody; TNF receptor superfamily member 11b antibody; TNFRSF 11B antibody; TNFRSF11B antibody; TR 1 antibody; TR1 antibody; TR11B_HUMAN antibody; Tumor necrosis factor receptor superfamily member 11B antibody;	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Osteoprotegerin Antibody (YA3535) is an unconjugated, approximately 46 kDa,mouse-derived, anti-OPG monoclonal antibody. OPG Antibody can be used for: WB, IF-Cell, IHC-P expriments in human, mouse, rat background without labeling.

HY-P83792

	Osteoprotegerin Antibody (YA3489) OPG; TR1; OCIF; MGC29565; TNFRSF11B	ICC/IF, FC, ELISA	Human
	Osteoprotegerin Antibody (YA3489) is a mouse-derived and non-conjugated IgG1 antibody, targeting to TNFRSF11B. It can be applicated for ICC/IF, FC, ELISA assays, in the background of human.

HY-P85305

	Osteoprotegerin Antibody (YA4997) TNFRSF11B; OCIF; OPG; Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin	WB, ICC/IF, FC, ELISA	Human
	Osteoprotegerin Antibody (YA4997) is a mouse-derived and non-conjugated monoclonal antibody, targeting to OPG. It can be applicated for WB, ICC/IF, FC, ELISA assays, in the background of human.

HY-P85306

	Osteoprotegerin Antibody (YA4998) TNFRSF11B; OCIF; OPG; Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin	WB, IHC-P, ICC/IF, ELISA	Human
	Osteoprotegerin Antibody (YA4998) is a mouse-derived and non-conjugated monoclonal antibody, targeting to OPG. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS24031

Tnfrsf11b Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Tnfrsf11b Rat Pre-designed siRNA Set A contains three designed siRNAs for Tnfrsf11b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17571

Tnfrsf11b Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Tnfrsf11b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tnfrsf11b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14802

TNFRSF11B Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TNFRSF11B Human Pre-designed siRNA Set A contains three designed siRNAs for TNFRSF11B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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