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Results for "

NS5A inhibitor

" in MedChemExpress (MCE) Product Catalog:

57

Inhibitors & Agonists

1

Peptides

1

Natural
Products

9

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-101662
    Pibrentasvir

    ABT-530

    		 HCV Infection
    Pibrentasvir is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with EC50s ranging from 1.4 to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6.
    Pibrentasvir
  • HY-12373
    AV-4025 hydrochloride

    		HCV Protease Influenza Virus Infection
    AV-4025 (hydrochloride) (Compound 13a) is an orally active NS5A inhibitor. AV-4025 is active against the HCV replicon GT1b (EC50 = 0.003 nM). AV-4025 can be used for research on hepatitis C infection .
    AV-4025 hydrochloride
  • HY-123808
    MK-8325

    		HCV Infection
    MK-8325 (Compound 1) is an orally active HCV NS5A inhibitor. MK-8325 exhibits minimal inhibitory activity against hERG at a concentration of 30 mM. MK-8325 may be used in hepatitis C research .
    MK-8325
  • HY-145375
    NS5A-IN-1

    		HCV Protease Infection
    NS5A-IN-1 is a proagent of the HCV NS5A inhibitor Pibrentasvir (ABT-530).
    NS5A-IN-1
  • HY-115982
    NS5A-IN-3

    		HCV Protease Infection
    NS5A-IN-3 (Compound 15) is a potent inhibitor of NS5A. NS5A-IN-3 has extremely high potency against HCV genotype 1b, improved activity against genotype 3a (GT 3a) and good metabolic stability. NS5A-IN-3 exhibits a higher resistance barrier than daclatasvir against genotype 1b . NS5A-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    NS5A-IN-3
  • HY-115981
    NS5A-IN-2

    		HCV Protease Infection
    NS5A-IN-2 (Compound 33) is a potent inhibitor of NS5A. NS5A-IN-2 has extremely high potency against HCV genotype 1b, improved activity against genotype 3a (GT 3a) and good metabolic stability . NS5A-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    NS5A-IN-2
  • HY-123649
    MK-4882

    		HCV Others
    MK-4882 is an HCV NS5A inhibitor with activity in reducing viral load in a chimpanzee model of HCV infection, but with issues of viral breakthrough, prompting the development of compounds with greater potency against more genotypes and NS5A resistance mutations.
    MK-4882
  • HY-145335
    GSK2818713

    		HCV Protease Infection
    GSK2818713 is a novel Hepatitis C NS5A replication complex inhibitor.
    GSK2818713
  • HY-133248
    Daclatasvir Impurity C

    		Drug Metabolite Others
    Daclatasvir Impurity C is the impurity of Daclatasvir. Daclatasvir is a potent HCV NS5A protein inhibitor .
    Daclatasvir Impurity C
  • HY-133247
    Daclatasvir Impurity B

    		Drug Metabolite Others
    Daclatasvir Impurity B is the impurity of Daclatasvir. Daclatasvir is a potent HCV NS5A protein inhibitor .
    Daclatasvir Impurity B
  • HY-117967
    MK-6169

    		HCV Protease Infection
    MK-6169 is a potent, pan-genotypic hepatitis C virus NS5A inhibitor .
    MK-6169
  • HY-168987
    Netanasvir

    		HCV HCV Protease Infection Inflammation/Immunology
    Netanasvir, a NS5A inhibitor, possesses antiviral activity. Netanasvir can be used in the study for HCV study .
    Netanasvir
  • HY-N8188
    Dehydrojuncusol

    		HCV HCV Protease Infection
    Dehydrojuncusol, a potent HCV inhibitor, targets HCV NS5A and is able to inhibit RNA replication of replicons harboring resistance mutations to anti-NS5A direct-acting antivirals. Dehydrojuncusol significantly inhibits HCV infection when added after virus inoculation of HCV genotype 2a (EC50=1.35?μM) .
    Dehydrojuncusol
  • HY-146126
    NS5A-IN-4

    		HCV Protease Infection
    NS5A-IN-4 (Compound 1.12) is an orally active pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with IC50 values of 1.2, 2296, 4.6, 362, 10.3 and 693 pM against gT1b, gT1a, gT2a, gT3a, gT4a and gT5a . NS5A-IN-4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    NS5A-IN-4
  • HY-124182
    Odalasvir

    ACH-3102; JNJ64289901

    		 HCV Infection
    Odalasvir (ACH-3102) is a potent and selective inhibitor of HCV NS5A, and can be used in research on hepatitis C virus infection .
    Odalasvir
  • HY-111087
    AZD-7295

    		HCV Protease Infection Inflammation/Immunology
    AZD-7295 is a HCV NS5A protein inhibitor, with an EC50 of 7 nM for GT-1b replicon .
    AZD-7295
  • HY-120713
    MK-8325 dihydrochloride

    		HCV Infection
    MK-8325 (dihydrochloride) is an inhibitor of HCV NS5A with oral activity. MK-8325 exhibits minimal inhibition on hERG at the concentration of 30 mM .
    MK-8325 dihydrochloride
  • HY-133246
    Monodes(N-carboxymethyl)valine Daclatasvir

    Daclatasvir Impurity A

    		 HCV Infection
    Monodes(N-carboxymethyl)valine Daclatasvir (Daclatasvir Impurity A) is the main degradation product of Daclatasvir. Daclatasvir is a potent HCV NS5A protein inhibitor .
    Monodes(N-carboxymethyl)valine Daclatasvir
  • HY-101663
    Ruzasvir

    MK-8408

    		 HCV Infection
    Ruzasvir (MK-8408) is an orally active inhibitor for genotypic HCV nonstructural protein 5A (NS5A), which inhibits the replication of NS5A mutants GT1a, GT1a L31V, GT1a Y93H, GT2b, GT3a and GT4a with EC90 ranging from 0.003 to 0.067 nM. Ruzasvir exhibits good pharmacokinetic characters in rhesus monkey model .
    Ruzasvir
  • HY-117411A
    Coblopasvir dihydrochloride

    KW-136 dihydrochloride

    		 HCV HCV Protease Infection
    Coblopasvir (KW-136) dihydrochloride is a pangenotypic non-structural protein 5A (NS5A) inhibitor. Coblopasvir dihydrochloride can be used for research of chronic hepatitis C virus infection .
    Coblopasvir dihydrochloride
  • HY-147358A
    Yimitasvir

    Emitasvir; DAG-181

    		 HCV Infection
    Yimitasvir (Emitasvir) is an orally active hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor. Yimitasvir can be used for research of chronic HCV infection .
    Yimitasvir
  • HY-117411
    Coblopasvir

    KW-136

    		 HCV HCV Protease Infection Inflammation/Immunology
    Coblopasvir (KW-136) is a pangenotypic non-structural protein 5A (NS5A) inhibitor. Coblopasvir can be used for research of chronic hepatitis C virus infection .
    Coblopasvir
  • HY-15602B
    Ledipasvir D-tartrate
    30+ Cited Publications

    GS-5885 D-tartrate

    		 HCV Infection
    Ledipasvir D-tartrate is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.
    Ledipasvir D-tartrate
  • HY-136267
    HCV-IN-30

    		HCV Infection
    HCV-IN-30 (compound 48) is a HCV NS5A replication complex inhibitor, with IC50s of 901 and 102 nM for genotypes 1a and 1b replicons, respectively .
    HCV-IN-30
  • HY-147358
    Yimitasvir diphosphate

    Emitasvir diphosphate; DAG-181 diphosphate

    		 HCV Infection
    Yimitasvir (Emitasvir) diphosphate is an orally active hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor and can be used for research of chronic hepatitis C virus infection .
    Yimitasvir diphosphate
  • HY-147358C
    (1R,4S)-Yimitasvir diphosphate

    (1R,4S)-Emitasvir diphosphate; (1R,4S)-DAG-181 diphosphate

    		 HCV Infection
    Yimitasvir (Emitasvir) diphosphate is an orally active hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor and can be used for research of chronic hepatitis C virus infection .
    (1R,4S)-Yimitasvir diphosphate
  • HY-13997
    Ombitasvir
    5+ Cited Publications

    ABT-267

    		 HCV Infection
    Ombitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5, and 366 pM against genotype 6a.
    Ombitasvir
  • HY-15789
    Elbasvir
    5+ Cited Publications

    MK-8742

    		 HCV Infection
    Elbasvir (MK-8742) is a hepatitis C virus nonstructural protein 5A (HCV NS5A) inhibitor with EC50s of 4, 3 and 3 nM against genotype 1a, 1b, and 2a, respectively.
    Elbasvir
  • HY-15602D
    Ledipasvir (diacetone)

    GS-5885 (diacetone)

    		 HCV Infection
    Ledipasvir diacetone (GS-5885 diacetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.
    Ledipasvir (diacetone)
  • HY-15602A
    Ledipasvir (acetone)
    30+ Cited Publications

    GS-5885 (acetone)

    		 HCV Infection
    Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.
    Ledipasvir (acetone)
  • HY-16784
    Samatasvir
    1 Publications Verification

    IDX719; IDX18719

    		 HCV HCV Protease Infection
    Samatasvir (IDX71) is a potent, orally active NS5A inhibitor of HCV replication. Samatasvir is effective and selective against infectious HCV and replicons, with EC50s falling within a tight range of 2 to 24 pM in genotype 1 through 5 replicons .
    Samatasvir
  • HY-15602C
    Ledipasvir hydrochloride

    GS-5885 hydrochloride

    		 HCV SARS-CoV Infection
    Ledipasvir (GS-5885) hydrochloride is an inhibitor of the hepatitis C virus NS5A, with EC50s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir hydrochloride is also a SARS-CoV 3CL pro inhibitor with an IC50 of 1.62 μM .
    Ledipasvir hydrochloride
  • HY-15602
    Ledipasvir
    30+ Cited Publications

    GS-5885

    		 HCV SARS-CoV Infection
    Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC50s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 1.62 μM .
    Ledipasvir
  • HY-114216
    DBPR110

    		Endogenous Metabolite Infection
    DBPR110 is a nonstructural protein 5A (NS5A) inhibitor with inhibitory activity against hepatitis C virus (HCV). DBPR110 exhibited a 50% effective concentration (EC50) of 3.9 ± 0.9 pM and a selectivity index value of over 12,800,000 by reducing HCV1b replicon reporter expression. DBPR110 also effectively reduced the activity of HCV2a replicon with an EC50 of 228.8 pM and a selectivity index value of over 173,130. DBPR110 showed synergy with interferon alpha (IFN-α), NS3 protease inhibitors, and NS5B polymerase inhibitors. The results of DBPR110 suggest that it may be an effective small molecule inhibitor against HCV NS5A .
    DBPR110
  • HY-13997R
    Ombitasvir (Standard)

    		HCV Infection
    Ombitasvir (Standard) is the analytical standard of Ombitasvir. This product is intended for research and analytical applications. Ombitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5, and 366 pM against genotype 6a.
    Ombitasvir (Standard)
  • HY-15789R
    Elbasvir (Standard)

    MK-8742 (Standard)

    		 Reference Standards HCV Infection
    Elbasvir (Standard) is the analytical standard of Elbasvir. This product is intended for research and analytical applications. Elbasvir (MK-8742) is a hepatitis C virus nonstructural protein 5A (HCV NS5A) inhibitor with EC50s of 4, 3 and 3 nM against genotype 1a, 1b, and 2a, respectively.
    Elbasvir (Standard)
  • HY-12530
    Velpatasvir
    5+ Cited Publications

    GS-5816

    		 HCV SARS-CoV Infection Inflammation/Immunology Cancer
    Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. Velpatasvir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 2.16 μM .
    Velpatasvir
  • HY-15602S
    Ledipasvir-d6

    GS-5885-d6

    		 HCV SARS-CoV Infection
    Ledipasvir-d6 is the deuterium labeled Ledipasvir. Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC50s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.62 μM .
    Ledipasvir-d6
  • HY-133246A
    Monodes(N-carboxymethyl)valine Daclatasvir TFA

    Daclatasvir Impurity A TFA

    		 HCV Infection
    Monodes(N-carboxymethyl)valine Daclatasvir TFA (Daclatasvir Impurity A TFA) is the TFA salt form of Monodes(N-carboxymethyl)valine Daclatasvir (HY-133246). Monodes(N-carboxymethyl)valine Daclatasvir TFA is the main degradation product of Daclatasvir (HY-10466). Daclatasvir is a potent HCV NS5A protein inhibitor .
    Monodes(N-carboxymethyl)valine Daclatasvir TFA
  • HY-15602AS
    Ledipasvir-d6 hydrochloride

    GS-5885-d6 hydrochloride

    		 HCV Isotope-Labeled Compounds Infection
    Ledipasvir-d6 hydrochloride is deuterated labeled Ledipasvir acetone (HY-15602A). Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.
    Ledipasvir-d6 hydrochloride
  • HY-133018
    HCV-IN-7

    		HCV Infection
    HCV-IN-7 is an orally active and potent pan-genotypic HCV NS5A inhibitor with IC50s of 3-47 pM. HCV-IN-7 shows a superior pan-genotypic profile and a good pharmacokinetic profile coupled with a favorable liver uptake. HCV-IN-7 has anti-viral activity .
    HCV-IN-7
  • HY-133018A
    HCV-IN-7 hydrochloride

    		HCV Cancer
    HCV-IN-7 hydrochloride is an orally active and potent pan-genotypic HCV NS5A inhibitor with IC50s of 3-47 pM. HCV-IN-7 hydrochloride shows a superior pan-genotypic profile and a good pharmacokinetic profile coupled with a favorable liver uptake. HCV-IN-7 hydrochloride has anti-viral activity .
    HCV-IN-7 hydrochloride
  • HY-124191
    Ravidasvir hydrochloride

    PPI-668 hydrochloride

    		 HCV Infection
    Ravidasvir hydrochloride (PPI-668 hydrochloride) is a pan-genotypic inhibitor for hepatitis C virus (HCV) NS5A protein. Ravidasvir hydrochloride inhibits the replication of HCV, with EC50 of 0.12, 0.01 and 1.14 nM, for HCV gt-1a, gt-1b, and gt-3a replicons, respectively. Ravidasvir hydrochloride exhibits good pharmacokinetic characters in rats .
    Ravidasvir hydrochloride
  • HY-P0162
    HCV-IN-4

    		HCV Infection
    HCV-IN-4 is a potent and orally active HCV NS5A inhibitor, shows great potency against GT1a, GT2b, GT3a, GT1a Y93H and GT1a L31V, with EC90s of 3 pM, 0.3 nM, 0.01 nM, 0.5 nM and 0.02 nM, respectively .
    HCV-IN-4
  • HY-15602S1
    Ledipasvir-d16

    GS-5885-d16

    		 Isotope-Labeled Compounds HCV SARS-CoV Infection
    Ledipasvir-d16 (GS-5885-d16) is deuterium labeled Ledipasvir. Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC50s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 1.62 μM .
    Ledipasvir-d16
  • HY-12530R
    Velpatasvir (Standard)

    GS-5816 (Standard)

    		 Reference Standards HCV SARS-CoV Infection Inflammation/Immunology Cancer
    Velpatasvir (Standard) is the analytical standard of Velpatasvir. This product is intended for research and analytical applications. Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. Velpatasvir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 2.16 μM .
    Velpatasvir (Standard)
  • HY-10466
    Daclatasvir
    Maximum Cited Publications
    47 Publications Verification

    BMS-790052; EBP 883

    		 HCV Infection
    Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC50s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC50s of 1.5 µM and 3.27 µM, respectively .
    Daclatasvir
  • HY-10465
    Daclatasvir dihydrochloride
    Maximum Cited Publications
    47 Publications Verification

    BMS-790052 dihydrochloride; EBP 883 dihydrochloride

    		 HCV Infection
    Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) is a potent and orally active HCV NS5A protein inhibitor with EC50s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir dihydrochloride is also an organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC50s of 1.5 μM and 3.27 μM, respectively .
    Daclatasvir dihydrochloride
  • HY-10466S
    Daclatasvir-d6

    BMS-790052-d6; EBP 883-d6

    		 Isotope-Labeled Compounds HCV Infection
    Daclatasvir-d6 is deuterium labeled Daclatasvir. Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC50s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC50s of 1.5 μM and 3.27 μM, respectively .
    Daclatasvir-d6
  • HY-12530S1
    Velpatasvir-d3

    GS-5816-d33

    		 Isotope-Labeled Compounds SARS-CoV HCV Infection Inflammation/Immunology Cancer
    Velpatasvir-d3 (GS-5816-d3) is deuterium labeled Velpatasvir. Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. Velpatasvir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 2.16 μM .
    Velpatasvir-d3

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