N-Myc

By Targets:	c-Myc (4) Apoptosis (5) Aurora Kinase (5) Bcr-Abl (1) DAPK (1) Histone Methyltransferase (1) Isocitrate Dehydrogenase (IDH) (1) Nuclear Hormone Receptor 4A/NR4A (1) PERK (1) PROTACs (2) Reference Standards (1) Small Interfering RNA (siRNA) (3) Transferrin Receptor (1)
By Research Areas:	Cancer (12)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Targets Recommended: c-Myc

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2068

Didymin 3 Publications Verification	Apoptosis	Cancer
Didymin, a flavonoid glycoside, possesses antioxidant and anticancer properties. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma .

HY-144878

VPC-70619 2 Publications Verification	c-Myc	Cancer
VPC-70619 is a potent, orally active *N-Myc* inhibitor. VPC-70619 blocks the N-Myc-Max heterocomplex from binding to DNA E-boxes and demonstrated strong inhibition activity against N-Myc-dependent cell lines as well as high bioavailability in both oral and intraperitoneal administration .

HY-134761

EN4	c-Myc	Cancer
EN4 is a covalent ligand that targets cysteine 171 (C171) of MYC. EN4 is selective for c-MYC over N-MYC and L-MYC. EN4 inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis .

HY-162470

DBPR728	Aurora Kinase	Cancer
DBPR728 is an acyl prodrug of 6K465 that carries fewer hydrogen bond donors. 6K465 acts as an Aurora kinase inhibitor that destabilizes MYC family cancer proteins and has antitumor efficacy. DBPR728 has the potential to inhibit cancers that overexpress C-MYC and N-MYC, with a 10-fold increase in oral bioavailability compared to 6K465 .

HY-171769

dAurAB2	PROTACs Aurora Kinase	Cancer
dAurAB2 is a dual-degrading PROTAC that potently degrades Aurora-A and Aurora-B with DC₅₀s of 59 nM and 39 nM, respectively. dAurAB2 reduces N-Myc levels in MYCN-amplified IMR32 neuroblastoma cells. dAurAB2 can be used for the study of neuroblastoma. (Pink, Aurora ligand (HY-10804); Blue, E3 ligand: (HY-103597); Black, linker (HY-W105740)) .

HY-115832

Ap44mSe	Transferrin Receptor	Cancer
Ap44mSe is a selenosemicarbazone that effectively depletes cellular Fe, resulting in transferrin receptor-1 up-regulation, ferritin down-regulation, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1. Ap44mSe forms redox active Cu complexes that target the lysosome to induce lysosomal membrane permeabilization .

HY-125090

PHA-680626	Aurora Kinase c-Myc Bcr-Abl Histone Methyltransferase Apoptosis	Cancer
PHA-680626 is an effective inhibitor of the interaction between Aurora-A and *N-Myc. PHA-680626 inhibits kinase activity of AURKA and Bcr-Abl, and induces N-Myc* degradation. PHA-680626 decreases phosphorylation of CrkL and histone H3. PHA-680626 shows anti-proliferative and pro-apoptotic activity on Imatinib (HY-15463)-resistant chronic myeloid leukemia cell lines and primary CD34+ cells .

HY-162469

6K465	Aurora Kinase c-Myc	Cancer
6K465 is a pyrimidine-based Aurora A (AURKA) inhibitor. 6K465 can reduce the levels of c-MYC and *N-MYC* oncoproteins, demonstrating anticancer activity .

HY-N2068R

Didymin (Standard)	Reference Standards Apoptosis	Cancer
Didymin (Standard) is the analytical standard of Didymin. This product is intended for research and analytical applications. Didymin, a flavonoid glycoside, possesses antioxidant and anticancer properties. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma .

HY-168439

HLB-0532259	PROTACs Aurora Kinase	Cancer
HLB-0532259 is a PROTAC degrader for Aurora-A and *N-Myc. HLB-0532259 degrades Aurora-Ain a non-MYCN amplified MCF-7 with a DC₅₀* of 20.2 nM, degrades *N-Myc* in MYCN amplified cells SK-N-BE and Kelly with DC₅₀ of 179 nM and 229 nM. HLB-0532259 exhibits antitumor efficacy in mouse models . (Pink: ligand for target protein (HY-168440); Black: linker (HY-W007957); Blue: ligand for E3 ligase Cereblon (HY-41547))

HY-153356

MRT-2359	Apoptosis	Cancer
MRT-2359 is a potent, orally active and selective GSPT1 depressant (IC₅₀: >30 nM and <300 nM) that specifically induces apoptosis dependent on protein translation. MRT-2359 exhibits significant and preferred anti-proliferative activity in a variety of cancer cell lines, especially MYC-driven cell lines, such as non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) with high expression of N-Myc or L-Myc. MRT-2359 inhibits the growth of drug-resistant NSCLC and SCLC cells, making it suitable for cancer research .

HY-RS23748

Mycn Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mycn Rat Pre-designed siRNA Set A contains three designed siRNAs for Mycn gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mycn Rat Pre-designed siRNA Set A Mycn Rat Pre-designed siRNA Set A

HY-112056

DIM-C-pPhCO2Me 1 Publications Verification	Nuclear Hormone Receptor 4A/NR4A Apoptosis DAPK Isocitrate Dehydrogenase (IDH) PERK	Cancer
DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhCO2Me induces Apoptosis. DIM-C-pPhCO2Me decreases PAX3-FOXO1A, *N-Myc, Rassf4, MyoD1, Grem1, and DAPK1* proteins. DIM-C-pPhCO2Me decreases expression of TXNDC5 and IDH1, induces markers of ER stress (CHOP, ATF4 and p-PERK). DIM-C-pPhCO2Me inhibits renal cell carcinoma, breast cancer. DIM-C-pPhCO2Me can also be used in rhabdomyosarcoma research .

HY-RS17293

Mycn Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mycn Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mycn gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mycn Mouse Pre-designed siRNA Set A Mycn Mouse Pre-designed siRNA Set A

HY-RS08884

MYCN Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MYCN Human Pre-designed siRNA Set A contains three designed siRNAs for MYCN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MYCN Human Pre-designed siRNA Set A MYCN Human Pre-designed siRNA Set A

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2068

Didymin 3 Publications Verification	Structural Classification Monophenols Flavonoids Classification of Application Fields Flavonones Source classification Rutaceae Phenols Plants Citrus Disease Research Fields Cancer	Apoptosis
Didymin, a flavonoid glycoside, possesses antioxidant and anticancer properties. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma .

HY-N2068R

Didymin (Standard)	Structural Classification Monophenols Flavonoids Flavonones Source classification Rutaceae Phenols Plants Citrus	Reference Standards Apoptosis
Didymin (Standard) is the analytical standard of Didymin. This product is intended for research and analytical applications. Didymin, a flavonoid glycoside, possesses antioxidant and anticancer properties. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma .

Species:	Human (2)
Tag:	His (2)
Source:	Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P70886

	NDRG1 Protein, Human (His) Protein NDRG1; Differentiation-Related Gene 1 Protein; DRG-1; N-Myc Downstream-Regulated Gene 1 Protein; Nickel-Specific Induction Protein Cap43; Reducing Agents and TunicaMycin-Responsive Protein; RTP; Rit42; NDRG1; CAP43; DRG1; RTP	Human	E. coli
	NDRG1 is a stress-responsive protein and an important tumor suppressor involved in hormone response and cell growth. It aids in Schwann cell transport, which is essential for the development of myelin in peripheral nerves. NDRG1 Protein, Human (His) is the recombinant human-derived NDRG1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P702776

	MYCN Protein, Human (sf9, His) bHLHe37; Class E basic helix-loop-helix protein 37; MODED; Mycn; Oncogene NMyc; pp65/67	Human	Sf9 insect cells
	The MYCN protein is critical in neuroblastoma cells and can positively regulate MYCNOS transcription through DNA binding, requiring heterodimerization with MAX. Interactions with KDM5A, KDM5B, and HUWE1 indicate involvement in multiple cellular processes. MYCN Protein, Human (Sf9, His) is the recombinant human-derived MYCN, expressed by Sf9 insect cells, with C-6*His labeled tag.

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HY-P83939

	MYCN Antibody (YA3636) NMyc; ODED; MODED; N-Myc; bHLHe37	IHC-P, FC, ELISA	Human
	MYCN Antibody (YA3636) is a mouse-derived and non-conjugated IgG1 antibody, targeting to MYCN. It can be applicated for IHC-P, FC, ELISA assays, in the background of human.

HY-P86982

	NDRG3 Antibody (YA6675) FLJ13556 antibody; N Myc downstream regulated gene 3 antibody; N-Myc downstream-regulated gene 3 protein antibody; NDRG family member 3 antibody; NDRG3 antibody; NDRG3_HUMAN antibody; Protein Ndr3 antibody; Protein NDRG3 antibody	WB, IHC-P, FC	Human, Rat

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Cat. No.	Product Name		Classification

HY-RS23748

Mycn Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Mycn Rat Pre-designed siRNA Set A contains three designed siRNAs for Mycn gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17293

Mycn Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Mycn Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mycn gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS08884

MYCN Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MYCN Human Pre-designed siRNA Set A contains three designed siRNAs for MYCN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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