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Results for "

MTA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Endogenous Metabolite (3) Histone Methyltransferase (18) Influenza Virus (1) Isotope-Labeled Compounds (1) Microtubule/Tubulin (1) Parasite (2) Reference Standards (2) Small Interfering RNA (siRNA) (7)
By Research Areas:	Cancer (21) Infection (1) Metabolic Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (3) siRNAs (7)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS19921

Mta1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mta1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mta1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mta1 Mouse Pre-designed siRNA Set A Mta1 Mouse Pre-designed siRNA Set A

HY-RS27290

Mta2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mta2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mta2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mta2 Rat Pre-designed siRNA Set A Mta2 Rat Pre-designed siRNA Set A

HY-RS08747

MTA2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MTA2 Human Pre-designed siRNA Set A contains three designed siRNAs for MTA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MTA2 Human Pre-designed siRNA Set A MTA2 Human Pre-designed siRNA Set A

HY-RS08748

MTA3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MTA3 Human Pre-designed siRNA Set A contains three designed siRNAs for MTA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MTA3 Human Pre-designed siRNA Set A MTA3 Human Pre-designed siRNA Set A

HY-RS20776

Mta2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mta2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mta2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mta2 Mouse Pre-designed siRNA Set A Mta2 Mouse Pre-designed siRNA Set A

HY-RS26423

Mta1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mta1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mta1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mta1 Rat Pre-designed siRNA Set A Mta1 Rat Pre-designed siRNA Set A

HY-RS08746

MTA1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MTA1 Human Pre-designed siRNA Set A contains three designed siRNAs for MTA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MTA1 Human Pre-designed siRNA Set A MTA1 Human Pre-designed siRNA Set A

HY-174983

*PRMT5-MTA-IN-6*	Histone Methyltransferase	Cancer
PRMT5-MTA-IN-6 (Compound 31) is a selective *MTA*-cooperative PRMT5 inhibitor. PRMT5-MTA-IN-6 exhibits potent inhibitory activity against *PRMT5・MTA* (IC₅₀: 6.6 nM). PRMT5-MTA-IN-6 selectively inhibits the growth of MTAP-deleted HCT-116 cells (IC₅₀: 319 nM). PRMT5-MTA-IN-6 can be used in the research of MTAP-deleted tumors .

HY-176702

*PRMT5-MTA-IN-5*	Histone Methyltransferase	Cancer
PRMT5-MTA-IN-5 (Compound 7) is an orally active, irreversible PRMT5-MTA complex (PRMT5•MTA) inhibitor (IC₅₀=1.15 nM). PRMT5-MTA-IN-5 blocks arginine methylation and inhibits ribosomal RNA processing and cell cycle-related protein expression. PRMT5-MTA-IN-5 potently inhibits proliferation in MTAP-deficient tumor cells. PRMT5-MTA-IN-5 is promising for research of MTAP-deficient solid tumors, such as liver, breast, and pancreatic cancers .

HY-163799

*PRMT5-MTA-IN-1*	Histone Methyltransferase	Cancer
PRMT5-MTA-IN-1 (Compound A9a) is an inhibitor for protein arginine methyltransferase *PRMT5-MTA. PRMT5-MTA-IN-1 inhibits the proliferation of colorectal cancer cell HCT116 wildtype and MTAP del mutant, with an IC₅₀* of 16 nM and 2.47 μM. PRMT5-MTA-IN-1 exhibits good liver microsomal stability and film permeability. PRMT5-MTA-IN-1 exhibits good pharmacokinetic characteristics in CD-1 mice .

HY-162989

*PRMT5-MTA-IN-2*	Histone Methyltransferase	Cancer
PRMT5-MTA-IN-2 (compund 1) is a MTA co-inhibitor of PRMT5 with IC₅₀ less than 1.5 nM .

HY-172733S

*PRMT5-MTA-IN-3-d3*	Isotope-Labeled Compounds Histone Methyltransferase	Cancer
PRMT5-MTA-IN-3-d₃ (compound P22) is the deuterium labeled PRMT5-MTA-IN-3 (HY-172733). PRMT5-MTA-IN-3-d₃ is an orally active *PRMT5-MTA* inhibitor. PRMT5-MTA-IN-3-d₃ has antiproliferative effects on HTC116-MTAP del and wild type colorectal cancer HCT-116 cell lines, with IC₅₀ values of 6 nM and 961 nM, respectively. PRMT5-MTA-IN-3-d₃ has anticancer effects, especially for MTAP-deficient tumors, such as non-small cell lung cancer (NSCLC), pancreatic cancer .

HY-139611

Navlimetostat 3 Publications Verification MRTX-1719	Histone Methyltransferase	Cancer
Navlimetostat is a potent, orally active, selective *PRMT5•MTA* complex inhibitor, with IC₅₀ of 3.6 and 20.5 nM for *PRMT5•MTA* and PRMT5. Navlimetostat binds to the *PRMT5•MTA* complex, with KD value of 0.14 pM. Navlimetostat shows antineoplastic activity in vitro and in vivo, and can be used for cancer study .

HY-176701

*PRMT5-MTA-IN-4*	Histone Methyltransferase	Cancer
PRMT5-MTA-IN-4 (Compound 30) is a potent irreversible protein arginine methyltransferase 5 (PRMT5) inhibitor (IC₅₀=8 nM). PRMT5-MTA-IN-4 blocks arginine methylation, inhibiting ribosomal RNA processing and cell cycle-related protein expression. PRMT5-MTA-IN-4 exhibits antiproliferative activity in multiple tumor cell lines (e.g., IC₅₀=0.3 μM in DLD-1 cells). PRMT5-MTA-IN-4 is promising for research of hematological malignancies, such as acute myeloid leukemia, diffuse large B-cell lymphoma .

HY-172733

*PRMT5-MTA-IN-3*	Histone Methyltransferase	Cancer
PRMT5-MTA-IN-3 (Compound P2A) is an orally active and selective protein arginine methyltransferase 5 (PRMT5) inhibitor. PRMT5-MTA-IN-3 inhibits cell proliferation in the MTAP-deficient colorectal cancer HCT - 116 cell line with an IC₅₀ value of 5 nM. PRMT5-MTA-IN-3 is promising for research of cancers, especially for MTAP-deficient tumors, such as colorectal cancer, non-small cell lung cancer, pancreatic cancer .

HY-139611B

(S)-Navlimetostat (S)-MRTX-1719	Histone Methyltransferase	Cancer
(S)-Navlimetostat (example 16-7) is the S-enantiomer of Navlimetostat. (S)-Navlimetostat is a *PRMT5/MTA* complex inhibitor, with an IC₅₀ of 7070 nM .

HY-156680

TNG-462	Histone Methyltransferase	Cancer
TNG-462 is an orally active and selective PRMT5 inhibitor with anti-tumor activity against methylthioadenosine phosphorylase (MTAP) deficiency and/or methylthioadenosine (MTA) accumulation cancers .

HY-163737

ST-401	Microtubule/Tubulin	Cancer
ST-401, a microtubule-targeting agent (MTA), is a brain-penetrant microtubule (MT) assembly inhibitor. ST-401 disrupts microtubule (MT) function through gentle and reverisible reduction in MT assembly that triggers mitotic delay and cell death in interphase. ST-401 shows a potent antitumor activity .

HY-139611C

Navlimetostat hydrochloride 3 Publications Verification MRTX-1719 hydrochloride	Histone Methyltransferase	Cancer
Navlimetostat hydrochloride is a potent first-in-class selective inhibitor of the *PRMT5/MTA* complex, with an IC₅₀ of less than 10 nM in PRMT5/MTA MTAP ^DEL SDMA cells .

HY-138684

MRTX9768	Histone Methyltransferase	Cancer
MRTX9768 is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor .

HY-138684A

MRTX9768 hydrochloride	Histone Methyltransferase	Cancer
MRTX9768 hydrochloride is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor .

HY-153390

AMG-193	Histone Methyltransferase	Cancer
AMG 193 is an orally active MTA-cooperative PRMT5 inhibitor with antitumor activity. AMG 193, when complexed with MTA, preferentially inhibits the growth of MTAP-deficient tumor cells by inhibiting PRMT5 (IC₅₀=0.107 μM), thereby protecting normal cells with wild-type MTAP .

HY-153390A

(R)-AMG-193	Histone Methyltransferase	Cancer
(R)-AMG-193 is an isomer of AMG 193 (HY-153390). AMG 193 is an orally active MTA-cooperative PRMT5 inhibitor with antitumor activity. AMG 193, when complexed with MTA, preferentially inhibits the growth of MTAP-deficient tumor cells by inhibiting PRMT5 (IC₅₀=0.107 μM), thereby protecting normal cells with wild-type MTAP .

HY-158143

PRMT5-IN-34	Histone Methyltransferase	Cancer
PRMT5-IN-34 (Compound C) is an inhibitor of MTA-cooperative Protein arginine methyltransferase 5 (PRMT5/MAT) .

HY-168842

PRMT5-IN-47	Histone Methyltransferase	Cancer
PRMT5-IN-47 (compound 20) is a potent, selectively and orally active, MTA cooperative PRMT5 inhibitor with an IC₅₀ value of 15 nM. PRMT5-IN-47 shows antiproliferative activity. PRMT5-IN-47 shows anticancer activity .

HY-162783

AZ-PRMT5i-1	Histone Methyltransferase	Cancer
AZ-PRMT5i-1 (Compound 28) is an effective and orally active MTAP-selective PRMT5 inhibitor. AZ-PRMT5i-1 also demonstrates MTA cooperativity and exhibits both in vitro and in vivo antitumor activities, and can be used to study MTAP-deficient cancers .

HY-16938

5'-Methylthioadenosine 5 Publications Verification 5'-(Methylthio)-5'-deoxyadenosine; 5'-Deoxy-5'-(methylthio)adenosine; 5'-S-Methyl-5'-thioadenosine	Endogenous Metabolite Apoptosis Parasite	Metabolic Disease Cancer
5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis . 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis .

HY-16938R

5'-Methylthioadenosine (Standard) 5'-(Methylthio)-5'-deoxyadenosine (Standard); 5'-Deoxy-5'-(methylthio)adenosine (Standard); 5'-S-Methyl-5'-thioadenosine (Standard)	Reference Standards Endogenous Metabolite Apoptosis Parasite	Metabolic Disease Cancer
5'-Methylthioadenosine (Standard) is the analytical standard of 5'-Methylthioadenosine. This product is intended for research and analytical applications. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2].

HY-N0086R

N6-Methyladenosine (Standard) 6-Methyladenosine (Standard); N-Methyladenosine (Standard)	Endogenous Metabolite Influenza Virus Reference Standards	Infection
N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion . N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-16938

5'-Methylthioadenosine 5 Publications Verification 5'-(Methylthio)-5'-deoxyadenosine; 5'-Deoxy-5'-(methylthio)adenosine; 5'-S-Methyl-5'-thioadenosine	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis Parasite
5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis . 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis .

HY-N0086R

N6-Methyladenosine (Standard) 6-Methyladenosine (Standard); N-Methyladenosine (Standard)	Structural Classification Natural Products Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite Influenza Virus Reference Standards
N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion . N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits .

HY-16938R

5'-Methylthioadenosine (Standard) 5'-(Methylthio)-5'-deoxyadenosine (Standard); 5'-Deoxy-5'-(methylthio)adenosine (Standard); 5'-S-Methyl-5'-thioadenosine (Standard)	Structural Classification Natural Products Microorganisms Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite Apoptosis Parasite
5'-Methylthioadenosine (Standard) is the analytical standard of 5'-Methylthioadenosine. This product is intended for research and analytical applications. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2].

Species:	Human (2)
Tag:	GST (1) Flag (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P702912

	METTL3 Protein, Human (sf9, FLAG) MTA70	Human	Sf9 insect cells
	METTL3 Protein, Human (sf9, FLAG) is the recombinant human-derived METTL3, expressed by Sf9 insect cells , with N-Flag labeled tag. ,

HY-P703029

	METTL3 Protein, Human (sf9, GST) MTA70	Human	Sf9 insect cells
	METTL3 Protein, Human (sf9, GST) is the recombinant human-derived METTL3, expressed by Sf9 insect cells , with GST labeled tag. ,

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HY-172733S

*PRMT5-MTA-IN-3-d3*
PRMT5-MTA-IN-3-d₃ (compound P22) is the deuterium labeled PRMT5-MTA-IN-3 (HY-172733). PRMT5-MTA-IN-3-d₃ is an orally active *PRMT5-MTA* inhibitor. PRMT5-MTA-IN-3-d₃ has antiproliferative effects on HTC116-MTAP del and wild type colorectal cancer HCT-116 cell lines, with IC₅₀ values of 6 nM and 961 nM, respectively. PRMT5-MTA-IN-3-d₃ has anticancer effects, especially for MTAP-deficient tumors, such as non-small cell lung cancer (NSCLC), pancreatic cancer .

PRMT5-MTA-IN-3-d3

PRMT5-MTA-IN-3-d₃ (compound P22) is the deuterium labeled PRMT5-MTA-IN-3 (HY-172733). PRMT5-MTA-IN-3-d₃ is an orally active PRMT5-MTA inhibitor. PRMT5-MTA-IN-3-d₃ has antiproliferative effects on HTC116-MTAP del and wild type colorectal cancer HCT-116 cell lines, with IC₅₀ values of 6 nM and 961 nM, respectively. PRMT5-MTA-IN-3-d₃ has anticancer effects, especially for MTAP-deficient tumors, such as non-small cell lung cancer (NSCLC), pancreatic cancer .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P84536

	MTA1 Antibody (YA4233)	WB, FC, ELISA	Human
	MTA1 Antibody (YA4233) is a mouse-derived and non-conjugated IgG2b antibody, targeting to MTA1. It can be applicated for WB, FC, ELISA assays, in the background of human.

HY-P83599

	MTA2 Antibody (YA3344) Mata1l1; Metastasis associated gene 1 like 1; Metastasis associated gene family member 2; MMTA2; MTA1L1; p53 target protein in deacetylase complex; PID	WB, IHC-P, ICC/IF, FC	Human
	MTA2 Antibody (YA3344) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3344), targeting MTA2, with a predicted molecular weight of 75 kDa (observed band size: 75 kDa). MTA2 Antibody (YA3344) can be used for WB, IHC-P, ICC/IF, FC experiment in human background.

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Mta1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Mta1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mta1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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