Search Result

Results for "

Nucleophilicity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aldehyde Dehydrogenase (ALDH) (3) Amine N-methyltransferase (1) Bacterial (3) Biochemical Assay Reagents (47) Cholinesterase (ChE) (5) Drug Intermediate (1) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (10) Fluorescent Dye (15) Isotope-Labeled Compounds (2) mTOR (1) Nucleoside Antimetabolite/Analog (2) Phospholipase (1) Ras (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (3) Infection (3) Inflammation/Immunology (1) Metabolic Disease (3) Neurological Disease (8)
Click Chemistry:	Azide (1) Alkynes (1)
Oligonucleotides:	Nucleotides and their Analogs (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W011985

H-Arg-NH2 hydrochloride	Biochemical Assay Reagents	Others
H-Arg-NH2 (hydrochloride) is a nucleophilic reagent that can be used in experiments related to enzyme activity center detection .

HY-W016286

2,6-Dithiopurine 2,6-Dimercaptopurine	Biochemical Assay Reagents	Cancer
2,6-Dithiopurine (2,6-Dimercaptopurine) is a nucleophilic scavenger for electrophilic carcinogens. 2,6-Dithiopurine abolishes both DNA adduct formation and the initiation of carcinogenesis .

HY-113128C

(Rac)-sn-Glycerol 3-phosphate DL-α-Glycerol phosphate	Endogenous Metabolite	Others
(Rac)-sn-Glycerol 3-phosphate is an a-site substrate analogue. (Rac)-sn-Glycerol 3-phosphate is bound to the a-site, the rate of reaction of indole and nucleophilic indole analogues with E(A-A) is strongly inhibited .

HY-151523

KRas G12R inhibitor 1	Ras	Cancer
KRas G12R inhibitor 1 is a covalent inhibitor targeting the common oncogenic mutant KRas G12R with selectivity for the mutant arginine. KRas G12R inhibitor 1 possesses an α,β-diketoamide and exploits strong nucleophilicity of the mutant cysteine and irreversibly binds in the Switch II region of KRas. KRas G12R inhibitor 1 can be researched for K-Ras (G12R)-driven cancer such as pancreatic ductal adenocarcinoma (PDAC) .

HY-W094511

Tetrachloroaurate(III) sodium dihydrate Gold chloride sodium dihydrate	Biochemical Assay Reagents	Others
Tetrachloroaurate III sodium dihydrate (Gold chloride sodium dihydrate) is utilized as catalyst in reactions like nucleophilic addition to multiple bonds, nucleophilic substitution of propargylic alcohols, and nonsymmetrical etherization .

HY-W032015

1-Bromooctane n-Octyl Bromide	Biochemical Assay Reagents	Others
1-Bromooctane (n-Octyl Bromide) posesses a terminal bromine. The bromine is a very good leaving group for nucleophilic substitution reactions.

HY-108776

(Rac)-sn-Glycerol 3-phosphate sodium DL-α-Glycerol phosphate sodium	Endogenous Metabolite	Inflammation/Immunology
(Rac)-sn-Glycerol 3-phosphate sodium is an a-site substrate analogue. (Rac)-sn-Glycerol 3-phosphate sodium is bound to the a-site, the rate of reaction of indole and nucleophilic indole analogues with E(A-A) is strongly inhibited .

HY-113128CR

(Rac)-sn-Glycerol 3-phosphate (Standard) DL-α-Glycerol phosphate (Standard)	Endogenous Metabolite	Others
(Rac)-sn-Glycerol 3-phosphate (Standard) is the analytical standard of (Rac)-sn-Glycerol 3-phosphate. This product is intended for research and analytical applications. (Rac)-sn-Glycerol 3-phosphate is an a-site substrate analogue. (Rac)-sn-Glycerol 3-phosphate is bound to the a-site, the rate of reaction of indole and nucleophilic indole analogues with E(A-A) is strongly inhibited .

HY-130893A

Biotin-EDA TFA	Biochemical Assay Reagents	Others
Biotin-EDA TFA is a nucleophilic biotinylation reagent used for the conjugation of various substrates and identification and quantification using biotin-conjugated fluorescent labels .

HY-D0066

7-Diethylaminocoumarin-3-carbohydrazide DCCH	Fluorescent Dye	Others
7-Diethylaminocoumarin-3-carbohydrazide is a coumarin. 7-Diethylaminocoumarin-3-carbohydrazide can be used to detect sugar chains and quantify biological carbonyl compounds .

HY-121564

Radermachol	Fluorescent Dye	Others
Radermachol is a red pigment that can be synthesized in four steps via a key ytterbium triflate-catalyzed furan cyclization and intramolecular nucleophilic acylation reaction .

HY-W100403

Choline tosylate Choline p-toluenesulfonate	Phospholipase	Cancer
Choline tosylate is a nucleophilic compound that inhibits phospholipase A2 and phospholipase C. Choline tosylate inhibits tumor growth in mice by inhibiting the formation of diacylglycerol (DAG) .

HY-N1635

1-Methoxyindole-3-carboxylic acid	Others	Others
1-Methoxyindole-3-carboxylic acid (compound 5) is synthetic from a phytoalexin nucleophilic substitution reaction selectively at the 2-position .

HY-W396413

(4-Chlorobutoxy)trimethylsilane	Biochemical Assay Reagents	Others
4-Chlorobutoxy(trimethyl)silane is a silane compound with a terminal cholorine. The cholorine (Cl) is a good leaving group for nucleophilic substitution reactions. The trimethylsilane is commonly used for surface modifications.

HY-W348170

tert-Butyl((5-iodopentyl)oxy)dimethylsilane	Biochemical Assay Reagents	Others
tert-Butyl((5-iodopentyl)oxy)dimethylsilane is a silane compound with a terminal iodine group. The trimethylsilane is commonly used for surface modifications. The iodine (I) is a very good leaving group for nucleophilic substitution reactions.

HY-W800806

Heptyl 8-bromooctanoate	Biochemical Assay Reagents	Others
Heptyl 8-bromooctanoate is an ester compound that has a terminal bromine. Heptyl 8-bromooctanoate is formed by coupling 8-Bromooctanoic acid to Heptanol. The bromine (Br) is a very good leaving group for nucleophilic substitution reactions.

HY-B1738

Pralidoxime	Cholinesterase (ChE)	Neurological Disease
Pralidoxime is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning .

HY-W800678

Bromoacetamido-PEG2-AZD	Biochemical Assay Reagents	Others
Bromoacetamido-PEG2-AZD is a PEG linker containing an AZD group and a bromide group which is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.

HY-B1200

Pralidoxime chloride 2-PAM chloride	Cholinesterase (ChE)	Neurological Disease
Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning .

HY-W878813

Tos-PEG22-Tos	Biochemical Assay Reagents	Others
Tos-PEG22-Tos is a PEG linker containing two tosyl groups. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

HY-W052066

tert-Butyl (3-chloropropyl)carbamate	Biochemical Assay Reagents	Others
tert-Butyl (3-chloropropyl)carbamate is a compound with a t-butyl and a terminal choloride. The cholorine (Cl) is a good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W190786

Bromoacetamido-PEG2-azide	Biochemical Assay Reagents	Others
Bromoacetamido-PEG2-azide is a heterobifunctional PEG linker containing a reactive bromoacetamido and a terminal azide.The bromoacetamidogroup is a very reactive group for nucleophilic substitution. The azide group can react with alkyne, BCN, DBCO via Click Chemistry.

HY-W053842

tert-Butyl 3-iodopropylcarbamate	Biochemical Assay Reagents	Others
tert-Butyl 3-iodopropylcarbamate is a compound with a t-butyl and a terminal iodine. The iodine (I) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W016455

6-Bromo-1-hexanol	Biochemical Assay Reagents	Others
6-Bromo-1-hexanol posesses a terminal bromine and hydroxylic group. The bromine is a very good leaving group for nucleophilic substitution reactions. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

HY-172720

Azide-PEG5-Ms	Biochemical Assay Reagents	Others
Azide-PEG5-Ms serves as a PEG linker containing an azide that reacts with BCN, DBCO, alkyne via Click Chemistry and mesyl group that is a good leaving group for nucleophilic substitution reactions. The PEG spacer imparts water solubility.

HY-B1738B

Pralidoxime methanesulfonate	Cholinesterase (ChE)	Neurological Disease
Pralidoxime methanesulfonate is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime methanesulfonate reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime methanesulfonate is an antidote for organophosphate poisoning .

HY-B1738A

Pralidoxime iodide	Cholinesterase (ChE)	Neurological Disease
Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning .

HY-W248726

tert-Butyl (6-iodohexyl)carbamate	Biochemical Assay Reagents	Others
tert-Butyl (6-iodohexyl)carbamate is a six carbon linker containing an iodine group and a t-butyl ester. The iodine (I) acts as a good leaving group for nucleophilic substitution reactions. The t-butyl ester groups can be deprotected under acidic conditions.

HY-W251756

3-(2-Iodoethoxy)prop-1-yne	Biochemical Assay Reagents	Others
3-(2-Iodoethoxy)prop-1-yne is a crosslinker that can be used in copper catalyzed azide-alkyne Click Chemistry to form a stable triazole linkage with azides. The iodine (I) acts as a good leaving group for nucleophilic substitution reactions.

HY-D2854B

FITC-PEG-CL (MW 2000)	Fluorescent Dye	Others
FITC-PEG-CL (MW 2000) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).

HY-D2856

FITC-PEG-Br (MW 1000)	Fluorescent Dye	Others
FITC-PEG-Br (MW 1000) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).

HY-D2854D

FITC-PEG-CL (MW 5000)	Fluorescent Dye	Others
FITC-PEG-CL (MW 5000) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).

HY-D2856A

FITC-PEG-Br (MW 2000)	Fluorescent Dye	Others
FITC-PEG-Br (MW 2000) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).

HY-W591972

6-Hydroxyhexyl 4-methylbenzenesulfonate	Biochemical Assay Reagents	Others
6-Hydroxyhexyl 4-methylbenzenesulfonate is a six carbon linker containing a hydroxyl group and a tosyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

HY-D2854E

FITC-PEG-CL (MW 10000)	Fluorescent Dye	Others
FITC-PEG-CL (MW 10000) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).

HY-D2854A

FITC-PEG-CL (MW 1000)	Fluorescent Dye	Others
FITC-PEG-CL (MW 1000) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).

HY-D2854C

FITC-PEG-CL (MW 3400)	Fluorescent Dye	Others
FITC-PEG-CL (MW 3400) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).

HY-W096068

Propargyl-PEG4-mesyl ester	Biochemical Assay Reagents	Others
Propargyl-PEG5-Ms represents a bifunctional linker possessing a proparygyl group reactive towards azides in copper (I) click chemistry to form stable triazoles with the target compound as well as a mesyl group which is a good leaving group for nucleophilic reactions.

HY-D2856B

FITC-PEG-Br (MW 3400)	Fluorescent Dye	Others
FITC-PEG-Br (MW 3400) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).

HY-D2854

FITC-PEG-CL (MW 400)	Fluorescent Dye	Others
FITC-PEG-CL (MW 400) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).

HY-D2856D

FITC-PEG-Br (MW 10000)	Fluorescent Dye	Others
FITC-PEG-Br (MW 10000) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).

HY-D2856C

FITC-PEG-Br (MW 5000)	Fluorescent Dye	Others
FITC-PEG-Br (MW 5000) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).

HY-W591971

5-((tert-Butoxycarbonyl)amino)pentyl 4-methylbenzenesulfonate	Biochemical Assay Reagents	Others
5-((tert-Butoxycarbonyl)amino)pentyl 4-methylbenzenesulfonate is a PEG linker containing a Boc protected amine and a tosyl group. The protected amine can be deprotected under mild acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

HY-W800661

Tos-PEG3-methyl ester	Biochemical Assay Reagents	Others
Tos-PEG3-methyl ester is a PEG linker with tosyl and methyl ester moieties. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG linker increases the water solubility of the compound. Methyl ester can be hydrolyzed under strong basic condition.

HY-W800662

Bromo-PEG2-methyl ester	Biochemical Assay Reagents	Others
Bromo-PEG2-methyl ester is a PEG linker containing a bromide moiety and a methyl ester. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media. Methyl ester can be hydrolyzed under strong basic condition.

HY-W590574

Propargyl-PEG4-Ms	Biochemical Assay Reagents	Others
Propargyl-PEG4-Ms has an alkyne group and a mesylate group. The mesylate group is a sulfonate ester for nucleophilic substitution reactions (SN2). The alkyne group can react with azides via copper catalyzed Click Chemistry reactions. The PEG units help increase the solubility of the molecule in aqueous environments.

HY-W591973

OTs-C6-NHBoc	Biochemical Assay Reagents	Others
OTs-C6-NHBoc is a six carbon linker containing a tosyl group and Boc-protected amine group. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form a free amine.

HY-W092078

tert-Butyl (4-iodobutyl)carbamate	Biochemical Assay Reagents	Others
tert-Butyl (4-iodobutyl)carbamate is a four carbon linker containing a Boc-protected amino group and an iodine group. The Boc group can be deprotected under mild acidic conditions to form the free amine. Iodine (I) is a very good leaving group for nucleophilic substitution reactions.

HY-19997

Mannose triflate TATM	Biochemical Assay Reagents	Cancer
Mannose triflate is a glucose analog. Mannose triflate is a precursor for 18F-FDG synthesis for PET applications. Mannose triflate binds to 18F via SN2 nucleophilic substitution reaction. Mannose triflate can be used for an imaging technique in detection of cancer .

HY-W591963

5-Azidopentyl 4-methylbenzenesulfonate Tos-pentane-azide	Biochemical Assay Reagents	Others
5-Azidopentyl 4-methylbenzenesulfonate (Tos-pentane-azide) is a linker containing an azide group and a tosyl group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The tosyl group is a good leaving group for nucleophilic substitution reactions.

Cat. No.	Product Name

HY-L0118V

Asinex Covalent Inhibitors Library	942 compounds
A unique set of molecules containing mild electrophilic moieties that covalently interact with amino acid residues in the target protein. The diversity of our compounds for covalent drug discovery ranges from natural product-like scaffolds to macrocycles, creating multiple opportunities in hit generation for a selected target.

HY-L914

Serine/Threonine Focused Covalent Fragment Library

3,293 compounds

In the research of covalent inhibitors targeting serine and threonine, scientists have found that the nucleophilicity of these hydroxyl groups is significantly enhanced due to the influence of their surrounding environment. This results in higher activity during catalytic reactions. Aspirin, which targets the non-catalytic domain serine (Ser529 in human COX1) of cyclooxygenase, exerts its anti-inflammatory effect through covalent binding. β-lactam antibiotics, which targets the catalytic domain serine of penicillin-binding proteins, interferes with bacterial cell wall synthesis.

Through careful selection, we constructed a structural filter containing over 110 electrophilic groups. By analyzing the electrophilic fragments selected by the structural filter, we removed any molecules with trivial or undesirable structural features. Ultimately, we obtained 3,300 fragment molecules which can target serine and threonine residues and can be used for fragment-based covalent drug discovery.

Cat. No.	Product Name	Type

HY-D0066

7-Diethylaminocoumarin-3-carbohydrazide DCCH	Dyes
7-Diethylaminocoumarin-3-carbohydrazide is a coumarin. 7-Diethylaminocoumarin-3-carbohydrazide can be used to detect sugar chains and quantify biological carbonyl compounds .

HY-D2854B

FITC-PEG-CL (MW 2000)	Fluorescent Dyes/Probes
FITC-PEG-CL (MW 2000) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).

HY-D2856

FITC-PEG-Br (MW 1000)	Fluorescent Dyes/Probes
FITC-PEG-Br (MW 1000) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).

HY-D2854D

FITC-PEG-CL (MW 5000)	Fluorescent Dyes/Probes
FITC-PEG-CL (MW 5000) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).

HY-D2856A

FITC-PEG-Br (MW 2000)	Fluorescent Dyes/Probes
FITC-PEG-Br (MW 2000) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).

HY-D2854E

FITC-PEG-CL (MW 10000)	Fluorescent Dyes/Probes
FITC-PEG-CL (MW 10000) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).

HY-D2854A

FITC-PEG-CL (MW 1000)	Fluorescent Dyes/Probes
FITC-PEG-CL (MW 1000) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).

HY-D2854C

FITC-PEG-CL (MW 3400)	Fluorescent Dyes/Probes
FITC-PEG-CL (MW 3400) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).

HY-D2856B

FITC-PEG-Br (MW 3400)	Fluorescent Dyes/Probes
FITC-PEG-Br (MW 3400) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).

HY-D2854

FITC-PEG-CL (MW 400)	Fluorescent Dyes/Probes
FITC-PEG-CL (MW 400) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).

HY-D2856C

FITC-PEG-Br (MW 5000)	Fluorescent Dyes/Probes
FITC-PEG-Br (MW 5000) is a fluorescent dye composed of FITC (HY-66019), PEG and chlorine (-Cl). The chlorine group is an electrophilic active group that can be used for nucleophilic substitution reactions and facilitate subsequent chemical modification (Ex/Em = 488/525 nm).

HY-158616

4-Methyl-7-(2-nitrophenoxy)-2H-chromen-2-one

Dyes

4-Methyl-7-(2-nitrophenoxy)-2H-chromen-2-one (compound 2f) is a selenol fluorescent probe designed based on a nucleophilic aromatic substitution mechanism. It can selectively recognize selenols in neutral aqueous solution without significant interference from biological thiols, amines or alcohols. It can be used to quantify the selenium content in selenoenzymes and to image the activity of endogenous selenols in living cells.

Cat. No.	Product Name	Type

HY-W094511

Tetrachloroaurate(III) sodium dihydrate Gold chloride sodium dihydrate	Biochemical Assay Reagents
Tetrachloroaurate III sodium dihydrate (Gold chloride sodium dihydrate) is utilized as catalyst in reactions like nucleophilic addition to multiple bonds, nucleophilic substitution of propargylic alcohols, and nonsymmetrical etherization .

HY-W100403

Choline tosylate Choline p-toluenesulfonate	Enzyme Substrates
Choline tosylate is a nucleophilic compound that inhibits phospholipase A2 and phospholipase C. Choline tosylate inhibits tumor growth in mice by inhibiting the formation of diacylglycerol (DAG) .

HY-19997

Mannose triflate TATM	Carbohydrates
Mannose triflate is a glucose analog. Mannose triflate is a precursor for 18F-FDG synthesis for PET applications. Mannose triflate binds to 18F via SN2 nucleophilic substitution reaction. Mannose triflate can be used for an imaging technique in detection of cancer .

HY-W099640

Tetraoctylammonium iodide

Tetra-n-octylammonium iodide

Cell Assay Reagents

Tetraoctylammonium iodideIt is an organic compound and belongs to the category of quaternary ammonium salts. It is often used as a phase transfer catalyst, meaning it facilitates a reaction between two immiscible phases, such as an aqueous phase and an organic phase. Tetraoctylammonium iodideIt has a variety of applications in organic synthesis, especially in reactions involving nucleophilic substitution, oxidation, and reduction. Additionally, it is used as a surfactant and emulsifier in industrial and laboratory settings.

HY-W042557

Tetrabutylammonium trifluoromethanesulfonate

Biochemical Assay Reagents

Tetrabutylammonium trifluoromethanesulfonate, commonly known as TBAOTf. TBAOTf is widely used as a strong acid catalyst and phase transfer agent in organic synthesis, especially for reactions involving nucleophilic substitution, elimination, and rearrangement, in addition, it is also used as an electrolyte additive for rechargeable batteries and a stabilizer of supercritical fluids Due to its high stability, solubility and selectivity, TBAOTf is considered to be a highly efficient and multifunctional reagent in various applications.

HY-Y0141

3-Amino-6-chloropyridazine	Biochemical Assay Reagents
3-Amino-6-chloropyridazine is a nitrogen-containing heterocyclic organic compound belonging to the pyridazine derivatives. 3-Amino-6-chloropyridazine has the basicity of amino groups and the nucleophilic substitution activity of chlorine atoms. 3-Amino-6-chloropyridazine can serve as an important intermediate for synthesizing some active compounds .

HY-32813

2-Amino-3-iodopyridine 1 Publications Verification 3-Iodopyridin-2-amine	Biochemical Assay Reagents
2-Amino-3-iodopyridine (3-Iodopyridin-2-amine) can be coupled with formyl derivatives under a copper-catalyzed indole synthesis method, and then constructed azide analogs through copper-mediated conjugated adducts things. The nucleophilicity of 2-Amino-3-iodopyridine is lower than that of the corresponding aniline used in the synthesis of indole, a potential obstacle for future synthesis .

HY-Y0971

Tetrabutylammonium (fluoride) (solution),1M in THF

TBAF

Biochemical Assay Reagents

Tetrabutylammonium fluoride is an organic compound containing both ammonium and fluorine functional groups. It is commonly used as a reagent in various chemical synthesis applications, especially as a source of fluoride ions for nucleophilic reactions. Tetrabutylammonium fluoride has several properties that make it suitable for these applications, including its high solubility in polar solvents and its ability to selectively activate certain chemical bonds. In addition, it can be used as a catalyst for organic reactions and as an electrolyte for batteries.

HY-W095635

Tetramethylammonium fluoride tetrahydrate

Biochemical Assay Reagents

Tetramethylammonium fluoride tetrahydrate (TMAF) is a quaternary ammonium salt. TMAF is commonly used as a weak base and a source of fluoride ions in various organic reactions, including nucleophilic substitution, functional group deprotection, and ring-opening polymerization. Unlike other fluoride sources, TMAF is compatible with many functional groups, making it a versatile tool in synthetic chemistry. Functional reagents, In addition, TMAF has been used as a fluorinating agent in medicinal chemistry, for the preparation of radiotracers and protein modification in biochemistry, and the tetrahydrate form of TMAF is more stable and easier to handle than the anhydrous form.

HY-130893A

Biotin-EDA TFA	Cell Assay Reagents
Biotin-EDA TFA is a nucleophilic biotinylation reagent used for the conjugation of various substrates and identification and quantification using biotin-conjugated fluorescent labels .

HY-15927

4-Nitrophenyl β-D-glucopyranoside

1 Publications Verification

Enzyme Substrates

4-Nitrophenyl β-D-glucopyranoside is a chromogenic substrate for β-glucosidase. 4-Nitrophenyl β-D-glucopyranoside is converted to a colored product, p-nitrophenol that is easily detected spectrophotometrically at 405 nm when used in a β-glycosidase assay. 4-Nitrophenyl β-D-glucopyranoside is hydrolysed through intramolecular nucleophilic catalysis by the phosphate group in the 2-position. 4-Nitrophenyl β-D-glucopyranoside is promising for research of postmenopausal osteoporosis .

HY-79647

Fmoc-OSu

N-(Fmoc-oxy)succinimide

Biochemical Assay Reagents

Fmoc-OSu (N-(Fmoc-oxy)succinimide) is an acylating agent that targets amino groups (-NH2). It can selectively protect the amino groups of amino acids by covalently binding with primary or secondary amines through nucleophilic substitution reactions. Fmoc-OSu forms a stable amide bond with the amino group to avoid side reactions of the amino group in peptide synthesis. It can also be used as a fluorescent labeling reagent to react with glycosylamines for efficient labeling of N-sugar chains. Fmoc-OSu can be used as an Fmoc protection strategy in peptide synthesis, and as a fluorescent labeling and analysis method for N-sugar chains .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113128C

(Rac)-sn-Glycerol 3-phosphate DL-α-Glycerol phosphate	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(Rac)-sn-Glycerol 3-phosphate is an a-site substrate analogue. (Rac)-sn-Glycerol 3-phosphate is bound to the a-site, the rate of reaction of indole and nucleophilic indole analogues with E(A-A) is strongly inhibited .

HY-N6856

4-Hydroxycoumarin	Infection Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Endogenous metabolite Disease Research Fields	Bacterial Endogenous Metabolite
4-Hydroxycoumarin is an orally active coumarin derivative, one of the most versatile heterocyclic scaffolds, often used in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin is an HIV protease inhibitor and tyrosine kinase inhibitor. 4-Hydroxycoumarin has anti-inflammatory, antibacterial and anti-tumor effects .

HY-113466

4-Hydroxynonenal 10+ Cited Publications 4-HNE	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer	Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite
4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria .

HY-N6856R

4-Hydroxycoumarin (Standard)	Structural Classification Source classification Coumarins Phenylpropanoids Endogenous metabolite	Bacterial Endogenous Metabolite
4-Hydroxycoumarin (Standard) is the analytical standard of 4-Hydroxycoumarin. This product is intended for research and analytical applications. 4-Hydroxycoumarin is an orally active coumarin derivative, one of the most versatile heterocyclic scaffolds, often used in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin is an HIV protease inhibitor and tyrosine kinase inhibitor. 4-Hydroxycoumarin has anti-inflammatory, antibacterial and anti-tumor effects .

HY-W013159

2'-Deoxyguanosine 5'-monophosphate disodium 1 Publications Verification 5′-dGMP disodium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Nucleoside Antimetabolite/Analog
2'-Deoxyguanosine 5'-monophosphate (5′-dGMP) disodium is a mononucleotide having guanine as the nucleobase. 2'-Deoxyguanosine 5'-monophosphate disodium is a reactant involved in analysis of self-assembling in solution and nucleation/growth of G-qudruplexes, nucleophilic trapping and reductive alkylation. 2'-Deoxyguanosine 5'-monophosphate disodium can be used as an oxidizable target. 2'-Deoxyguanosine 5'-monophosphate disodium is a nucleic acid guanosine triphosphate (GTP) derivative and is a nucleotide precursor used in DNA synthesis .

HY-108776

(Rac)-sn-Glycerol 3-phosphate sodium DL-α-Glycerol phosphate sodium	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
(Rac)-sn-Glycerol 3-phosphate sodium is an a-site substrate analogue. (Rac)-sn-Glycerol 3-phosphate sodium is bound to the a-site, the rate of reaction of indole and nucleophilic indole analogues with E(A-A) is strongly inhibited .

HY-113128CR

(Rac)-sn-Glycerol 3-phosphate (Standard) DL-α-Glycerol phosphate (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
(Rac)-sn-Glycerol 3-phosphate (Standard) is the analytical standard of (Rac)-sn-Glycerol 3-phosphate. This product is intended for research and analytical applications. (Rac)-sn-Glycerol 3-phosphate is an a-site substrate analogue. (Rac)-sn-Glycerol 3-phosphate is bound to the a-site, the rate of reaction of indole and nucleophilic indole analogues with E(A-A) is strongly inhibited .

HY-121564

Radermachol	Structural Classification Natural Products Source classification Radermachera xylocarpa (Roxb.) Roxb. ex K.Schum. Bignoniaceae Plants	Fluorescent Dye
Radermachol is a red pigment that can be synthesized in four steps via a key ytterbium triflate-catalyzed furan cyclization and intramolecular nucleophilic acylation reaction .

HY-N1635

1-Methoxyindole-3-carboxylic acid	Structural Classification Alkaloids Source classification Plants Brassicaceae Isatis indigotica Fortune Indole Alkaloids	Others
1-Methoxyindole-3-carboxylic acid (compound 5) is synthetic from a phytoalexin nucleophilic substitution reaction selectively at the 2-position .

HY-N3373R

Loganetin (Standard)	Structural Classification Human Gut Microbiota Metabolites Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants Endogenous metabolite	Bacterial
4-Hydroxycoumarin (Standard) is the analytical standard of 4-Hydroxycoumarin. This product is intended for research and analytical applications. 4-Hydroxycoumarin is an orally active coumarin derivative, one of the most versatile heterocyclic scaffolds, often used in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin is an HIV protease inhibitor and tyrosine kinase inhibitor. 4-Hydroxycoumarin has anti-inflammatory, antibacterial and anti-tumor effects .

HY-113466R

4-Hydroxynonenal (Standard)	Structural Classification Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite	Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite
4-Hydroxynonenal (Standard) is the analytical standard of 4-Hydroxynonenal. This product is intended for research and analytical applications. 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria .

Cat. No.	Product Name	Chemical Structure

HY-113466S

4-Hydroxynonenal-d3

4-Hydroxynonenal-d₃ is the deuterium labeled 4-Hydroxynonenal. 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria .

HY-W013159S

2'-Deoxyguanosine 5'-monophosphate-13C10,15N5 disodium

2'-Deoxyguanosine 5'-monophosphate- ¹³C₁₀, ¹⁵N₅ (dGMP- ¹³C₁₀, ¹⁵N₅) disodium is the ¹³C and ¹⁵N labeled 2'-Deoxyguanosine 5'-monophosphate disodium (HY-W013159). 2'-Deoxyguanosine 5'-monophosphate (5′-dGMP) disodium is a mononucleotide having guanine as the nucleobase. 2'-Deoxyguanosine 5'-monophosphate disodium is a reactant involved in analysis of self-assembling in solution and nucleation/growth of G-qudruplexes, nucleophilic trapping and reductive alkylation. 2'-Deoxyguanosine 5'-monophosphate disodium can be used as an oxidizable target. 2'-Deoxyguanosine 5'-monophosphate disodium is a nucleic acid guanosine triphosphate (GTP) derivative and is a nucleotide precursor used in DNA synthesis .

Cat. No.	Product Name		Classification

HY-W096068

Propargyl-PEG4-mesyl ester		Alkynes
Propargyl-PEG5-Ms represents a bifunctional linker possessing a proparygyl group reactive towards azides in copper (I) click chemistry to form stable triazoles with the target compound as well as a mesyl group which is a good leaving group for nucleophilic reactions.

HY-W190881

N3-PEG11-CH2CH2Br		Azide
N3-PEG11-CH2CH2Br is a PEG linker containing a bromine and an azide group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The bromine (Br) is a very good leaving group for nucleophilic substitution reactions.

Cat. No.	Product Name		Classification

HY-W013159

2'-Deoxyguanosine 5'-monophosphate disodium 1 Publications Verification 5′-dGMP disodium		Nucleotides and their Analogs
2'-Deoxyguanosine 5'-monophosphate (5′-dGMP) disodium is a mononucleotide having guanine as the nucleobase. 2'-Deoxyguanosine 5'-monophosphate disodium is a reactant involved in analysis of self-assembling in solution and nucleation/growth of G-qudruplexes, nucleophilic trapping and reductive alkylation. 2'-Deoxyguanosine 5'-monophosphate disodium can be used as an oxidizable target. 2'-Deoxyguanosine 5'-monophosphate disodium is a nucleic acid guanosine triphosphate (GTP) derivative and is a nucleotide precursor used in DNA synthesis .

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