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Results for "

KDM6B

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Apoptosis (2) Histone Demethylase (13) MMP (2) mTOR (2) PI3K (2) Reference Standards (1) Small Interfering RNA (siRNA) (3) TGF-beta/Smad (2)
By Research Areas:	Cancer (13) Endocrinology (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

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Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15648

GSK-J1 10+ Cited Publications	Histone Demethylase	Cancer
GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and *UTX/KDM6A, with IC₅₀* of 60 nM towards KDM6B.

HY-15648D

GSK-J1 lithium salt 10+ Cited Publications	Histone Demethylase	Cancer
GSK-J1 lithium salt is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and *UTX/KDM6A, with IC₅₀* of 60 nM towards KDM6B.

HY-15648A

GSK-J2 2 Publications Verification	Histone Demethylase	Cancer
GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.

HY-100764

YUKA1	Histone Demethylase	Cancer
YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC₅₀ of 2.66 μM, less active on KDM5C (IC₅₀, 7.12 μM), and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 increases H3K4me3 levels in human cells with anti-cancer activity .

HY-15648F

GSK-J4 hydrochloride Maximum Cited Publications 46 Publications Verification	Histone Demethylase	Cancer
GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases *JMJD3/KDM6B* and *UTX/KDM6A* with IC₅₀s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC₅₀ of 9 μM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1 .

HY-RS23655

Kdm6b Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Kdm6b Rat Pre-designed siRNA Set A contains three designed siRNAs for Kdm6b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kdm6b Rat Pre-designed siRNA Set A Kdm6b Rat Pre-designed siRNA Set A

HY-RS17203

Kdm6b Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Kdm6b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kdm6b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kdm6b Mouse Pre-designed siRNA Set A Kdm6b Mouse Pre-designed siRNA Set A

HY-RS07223

KDM6B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
KDM6B Human Pre-designed siRNA Set A contains three designed siRNAs for KDM6B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

KDM6B Human Pre-designed siRNA Set A KDM6B Human Pre-designed siRNA Set A

HY-15648G

GSK-J1 sodium	Histone Demethylase	Cancer
GSK-J1 sodium is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and *UTX/KDM6A, with IC₅₀* value of 60 nM towards KDM6B .

HY-15648I

GSK-J2 sodium	Histone Demethylase	Cancer
GSK-J2 sodium is the sodium form of GSK-J2 (HY-15648A). GSK-J2 is an isomer of GSK-J1, and does not have any specific activity. GSK-J1 (HY-15648) is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A .

HY-12304

IOX1 10+ Cited Publications	Histone Demethylase	Cancer
IOX1, 5-Carboxy-8-hydroxyquinoline, is a potent broad‐spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 inhibits KDM4C, KDM4E, KDM2A, KDM3A and KDM6B with IC₅₀ values of 0.6 μM, 2.3 μM, 1.8 μM, 0.1 μM and 1.4 μM, respectively . IOX1 also inhibits ALKBH5 .

HY-15648B

GSK-J4 Maximum Cited Publications 46 Publications Verification	Histone Demethylase Apoptosis	Cancer
GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases *JMJD3/KDM6B* and *UTX/KDM6A* with IC₅₀s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC₅₀ of 9 μM. GSK J4 is a cell permeable proagent of GSK-J1 . GSK-J4 induces endoplasmic reticulum stress-related apoptosis .

HY-15648FR

GSK-J4 hydrochloride (Standard)	Histone Demethylase	Cancer
GSK-J4 (hydrochloride) (Standard) is the analytical standard of GSK-J4 (hydrochloride). This product is intended for research and analytical applications. GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1 .

HY-N6896

Isoviolanthin 1 Publications Verification	TGF-beta/Smad PI3K Akt mTOR MMP Histone Demethylase	Endocrinology Cancer
Isoviolanthin is a flavonoid glycoside. Isoviolanthin can be extracted from Dendrobium officinale. Isoviolanthin has a strong affinity for binding to *KDM6B, CHAC2, ESCO2, and IPO4. Isoviolanthin decreases MMP-2* and MMP-9. Isoviolanthin inhibits TGF-β/Smad and PI3K/Akt/mTOR signaling pathways. Isoviolanthin increases Fhl3 expression. Isoviolanthin has cytoprotective effects. Isoviolanthin has anticancer activity against hepatocellular carcinoma .

HY-15648BR

GSK-J4 (Standard)	Histone Demethylase Apoptosis	Cancer
GSK-J4 (Standard) is the analytical standard of GSK-J4. This product is intended for research and analytical applications. GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK J4 is a cell permeable proagent of GSK-J1 . GSK-J4 induces endoplasmic reticulum stress-related apoptosis .

HY-N6896R

Isoviolanthin (Standard)	Reference Standards TGF-beta/Smad PI3K Akt mTOR MMP Histone Demethylase	Endocrinology Cancer
Isoviolanthin (Standard) is the analytical standard of Isoviolanthin (HY-N6896). This product is intended for research and analytical applications. Isoviolanthin is a flavonoid glycoside. Isoviolanthin can be extracted from Dendrobium officinale. Isoviolanthin has a strong affinity for binding to *KDM6B, CHAC2, ESCO2, and IPO4. Isoviolanthin decreases MMP-2* and MMP-9. Isoviolanthin inhibits TGF-β/Smad and PI3K/Akt/mTOR signaling pathways. Isoviolanthin increases Fhl3 expression. Isoviolanthin has cytoprotective effects. Isoviolanthin has anticancer activity against hepatocellular carcinoma .

Isoviolanthin 1 Publications Verification	Structural Classification Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	TGF-beta/Smad PI3K Akt mTOR MMP Histone Demethylase
Isoviolanthin is a flavonoid glycoside. Isoviolanthin can be extracted from Dendrobium officinale. Isoviolanthin has a strong affinity for binding to *KDM6B, CHAC2, ESCO2, and IPO4. Isoviolanthin decreases MMP-2* and MMP-9. Isoviolanthin inhibits TGF-β/Smad and PI3K/Akt/mTOR signaling pathways. Isoviolanthin increases Fhl3 expression. Isoviolanthin has cytoprotective effects. Isoviolanthin has anticancer activity against hepatocellular carcinoma .

Isoviolanthin (Standard)	Structural Classification Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	Reference Standards TGF-beta/Smad PI3K Akt mTOR MMP Histone Demethylase
Isoviolanthin (Standard) is the analytical standard of Isoviolanthin (HY-N6896). This product is intended for research and analytical applications. Isoviolanthin is a flavonoid glycoside. Isoviolanthin can be extracted from Dendrobium officinale. Isoviolanthin has a strong affinity for binding to *KDM6B, CHAC2, ESCO2, and IPO4. Isoviolanthin decreases MMP-2* and MMP-9. Isoviolanthin inhibits TGF-β/Smad and PI3K/Akt/mTOR signaling pathways. Isoviolanthin increases Fhl3 expression. Isoviolanthin has cytoprotective effects. Isoviolanthin has anticancer activity against hepatocellular carcinoma .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P702082

	KDM6B Protein, Human (sf9) KDM6B; Lysine-specific demethylase 6B; JmjC domain-containing protein 3; Jumonji domain-containing protein 3; Lysine demethylase 6B; [histone H3]-trimethyl-L-lysine(27) demethylase 6B	Human	Sf9 insect cells
	KDM6B protein is a histone demethylase targeting "Lys-27" of histone H3, which mainly affects the histone code. Demethylates H3 "Lys-27" to shape the epigenetic landscape. KDM6B Protein, Human (sf9) is the recombinant human-derived KDM6B protein, expressed by sf9 insect cells , with tag free.

HY-P702083

	KDM6B Protein, Human (sf9, His) KDM6B; Lysine-specific demethylase 6B; JmjC domain-containing protein 3; Jumonji domain-containing protein 3; Lysine demethylase 6B; [histone H3]-trimethyl-L-lysine(27) demethylase 6B	Human	Sf9 insect cells
	KDM6B protein is a histone demethylase targeting "Lys-27" of histone H3, which mainly affects the histone code. Demethylates H3 "Lys-27" to shape the epigenetic landscape. KDM6B Protein, Human (sf9, His) is the recombinant human-derived KDM6B protein, expressed by sf9 insect cells , with N-8*His labeled tag.

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Kdm6b Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Kdm6b Rat Pre-designed siRNA Set A contains three designed siRNAs for Kdm6b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kdm6b Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Kdm6b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kdm6b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

KDM6B Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
KDM6B Human Pre-designed siRNA Set A contains three designed siRNAs for KDM6B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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