Search Result

Results for "

MR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Apoptosis (2) Autophagy (1) Bacterial (1) Bcl-2 Family (1) Biochemical Assay Reagents (1) CCR (1) CD20 (1) CD3 (1) Cholinesterase (ChE) (2) Endogenous Metabolite (6) ERK (1) Estrogen Receptor/ERR (1) Fluorescent Dye (1) G protein-coupled Bile Acid Receptor 1 (2) GABA Receptor (1) GHSR (1) Glucocorticoid Receptor (2) Glycosidase (1) Hippo (MST) (1) Histamine Receptor (2) Histone Methyltransferase (1) IFNAR (1) Interleukin Related (2) Isotope-Labeled Compounds (3) JNK (1) mAChR (6) Melanocortin Receptor (3) MHC (3) Mineralocorticoid Receptor (10) NF-κB (1) NO Synthase (1) NOD-like Receptor (NLR) (1) Opioid Receptor (1) Phosphodiesterase (PDE) (1) Progesterone Receptor (1) Radionuclide-Drug Conjugates (RDCs) (1) Reactive Oxygen Species (ROS) (1) Reference Standards (4) Salt-inducible Kinase (SIK) (1) Ser/Thr Protease (1) Small Interfering RNA (siRNA) (5) TNF Receptor (4) Transmembrane Glycoprotein (1) ULK (1) WDR5 (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (11) Endocrinology (4) Infection (1) Inflammation/Immunology (14) Metabolic Disease (9) Neurological Disease (14)
Oligonucleotides:	Cationic Lipids (1) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (2) siRNAs (5)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3304

MR 409	GHSR	Neurological Disease Cancer
MR 409 is a selected growth hormone-releasing hormone (GHRH) agonist. MR 409 has remarkable neuroprotective effects through enhancing endogenous neurogenesis in cerebral ischemic mice. MR 409 also inhibits the in vivo growth of lung cancer .

HY-138283

MR837 1 Publications Verification	Histone Methyltransferase	Cancer
MR837 is an inhibitor of NSD2-PWWP1. MR837 can bind with human nuclear receptor binding SET domain protein 2 (PWWP domain) .

HY-12206A

Thioperamide maleate 3 Publications Verification MR-12842 maleate	Histamine Receptor	Neurological Disease
Thioperamide maleate (MR-12842 maleate) is a potent, orally available, brain penetrant and selective H3 receptor antagonist with a K_i of 4.3 nM for inhibition of [ ³H]histamine release. Thioperamide maleate inhibits [ ³H]histamine synthesis with a K_i of 31 nM .

HY-12206

Thioperamide 3 Publications Verification MR-12842	Histamine Receptor	Neurological Disease
Thioperamide (MR-12842) is a potent, orally available, brain penetrant and selective H3 receptor antagonist with a K_i of 4.3 nM for inhibition of [ ³H]histamine release. Thioperamide inhibits [ ³H]histamine synthesis with a K_i of 31 nM .

HY-100981

MR-16728 hydrochloride	Endogenous Metabolite	Neurological Disease
MR-16728 hydrochloride is a compound that promotes the release of acetylcholine and has activity that enhances the release of acetylcholine. MR-16728 hydrochloride inhibits acetylcholine release induced by KCl depolarization. MR-16728 hydrochloride also inhibits Ca(2+)-ATPase activity in pure presynaptic membranes. The half-maximal effect of MR-16728 hydrochloride occurs at a concentration of 13.5 μM. MR-16728 hydrochloride significantly enhances the release of acetylcholine in the presence of low concentrations of calcium (approximately 10 μM range). Enhanced acetylcholine release was also observed with MR-16728 hydrochloride in proteoliposomes loaded with mediator proteins .

HY-162100

MR-2088	ULK Autophagy	Cancer
MR-2088 is a selective ULK1/ULK2 inhibitor with pEC₅₀ values of 8.3 and 8.7, respectively. MR-2088 selectively inhibits autophagy through ULK1/2 mediated inhibition .

HY-149087

MR2938	Cholinesterase (ChE) NF-κB Interleukin Related TNF Receptor CCR NOD-like Receptor (NLR) JNK NO Synthase	Neurological Disease Inflammation/Immunology
MR2938 is a potent AChE inhibitor, with an IC₅₀ of 5.04 μM. MR2938 also suppresses NO production obviously (IC₅₀ = 3.29 μM). MR2938 suppresses the neuroinflammation through blocking MAPK/JNK and NF-κB signaling pathways. MR2938 can be used for Alzheimer’s disease (AD) research .

HY-149075

MR22	Salt-inducible Kinase (SIK)	Cancer
MR22 is a potent pan-SIK (salt-inducible kinase) inhibitor. MR22 no longer exhibits activity on STE group kinases and displays excellent selectivity in a representative kinase panel. MR22-dependent SIK inhibition led to centrosome dissociation and subsequent cell-cycle arrest in ovarian cancer cells .

HY-162591

MR33317	Cholinesterase (ChE) 5-HT Receptor	Neurological Disease
MR33317 is an inhibitor of acetylcholinesterase with an IC₅₀ value of 41nM. MR33317 is also an agonist at brain 5-HT₄ receptors .

HY-157932

MR24	Hippo (MST)	Cancer
MR24, a G-5555 (HY-19635) derivative, is a mammalian STE20-like (MST) kinase inhibitor. MR24 shows selectively to MST3/4 over MST1/2, with EC₅₀ values of 57 and 583 nM, respectively. MR24 induces G1 phase cell cycle arrest. MR24 can be used for cancer research, such as breast, liver and lung cancers .

HY-159993

MR44397	WDR5	Cancer
MR44397 is a WD40 repeat (WDR) 5 ligand, can be used for cancer research .

HY-106448

Midesteine MR 889	Ser/Thr Protease	Inflammation/Immunology
Midesteine (MR 889) is a proteinase inhibitor that can inhibit porcine pancreatic elastase, human neutrophil elastase and bovine chymotrypsin. Midesteine has the potential for chronic obstructive pulmonary disease (COPD) and chronic bronchitis research .

HY-123389

MR2034 (R)-UM-1071	Opioid Receptor	Endocrinology
MR2034 ((R)-UM-1071) is a κ-opioid receptor agonist with activity that stimulates the hypothalamic-pituitary-adrenal axis. MR2034 has shown the potential to promote mood and inhibit addictive behaviors in animal models and can be used to study inhibitory approaches related to mood and addictive disorders. MR2034 is selective for κ-opioid receptors and can effectively modulate biological processes related to stress and mood .

HY-RS08637

MR1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MR1 Human Pre-designed siRNA Set A contains three designed siRNAs for MR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MR1 Human Pre-designed siRNA Set A MR1 Human Pre-designed siRNA Set A

HY-128358

MR-L2	Phosphodiesterase (PDE)	Neurological Disease
MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC₅₀ of 1.2 μM .

HY-108035

(-)-JM-1232 MR04A3	GABA Receptor	Neurological Disease
(-)-JM-1232 (MR04A3) targets GABA _A receptors and exerts its analgesic effects by binding to the benzodiazepine binding site of GABA _A receptors. (-)-JM-1232 demonstrates potent analgesic effects in mice against acute thermal stimuli, mechanically induced pain, and visceral pain, with CI₅₀ values of 2.96, 3.06, and 2.27 mg/kg, respectively. (-)-JM-1232 can be used in research related to pain and analgesia .

HY-U00100

Parcetasal MR-897	Apoptosis	Inflammation/Immunology
Paclitaxal is a non-steroidal anti-inflammatory analgesic.

HY-12527

Pyridoclax 1 Publications Verification MR-29072	Bcl-2 Family	Cancer
Pyridoclax is a potential Mcl-1 inhibitor.

HY-RS19618

Mrc1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mrc1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mrc1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mrc1 Mouse Pre-designed siRNA Set A Mrc1 Mouse Pre-designed siRNA Set A

HY-136969

RU 752	Mineralocorticoid Receptor	Cardiovascular Disease
RU 752 is a potent mineralocorticoid receptors (type I or MR) antagonist .

HY-P990134

Anti-Mouse CD40L/CD154 Antibody (MR-1)	TNF Receptor IFNAR	Inflammation/Immunology Cancer
Anti-Mouse CD40L/CD154 Antibody (MR-1) is an anti-mouse CD40L/CD154 IgG monoclonal antibody. Anti-Mouse CD40L/CD154 Antibody (MR-1) reduces the expression of IFN signaling pathway and lowers the level of IFN-β. Anti-Mouse CD40L/CD154 Antibody (MR-1) can prolong the survival time of transplants. Anti-Mouse CD40L/CD154 Antibody (MR-1) can be used for researches on cancer, inflammation conditions and xenotransplantation such as pancreatic cancer and autoimmune cholangitis .

HY-P990269

Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1)	TNF Receptor	Inflammation/Immunology Cancer
Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse CD40L/CD154. Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) is a chimeric version of the original MR-1 antibody (HY-P990134). The variable domain sequences are identical to the original MR-1 but the constant region sequences have been switched from Armenian hamster IgG to mouse IgG2a. Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) contains a LALA-PG mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors. Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) blocks CD40/CD40L signaling. Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) can be used for researches of cancer, inflammation and immunology.

HY-P990270

Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1)	TNF Receptor	Inflammation/Immunology Cancer
Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse CD40L/CD154. Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1) is a chimeric version of the original MR-1 antibody (HY-P990134). The variable domain sequences are identical to the original MR-1 but the constant region sequences have been switched from Armenian hamster IgG to mouse IgG1. Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1) contains a D265A mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors. Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1) blocks CD40/CD40L signaling. Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1) can be used for researches of cancer, inflammation and immunology.

HY-120274

Balcinrenone AZD9977	Mineralocorticoid Receptor	Cardiovascular Disease Metabolic Disease
Balcinrenone (AZD9977) is a potent, selective, and orally active mineralocorticoid receptor (MR) modulator. Balcinrenone is used for heart failure, and chronic kidney disease research .

HY-N0179

Ecdysone 1 Publications Verification α-Ecdysone	Endogenous Metabolite Apoptosis	Metabolic Disease
Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979) .

HY-W585888

Fructose-isoleucine	Others	Others
Fructose-isoleucine, an amadori compound, is an aroma precursor that formed in the initial phase of the Maillard reaction (MR). Fructose-isoleucine can be isolated from tobacco. Fructose-isoleucine can be isolated from tobacco, miso and white wine. Fructose-isoleucine significantly induces oxidative browning and correlates Maillard product (such as Maltol, furaneol and 5-methyl furfural) with a roasted and sweet aroma. Fructose-isoleucine can be used for food industry and tobacco processing research .

HY-W585933

Fructose-alanine Fru-Ala	Others	Others
Fructose-alanine, an amadori compound, is an aroma precursor that formed in the initial phase of the Maillard reaction (MR). Fructose-alanine can be isolated from tobacco, miso and white wine. Fructose-alanine significantly induces oxidative browning and correlates with Maillard product (furfuryl alcohol) with a roasted and sweet aroma. Fructose-alanine can be used for food industry and tobacco processing research .

HY-163122

5-Formylsalicylic acid	Others	Inflammation/Immunology
5-Formylsalicylic acid (5-F-SA), a hapten, strongly upregulates MR1 expression (MR1 ligand) .

HY-W168754

DB28	MHC	Others
DB28 is a novel *MR1* ligand. DB28 decreases cell surface expression of MR1 and competitively inhibits activation of MAIT cells by agonist ligands .

HY-W585933S

Fructose-alanine-13C6 Fru-Ala-¹³C₆	Isotope-Labeled Compounds	Others
Fructose-alanine- ¹³C₆ is ¹³C labeled Fructose-alanine. Fructose-alanine, an amadori compound, is an aroma precursor that formed in the initial phase of the Maillard reaction (MR). Fructose-alanine can be isolated from tobacco, miso and white wine. Fructose-alanine significantly induces oxidative browning and correlates with Maillard product (furfuryl alcohol) with a roasted and sweet aroma. Fructose-alanine can be used for food industry and tobacco processing research .

HY-RS08804

Mtnr1a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mtnr1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mtnr1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mtnr1a Mouse Pre-designed siRNA Set A Mtnr1a Mouse Pre-designed siRNA Set A

HY-RS09548

Nr3c2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nr3c2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nr3c2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nr3c2 Mouse Pre-designed siRNA Set A Nr3c2 Mouse Pre-designed siRNA Set A

HY-107631

Oxprenoate potassium RU 28318	Mineralocorticoid Receptor	Endocrinology
Oxprenoate potassium is a potent mineralocorticoid (MR) antagonist. Oxprenoate potassium accentuates DEX (dexamethasone)-induced apoptosis .

HY-157281

Photolumazine III PLIII	Transmembrane Glycoprotein	Inflammation/Immunology
Photolumazine III is a MHC class I related-1 molecule (MR1) antigen .

HY-W145667

Mannan 1 Publications Verification	Endogenous Metabolite Glycosidase Bacterial Interleukin Related Reactive Oxygen Species (ROS)	Infection Metabolic Disease Inflammation/Immunology
Mannan is an orally active polysaccharide compound that binds to the mannose receptor (MR). Mannan promotes bacterial uptake and endosomal degradation by binding to MR, thereby enhancing the production of IL-12 in immune cells. Mannan enhances ROS production. Mannan modulates immunity, inhibits Aflatoxin B₁ (HY-N6615)-induced toxicity, and reduces lipid .

HY-117965

Miricorilant CORT 118335	Glucocorticoid Receptor Mineralocorticoid Receptor	Endocrinology
Miricorilant (CORT 118335) is a dual selective glucocorticoid (GR) modulator/mineralocorticoid (MR) antagonist. Miricorilant can be used for the research of hypothalamic-pituitary-adrenal (HPA) axis related disorders .

HY-N0471

L-Hyoscyamine 2 Publications Verification Hyoscyamine	mAChR	Neurological Disease
L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205) .

HY-N0471C

L-Hyoscyamine sulfate hydrate Daturine sulfate hydrate	mAChR	Neurological Disease
L-Hyoscyamine sulfate hydrate, a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine sulfate hydrate is a levo-isomer to Atropine (HY-B1205) .

HY-N0471A

L-Hyoscyamine sulfate 2 Publications Verification Daturine sulfate	mAChR	Neurological Disease
L-Hyoscyamine sulfate (Daturine sulfate), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine sulfate is a levo-isomer to Atropine (HY-B1205) .

HY-RS09547

NR3C2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NR3C2 Human Pre-designed siRNA Set A contains three designed siRNAs for NR3C2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NR3C2 Human Pre-designed siRNA Set A NR3C2 Human Pre-designed siRNA Set A

HY-172937

ERα degrader 13	Estrogen Receptor/ERR	Cancer
ERα degrader 13 (compound MR3) is potent ERα degrader with an IC₅₀ of 0.55 μM. ERα degrader 13 induces an obvious tumor regression in the breast cancer xenograft mouse model .

HY-150979

Gd-NMC-3	Fluorescent Dye	Cancer
Gd-NMC-3 is a near-infrared fluorescence/magnetic resonance (NIRF/MR) bimodal imaging probe. Gd-NMC-3 shows high resolution and sensitivity in tumor imaging with good biocompatibility, indicating huge application potential .

HY-12738

PF-3882845	Mineralocorticoid Receptor Progesterone Receptor	Cardiovascular Disease Metabolic Disease
PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC₅₀=2.7 nM) antagonist for hypertension and nephropathy. PF-3882845 also binds to progesterone receptor (PR) with the binding IC₅₀ of 310 nM .

HY-N0471S

L-Hyoscyamine-d3 Daturine-d₃	mAChR	Neurological Disease
L-Hyoscyamine-d₃ is the deuterium labeled L-Hyoscyamine. L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205) .

HY-W034551

DOTA-tri(t-butyl ester)	Radionuclide-Drug Conjugates (RDCs)	Others Cancer
DOTA-tri(t-butyl ester) belongs to the DOTA class of chelating agents. DOTA-tri(t-butyl ester) is a key raw material for synthesizing nanospherical magnetic resonance imaging (MRI) contrast agents, which are used in MR angiography and tumor angiogenesis imaging .

HY-113313

Aldosterone Maximum Cited Publications 8 Publications Verification	Endogenous Metabolite	Cardiovascular Disease
Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level .

HY-N0471R

L-Hyoscyamine (Standard) Hyoscyamine (Standard)	Reference Standards mAChR	Neurological Disease
L-Hyoscyamine (Standard) is the analytical standard of L-Hyoscyamine. This product is intended for research and analytical applications. L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205) .

HY-P99776

Plamotamab XmAb-13676	CD20 CD3	Cancer
Plamotamab (XmAb-13676) is a human bispecific antibody (bsAb) that binds CD3 and CD20. Plamotamab recruits cytotoxic T cells to kill CD20 ⁺ expressing tumor cells. Plamotamab induces a mild hematologic reaction (MR), and results in tumor regression in vivo .

HY-124004

Acetyl-6-formylpterin Ac-6-FP	Biochemical Assay Reagents	Inflammation/Immunology
Acetyl-6-formylpterin (Ac-6-FP) is a hapten that covalently binds to MR1 through residue Lys43 of the protein, resulting in protein upregulation. Acetyl-6-formylpterin (Ac-6-FP) can be used in the study of inflammation .

HY-111372A

(Rac)-Finerenone (Rac)-BAY 94-8862	Mineralocorticoid Receptor	Cardiovascular Disease
(Rac)-Finerenone ((Rac)-BAY 94-8862) is the racemate of Finerenone. Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC₅₀=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold) .

Cat. No.	Product Name	Type

HY-150979

Gd-NMC-3	Fluorescent Dyes/Probes
Gd-NMC-3 is a near-infrared fluorescence/magnetic resonance (NIRF/MR) bimodal imaging probe. Gd-NMC-3 shows high resolution and sensitivity in tumor imaging with good biocompatibility, indicating huge application potential .

Cat. No.	Product Name	Type

HY-W145667

Mannan 1 Publications Verification	Carbohydrates
Mannan is an orally active polysaccharide compound that binds to the mannose receptor (MR). Mannan promotes bacterial uptake and endosomal degradation by binding to MR, thereby enhancing the production of IL-12 in immune cells. Mannan enhances ROS production. Mannan modulates immunity, inhibits Aflatoxin B₁ (HY-N6615)-induced toxicity, and reduces lipid .

Cat. No.	Product Name	Target	Research Area

HY-P3304

MR 409	GHSR	Neurological Disease Cancer
MR 409 is a selected growth hormone-releasing hormone (GHRH) agonist. MR 409 has remarkable neuroprotective effects through enhancing endogenous neurogenesis in cerebral ischemic mice. MR 409 also inhibits the in vivo growth of lung cancer .

HY-P1838

Proadrenomedullin (45-92), human	Peptides	Cardiovascular Disease
Proadrenomedullin (45-92), human, a mid-regional fragment of proadrenomedullin (MR-proADM), comprises amino acids 45–92 of pre-proADM. Proadrenomedullin (45-92), human has a longer half-life, is relatively stable and is produced in equimolar amounts to adrenomedullin (ADM), making it a surrogate for plasma levels of ADM gene products .

Cat. No.	Product Name	Target	Research Area

HY-P990134

Anti-Mouse CD40L/CD154 Antibody (MR-1)	TNF Receptor IFNAR	Inflammation/Immunology Cancer
Anti-Mouse CD40L/CD154 Antibody (MR-1) is an anti-mouse CD40L/CD154 IgG monoclonal antibody. Anti-Mouse CD40L/CD154 Antibody (MR-1) reduces the expression of IFN signaling pathway and lowers the level of IFN-β. Anti-Mouse CD40L/CD154 Antibody (MR-1) can prolong the survival time of transplants. Anti-Mouse CD40L/CD154 Antibody (MR-1) can be used for researches on cancer, inflammation conditions and xenotransplantation such as pancreatic cancer and autoimmune cholangitis .

HY-P990269

Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1)	TNF Receptor	Inflammation/Immunology Cancer
Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse CD40L/CD154. Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) is a chimeric version of the original MR-1 antibody (HY-P990134). The variable domain sequences are identical to the original MR-1 but the constant region sequences have been switched from Armenian hamster IgG to mouse IgG2a. Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) contains a LALA-PG mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors. Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) blocks CD40/CD40L signaling. Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) can be used for researches of cancer, inflammation and immunology.

HY-P99776

Plamotamab XmAb-13676	CD20 CD3	Cancer
Plamotamab (XmAb-13676) is a human bispecific antibody (bsAb) that binds CD3 and CD20. Plamotamab recruits cytotoxic T cells to kill CD20 ⁺ expressing tumor cells. Plamotamab induces a mild hematologic reaction (MR), and results in tumor regression in vivo .

HY-P990270

Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1)	TNF Receptor	Inflammation/Immunology Cancer
Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse CD40L/CD154. Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1) is a chimeric version of the original MR-1 antibody (HY-P990134). The variable domain sequences are identical to the original MR-1 but the constant region sequences have been switched from Armenian hamster IgG to mouse IgG1. Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1) contains a D265A mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors. Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1) blocks CD40/CD40L signaling. Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1) can be used for researches of cancer, inflammation and immunology.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0179

Ecdysone 1 Publications Verification α-Ecdysone	Animals Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite Apoptosis
Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979) .

HY-W145667

Mannan 1 Publications Verification	Human Gut Microbiota Metabolites Polysaccharides Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields Saccharides	Endogenous Metabolite Glycosidase Bacterial Interleukin Related Reactive Oxygen Species (ROS)
Mannan is an orally active polysaccharide compound that binds to the mannose receptor (MR). Mannan promotes bacterial uptake and endosomal degradation by binding to MR, thereby enhancing the production of IL-12 in immune cells. Mannan enhances ROS production. Mannan modulates immunity, inhibits Aflatoxin B₁ (HY-N6615)-induced toxicity, and reduces lipid .

HY-N0471

L-Hyoscyamine 2 Publications Verification Hyoscyamine	Alkaloids Hyoscyamus niger L. Other Alkaloids Source classification Solanaceae Plants	mAChR
L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205) .

HY-N0471A

L-Hyoscyamine sulfate 2 Publications Verification Daturine sulfate	Alkaloids other families Other Alkaloids Source classification Plants	mAChR
L-Hyoscyamine sulfate (Daturine sulfate), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine sulfate is a levo-isomer to Atropine (HY-B1205) .

HY-113313

Aldosterone Maximum Cited Publications 8 Publications Verification	Cardiovascular Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level .

HY-N0471R

L-Hyoscyamine (Standard) Hyoscyamine (Standard)	Alkaloids Hyoscyamus niger L. Other Alkaloids Source classification Solanaceae Plants	Reference Standards mAChR
L-Hyoscyamine (Standard) is the analytical standard of L-Hyoscyamine. This product is intended for research and analytical applications. L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205) .

HY-N0471AR

L-Hyoscyamine sulfate (Standard) Daturine sulfate (Standard)	Alkaloids other families Other Alkaloids Source classification Plants	Reference Standards mAChR
L-Hyoscyamine (sulfate) (Standard) is the analytical standard of L-Hyoscyamine (sulfate). This product is intended for research and analytical applications. L-Hyoscyamine sulfate (Daturine sulfate), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine sulfate is a levo-isomer to Atropine (HY-B1205) .

HY-113313R

Aldosterone (Standard)	Cardiovascular Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids	Reference Standards Endogenous Metabolite
Aldosterone (Standard) is the analytical standard of Aldosterone. This product is intended for research and analytical applications. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level .

Species:	Human (5) Mouse (2) Cynomolgus (1)
Tag:	His (5) Avi (1) Fc (3)
Source:	HEK293 (8)

Cat. No.	Compare	Product Name	Species	Source

HY-P77992

	DEC-205/CD205 Protein, Mouse (HEK293, His) Ly-75; DEC-205; CD205; CLEC13B; GP200-MR6	Mouse	HEK293
	DEC-205/CD205 protein acts as an endocytic receptor, directing antigens to an antigen-processing compartment.It also reduces B lymphocyte proliferation.DEC-205/CD205 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DEC-205/CD205 protein, expressed by HEK293 , with C-His labeled tag.

HY-P71133

	Serpin E1 Protein, Mouse (HEK293, His) 1 Publications Verification Plasminogen activator inhibitor 1; Endothelial plasminogen activator inhibitor; Serpin E1; MR1; Pai1; Planh1;	Mouse	HEK293
	Serpin E1 protein is a serine protease inhibitor that regulates TMPRSS7 and is a major inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU).It can significantly downregulate fibrinolysis and control thrombus degradation.Serpin E1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin E1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P705394

	MR1-B2M Complex Protein, Human (Biotinylated, HEK293, His-Avi) MR1 & B2M; Major histocompatibility complex class I-related protein 1; MR1; MHC class I-related protein 1; Class I histocompatibility antigen-like protein; MR1	Human	HEK293

HY-P701022

	DEC-205/CD205 Protein, Cynomolgus (HEK293, His) Ly-75; DEC-205; CD205; CLEC13B; GP200-MR6; LY75	Cynomolgus	HEK293
	DEC-205/CD205 Protein, an endocytic receptor, transports captured antigens to a specialized processing compartment, placing it at the forefront of antigen presentation. This role is crucial for immune surveillance and initiating immune responses. DEC-205/CD205's involvement also downregulates B-lymphocyte proliferation, showcasing its regulatory impact on immune cell dynamics and responses. DEC-205/CD205 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived DEC-205/CD205 protein, expressed by HEK293 , with C-His labeled tag.

HY-P702520

	LRP-1 Cluster II Protein, Human (HEK293, His) A2MR; Alpha-2-Macroglobulin Receptor; APOER; APR; CD91; LRP1 Cluster II; LRP-1 Cluster II; LRP1; TGFBR5	Human	HEK293
	LRP-1 Cluster II protein is involved in endocytosis and phagocytosis of apoptotic cells. The LRP-1 Cluster II protein also serves as a receptor for Pseudomonas aeruginosa exotoxin A during microbial infection. LRP-1 Cluster II Protein, Human (HEK293, His) is the recombinant human-derived LRP-1 Cluster II protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P704765

	LRP-1 Cluster II Protein, Human (HEK293, Fc) A2MR; Alpha-2-Macroglobulin Receptor; APOER; APR; CD91; LRP1 Cluster II; LRP-1 Cluster II; LRP1; TGFBR5	Human	HEK293
	LRP-1 Cluster II protein is involved in endocytosis and phagocytosis of apoptotic cells. The LRP-1 Cluster II protein also serves as a receptor for Pseudomonas aeruginosa exotoxin A during microbial infection. LRP-1 Cluster II Protein, Human (HEK293, Fc) is the recombinant human-derived LRP-1 Cluster II protein, expressed by HEK293, with C-hFc labeled tag.

HY-P704766

	LRP-1 Cluster III Protein, Human (HEK293, Fc) A2MR; Alpha-2-Macroglobulin Receptor; APOER; APR; CD91; LRP1 Cluster II; LRP-1 Cluster II; LRP1; TGFBR5	Human	HEK293
	LRP-1 Cluster III protein is involved in endocytosis and phagocytosis of apoptotic cells. The LRP-1 Cluster III protein also serves as a receptor for Pseudomonas aeruginosa exotoxin A during microbial infection. LRP-1 Cluster III Protein, Human (HEK293, Fc) is the recombinant human-derived LRP-1 Cluster III protein, expressed by HEK293, with C-hFc labeled tag.

HY-P704767

	LRP-1 Cluster IV Protein, Human (HEK293, Fc) A2MR; Alpha-2-Macroglobulin Receptor; APOER; APR; CD91; LRP1 Cluster II; LRP-1 Cluster II; LRP1; TGFBR5	Human	HEK293
	LRP-1 Cluster Ⅳ protein is involved in endocytosis and phagocytosis of apoptotic cells. The LRP-1 Cluster Ⅳ protein also serves as a receptor for Pseudomonas aeruginosa exotoxin A during microbial infection. LRP-1 Cluster Ⅳ Protein, Human (HEK293, Fc) is the recombinant human-derived LRP-1 Cluster Ⅳ protein, expressed by HEK293, with C-hFc labeled tag.

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Source
Tag
Accession
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Cat. No.	Product Name	Chemical Structure

HY-N0471S

L-Hyoscyamine-d3
L-Hyoscyamine-d₃ is the deuterium labeled L-Hyoscyamine. L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205) .

HY-113313S1

Aldosterone-d7

Aldosterone-d₇ is the deuterium labeled Aldosterone. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level .

HY-W585933S

Fructose-alanine-13C6

Fructose-alanine- ¹³C₆ is ¹³C labeled Fructose-alanine. Fructose-alanine, an amadori compound, is an aroma precursor that formed in the initial phase of the Maillard reaction (MR). Fructose-alanine can be isolated from tobacco, miso and white wine. Fructose-alanine significantly induces oxidative browning and correlates with Maillard product (furfuryl alcohol) with a roasted and sweet aroma. Fructose-alanine can be used for food industry and tobacco processing research .

HY-126855S

Cholic acid 7-sulfate-d4

Cholic acid 7-sulfate-d₄ (7-Sulfocholic acid-d₄) is the deuterium labeled Cholic acid 7-sulfate (HY-126855). Cholic acid 7-sulfate is a selective agonist targeting TGR5 (EC₅₀=0.17 μM) and a ligand for MHC class I-related protein (MR1). As a gut-restricted TGR5 agonist, cholic acid 7-sulfate binds to TGR5 on enteroendocrine L cells, induces GLP-1 secretion, and improves glucose tolerance in a TGR5-dependent manner. Cholic acid 7-sulfate also acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells MAIT and the expression of homeostatic gene signatures, affecting MAIT cell development and function. Cholic acid 7-sulfate is mainly used in the research of diabetes and MAIT cell-related immune regulation .

HY-111372S

Finerenone-d3

Finerenone-d3 is the deuterium labeled finerenone (HY-111372). Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC₅₀=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease .

HY-111372S1

Finerenone-d5

Finerenone-d₅ (BAY 94-8862-d₅) is deuterium labeled Finerenone. Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC₅₀=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80746

	LRP1 Antibody (YA306) A2MR; alpha 2MR; Alpha 2 macroglobulin receptor; CD91; APR; LRP1; LRP85; TGFBR5	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	LRP1 Antibody (YA306) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LRP1.

HY-P83714M

	Rat Anti-Mouse CD206 Antibody (APC) 1 Publications Verification MMR; MR; MRC1; macrophage mannose receptor; mannose receptor	FC	Mouse
	Rat Anti-Mouse CD206 Antibody (APC) is a rat-derived and allophycocyanin (APC) IgG2a monoclonal antibody, targeting to CD206.

HY-P81517

	LY75 Antibody (YA1262) CD205; CLEC13B; DEC-205; gp200-MR6; Ly-75; LY75	IHC-P	Human
	LY75 Antibody (YA1262) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LY75.

HY-P81682

	LMAN1 Antibody (YA1427) ERGIC5; F5F8D; FMFD1; Gp58; Lman1; MCFD1; MR60	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	LMAN1 Antibody (YA1427) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LMAN1.

HY-P84718

	MR1 Antibody (YA4415) HLALS	IHC-P, ICC/IF, FC, ELISA	Human
	MR1 Antibody (YA4415) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MR1.

HY-P86569

	LRP1 Antibody (YA6261) LRP1; A2MR; APR; Prolow-density lipoprotein receptor-related protein 1; LRP-1; Alpha-2-macroglobulin receptor; A2MR; Apolipoprotein E receptor; APOER; CD antigen CD91	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	LRP1 Antibody (YA6261) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LRP1.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

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