MRE11A Protein, Human (His, GST)

The MRE11A protein is an important component of the DNA double-strand break repair mechanism and participates in the homologous recombination (HR) pathway. It interacts with RAD50 and NBS1 to form the MRN complex, which is essential for sensing and repairing DNA damage. MRE11A Protein, Human (His, GST) is the recombinant human-derived MRE11A protein, expressed by E. coli , with N-6*His, N-GST labeled tag.

CXADR, a key component of the epithelial apical junction complex, functions as a homophilic cell adhesion molecule crucial for maintaining tight junction integrity. Additionally, CXADR plays a pivotal role in mediating the transepithelial migration of leukocytes through adhesive interactions with JAML, a transmembrane protein on the plasma membrane of leukocytes. This interaction not only facilitates leukocyte migration but also activates gamma-delta T-cells, a specialized T-cell subpopulation residing in epithelial tissues involved in tissue homeostasis and repair. Upon binding to epithelial CXADR, JAML initiates downstream signaling in gamma-delta T-cells through PI3-kinase and MAP kinases, leading to T-cell proliferation and the production of cytokines and growth factors. These factors, in turn, stimulate the repair processes in epithelial tissues. Notably, CXADR also acts as a receptor for adenovirus type C, highlighting its role in microbial infection.

Human

E. coli

N-6*His;N-GST

P49959 (M1-E411)

4361

Partial

Greater than 90% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl, pH7.5, 200 mM NaCl, 20% glycerol.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.