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LD50

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W103488

Chloridazon	Herbicide	Others
Chloridazon is a herbicide with an *LD₅₀* value of 76.6 ppm at genotoxicity assay .

HY-W131444

Insecticidal agent 15	Insecticide	Others
Insecticidal agent 15 (compound 8f) is a potent insecticidal agent that shows *LD₅₀* of 4.27 nmol/mg for adult female Ae. Aegypti .

HY-135286A

(+)-Neomenthol	Parasite	Infection
(+)-Neomenthol is a potent miticide. (+)-Neomenthol shows acaricidal activitie with *LD₅₀* values of 0.32, 0.256 µg/mL for Dermatophagoides farinae and Dermatophagoides pteronyssinus, respectively .

HY-125721

Tetranactin	Fungal Bacterial Antibiotic	Infection
Tetranactin is an orally active antibiotic that has insecticidal properties and can inhibit the growth of Gram-positive bacteria and plant pathogenic fungal in vitro. Tetranactin *LD₅₀* for intraperitoneal injection in mice is greater than 300 mg/kg, and the *LD₅₀* is greater than 15,000 mg/kg .

HY-129733

LND 623	Na+/K+ ATPase	Cardiovascular Disease
LND 623 is an inotropic aminosteroid with positive inotropic properties. LND 623 inhibits Na ⁺/K ⁺ ATPase activity. The *LD₅₀* of LND 623 infused i.v. is around 45 mg/kg, a value ten times higher than the *LD₅₀* for Ouabain (HY-B1457) .

HY-129208

Viridicatumtoxin	Antibiotic Fungal	Infection
Viridicatumtoxin is a new mycotoxin extracted from Penicillium viridicatum with a *LD₅₀* of 122.4 mg/kg in rats.

HY-126715

Pimelautide RP 44102	HIV Virus Protease	Inflammation/Immunology
Pimelautide (RP 44102), a desmuramyl peptidolipid, is an adjuvant. Pimelautide shows a LD₅₀ of 410 mg/kg (i.v, mouse) .

HY-114614

Clenpirin	Parasite	Infection
Clenpirin is a insecticide against cattle ticks Boophilus microplus. Clenpirin exhibits slightly toxicity to rats with LD₅₀ of 3050 mg/kg .

HY-157162

Insecticidal agent 5	Cholinesterase (ChE)	Others
Insecticidal agent 5 (compound 8) is an AChE-targeting insecticide with an LD50 of 27.65 ppm against the cotton leafworm Spodoptera littoralis .

HY-124132

Autophagy-IN-4	Autophagy	Cancer
Autophagy-IN-4 (Compound 34) is an autophagy inhibitor, with an *EC₅₀* of 0.5 μM and a LD50 of 27 μM for U2OS cells .

HY-128430

Farnesyl acetate	Parasite DNA/RNA Synthesis	Infection
Farnesyl acetate is a sesquiterpene isolated from the leaves of Amomum gagnepainii. Farnesyl acetate has significant toxicity against red palm weevil larvae with a LD₅₀ of 7867 ppm .

HY-W099757

(±)-Coniine hydrochloride 2-Propylpiperidine hydrochloride	nAChR	Neurological Disease
(±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an *EC₅₀* value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD₅₀ value of 7.7 mg/kg .

HY-103272

iMAC2	Apoptosis	Inflammation/Immunology Cancer
iMAC2 is a potent MAC inhibitor with an *IC₅₀* of 28 nM and an *LD₅₀* of 15000 nM. iMAC2 shows anti-apoptotic effect. iMAC2 blocks cytochrome c release .

HY-138100

Hyalodendrin (+)-Hyalodendrin	Fungal	Infection
Hyalodendrin ((+)-Hyalodendrin) is a fungal growth inhibitor with inhibitory activity against wood decay fungi. Hyalodendrin has low phytotoxicity, with an acute toxicity (LD50) of 75 mg/kg in mice .

HY-D1163

Chromium(III) acetate 1 Publications Verification Chromium acetate; Chromic acetate; Chromium triacetate	AMPK	Metabolic Disease
Chromium(III) acetate (Chromic acetate) is an AMPK inhibitor that promotes lipogenesis by inhibiting AMPK phosphorylation. Chromium(III) acetate has low toxicity in mammals, with an *LD₅₀* of 2365 mg/kg in rats .

HY-129469

Saframycin S	Antibiotic	Infection
Saframycin S is an antibiotic with a racemomycin group that exhibits inhibitory activity against Ehrlich ascites tumors. The LD₅₀ of Saframycin S in ddY mice is 3.2 mg/kg (i.p.) .

HY-N0531

Filixic acid ABA	Parasite	Infection
Filixic acid ABA is a molluscicidal agent against B. peregrina adult snails, with an *LD₅₀* of 8.40 ppm. Filixic acid ABA shows 100% mortality of B. peregrina at 15 ppm .

HY-121229A

(±)-Coniine 2-Propylpiperidine	nAChR	Others
(±)-Coniine (2-Propylpiperidine) is a piperidine alkaloid and nAChR agonist (EC₅₀=0.3 mM). (±)-Coniine is acutely toxic to mice with an LD50 value of 7.7 mg/kg .

HY-N10695

Celangulatin C	Parasite	Infection
Celangulatin C is an insecticidal sesquiterpene polyol ester, that can be isolated from the root bark of Pseudolarix kaempferi. Celangulatin C shows *LD₅₀* against Mythimna separata of 280.4 μg/mL .

HY-B0824

Bifenthrin 1 Publications Verification	Sodium Channel	Neurological Disease
Bifenthrin is a synthetic pyrethroid insecticide. Bifenthrin prolongs the opening time of Nav1.8 sodium channels, leading to membrane depolarization and conductance block in the insect nervous system, thereby disrupting neural function. Bifenthrin was effective in inhibiting A. gambiae (LD₅₀=0.15 ng/mg) and C. quinquefasciatus (LD₅₀=0.16 ng/mg). Bifenthrin has good lethality against susceptible and resistant mosquitoes and is very effective in inhibiting blood sucking and can be developed as a mosquito-removal netting material .

HY-110073

iMAC2 hydrochloride	Apoptosis	Inflammation/Immunology Cancer
iMAC2 hydrochloride is a potent MAC (mitochondrial apoptosis-induced channel) inhibitor, with an *IC₅₀* of 28 nM and a *LD₅₀* of 15000 nM. iMAC2 hydrochloride shows anti-apoptotic effect. iMAC2 hydrochloride blocks cytochrome c release .

HY-N14048

Cepacin A	Antibiotic Bacterial	Infection
Cepacin A is an acetylenic antibiotic. Cepacin A has antibacterial activity, with a MIC of 0.2 μg/mL against staphylococci. In addition, Cepacin A is somewhat toxic to mice, with an *LD₅₀* of 30 mg/kg when administered intraperitoneally .

HY-114806

Fenclofenac Flenac; R 67408	Thyroid Hormone Receptor	Inflammation/Immunology
Fenclofenac is an orally active anti-inflammatory agent with a low ulcerogenic effect. Fenclofenac also exhibits antipyretic and analgesic activities, with an oral *LD₅₀* of 2280 mg/kg in rats. Fenclofenac can be utilized in inflammation research .

HY-16172

DMAPT 2 Publications Verification Dimethylamino Parthenolide	NF-κB	Cancer
DMAPT (Dimethylamino Parthenolide), an analogue of Parthenolide (PTL), is an oral active NF-κB inhibitor, with a LD₅₀ of 1.7 μM for cell population in AML cells. Has potential anti-cancer and anti-metastatic effect .

HY-126645

Atelopidtoxin	Sodium Channel	Cardiovascular Disease
Atelopidtoxin (zetekitoxin) is a toxin (LD₅₀=0.016 mg/kg for mice), which can be isolated from Panamanian frog Atelopus zeteki. Atelopidtoxin causes hypotension and ventricular fibrillation in rabbits. Atelopidtoxin an inhibitor for sodium channel .

HY-16172A

(S)-DMAPT (S)-Dimethylamino Parthenolide	NF-κB	Cancer
(S)-DMAPT (Dimethylamino Parthenolide), an analogue of Parthenolide (PTL), is an oral active NF-κB inhibitor, with a LD₅₀ of 1.7 μM for cell population in AML cells. Has potential anti-cancer and anti-metastatic effect .

HY-B0824R

Bifenthrin (Standard)	Reference Standards Sodium Channel	Neurological Disease
Bifenthrin (Standard) is the analytical standard of Bifenthrin. This product is intended for research and analytical applications. Bifenthrin is a synthetic pyrethroid insecticide. Bifenthrin prolongs the opening time of Nav1.8 sodium channels, leading to membrane depolarization and conductance block in the insect nervous system, thereby disrupting neural function. Bifenthrin was effective in inhibiting A. gambiae (LD50=0.15 ng/mg) and C. quinquefasciatus (LD50=0.16 ng/mg). Bifenthrin has good lethality against susceptible and resistant mosquitoes and is very effective in inhibiting blood sucking and can be developed as a mosquito-removal netting material .

HY-121182

Chalcomycin	Antibiotic Bacterial	Infection
Chalcomycin is a macrolide antibiotic, which exhibits antimicrobial activities against gram-positive Staphylococcus aureus and Streptococcus pyogenes. Chalcomycin protects mice from infection with a variety of staphylococci and streptococc, without significant toxicity (LD₅₀ >2500 mg/kg) .

HY-135526

Demethoxyviridiol Desmethoxyviridiol	PI3K	Infection
Demethoxyviridiol is a mycotoxin originally isolated from N. hinnuleum. Demethoxyviridiol induces lethality in day-old cockerels (LD₅₀=4.2 mg/kg). Demethoxyviridiol is also an inhibitor of phosphatidylinositol 3-kinase (PI3K).

HY-135286AR

(+)-Neomenthol (Standard)	Reference Standards Parasite	Infection
(+)-Neomenthol (Standard) is the analytical standard of (+)-Neomenthol. This product is intended for research and analytical applications. (+)-Neomenthol is a potent miticide. (+)-Neomenthol shows acaricidal activitie with LD50 values of 0.32, 0.256 µg/mL for Dermatophagoides farinae and Dermatophagoides pteronyssinus, respectively[1].

HY-N2542

Tubeimoside III	Interleukin Related NO Synthase	Metabolic Disease Inflammation/Immunology Cancer
Tubeimoside III is a triterpenoid saponin. Tubeimoside III has anti-inflammatory and antitumor effects. Tubeimoside III has an *LD₅₀* of 15 mg/kg by intraperitoneal injection in ICR mice. Tubeimoside III can be used for the research of tumors and inflammatory diseases .

HY-N10697

Angulatin G Celangulatin E	Parasite	Infection
Angulatin G (Celangulatin E) is an insecticidal sesquiterpene polyol ester with a β-dihydroagarofuran sesquiterpene skeleton, which can be isolated from the root bark of Celastrus angulatus. Angulatin G shows *LD₅₀* against Mythimna separata of 1656.4 μg/mL .

HY-127165

Velnacrine HP 029 free base; Hydroxytacrine	Cholinesterase (ChE)	Neurological Disease
Velnacrine (HP 029 free base) is an inhibitor for acetylcholinesterase (AChE), with an *IC₅₀* of 3.27 μM. Velnacrine reverses the Scopolamine (HY-N0296)-induced amnesia in rat models, and exhibits acute toxicity with LD₅₀ of 65 mg/kg .

HY-116498

Penigequinolone A	Others	Infection
Penigequinolone A is an alkaloid isolated from Penicillium. It is lethal to P. penetrans (LD50=100 mg/L) but has no effect on C. elegans at concentrations up to 1000 mg/L.1 Penigequinolone A also accelerates the root growth of rice seedlings in a dose-dependent manner.

HY-N14195

Mathemycin A	Fungal	Infection
Mathemycin A has an inhibitory effect on pathogenic fungi. Mathemycin A inhibits the Phytophthora infestans JO8 in vitro (MIC is 7.8 μg/mL), and it inhibits JO8 in greenhouse (LD₅₀ is 42 X 10 ^-6, LC₉₀ is 500 X 10 ^-6) .

HY-N15473

Isopaucifloral F (±)-Isopaucifloral F	Estrogen Receptor/ERR Drug Derivative	Inflammation/Immunology
Isopaucifloral F ((±)-Isopaucifloral F) is a Resveratrol (HY-16561)-derived sesquiterpenes. Isopaucifloral F is an orally active ERβ agonist (EC₅₀: 46.96 μM). Isopaucifloral F has antiosteoporosis activity. LD₅₀ in rats: > 5 mg/kg .

HY-120367

DTP348	Carbonic Anhydrase	Cancer
DTP348 is an inhibitor for carbonic anhydrase IX with a K_i of 8.3 nM in vitro and an *IC₅₀* of 19.26 μM in Xenopus oocytes. DTP348 exhibits slight toxicity in zebrafish embryos with *LD₅₀* of 3.5 mM. DTP348 can be used in the anti-cancer research .

HY-121104A

Bactobolin hydrochloride	Antibiotic Bacterial	Infection Cancer
Bactobolin hydrochloride (Compound 1) is an antibiotic, which inhibits Escherichia coli, Salmonella, Shigella, Staphylococcus and Bacillus subtilis, with MICs of 0.3-6.25 μg/mL. Bactobolin hydrochloride exhibits antitumor efficacy against leukemia, with a *LD₅₀* value of 6.25-12.5 mg/kg .

HY-121104

Bactobolin	Antibiotic Bacterial	Infection Cancer
Bactobolin (Compound 1) is an antibiotic, which inhibits Escherichia coli, Salmonella, Shigella, Staphylococcus and Bacillus subtilis, with MICs of 0.3-6.25 μg/mL. Bactobolin exhibits antitumor efficacy against leukemia, with a *LD₅₀* value of 6.25-12.5 mg/kg .

HY-126788

Antibiotic DC 102 DC 102	Antibiotic	Infection Metabolic Disease
Antibiotic DC 102 is a new glycosidic pyrrole(1,4)benzodiazepine antibiotic with a MIC value of 42 μg/mL target Bacillus subtilis No. 10707. Antibiotic DC 102 has an *LD₅₀* value of 1.5mg/mL(i.p) in mouse .

HY-B1869

Metsulfuron-methyl 1 Publications Verification	Herbicide	Others
Metsulfuron-methyl is a systemic sulfonylurea herbicide that has been widely used to control broadleaf weeds and annual grasses in rice, corn, wheat, and barley. Metsulfuron-methyl exhibits high herbicidal activity and low mammalian toxicity, with an **LD₅₀ for rats exceeding 5000 mg/kg .**

HY-120407

Looplure ENT-33266	Insecticide	Others
Looplure (ENT-33266) is an insect attractant with acute toxicity studies in different animal models showing activity at oral and dermal median lethal doses (LD50) and median lethal concentrations (LC50) for fish with some values, and low toxicity in most cases except for some cases.

HY-W663230

Eugenitin	Parasite	Infection
Eugenitin is a polyketide isolated from the fungus Mycoleptodiscus indicus that is related to the South American medicinal plant. Eugenitin inhibits Leishmania major with *LD₅₀*=39.9 μM. Eugenitin has low cytotoxicity (IC₅₀ >131 μM) against several human cancer cell lines .

HY-137139

10'-Desmethoxystreptonigrin	Antibiotic Bacterial Farnesyl Transferase	Infection Cancer
10'-Desmethoxystreptonigrin is an inhibitor for Ras Farnesyltransferase with an *IC₅₀* of 21 μM. 10'-Desmethoxystreptonigrin is a broad-spectrum antibiotic with antibacterial activity. 10'-Desmethoxystreptonigrin exhibits antitumor activity against P388 leukemia, without significant cytotoxicity (LD₅₀ is 8.8 mg/kg) .

HY-114806R

Fenclofenac (Standard) Flenac (Standard); R 67408 (Standard)	Thyroid Hormone Receptor Reference Standards	Inflammation/Immunology
Fenclofenac (Standard) is the analytical standard of Fenclofenac. This product is intended for research and analytical applications. Fenclofenac is an orally active anti-inflammatory agent with a low ulcerogenic effect. Fenclofenac also exhibits antipyretic and analgesic activities, with an oral LD50 of 2280 mg/kg in rats. Fenclofenac can be utilized in inflammation research .

HY-D1005A16

Poloxamer 235 (P85) PEG-PPG-PEG, 4600 (Averag)	Biochemical Assay Reagents	Others
Poloxamer 235 P85 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 4600. Poloxamer 235 P85 exhibits acute and subchronic toxicity in albino rats with an oral *LD₅₀* of >34.6 g/kg. Poloxamer 235 P85 induces ocular irritation in rabbits .

HY-W024485

SARS-CoV-2-IN-86	SARS-CoV	Infection
SARS-CoV-2-IN-86 (Compound 2734589) is a dual inhibitor of the methyltransferases nsp14 and nsp16 of SARS-CoV-2. SARS-CoV-2-IN-86 exhibits low toxicity with a LD₅₀ of 700 mg/kg according to toxicity analysis predict .

HY-152927

Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da)	Biochemical Assay Reagents	Others
Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is a cosolvent for preparing SDDs of low-solubility agents. Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) exhibits no acute/subchronic/chronic toxicity in rats, with oral activity and LD₅₀ >2.5 g/kg .

HY-78086

m-Tolualdehyde 3-MethylbenzaLDehyde	Endogenous Metabolite Bacterial	Infection
m-Tolualdehyde (3-Methylbenzaldehyde) is a natural product. m-Tolualdehyde can be isolated from Ficus carica L. and Myosotis arvensis. m-Tolualdehyde has food protective effects. m-Tolualdehyde shows acaricidal activities for Tyrophagus putrescentiae with a *LD₅₀* of 1.97 μg/cm ³ .

HY-B1169

Timonacic 1 Publications Verification 1,3-Thiazolidine-4-carboxylic acid	Amino Acid Derivatives	Cardiovascular Disease Cancer
Timonacic (1,3-Thiazolidine-4-carboxylic acid) is an orally active thiol antioxidant. Timonacic has anti-aging and anti-hepatotoxic effects. Timonacic has a *LD₅₀* of 400 mg/kg for mice. Timonacic can be used in the research of liver diseases, gastrointestinal diseases, and cancer .

Cat. No.	Product Name	Type

HY-Y1275

N-Methylpyrrolidone NMP; 1-Methyl-2-pyrrolidinone	Co-solvents
N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a *LD₅₀* value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals .

HY-D1005A6

Poloxamer 124 (L44)

PEG-PPG-PEG, 2200 (Average)

Co-solvents

Poloxamer 124 L44 is a block polymer of polyoxyethylene and polyoxypropylene and a hydrophobic surfactant. Poloxamer 124 L44 causes eye irritation and exhibits oral toxicity in albino rats with an LD₅₀ of 5 g/kg. Poloxamer 124 L44 has reversible adverse effects on triglyceride and cholesterol transport in the lymphatic system of rats. Poloxamer 124 L44 can form thermoreversible hydrogels and is used as a food additive and as a drug delivery vehicle in cosmetics, pharmaceuticals, and tissue engineering[1][2][3].

HY-D1005A16

Poloxamer 235 (P85) PEG-PPG-PEG, 4600 (Averag)	Co-solvents
Poloxamer 235 P85 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 4600. Poloxamer 235 P85 exhibits acute and subchronic toxicity in albino rats with an oral *LD₅₀* of >34.6 g/kg. Poloxamer 235 P85 induces ocular irritation in rabbits .

Cat. No.	Product Name	Target	Research Area

HY-P2047

Lavendomycin Antibiotic FR-900201	Antibiotic Bacterial	Infection
Lavendomycin is a peptide antibiotic from Streptomyces. Lavendomycin inhibits Gram-positive bacteria .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-135286A

(+)-Neomenthol	Structural Classification Natural Products Acacia farnesiana (Linn.) Willd. Labiatae Source classification Plants	Parasite
(+)-Neomenthol is a potent miticide. (+)-Neomenthol shows acaricidal activitie with *LD₅₀* values of 0.32, 0.256 µg/mL for Dermatophagoides farinae and Dermatophagoides pteronyssinus, respectively .

HY-W099757

(±)-Coniine hydrochloride 2-Propylpiperidine hydrochloride	Structural Classification Alkaloids Ligularia veitchiana (Hemsl.) Greenm. Source classification Pyridine Alkaloids Plants Umbelliferae	nAChR
(±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an *EC₅₀* value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD₅₀ value of 7.7 mg/kg .

HY-125721

Tetranactin	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification	Fungal Bacterial Antibiotic
Tetranactin is an orally active antibiotic that has insecticidal properties and can inhibit the growth of Gram-positive bacteria and plant pathogenic fungal in vitro. Tetranactin *LD₅₀* for intraperitoneal injection in mice is greater than 300 mg/kg, and the *LD₅₀* is greater than 15,000 mg/kg .

HY-129208

Viridicatumtoxin	Other Terpenoids Infection Microorganisms Classification of Application Fields Terpenoids Source classification Disease Research Fields	Antibiotic Fungal
Viridicatumtoxin is a new mycotoxin extracted from Penicillium viridicatum with a *LD₅₀* of 122.4 mg/kg in rats.

HY-128430

Farnesyl acetate	Infection Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Disease Research Fields	Parasite DNA/RNA Synthesis
Farnesyl acetate is a sesquiterpene isolated from the leaves of Amomum gagnepainii. Farnesyl acetate has significant toxicity against red palm weevil larvae with a LD₅₀ of 7867 ppm .

HY-138100

Hyalodendrin (+)-Hyalodendrin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Fungal
Hyalodendrin ((+)-Hyalodendrin) is a fungal growth inhibitor with inhibitory activity against wood decay fungi. Hyalodendrin has low phytotoxicity, with an acute toxicity (LD50) of 75 mg/kg in mice .

HY-129469

Saframycin S	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic
Saframycin S is an antibiotic with a racemomycin group that exhibits inhibitory activity against Ehrlich ascites tumors. The LD₅₀ of Saframycin S in ddY mice is 3.2 mg/kg (i.p.) .

HY-N0531

Filixic acid ABA	Infection Quinones Urticaceae Classification of Application Fields Debregeasia wallichiana (Wedd.) Wedd. Source classification Phenols Polyphenols Benzene Quinones Plants Disease Research Fields	Parasite
Filixic acid ABA is a molluscicidal agent against B. peregrina adult snails, with an *LD₅₀* of 8.40 ppm. Filixic acid ABA shows 100% mortality of B. peregrina at 15 ppm .

HY-121229A

(±)-Coniine 2-Propylpiperidine	Alkaloids Piperidine Alkaloids Structural Classification Tsuga chinensis (Franch.) Pritz. Classification of Application Fields Pinaceae Source classification Other Diseases Plants Disease Research Fields	nAChR
(±)-Coniine (2-Propylpiperidine) is a piperidine alkaloid and nAChR agonist (EC₅₀=0.3 mM). (±)-Coniine is acutely toxic to mice with an LD50 value of 7.7 mg/kg .

HY-N10695

Celangulatin C	Structural Classification Pinaceae Terpenoids Sesquiterpenes Source classification Pseudolarix amabilis (J. Nelson) Rehder Plants	Parasite
Celangulatin C is an insecticidal sesquiterpene polyol ester, that can be isolated from the root bark of Pseudolarix kaempferi. Celangulatin C shows *LD₅₀* against Mythimna separata of 280.4 μg/mL .

HY-N14048

Cepacin A	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial
Cepacin A is an acetylenic antibiotic. Cepacin A has antibacterial activity, with a MIC of 0.2 μg/mL against staphylococci. In addition, Cepacin A is somewhat toxic to mice, with an *LD₅₀* of 30 mg/kg when administered intraperitoneally .

HY-126645

Atelopidtoxin	Structural Classification Natural Products Animals Source classification Animal Venoms	Sodium Channel
Atelopidtoxin (zetekitoxin) is a toxin (LD₅₀=0.016 mg/kg for mice), which can be isolated from Panamanian frog Atelopus zeteki. Atelopidtoxin causes hypotension and ventricular fibrillation in rabbits. Atelopidtoxin an inhibitor for sodium channel .

HY-121182

Chalcomycin	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification	Antibiotic Bacterial
Chalcomycin is a macrolide antibiotic, which exhibits antimicrobial activities against gram-positive Staphylococcus aureus and Streptococcus pyogenes. Chalcomycin protects mice from infection with a variety of staphylococci and streptococc, without significant toxicity (LD₅₀ >2500 mg/kg) .

HY-135286AR

(+)-Neomenthol (Standard)	Structural Classification Natural Products Acacia farnesiana (Linn.) Willd. Labiatae Source classification Plants	Reference Standards Parasite
(+)-Neomenthol (Standard) is the analytical standard of (+)-Neomenthol. This product is intended for research and analytical applications. (+)-Neomenthol is a potent miticide. (+)-Neomenthol shows acaricidal activitie with LD50 values of 0.32, 0.256 µg/mL for Dermatophagoides farinae and Dermatophagoides pteronyssinus, respectively[1].

HY-N2542

Tubeimoside III	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Plants Bolbostemma paniculaum (Maxim)Franguet Inflammation/Immunology Disease Research Fields	Interleukin Related NO Synthase
Tubeimoside III is a triterpenoid saponin. Tubeimoside III has anti-inflammatory and antitumor effects. Tubeimoside III has an *LD₅₀* of 15 mg/kg by intraperitoneal injection in ICR mice. Tubeimoside III can be used for the research of tumors and inflammatory diseases .

HY-N10697

Angulatin G Celangulatin E	Structural Classification Terpenoids Sesquiterpenes Source classification Celastraceae Celastrus angulatus Maxim. Plants	Parasite
Angulatin G (Celangulatin E) is an insecticidal sesquiterpene polyol ester with a β-dihydroagarofuran sesquiterpene skeleton, which can be isolated from the root bark of Celastrus angulatus. Angulatin G shows *LD₅₀* against Mythimna separata of 1656.4 μg/mL .

HY-116498

Penigequinolone A	Microorganisms Source classification	Others
Penigequinolone A is an alkaloid isolated from Penicillium. It is lethal to P. penetrans (LD50=100 mg/L) but has no effect on C. elegans at concentrations up to 1000 mg/L.1 Penigequinolone A also accelerates the root growth of rice seedlings in a dose-dependent manner.

HY-N14195

Mathemycin A	Structural Classification Natural Products Microorganisms Source classification	Fungal
Mathemycin A has an inhibitory effect on pathogenic fungi. Mathemycin A inhibits the Phytophthora infestans JO8 in vitro (MIC is 7.8 μg/mL), and it inhibits JO8 in greenhouse (LD₅₀ is 42 X 10 ^-6, LC₉₀ is 500 X 10 ^-6) .

HY-N15473

Isopaucifloral F (±)-Isopaucifloral F	Structural Classification Source classification Phenols Polyphenols Plants Dipterocarpaceae Vatica pauciflora (Korth.) Blume	Estrogen Receptor/ERR Drug Derivative
Isopaucifloral F ((±)-Isopaucifloral F) is a Resveratrol (HY-16561)-derived sesquiterpenes. Isopaucifloral F is an orally active ERβ agonist (EC₅₀: 46.96 μM). Isopaucifloral F has antiosteoporosis activity. LD₅₀ in rats: > 5 mg/kg .

HY-121104

Bactobolin	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial
Bactobolin (Compound 1) is an antibiotic, which inhibits Escherichia coli, Salmonella, Shigella, Staphylococcus and Bacillus subtilis, with MICs of 0.3-6.25 μg/mL. Bactobolin exhibits antitumor efficacy against leukemia, with a *LD₅₀* value of 6.25-12.5 mg/kg .

HY-126788

Antibiotic DC 102 DC 102	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic
Antibiotic DC 102 is a new glycosidic pyrrole(1,4)benzodiazepine antibiotic with a MIC value of 42 μg/mL target Bacillus subtilis No. 10707. Antibiotic DC 102 has an *LD₅₀* value of 1.5mg/mL(i.p) in mouse .

HY-W663230

Eugenitin	Structural Classification Natural Products Microorganisms Source classification	Parasite
Eugenitin is a polyketide isolated from the fungus Mycoleptodiscus indicus that is related to the South American medicinal plant. Eugenitin inhibits Leishmania major with *LD₅₀*=39.9 μM. Eugenitin has low cytotoxicity (IC₅₀ >131 μM) against several human cancer cell lines .

HY-137139

10'-Desmethoxystreptonigrin	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial Farnesyl Transferase
10'-Desmethoxystreptonigrin is an inhibitor for Ras Farnesyltransferase with an *IC₅₀* of 21 μM. 10'-Desmethoxystreptonigrin is a broad-spectrum antibiotic with antibacterial activity. 10'-Desmethoxystreptonigrin exhibits antitumor activity against P388 leukemia, without significant cytotoxicity (LD₅₀ is 8.8 mg/kg) .

HY-78086

m-Tolualdehyde 3-MethylbenzaLDehyde	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Labiatae Source classification Other Diseases Plants Disease Research Fields Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Endogenous Metabolite Bacterial
m-Tolualdehyde (3-Methylbenzaldehyde) is a natural product. m-Tolualdehyde can be isolated from Ficus carica L. and Myosotis arvensis. m-Tolualdehyde has food protective effects. m-Tolualdehyde shows acaricidal activities for Tyrophagus putrescentiae with a *LD₅₀* of 1.97 μg/cm ³ .

HY-N0381

Maackiain DL-Maackiain	Infection Natural Products Monophenols other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields	Parasite Apoptosis
Maackiain (DL-Maackiain) is isolated from Maackia amurensis Rupr.et Maxim. Maackiain (DL-Maackiain) is a larvicidal agent against Aedes aegypti mosquito.xp Parasitol with a *LD₅₀* of 21.95 µg/mL . Maackiain (DL-Maackiain) induces fragmentations of DNA to oligonucleosomal-sized fragments that like a characteristic of apoptosis in the HL-60 cells .

HY-N2542R

Tubeimoside III (Standard)	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Plants Bolbostemma paniculaum (Maxim)Franguet	Reference Standards Interleukin Related NO Synthase
Tubeimoside III (Standard) is the analytical standard of Tubeimoside III (HY-N2542). This product is intended for research and analytical applications. Tubeimoside III is a triterpenoid saponin. Tubeimoside III has anti-inflammatory and antitumor effects. Tubeimoside III has an *LD₅₀* of 15 mg/kg by intraperitoneal injection in ICR mice. Tubeimoside III can be used for the research of tumors and inflammatory diseases .

HY-N9495

(-)-trans-Myrtanol	Structural Classification Natural Products Source classification Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae	Bacterial
(-)-trans-Myrtanol is an antimicrobial and acaricide agent. (-)-trans-Myrtanol exhibits potent antimicrobial activities against harmful intestinal bacteria. (-)-trans-Myrtanol shows acaricidal activities for D. farinae, D. pteronyssinus, T. putrescentiae with *LD₅₀* values of 2.30 µg/cm ², 2.22 µg/cm ², 12.95 µg/cm ², respectively .

HY-129278

Lunarine	Structural Classification Alkaloids Lunaria annua L. Other Alkaloids Source classification Plants Brassicaceae	Parasite
Lunarine is an alkaloid, which can be isolated from the seeds of kale (Lunaria annua). Lunarine lowers the blood pressure, stimulates small intestinal motility, inhibits spontaneous contractions of uterus and nervous system, and exhibits an acute toxicity with LD₅₀ of 62.3 mg/kg in dogs and rabbits. Lunarine exhibits antiparasitic activity through a competitive inhibition of protozoan oxidoreductase trypanothione reductase (TryR) with K_i of 304 μM .

HY-78086R

m-Tolualdehyde (Standard) 3-MethylbenzaLDehyde (Standard)	Structural Classification Ketones, Aldehydes, Acids Labiatae Source classification Plants Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Reference Standards Endogenous Metabolite Bacterial
m-Tolualdehyde (Standard) is the analytical standard of m-Tolualdehyde. This product is intended for research and analytical applications. m-Tolualdehyde (3-Methylbenzaldehyde) is a natural product. m-Tolualdehyde can be isolated from Ficus carica L. and Myosotis arvensis. m-Tolualdehyde has food protective effects. m-Tolualdehyde shows acaricidal activities for Tyrophagus putrescentiae with a *LD₅₀* of 1.97 μg/cm ³ .

HY-130596

DC-86-M	Structural Classification Microorganisms Antibiotics Source classification Disease Research Anticancer	Antibiotic Bacterial
DC-86-M is an antibiotic, which can be isolated from Streptomyces luteogriseus. DC-86-M exhibits antibacterial activities against Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Vibrio anguillarum, and Proteus vulgaris, with MIC <1 μg/mL. DC-86-M exhibits antitumor activity against mouse sarcoma 180 with LD₅₀ of 25 mg/kg .

HY-N15424

Himachalol	Structural Classification Cedrus deodara (Roxburgh) G. Don Pinaceae Terpenoids Sesquiterpenes Source classification Plants	Apoptosis Bcl-2 Family
Himachalol, a sesquiterpene, is an orally active antispasmodic and anticancer constituent found in the wood of Cedrus deodara. Himachalol has anti-proliferative activity against the melanoma cells, and induces apoptosis (decreases Bcl-2 level and increases Bax level). Himachalol has systemic hypotension and peripheral vasodilation effect. Himachalol inhibits Carbachol-induced spasm of the intestine. The LD₅₀ of Himachalol in mice is 265 mg/kg (p.o.) and 247 mg/kg (i.p.) .

HY-N4202

Dihydrorotenone	Structural Classification Erycibe ferruginea C. Y. Wu Flavonoids Neurological Disease Classification of Application Fields Isoflavanones Source classification Plants Convolvulaceae Disease Research Fields Biological Pesticide Research Agricultural Research	Insecticide Apoptosis p38 MAPK
Dihydrorotenone is an insecticide and irreversible inhibitor of mitochondrial complex I and can cross the blood-brain barrier. Dihydrorotenone may induce Parkinson's disease. Dihydrorotenone induces apoptosis in human plasma cells by triggering endoplasmic reticulum stress and activating the p38 signaling pathway. The oral LD₅₀ of dihydrorotenone in rats is approximately 2.5 g/kg. Dihydrorotenone exhibits insecticide activity and cytotoxicity to plasma cells. Dihydrorotenone can be used to establish animal models of Parkinson's disease, safety assessment of natural pesticides, and potential cancer chemoprevention studies .

HY-N6715

Tenuazonic acid	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Biological Pesticide Research Agricultural Research	Influenza Virus Bacterial Enterovirus Photosystem II
Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a *photosystem II (PSII)* inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

HY-N6715R

Tenuazonic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Reference Standards Influenza Virus Bacterial Enterovirus Photosystem II
Tenuazonic acid (Standard) is the analytical standard of Tenuazonic acid. This product is intended for research and analytical applications. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a *photosystem II (PSII)* inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

HY-N15404

Glaucarubin	Structural Classification Natural Products Simaroubaceae Source classification Simarouba glauca DC. Plants	Parasite
Glaucarubin is a bitter lactone found in Simaruba glauca. Glaucarubin can be used as an amœbicide for amebiasis research. Glaucarubin is well tolerated, with LD₅₀s of 1,600 mg/kg for mice and 6,400 mg/kg for rats .

HY-N0440

Germacrone 1 Publications Verification	Infection Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Curcuma longa Disease Research Fields Zingiberaceae	Influenza Virus NF-κB 5 alpha Reductase Keap1-Nrf2 Lactate Dehydrogenase Apoptosis
Germacrone is a sesquiterpene compound with multiple biological activities. Germacrone inhibits the H1N1 and H3N2 inﬂuenza A virus and the inﬂuenza B virus. Germacrone blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone inhibits 5α-reductase and has anti-androgenic effect. Germacrone has neuroprotective functions and can be used for the study of traumatic brain injury (TBI). Germacrone also has antioxidant activity .

Cat. No.	Product Name	Chemical Structure

HY-Y1275S

N-Methylpyrrolidone-d9

N-Methylpyrrolidone-d₉ (NMP-d₉) is deuterium labeled N-Methylpyrrolidone. N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD₅₀ value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals .

HY-W653921

Tenuazonic acid-d13

Tenuazonic acid-d₁₃ is deuterium labeled Tenuazonic acid. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

HY-N6715S

Tenuazonic acid-13C10

Tenuazonic acid- ¹³C₁₀ is ¹³C labeled Tenuazonic acid (HY-N6715). Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

Cat. No.	Product Name		Classification

HY-151829

Fmoc-L-Asn(EDA-N3)-OH		Azide
Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification