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Results for "

NfL

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Fluorescent Dye

3

Recombinant Proteins

7

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W611371A
    FP802 hydrochloride

    		TRP Channel iGluR Neurological Disease
    FP802 hydrochloride is an orally active potent TwinF interface inhibitor that disrupts and detoxifies the NMDAR/TRPM4 death complex. FP802 hydrochloride exerts powerful neuroprotective effects in the 5xFAD mouse model of Alzheimer’s disease (AD) by preventing cognitive decline, preserving neuronal structural integrity, reducing amyloid-β plaque formation, and mitigating mitochondrial pathology . FP802 hydrochloride stops loss of motor neurons, reduces serum neurofilament light chain (NfL) levels, improves motor performance, and extends life in a mouse model of amyotrophic lateral sclerosis (ALS) . FP802 hydrochloride can be used for AD and ALS research [1][2].
    FP802 hydrochloride
  • HY-D2279
    NFL-NH2

    		Fluorescent Dye Inflammation/Immunology
    NFL-NH2 is a mitochondrial-targeted near-infrared ratiometric fluorescent probe. NFL-NH2 can rapidly detect NO levels associated with the inflammatory damage degree in rheumatoid arthritis (RA) mice models by ratiometric fluorescence imaging. The excitation wavelength and emission wavelength are 650 nm and 780 nm, respectively .
    NFL-NH2
  • HY-176783
    GNE-5152

    		Toll-like Receptor (TLR) Neurological Disease
    GNE-5152 is an orthosteric SARM1 base-exchange (BE) inhibitor. GNE-5152 sustainably activates SARM1 at subinhibitory concentrations under mildly activating conditions, and this synergistic adverse effect increases NAD consumption, induces axon degradation and neurodegeneration and releases neurofilament-light (NfL) in cortical neurons. GNE-5152 can be used for neurodegenerative diseases research .
    GNE-5152
  • HY-W611371
    FP802

    		TRP Channel iGluR Neurological Disease
    FP802 is an orally active potent TwinF interface inhibitor that disrupts and detoxifies the NMDAR/TRPM4 death complex. FP802 exerts powerful neuroprotective effects in the 5xFAD mouse model of Alzheimer’s disease (AD) by preventing cognitive decline, preserving neuronal structural integrity, reducing amyloid-β plaque formation, and mitigating mitochondrial pathology . FP802 stops loss of motor neurons, reduces serum neurofilament light chain (NfL) levels, improves motor performance, and extends life in a mouse model of amyotrophic lateral sclerosis (ALS) . FP802 can be used for AD and ALS research [1][2].
    FP802
  • HY-RS23998
    Nefl Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Nefl Rat Pre-designed siRNA Set A contains three designed siRNAs for Nefl gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Nefl Rat Pre-designed siRNA Set A
    Nefl Rat Pre-designed siRNA Set A
  • HY-RS17540
    Nefl Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Nefl Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nefl gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Nefl Mouse Pre-designed siRNA Set A
    Nefl Mouse Pre-designed siRNA Set A
  • HY-RS09184
    NEFL Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    NEFL Human Pre-designed siRNA Set A contains three designed siRNAs for NEFL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    NEFL Human Pre-designed siRNA Set A
    NEFL Human Pre-designed siRNA Set A
  • HY-173276
    SARM1-IN-4

    		Toll-like Receptor (TLR) Neurological Disease
    SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor. After being orally administered at a dose of 50 mg/kg in a mouse model, it can reduce the level of plasma neurofilament light chain (NfL). SARM1-IN-4 prevents programmed axonal degeneration by inhibiting the NAD+ hydrolase activity of SARM1, and it can be used in research related to neurodegenerative diseases and neurological disorders (such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathies, etc.).
    SARM1-IN-4

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