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Results for "

LN

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Androgen Receptor (1) Apoptosis (1) Aurora Kinase (1) Autophagy (2) Cathepsin (1) CXCR (1) DNA/RNA Synthesis (2) Drug Derivative (1) HIF/HIF Prolyl-Hydroxylase (2) KLF (1) MDM-2/p53 (1) Microtubule/Tubulin (1) Monoamine Oxidase (1) mRNA (1) NOD-like Receptor (NLR) (1) p38 MAPK (1) Parasite (1) Prostaglandin Receptor (1) RAD51 (1) Reactive Oxygen Species (ROS) (1) VEGFR (1)
By Research Areas:	Cancer (15) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (2)
Oligonucleotides:	mRNA (1)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-149482

LN5P45 1 Publications Verification	Cathepsin	Cancer
LN5P45 is an OTUB2 inhibitor (IC₅₀: 2.3 μM). LN5P45 induces monoubiquitination of OTUB2 on lysine 31. LN5P45 can be used for research of tumor progression and metastasis .

HY-18777

KC7F2 Maximum Cited Publications 19 Publications Verification	HIF/HIF Prolyl-Hydroxylase	Cancer
KC7F2 is a potent hypoxia inducible factor-1 (HIF-1) pathway inhibitor with an IC₅₀ of 20 μM in LN229-HRE-AP cells, and with potential as a cancer therapy agent .

HY-W278944

Antiproliferative agent-15	Drug Derivative	Cancer
Antiproliferative agent-15 is an thienopyrimidine derivated anticancer agent. Antiproliferative agent-15 shows antiproliferative activity against human colon (HCT116 and HCT15) and brain (LN-229 and GBM-10) cancer cell lines .

HY-169213

LN-439A	KLF RAD51	Cancer
LN-439A (compound LN-439A) is a BAP1 inhibitor that inhibits the growth of basal-like breast cancer by degrading KLF5. .

HY-172541

LN6023 hydrochloride	CXCR	Cardiovascular Disease
LN6023 (hydrochloride) (Compound 27) is a CXCR7 agonist. LN6023 (hydrochloride) induces the recruitment of β-arrestin in HEK293T cells expressing human CXCR7 (EC₅₀ = 3.5 µM). LN6023 (hydrochloride) reduces the surface level of P-selectin in isolated and washed human platelets. LN6023 (hydrochloride) can be used to study platelet-mediated thrombosis .

HY-162903

LN002	Parasite	Infection
LN002 is an orally active anti-Cryptosporidium oxidase inhibitor for the study of cryptosporidiosis .

HY-150794

FLDP-8	Others	Cancer
FLDP-8 is a curcuminoid analogues, has potent anti-cancer effects. FLDP-8 can induce cell death with an IC₅₀ value of 4 μM in LN-18 cells .

HY-P6084

RP-220	NOD-like Receptor (NLR) p38 MAPK Apoptosis	Inflammation/Immunology
RP-220 is a renalase peptide targeting NLRP3. RP220 has anti-inflammatory and anti-apoptotic activities. RP220 inhibits renal tubular epithelial cells apoptosis with alkaline insult by activating MAPK signaling pathway. RP220 significantly inhibits NLRP3 expression and reduces macrophage infiltration and kidney tissue damage in acute kidney injury (AKI) mice model. RP-220 can be uses for systemic lupus erythematosus (SLE) and its complication lupus nephritis (LN) research .

HY-174732

Human CSF3 mRNA	mRNA	Inflammation/Immunology
Human CSF3 mRNA encodes the human colony stimulating factor 3 (CSF3) protein, a member of the IL-6 superfamily of cytokines. CSF3 controls the production, differentiation, and function of granulocytes.

HY-168721

Tubulin inhibitor 48	Microtubule/Tubulin	Cancer
Tubulin inhibitor 48 (compound 16) is an anti-cancer agent targeting tubulin. Tubulin inhibitor 48 has an IC₅₀ of 0.1 and 0.07 μM for LN-229 and Capan-1 cell, respectively .

HY-149515

MAO-IN-3	Monoamine Oxidase	Cancer
MAO-IN-3 (Compound 5) is a reversible and competitive MAO inhibitor (K_i: 0.6 and 0.2 μM for MAO A and MAO B). MAO-IN-3 inhibits LN-229 glioblastoma cell proliferation with an IC₅₀ of 0.8 μM. MAO-IN-3 can be used for cancer research .

HY-150791

FLDP-5	Reactive Oxygen Species (ROS) DNA/RNA Synthesis	Cancer
FLDP-5 is a blood-brain barrier (BBB) penetrant curcuminoid analogues. FLDP-5 can induce production of ROS (Reactive Oxygen Species), DNA damage and cell cycle S phase arrest. FLDP-5 exhibits highly potent tumour-suppressive effects with anti-proliferative and anti-migratory activities on LN-18 cells .

HY-108637A

PhiKan 083 hydrochloride	MDM-2/p53	Cancer
PhiKan 083 hydrochloride is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a K_d of 167 μM , and a relative binding affinity (K_d) of 150 μM in Ln229 cells .

HY-12855A

Lys05 4 Publications Verification Lys01 trihydrochloride	Autophagy	Cancer
Lys05 (Lys01 trihydrochloride) is a novel lysosomal autophagy inhibitor with IC₅₀ values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay.

HY-18259

103D5R	HIF/HIF Prolyl-Hydroxylase	Cancer
103D5R (Compound 15) is an inhibitor for the activation of hypoxia-inducible factor-1 (HIF-1) with an IC₅₀ of 35 µM, through reduction of the HIF-1α protein synthesis. 103D5R inhibits the proliferation of LN229 with IC₅₀ of 26 µM .

HY-168437

LIN28-IN-2	DNA/RNA Synthesis	Cancer
LIN28-IN-2 (Compound Ln268) blocks the binding of the zinc finger domain (ZKD) of Lin28 to RNA substrates, and inhibits Lin28a and Lin28b. LIN28-IN-2 inhibits the proliferation of Lin28-positive cancer cell and spheroid growth .

HY-12855

Lys01	Autophagy	Cancer
Lys01, a dimeric form of Chloroquine (HY-17589A), is an autophagy inhibitor. Lys01 inhibits cell viability of 1205Lu, c8161, LN229, HT-29 cells with IC₅₀s of 3.6, 3.8, 7.9, 6.0 μM. Lys01 can be used for anticancer research .

HY-155464

VEGFR-2/AURKA-IN-1	VEGFR Aurora Kinase	Cancer
VEGFR-2/AURKA-IN-1 (compound 5e) is a thiazolidin-4-one derivative with antiglioma activity (IC₅₀: 6.43 μM, LN229). VEGFR-2/AURKA-IN-1 has affinity for AURKA and VEGFR-2 and is a potential ligand. VEGFR-2/AURKA-IN-1 causes DNA strand breaks and exhibits cytotoxic and anticancer potential .

HY-403733B

(+)-JJ-450	Androgen Receptor Prostaglandin Receptor	Cancer
(+)-JJ-450 is a non-competitive antagonist targeting the androgen receptor (AR) that inhibits AR nuclear localization and transcriptional activity in the absence of androgen. (+)-JJ-450 is less active than (-)-JJ-450 (HY-403733A) in inhibiting prostate-specific antigen (PSA) expression in LN95 cells, possibly because (+)-JJ-450 targets the ligand binding domain (LBD) of AR. (+)-JJ-450 inhibits the transcriptional activity of AR and its splice variants (e.g., ARv7) by promoting the degradation of unliganded AR in the nucleus and reducing the binding of AR to androgen response elements (AREs). (+)-JJ-450 can be used in castration-resistant prostate cancer (CRPC) studies that are resistant to enzalutamide (MDV3100) (HY-70003) .

Cat. No.	Product Name	Target	Research Area

HY-P6084

RP-220	NOD-like Receptor (NLR) p38 MAPK Apoptosis	Inflammation/Immunology
RP-220 is a renalase peptide targeting NLRP3. RP220 has anti-inflammatory and anti-apoptotic activities. RP220 inhibits renal tubular epithelial cells apoptosis with alkaline insult by activating MAPK signaling pathway. RP220 significantly inhibits NLRP3 expression and reduces macrophage infiltration and kidney tissue damage in acute kidney injury (AKI) mice model. RP-220 can be uses for systemic lupus erythematosus (SLE) and its complication lupus nephritis (LN) research .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P75796

	GPR56 Protein, Human (HEK293, His) Adhesion G-protein coupled receptor G1; ADGRG1 NT; ADGRG1; GPR56; TM7LN4; TM7XN1	Human	HEK293
	GPR56, a cell adhesion receptor, mediates cell-matrix adhesion in developing neurons and hematopoietic stem cells. It acts as a receptor for collagen III (COL3A1), influencing cortical development and hematopoietic stem cell maintenance. Additionally, GPR56 plays a pivotal role in cancer progression by inhibiting angiogenesis via PRKCA-mediated signaling and is essential for testis development. GPR56 Protein, Human (HEK293, His) is the recombinant human-derived GPR56 protein, expressed by HEK293 , with C-His labeled tag.

HY-P704646

	GPR56 Protein-VLP, Human (HEK293) Adhesion G-protein coupled receptor G1; ADGRG1 NT; ADGRG1; GPR56; TM7LN4; TM7XN1	Human	HEK293
	GPR56, a cell adhesion receptor, mediates cell-matrix adhesion in developing neurons and hematopoietic stem cells. It acts as a receptor for collagen III (COL3A1), influencing cortical development and hematopoietic stem cell maintenance. Additionally, GPR56 plays a pivotal role in cancer progression by inhibiting angiogenesis via PRKCA-mediated signaling and is essential for testis development. GPR56 Protein-VLP, Human (HEK293) is the recombinant human-derived GPR56 protein, expressed by HEK293, with tag free.Formed in HEK293 cultures, these VLPs concentrate membrane proteins on the cell surface, producing high-concentration proteins ideal for immunization and antibody screening. Given the high immunogenicity of VLPs, the immunization protocol such as antigen dose, schedule, and adjuvant, requires optimization. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80665

	F4/80 Antibody (YA002) 1 Publications Verification Emr1; Ly71; Gpf480; TM7LN3; DD7A5-7; EGF-TM7	IHC-P, ICC/IF, FC	Mouse
	F4/80 Antibody is a non-conjugated and Rat origined monoclonal antibody, targeting to F4/80. It can be used for IHC-P,ICC/IF,FC assays with tag free, in the background of Mouse.

HY-P81083

	F4/80 Antibody (YA920) F4/80 (mouse); Adhesion G protein-coupled receptor E1; Cell surface glycoprotein EMR1; Cell surface glycoprotein F4/80; DD7A5 7; Egf like module containing mucin like hormone receptor like 1; Egf like module containing mucin like hormone receptor like sequence 1; EGF like module receptor 1; EGF TM7; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EGFTM7; EMR 1; EMR1; EMR-1; EMR1 hormone receptor; EMR1_HUMAN; AGRE1_HUMAN; Gpf480; Ly71; Lymphocyte antigen 71; TM7LN3.	WB, IHC-P, IHC-F, ICC/IF	Mouse, Rat
	F4/80 Antibody (YA920) is an unconjugated, approximately 102 kDa, rabbit-derived, anti-ADGRE1 (F4/80) (YA920) monoclonal antibody. F4/80 Antibody (YA920) can be used for: WB, IHC-P, IF-Tissue, IHC-Fr expriments in mouse, rat background without labeling.

HY-P84353

	CD97 Antibody (YA4050) ADGRE5; TM7LN1	IHC-P, FC, ELISA	Human
	CD97 Antibody (YA4050) is a mouse-derived and non-conjugated IgG2a antibody, targeting to CD97. It can be applicated for IHC-P, FC, ELISA assays, in the background of human.

HY-P84901

	GPR56 Antibody (YA4598) BFPP; BPPR; ADGRG1; TM7LN4; TM7XN1	IHC-P, FC, ELISA	Human
	GPR56 Antibody (YA4598) is a mouse-derived and non-conjugated IgG1 antibody, targeting to GPR56. It can be applicated for IHC-P, FC, ELISA assays, in the background of human.

HY-P81399

	CD97 Antibody (YA1144) ADGRE5; Adhesion G protein-coupled receptor E5; CD97 antigen; Leukocyte antigen CD97; Seven span transmembrane protein; TM7LN1	IHC-P	Human
	CD97 Antibody (YA1144) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1144), targeting CD97. CD97 Antibody (YA1144) can be used for IHC-P experiment in human background.

HY-P85014

	GPR56 Antibody (YA4706) GPR56; TM7LN4; TM7XN1; G-protein coupled receptor 56; Protein TM7XN1; GPR56 nanobody	ELISA, FC	Human
	GPR56 Antibody (YA4706) is a mouse-derived and non-conjugated monoclonal antibody, targeting to GPR56. It can be applicated for ELISA, FC assays, in the background of human.

HY-P80744

	LIN28A Antibody (YA711) CSDD1; FLJ12457; LIN 28; Lin-28A; LIN28; LIN28A; LN28A_HUMAN; Protein lin-28 homolog A; ZCCHC1; Zinc finger CCHC domain-containing protein 1.	WB	Human, Mouse
	LIN28A Antibody (YA711) is a non-conjugated and Mouse origined monoclonal antibody about 23 kDa, targeting to LIN28A (2C1). It can be used for WB assays with tag free, in the background of Human, Mouse.

HY-P85574

	LIN28A Antibody (YA5266) CSDD1; FLJ12457; LIN 28; Lin-28A; LIN28; LIN28A; LN28A_HUMAN; Protein lin-28 homolog A; ZCCHC1; Zinc finger CCHC domain-containing protein 1.	WB	Human, Mouse
	LIN28A Antibody (YA5266) is a mouse-derived and non-conjugated monoclonal antibody, targeting to LIN28A. It can be applicated for WB assays, in the background of human, mouse.

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Cat. No.	Product Name		Classification

HY-174732

Human CSF3 mRNA		mRNA
Human CSF3 mRNA encodes the human colony stimulating factor 3 (CSF3) protein, a member of the IL-6 superfamily of cytokines. CSF3 controls the production, differentiation, and function of granulocytes.

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