Osteoprotegerin Antibody (YA3489)

Cat. No.: HY-P83792: Data Sheet User Guide for Antibodies
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Osteoprotegerin Antibody (YA3489) is a mouse-derived and non-conjugated IgG1 antibody, targeting to TNFRSF11B. It can be applicated for ICC/IF, FC, ELISA assays, in the background of human.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

Biological Activity
Technical Parameters
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Description	Osteoprotegerin Antibody (YA3489) is a mouse-derived and non-conjugated IgG1 antibody, targeting to TNFRSF11B. It can be applicated for ICC/IF, FC, ELISA assays, in the background of human.
Background	OPG acts as a decoy receptor for TNFSF11/RANKL, thereby neutralizing its function in osteoclastogenesis. It inhibits osteoclast activation and promotes osteoclast apoptosis in vitro. Bone homeostasis appears to depend on the local ratio between TNFSF11 and TNFRSF11B. Additionally, OPG may play a role in preventing arterial calcification and can act as a decoy receptor for TNFSF10/TRAIL, protecting against apoptosis. The binding of TNFSF10/TRAIL blocks the inhibition of osteoclastogenesis. by similar: OPG may be involved in protective mechanisms against apoptosis.
Gene ID	4982 [NCBI]
SwissProt ID	O00300
Synonyms	OPG; TR1; OCIF; MGC29565; TNFRSF11B
Molecular Weight	Predicted band size: 46 kDa; Observed band size: 46 kDa
Purity	affinity purified.
Conjugation	Non-conjugated
Product Categories	Primary Antibody; Mouse Monoclonal Antibody
Host	Mouse
Reactivity	Human
Dilution Ratio	IF: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000
Application	ICC/IF, FC, ELISA
Appearance	Liquid
Formulation	Supplied in PBS with 0.05% sodium azide.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG1
Immunogen	Purified recombinant fragment of human TNFRSF11B expressed in E. Coli.
Documentation	Data Sheet (234 KB) User Guide for Antibodies (1077 KB)

Osteoprotegerin Antibody (YA3489) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Osteoprotegerin Antibody (YA3489)

Biological Activity

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Osteoprotegerin Antibody (YA3489) Related Classifications

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