2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. MRE11 Antibody (YA283)

MRE11 Antibody (YA283) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MRE11.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

MRE11 Antibody (YA283) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MRE11.
Background

Mre11 is the core component of the MRN complex, playing a central role in double-strand break (DSB) repair, DNA recombination, telomere integrity maintenance, and meiosis. The MRN complex repairs DSBs via homologous recombination (HR), primarily during the S and G2 phases, by (1) mediating end resection of damaged DNA to generate single-stranded DNA (ssDNA), a key initial step in HR, and (2) recruiting other repair factors and activating ATM and ATR in response to DNA damage. MRE11 possesses both single-strand endonuclease and double-strand-specific 3'-5' exonuclease activities, collaborating with RBBP8/CtIP at DSB sites to initiate end resection. It first cleaves the 5' strand endonucleolytically to suppress non-homologous end joining (NHEJ) and license HR, then generates an ssDNA gap via 3' to 5' exonucleolytic degradation to enable EXO1- and DNA2-mediated long-range resection. RBBP8/CtIP enhances MRE11's endonuclease activity to clear protein-DNA adducts (By similar). The MRN complex also activates ATM and ATR for DNA damage signaling and processes R-loops. In telomeres, it may modulate t-loop formation. MRE11 contains two DNA-binding domains (DBDs) for binding both ssDNA and dsDNA.
Tag

Free
Gene ID
SwissProt ID
Molecular Weight

Predicted band size: 81 kDa; Observed band size: 81 kDa
Purity

Protein A affinity purified.
Subcellular Location

Nucleus.
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Research Field

Epigenetics and Nuclear Signaling
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1:500-1:1,000 ;IHC-P: 1:50-1:200
Application

WB, IHC-P
Appearance

Liquid
Formulation

Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

Synthetic peptide corresponding to Human Mre11.AA range:465-498.
Database

Entrez Gene: 4361 Human ; 17535 Mouse ; 64046 Rat

SwissProt: P49959 Human ; Q61216 Mouse ; Q9JIM0 Rat

OMIM: 604391 Human

Documentation
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

MRE11 Antibody (YA283) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
MRE11 Antibody (YA283)
Cat. No.:
HY-P80229
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