Search Result

Results for "

MRE11

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) ATM/ATR (2) Endonuclease (5) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (7)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-120951

PFM39	Endonuclease	Cancer
PFM39, a Mirin analog, is a potent and selective MRE11 exonuclease inhibitor. PFM39 inhibits phosphate rotation for dsDNA exonuclease activity. PFM39 does not inhibit TmMre11 or human MRE11/MRN endonuclease activity .

HY-19959

Mirin 5 Publications Verification	ATM/ATR Apoptosis	Cancer
Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC₅₀=12 μM) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activity. Mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells. Mirin prevents ATM activation in response to DNA double-strand breaks (DSBs) and blocks homology-directed repair (HDR) in mammalian cells .

HY-116770

PFM01 4 Publications Verification	Endonuclease	Cancer
PFM01, N-alkylated Mirin derivative, is a MRE11 endonuclease inhibitor. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR) .

HY-148078

PFM03 2 Publications Verification	Endonuclease	Others
PFM03 is a MRE11 Endonuclease inhibitor. PFM03 regulates DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) .

HY-170844

MU147	Endonuclease	Cancer
MU147 is an *MRE11* nuclease inhibitor and chemical probe with anticancer activity, which is lethal to Ehrlich ascites tumor cells both in vitro and in vivo. MU147 also eliminates the double-strand break repair mechanism dependent on the MRE11 nuclease activity without impairing the activation of ATM. MU147 also impairs the degradation of nascent strands of stalled replication FOX and selectively affects brca2-deficient cells .

HY-117693

(E/Z)-Mirin Maximum Cited Publications 7 Publications Verification	ATM/ATR	Cancer
(E/Z)-Mirin is a mixture of (E)-Mirin and Mirin ((Z)-Mirin) (HY-19959) configurations. Among them, Mirin is an inhibitor of MRN (Mre11-Rad50-Nbs1). Mirin prevents MRN-dependent ATM activation without affecting ATM protein kinase activity .

HY-170845

MU1409	Endonuclease	Cancer
MU1409 is an inhibitor of *MRE11* nuclease with an IC₅₀ of 12.1 μM. Additionally, MU1409 also inhibits FEN1 and EXO1, with IC₅₀ values of 24.2 and 176.4 μM, respectively. MU1409 affects DNA repair in cells, preventing the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for research on BRCA2 mutation-induced cancers .

HY-RS24170

Mre11 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mre11 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mre11 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mre11 Rat Pre-designed siRNA Set A Mre11 Rat Pre-designed siRNA Set A

HY-RS08643

MRE11 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MRE11 Human Pre-designed siRNA Set A contains three designed siRNAs for MRE11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MRE11 Human Pre-designed siRNA Set A MRE11 Human Pre-designed siRNA Set A

HY-149972

Antitumor agent-96	Apoptosis	Cancer
Antitumor agent-96 (Compound D34) is a potent *MRE11* inhibitor. Antitumor agent-96 down-regulates the HR pathway by binding with MRE11 and suppressing its endonuclease functions. Antitumor agent-96 induces CM cells apoptosis .

Cat. No.	Compare	Product Name	Species	Source

HY-P702002

	MRE11A Protein, Human (His, GST) MRE11; Double-strand break repair protein MRE11; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A	Human	E. coli
	The MRE11A protein is an important component of the DNA double-strand break repair mechanism and participates in the homologous recombination (HR) pathway. It interacts with RAD50 and NBS1 to form the MRN complex, which is essential for sensing and repairing DNA damage. MRE11A Protein, Human (His, GST) is the recombinant human-derived MRE11A protein, expressed by E. coli , with N-6*His, N-GST labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80229

	Mre11 Antibody (YA283)	WB, IHC-P	Human, Mouse, Rat
	Mre11 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 81 kDa, targeting to Mre11. It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P84362

	MRE11 Antibody (YA4059) ATLD; HNGS1; MRE11A; MRE11B	WB, IHC-P, FC, ELISA	Human, Mouse, Monkey, Rat
	MRE11 Antibody (YA4059) is a mouse-derived and non-conjugated IgG2b antibody, targeting to MRE11. It can be applicated for WB, IHC-P, FC, ELISA assays, in the background of human, mouse, monkey, rat.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Mre11 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Mre11 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mre11 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

MRE11 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MRE11 Human Pre-designed siRNA Set A contains three designed siRNAs for MRE11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.