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Results for "

Liver necrosis

" in MedChemExpress (MCE) Product Catalog:

17

Inhibitors & Agonists

5

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-Y0698
    Thioacetamide
    2 Publications Verification

    Acetothioamide; TAA; Thiacetamide

    		 Necroptosis Inflammation/Immunology
    Thioacetamide (TAA) is an indirect hepatotoxin and causes parenchymal cell necrosis. Thioacetamide requires metabolic activation by microsomal CYP2E1 to thioacetamide-S-oxide initially and then to thioacetamide-S-dioxide, which is a highly reactive metabolite, and its reactive metabolites covalently bind to proteins and lipids thereby causing oxidative stress and centrilobular necrosis. Thioacetamide can induce chronic liver fibrosis, encephalopathy and other events model .
    Thioacetamide
  • HY-101063
    Amthamine dihydrobromide

    		Histamine Receptor Inflammation/Immunology
    Amthamine is a histamine receptor (H1R-H4R) agonist. Amthamine can produce liver congestion and necrosis of liver cells. Amthamine can be used to study the induction effect of H1R-H4 agonist on hepatotoxicity .
    Amthamine dihydrobromide
  • HY-156119
    MLKL-IN-6

    		Mixed Lineage Kinase Necroptosis Metabolic Disease Cancer
    MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor targeting Mixed Lineage Kinase domain-like (MLKL). MLKL-IN-6 inhibits cell necrosis. MLKL-IN-6 inhibits MLKL phosphorylation and oligomerization during cell necrosis, inhibits immune cell death, and reduces the expression of adhesion factors. MLKL-IN-6 has low cytotoxicity, and it inhibits hepatic stellate cell activation, reduces liver fibrosis marker levels, and has anti-fibrotic effects .
    MLKL-IN-6
  • HY-W011711
    Benzarone

    Fragivix

    		 URAT1 Oxidative Phosphorylation Apoptosis Metabolic Disease
    Benzarone (Fragivix) is an oral inhibitor of human urate transporter 1 (hURAT1) with an IC50 value of 2.8 μM, and it also acts as an uncoupler of oxidative phosphorylation. Benzarone can cause liver damage and promote cell apoptosis and necrosis. Benzarone can be used to lower serum uric acid levels and for research in vascular diseases .
    Benzarone
  • HY-117926
    AGN 191701

    		RAR/RXR Cancer
    AGN 191701 is a selective retinoic acid X receptor (RXR) agonist that causes liver enlargement in rats without hepatocellular necrosis .
    AGN 191701
  • HY-N1214A
    (E/Z)-Squalene

    (E/Z)-Super Squalene; (E/Z)-AddaVax

    		 Apoptosis Cancer
    (E/Z)-Squalene ((E/Z)-Super Squalene; (E/Z)-AddaVax) is a triterpenic compound. (E/Z)-Squalene accumulates and reduces liver cholesterol and triglycerides in the liver. (E/Z)-Squalen regulates the production of intracellular active oxidants (ROS) and induces apoptosis and necrosis in a concentration-and time-dependent manner .
    (E/Z)-Squalene
  • HY-129508
    Amthamine

    		Histamine Receptor Inflammation/Immunology
    Amthamine is a histamine receptor (H1R-H4R) agonist. Amthamine can produce liver congestion and necrosis of liver cells. Amthamine can be used to study the induction effect of H1R-H4 agonist on hepatotoxicity .
    Amthamine
  • HY-176218
    TTTE

    		Drug Derivative Inflammation/Immunology
    TTTE is a sulfone bischalcone derivative. TTTE has major anti-necrotic, anti-inflammatory and anti-fibrotic activities. TTTE exerts regulatory effects by downregulating key molecules such as Caspase-3, TNF-α, NF-κB and TGF-β. TTTE can be used in the study of liver injury .
    TTTE
  • HY-145855
    J-1063

    		TGF-β Receptor Inflammation/Immunology
    J-1063 is a potent, selective and orally active ALK5 inhibitor with an IC50 of 0.039 µM. J-1063 shows anti-fibrotic effect by the inhibition of inflammatory infiltration, collagen deposition, and hepatocytes necrosis. J-1063 has the potential for the research of liver fibrosis .
    J-1063
  • HY-N13208
    Stevia Powder

    		MMP TGF-beta/Smad Others
    Stevia Powder is a natural sweetener with antioxidant activity. Stevia Powder can downregulate pro fibrotic pathways in cirrhotic rats, including reduced hepatic myofibroblasts and decreased expression of matrix metalloproteinases MMP2 and MMP13, upregulate anti fibrotic molecule Smad7, prevent serum necrosis and elevated bile stasis markers, thereby inhibiting the development of liver fibrosis .
    Stevia Powder
  • HY-136063R
    Mefentrifluconazole (Standard)

    		Reference Standards Fungal Cytochrome P450 Infection
    Mefentrifluconazole (Standard) is the analytical standard of Mefentrifluconazole. This product is intended for research and analytical applications. Mefentrifluconazole is a novel azole derivative and used as an agrochemical broad-spectrum antifungal agent. Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM)[1].
    Mefentrifluconazole (Standard)
  • HY-136063
    Mefentrifluconazole

    		Fungal Cytochrome P450 Infection
    Mefentrifluconazole is a novel azole derivative and used as an agrochemical broad-spectrum antifungal agent. Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM) .
    Mefentrifluconazole
  • HY-N0545
    Taurocholic acid sodium
    Maximum Cited Publications
    21 Publications Verification

    Sodium taurocholate; N-Choloyltaurine sodium

    		 VEGFR Endogenous Metabolite Inflammation/Immunology
    Taurocholic acid sodium (Sodium taurocholate) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid sodium has immunoregulation effect .
    Taurocholic acid sodium
  • HY-N0545R
    Taurocholic acid sodium (Standard)
    5 Publications Verification

    Sodium taurocholate (Standard); N-Choloyltaurine sodium (Standard)

    		 Reference Standards VEGFR Endogenous Metabolite Inflammation/Immunology
    Taurocholic acid (sodium) (Standard) is the analytical standard of Taurocholic acid (sodium). This product is intended for research and analytical applications. Taurocholic acid sodium (Sodium taurocholate) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid sodium has immunoregulation effect .
    Taurocholic acid sodium (Standard)
  • HY-B1788R
    Taurocholic acid (Standard)

    Taurocholic Acid (Standard)

    		 Reference Standards Endogenous Metabolite Inflammation/Immunology
    Taurocholic acid (Standard) is the analytical standard of Taurocholic acid. This product is intended for research and analytical applications. Taurocholic acid (N-Choloyltaurine) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid has immunoregulation effect .
    Taurocholic acid (Standard)
  • HY-B1788
    Taurocholic acid
    Maximum Cited Publications
    21 Publications Verification

    N-Choloyltaurine

    		 Endogenous Metabolite Inflammation/Immunology
    Taurocholic acid (N-Choloyltaurine) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid has immunoregulation effect .
    Taurocholic acid
  • HY-N8501
    Emestrin

    		Bacterial Infection
    Emestrin is a mycotoxin originally isolated from E. striata that has antimicrobial, immunomodulatory, and cytotoxic activities. It is active against the fungi C. albicans and C. neoformans, as well as the bacteria E. coli, S. aureus, and methicillin-resistant S. aureus (MRSA; IC50s=3.94, 0.6, 2.21, 4.55, and 2.21 μg/mL, respectively).2 Emestrin is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50=5.4 μM in a radioligand binding assay using isolated human monocytes).3 Emestrin (0.1 μg/mL) induces apoptosis in HL-60 cells. It induces heart, thymus, and liver tissue necrosis in mice when administered at doses ranging from 18 to 30 mg/kg.
    Emestrin

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