Nef

By Targets:	Apoptosis (1) Cadherin (1) Caspase (1) Chloride Channel (1) CXCR (1) GSK-3 (1) HIV (13) Ligands for E3 Ligase (1) PROTACs (2) Small Interfering RNA (siRNA) (1) Src (2) VEGFR (1)
By Research Areas:	Cancer (4) Infection (10)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138562

*HIV-1 Nef-IN-1*	HIV	Infection
HIV-1 Nef-IN-1 is an HIV-1 Nef protein inhibitor that efficiently competes for Nef-SH3Hck interactions with a K_d of 6.7 μM .

HY-125028

Hck-IN-1 1 Publications Verification	Src HIV	Infection
Hck-IN-1 (compound B9), a diphenylpyrazolo compound, is a selective Nef-dependent Hck inhibitor with IC₅₀s of 2.8 μM, >20 μM for Nef:Hck complex and Hck, respectively. Hck-IN-1 is a direct and wide HIV-1 Nef antagonists with an IC₅₀ of 100-300 nM for wild-type HIV-1 replication. Hck-IN-1 binds pocket residue Asn126 and has anti-retroviral activity .

HY-171862

Nef ligand-2	Ligands for E3 Ligase HIV	Infection
Nef ligand-2 is a binder of *Nef. Nef* ligand-2 is Ligands for E3 Ligase. Nef ligand-2 is the Nef Binder portion of FC-14369 (HY-171860) .

HY-171861

Nef ligand-1	HIV	Cancer
Nef ligand-1 is the Nef binding part of FC-14367 (HY-171859) .

HY-P10971

Nef-M1	CXCR Apoptosis VEGFR GSK-3 Cadherin Caspase	Cancer
Nef-M1 (Nef-Motif-1) is an antagonist peptide targeting CXCR4 and an apoptosis inducer derived from a myristoylated protein encoded by the nef gene in HIV. Nef-M1 inhibits tumor angiogenesis and epithelial-mesenchymal transition (EMT). Nef-M1 activates the apoptosis pathway by increasing the level of caspase-3 in cancer cells. Nef-M1 simultaneously inhibits VEGF-A, p-GSK-3β and vimentin, and enhances E-cadherin, thereby inhibiting angiogenesis and EMT processes. Nef-M1 can be used in the study of colorectal cancer and breast cancer .

HY-121718

DQBS	HIV	Infection
DQBS can bind to HIV-1 nef protein, and inhibits Nef-dependent HIV replication .

HY-119210

ZINC04177596	HIV	Infection
ZINC04177596 is a potent HIV-negative factor *(HIV-Nef) protein* inhibitor. Nef is an accessory gene product of HIV and has an imperative role in viral replication and AIDS pathogenesis .

HY-171860

FC-14369	PROTACs HIV	Cancer
FC-14369 is a PROTAC degrader targeting *HIV-1 Nef* protein with a DC₅₀** value of 160 nM. FC-14369 binds to both Nef and Cereblon E3 ubiquitin ligase via its bifunctional structure, inducing Nef ubiquitination and proteasomal degradation to restore cell-surface CD4 and MHC-I expression and inhibit HIV-1 replication. FC-14369 can be used in research on HIV infection and AIDS . (Pink: Nef ligand-2 (HY-171862); Black: Ethylenediamine (HY-Y0275); Blue: Thalidomide (HY-14658))

HY-171859

FC-14367	PROTACs HIV	Cancer
FC-14367 is a PROTAC degrader targeting *HIV-1 Nef* protein*. FC-14367 forms a ternary complex by binding Nef* and Cereblon E3 ubiquitin ligase, inducing Nef ubiquitination and proteasomal degradation, restoring cell-surface CD4 and MHC-I expression and inhibiting HIV-1 replication. FC-14367 can be used in research on HIV infection and AIDS . (Black: Glycolic acid (HY-W015967); Blue: 2-(2,6-Dioxopiperidin-3-yl)phthalimidine (HY-138793))

HY-120465

ZINC36617540	HIV	Infection
ZINC36617540 is a novel Nef protein inhibitor with anti-HIV activity. ZINC36617540 exhibits superior binding affinity by binding to Nef protein. ZINC36617540 shows a similar binding mode to the prototype molecule B9 in molecular docking. The mechanism of action of ZINC36617540 mainly depends on its hydrophobic and electrostatic interactions with Nef protein .

HY-12693

R(+)-Methylindazone 5 Publications Verification R(+)-IAA-94	Chloride Channel	Others
R(+)-Methylindazone (R(+)-IAA-94) is a potent indanyloxyacetic acid blocker of epithelial chloride channels. R(+)-Methylindazone inhibits Nef-sdAb19 (single-domain antibody) interaction and binds to negative factor (Nef) .

HY-147314

HIV-IN-6	HIV Src	Infection
HIV-IN-6 is a HIV-Ⅰ viral replication inhibitor by targeting Src family kinases (SFK) that interact with Nef protein of the virus, such as Hck .

HY-117472

DLC27-14	HIV	Infection
DLC27-14 is a HIV Nef inhibitor with the IC₅₀ of 15.92 μM. DLC27-14 can be used for study of HIV-1 .

HY-RS12387

S100B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
S100B Human Pre-designed siRNA Set A contains three designed siRNAs for S100B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

S100B Human Pre-designed siRNA Set A S100B Human Pre-designed siRNA Set A

HY-P2260B

Tat-beclin 1 scrambled	HIV	Infection
Tat-beclin 1 scrambled is the scrambled part and a scrambled control of Tat-beclin 1 (HY-P2260), which is derived from a region of the autophagy protein, beclin 1. beclin 1 induces autophagy via binding human immunodeficiency virus, HIV-1 Nef and interacting with negative regulator GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens, such as HIV-1. Tat-beclin 1 also reduces mortality in mice infected with chikungunya or West Nile virus .

HY-P2260C

Tat-beclin 1 scrambled TFA	HIV	Infection
Tat-beclin 1 scrambled TFA is the scrambled part and a scrambled control of Tat-beclin 1 (HY-P2260), which is derived from a region of the autophagy protein, beclin 1. beclin 1 induces autophagy via binding human immunodeficiency virus, HIV-1 Nef and interacting with negative regulator GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens, such as HIV-1. Tat-beclin 1 also reduces mortality in mice infected with chikungunya or West Nile virus .

Cat. No.	Product Name	Target	Research Area

HY-P2260B

Tat-beclin 1 scrambled	HIV	Infection
Tat-beclin 1 scrambled is the scrambled part and a scrambled control of Tat-beclin 1 (HY-P2260), which is derived from a region of the autophagy protein, beclin 1. beclin 1 induces autophagy via binding human immunodeficiency virus, HIV-1 Nef and interacting with negative regulator GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens, such as HIV-1. Tat-beclin 1 also reduces mortality in mice infected with chikungunya or West Nile virus .

HY-P2260C

Tat-beclin 1 scrambled TFA	HIV	Infection
Tat-beclin 1 scrambled TFA is the scrambled part and a scrambled control of Tat-beclin 1 (HY-P2260), which is derived from a region of the autophagy protein, beclin 1. beclin 1 induces autophagy via binding human immunodeficiency virus, HIV-1 Nef and interacting with negative regulator GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens, such as HIV-1. Tat-beclin 1 also reduces mortality in mice infected with chikungunya or West Nile virus .

HY-P10971

Nef-M1	CXCR Apoptosis VEGFR GSK-3 Cadherin Caspase	Cancer
Nef-M1 (Nef-Motif-1) is an antagonist peptide targeting CXCR4 and an apoptosis inducer derived from a myristoylated protein encoded by the nef gene in HIV. Nef-M1 inhibits tumor angiogenesis and epithelial-mesenchymal transition (EMT). Nef-M1 activates the apoptosis pathway by increasing the level of caspase-3 in cancer cells. Nef-M1 simultaneously inhibits VEGF-A, p-GSK-3β and vimentin, and enhances E-cadherin, thereby inhibiting angiogenesis and EMT processes. Nef-M1 can be used in the study of colorectal cancer and breast cancer .

Cat. No.	Compare	Product Name	Species	Source

HY-P700820

	S100B Protein, Canine (HEK293, Fc) Protein S100; S100 calcium-binding; Nef; S100; 100beta; S100-B	Canine	HEK293
	The S100B protein is a small zinc and calcium binding protein abundant in astrocytes with unique calcium and zinc binding sites of varying affinities. Although it binds weakly to calcium, it binds tightly to zinc, and potassium ions antagonize both. S100B Protein, Canine (HEK293, Fc) is the recombinant canine-derived S100B protein, expressed by HEK293 , with N-hFc labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82784

	Neurofilament Medium Antibody (YA2529) NefM; Nef3; NFM; Neurofilament medium polypeptide; NF-M; 160 kDa neurofilament protein; Neurofilament 3; Neurofilament triplet M protein	WB, IHC-P, ICC/IF, IP	Human
	Neurofilament Medium Antibody (YA2529) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2529), targeting Neurofilament Medium, with a predicted molecular weight of 102 kDa (observed band size: 160 kDa). Neurofilament Medium Antibody (YA2529) can be used for WB, IHC-P, ICC/IF, IP experiment in human background.

HY-P80891

	S100B Antibody Nef; Protein S100 B; Protein S100-B; S 100 calcium binding protein beta chain; S 100 protein beta chain; S-100 protein beta chain; S-100 protein subunit beta; S100; S100 calcium binding protein beta (neural); S100 calcium-binding protein B; S100 protein b	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Goat
	S100B Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 11 kDa, targeting to S100B. It can be used for WB,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat, Goat.

HY-P83983

	NEFM Antibody (YA3680) NFM; Nef3; NF-M	ICC/IF, FC, ELISA	Human
	NEFM Antibody (YA3680) is a mouse-derived and non-conjugated IgG1 antibody, targeting to NEFM. It can be applicated for ICC/IF, FC, ELISA assays, in the background of human.

HY-P83943

	S100B Antibody (YA3640) Nef; S100; S100beta	IHC-P, ELISA	Human
	S100B Antibody (YA3640) is a mouse-derived and non-conjugated IgG1 antibody, targeting to S100B. It can be applicated for IHC-P, ELISA assays, in the background of human.

HY-P82322

	alpha Internexin Antibody (YA2067) INA; Nef5; Alpha-internexin; Alpha-Inx; 66 kDa neurofilament protein; NF-66; Neurofilament-66; Neurofilament 5	WB	Human, Mouse, Rat
	alpha Internexin Antibody (YA2067) is a non-conjugated IgG antibody, targeting alpha Internexin, with a predicted molecular weight of 55 kDa (observed band size: 55 kDa). alpha Internexin Antibody (YA2067) can be used for WB experiment in human, mouse, rat background.

HY-P86372

	S100B Antibody (YA6064) Nef; Protein S100 B; Protein S100-B; S 100 calcium binding protein beta chain; S 100 protein beta chain; S-100 protein beta chain; S-100 protein subunit beta; S100; S100 calcium binding protein beta (neural); S100 calcium-binding protein B; S100 protein beta chain; S100B; S100B_HUMAN; S100beta	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	S100B Antibody (YA6064) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to S100B. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS12387

S100B Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
S100B Human Pre-designed siRNA Set A contains three designed siRNAs for S100B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Oligonucleotides

Name
Email *

	Sorry, but the email address you supplied was invalid.