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Pathways Recommended:	Antibody-drug Conjugate/ADC Related

Results for "

IgG4 antibody

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (4) Antibody-Drug Conjugates (ADCs) (2) Akt (1) Amyloid-β (1) ANGPTL (1) Apoptosis (8) ATGL (1) c-Fms (1) c-Met/HGFR (2) c-Myc (1) C-type Lectin-like Receptors (CTLRs) (1) Cadherin (1) Caspase (1) CCR (2) CD20 (1) CD22 (3) CD28 (4) CD3 (8) CD38 (2) CD47 (6) CD73 (1) CGRP Receptor (1) Complement System (4) CTLA-4 (1) CXCR (5) Dan family (1) DNA/RNA Synthesis (1) EGFR (2) Factor VIII (1) Factor Xa (4) Fc Receptor (FcR) (1) Ferroportin (1) GCGR (1) HIV (4) Human leukocyte immunoglobulin (Ig)-like receptors (LILR) (1) IFNAR (1) IGF-1R (1) Integrin (3) Interleukin Related (24) LAG-3 (7) MMP (1) Mucin (2) MyD88 (1) NAMPT (1) Natriuretic Peptide Receptor (NPR) (2) Neuropeptide Y Receptor (1) NF-κB (2) NOD-like Receptor (NLR) (1) NTPDase (1) Orexin Receptor (OX Receptor) (2) P-selectin (1) p38 MAPK (1) PACAP Receptor (1) PAI-1 (1) PCSK9 (2) PD-1/PD-L1 (27) PSMA (2) RANKL/RANK (1) SARS-CoV (2) Ser/Thr Protease (2) Small Interfering RNA (siRNA) (1) Tau Protein (4) TGF-beta/Smad (4) TGF-β Receptor (3) Thrombin (1) Tim3 (2) TNF Receptor (14) Toll-like Receptor (TLR) (4) Transmembrane Glycoprotein (15) Trk Receptor (1) VEGFR (3) β-catenin (1)
By Research Areas:	Cancer (80) Cardiovascular Disease (14) Infection (6) Inflammation/Immunology (118) Metabolic Disease (4) Neurological Disease (8)

By Targets:

ADC Antibody (4)

Antibody-Drug Conjugates (ADCs) (2)

Akt (1)

Amyloid-β (1)

ANGPTL (1)

Apoptosis (8)

ATGL (1)

c-Fms (1)

c-Met/HGFR (2)

c-Myc (1)

C-type Lectin-like Receptors (CTLRs) (1)

Cadherin (1)

Caspase (1)

CCR (2)

CD20 (1)

CD22 (3)

CD28 (4)

CD3 (8)

CD38 (2)

CD47 (6)

CD73 (1)

CGRP Receptor (1)

Complement System (4)

CTLA-4 (1)

CXCR (5)

Dan family (1)

DNA/RNA Synthesis (1)

EGFR (2)

Factor VIII (1)

Factor Xa (4)

Fc Receptor (FcR) (1)

Ferroportin (1)

GCGR (1)

HIV (4)

Human leukocyte immunoglobulin (Ig)-like receptors (LILR) (1)

IFNAR (1)

IGF-1R (1)

Integrin (3)

Interleukin Related (24)

LAG-3 (7)

MMP (1)

Mucin (2)

MyD88 (1)

NAMPT (1)

Natriuretic Peptide Receptor (NPR) (2)

Neuropeptide Y Receptor (1)

NF-κB (2)

NOD-like Receptor (NLR) (1)

NTPDase (1)

Orexin Receptor (OX Receptor) (2)

P-selectin (1)

p38 MAPK (1)

PACAP Receptor (1)

PAI-1 (1)

PCSK9 (2)

PD-1/PD-L1 (27)

PSMA (2)

RANKL/RANK (1)

SARS-CoV (2)

Ser/Thr Protease (2)

Small Interfering RNA (siRNA) (1)

Tau Protein (4)

TGF-beta/Smad (4)

TGF-β Receptor (3)

Thrombin (1)

Tim3 (2)

TNF Receptor (14)

Toll-like Receptor (TLR) (4)

Transmembrane Glycoprotein (15)

Trk Receptor (1)

VEGFR (3)

β-catenin (1)

By Research Areas:

Cancer (80)

Cardiovascular Disease (14)

Infection (6)

Inflammation/Immunology (118)

Metabolic Disease (4)

Neurological Disease (8)

183

Inhibitors & Agonists

209

Inhibitory Antibodies

Antibodies

Pembrolizumab Maximum Cited Publications 24 Publications Verification MK-3475; Lambrolizumab	PD-1/PD-L1	Cancer
Pembrolizumab (MK-3475) is a humanized IgG4 antibody inhibiting the programmed cell death 1 (PD-1) receptor, used in cancer immunotherapy.

Lemzoparlimab 1 Publications Verification TJ011133; TJC4	CD47	Cancer
Lemzoparlimab (TJ011133; TJC4) is a humanized anti-CD47 IgG4 antibody. Lemzoparlimab has a strong anti-tumor activity .

Tesnatilimab JNJ-64304500; IPH-2301; NN-8555	C-type Lectin-like Receptors (CTLRs)	Inflammation/Immunology
Tesnatilimab (JNJ-64304500) is a human IgG4 monoclonal antibody targeting NKG2D. Tesnatilimab can be studied in research for diseases such as Crohn’s disease (CD) and Inflammatory Bowel Disease (IBD). Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Galcanezumab 1 Publications Verification LY 2951742	CGRP Receptor	Neurological Disease
Galcanezumab (LY 2951742) is a humanized IgG4 monoclonal antibody against the CGRP ligand. Galcanezumab can be used for migraine or cluster headaches research .

Garadacimab 1 Publications Verification CSL312	Factor Xa	Cardiovascular Disease
Garadacimab (CSL312) is a first-in-class, fully human IgG4 monoclonal antibody targeting activated factor XII (FXIIa). Garadacimab has the potential for hereditary angioedema research .

Garetosmab 1 Publications Verification REGN 2477	TGF-β Receptor	Inflammation/Immunology
Garetosmab (REGN 2477) is a fully human IgG4 monoclonal antibody that specifically inhibits activin A. Garetosmab can be used for fibrodysplasia ossificans progressiva (FOP) research .

Tralokinumab 2 Publications Verification CAT354	Interleukin Related Apoptosis Caspase Cadherin	Inflammation/Immunology
Tralokinumab (CAT354) is a humanized IgG4 monoclonal antibody that specifically binds to and neutralizes IL-13. Tralokinumab can be used in the research of diseases such as asthma, atopic dermatitis, and pulmonary fibrosis .

Bepranemab UCB 0107	Tau Protein	Neurological Disease
Bepranemab (UCB 0107) is a humanized, full-length IgG4 monoclonal antibody. Bepranemab targets the central portion of tau, specifically amino acids 235 to 246. Bepranemab can be used for Alzheimer’s disease (AD) research .

Frovocimab LY 3015014	PCSK9	Metabolic Disease
Frovocimab (LY 3015014) is a humanized IgG4 monoclonal antibody (mAb) that neutralizes PCSK9. Frovocimab inhibits PCSK9 binding to LDL receptor (LDLR) while permitting the normal proteolytic cleavage of the bound intact PCSK9 .

Ibalizumab TMB-355; TNX-355	HIV	Infection
Ibalizumab (TMB-355) is a humanized anti-CD4 IgG4 monoclonal antibody. Ibalizumab prevents HIV cell entry by binding to CD4 receptor. Ibalizumab can be used for the research of infection, such as HIV-1 infection .

CT140	PAI-1	Cardiovascular Disease
CT140 is a human IgG4 monoclonal antibody (mAb) targeting PAI-1. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003).

Ubletamig	Mucin	Others
Ubletamig is an anti-MUC16 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003) .

Amrecibart	Factor Xa	Cardiovascular Disease
Amrecibart is an anti-coagulation factor 11 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003) .

Acrixolimab	PD-1/PD-L1	Cancer
Acrixolimab a humanized IgG4-κ antibody, targeting to PD-1 .

Zemocimig	Factor Xa	Cardiovascular Disease
Zemocimig is an anti-coagulation factor F9 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003) .

Eltrekibart LY-3041658	CXCR	Inflammation/Immunology
Eltrekibart is an anti-CXCL human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Venanprubart LY-3361237	CD28	Inflammation/Immunology
Venanprubart is an anti-BTLA human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Sabatolimab 1 Publications Verification MBG453	Tim3	Inflammation/Immunology
Sabatolimab (MBG453) is a high-affinity, humanized, IgG4 (S228P) antibody targeting TIM-3, an inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab is a potential immunosuppression agent that can target TIM-3 on immune and myeloid cells .

Pamvatamig	EGFR	Inflammation/Immunology
Pamvatamig is an anti-EGFR/MET human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

SSGJ-707	PD-1/PD-L1 VEGFR	Cancer
SSGJ-707 is a bispecific, recombinant humanized IgG4 monoclonal antibody inhibitor targeting PD-1 and VEGF. SSGJ-707 can be used for cancers research, such as advanced non-small cell lung cancer (NSCLC) and recurrent endometrial cancer

Abiprubart	TNF Receptor	Inflammation/Immunology
Abiprubart is an anti-CD40 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Pradusinstobart LVGN-3616	PD-1/PD-L1	Inflammation/Immunology
Pradusinstobart is an anti-PDCD1 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Negalstobart	LAG-3	Inflammation/Immunology
Negalstobart is an anti-LAG3 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Roconkibart	Interleukin Related	Inflammation/Immunology
Roconkibart is an anti-IL17A human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Vipalanebart	Small Interfering RNA (siRNA)	Inflammation/Immunology
Vipalanebart is an anti-ADCYAP1R human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Nelmastobart	Transmembrane Glycoprotein	Inflammation/Immunology
Nelmastobart is an anti-BTN1A1 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Anti-IL11RA Antibody (X209) EnX209	Interleukin Related	Inflammation/Immunology
Anti-IL11RA Antibody (X209) is a human-derived IgG4, κ type antibody inhibitor, targeting to human IL-11RA. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003).

ALT-100 (Human IgG4)	NAMPT	Inflammation/Immunology
ALT-100 (Human IgG4) is a humanized antibody expressed in CHO, targeting NAMPT. ALT-100 (Human IgG4) consists of a huIgG1/huIgG4 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. For inflammatory or fibrotic diseases, the isotype control for ALT-100 (Human IgG4) can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

COM902	Transmembrane Glycoprotein	Cancer
COM902 is a human IgG4 monoclonal antibody (mAb) targeting TIGIT. COM902 enhances anti-tumor immune responses. COM902 can be used in Multiple myeloma, Solid tumours and Colorectal cancer research. Recommended isotype control: IgG4-lambda .

Nezastomig REGN-5678	CD28	Inflammation/Immunology
Nezastomig is an anti-FOLH1/CD28 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Inclacumab 1 Publications Verification Anti-Human selectin P Recombinant antibody	P-selectin	Cardiovascular Disease
Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets P-selectin with a K_d value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC₅₀ value of 1.9 μg/mL and strongly inhibits cell adhesion .

Gamgertamig	TNF Receptor CD3	Inflammation/Immunology Cancer
Gamgertamig is a humanized IgG4 bispecific antibody targeting TNFRSF17 & CD3E .

Vilamakitug XB-2001	Interleukin Related	Inflammation/Immunology
Vilamakitug (XB-2001) is an anti-IL-1α human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Ciduvectamig	CD3	Inflammation/Immunology
Ciduvectamig is an anti-CD3E/TMEFF2 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Balstilimab AGEN2034	PD-1/PD-L1	Inflammation/Immunology Cancer
Balstilimab (AGEN2034) is a fully human monoclonal IgG4 antibody against PD-1 .

ENx-108A	Interleukin Related	Inflammation/Immunology
ENx-108A is a human IgG4 monoclonal antibody (mAb) targeting IL-11. BI-765423 can be used in fibrotic diseases research. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003) .

Cedelizumab RWJ 49004	HIV	Inflammation/Immunology
Cedelizumab (RWJ 49004) is a IgG4 monoclonal antibody targeting CD4. Cedelizumab has immunosuppressant properties .

Ichorcumab JNJ-375; JNJ-64179375; JNJ-9375	Thrombin	Cardiovascular Disease
Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets Thrombin. Ichorcumab binds to exosite 1 on thrombin and inhibits substrate binding but not catalytic activity. The isotype control for Ichorcumab can refer to Human IgG4 kappa, Isotype Control (HY-P99003) .

Cemiplimab REGN-2810; SAR-439684	PD-1/PD-L1	Cancer
Cemiplimab (Anti-Human PD-1) is a high-affinity programmed death receptor-1 (PD-1) monoclonal IgG4 antibody that blocks PD-1/PD-L1-mediated T-cell suppression. Cemiplimab is commonly used in squamous cell skin cancer research .

Sasanlimab PF-06801591	PD-1/PD-L1	Others Cancer
Sasanlimab (PF-06801591) is a humanized IgG4-κ antibody targeting PD-1. Mainly expressed by CHO (Chinese Hamster Ovary) cells .

IMP-761	LAG-3	Cancer
IMP-761 is a human IgG4 monoclonal antibody (mAb) targeting CD223/LAG3. IMP-761 binds to D1 of human LAG32. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003) .

Ieramilimab LAG525; IMP701; Hu5A8	LAG-3	Cancer
Ieramilimab (LAG525; IMP701) is a humanized IgG4 monoclonal antibody that binds to LAG-3, resulting in inhibition of LAG-3 interaction with MHC-II molecules. Ieramilimab restores T-cell and NK-cell-mediated antileukemic immunity by reducing exhaustion and augmenting cytokine output and cytotoxicity. Ieramilimab increases the infiltration of cytotoxic T lymphocytes and reduces baseline densities of regulatory T cells (Tregs) and ADAM10-expressing tumor cells. Ieramilimab can be used for the study of various malignancies including melanoma, RCC, and advanced solid tumors .

Metelimumab 3 Publications Verification CAT-192; Anti-TGFB1 Recombinant antibody	TGF-β Receptor	Inflammation/Immunology
Metelimumab (CAT-192) is a human IgG4 monoclonal antibody that can selectively neutralize TGFβ1 .

Nebaprubart	Fc Receptor (FcR)	Inflammation/Immunology
Nebaprubart is a humanized IgG4κ antibody targeting FCAR/CD89. The corresponding isotype control is: Human IgG4 kappa, Isotype Control (HY-P99003) .

Ponumkibart	Interleukin Related	Inflammation/Immunology
Ponumkibart is a humanized IgG4κ antibody targeting IL-17RB. The corresponding isotype control is: Human IgG4 kappa, Isotype Control (HY-P99003) .

Baloncibart	Natriuretic Peptide Receptor (NPR)	Inflammation/Immunology
Baloncibart is a human IgG4K antibody targeting NPR1. The corresponding isotype control is: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83582

	*Human IgG4* Antibody (YA3327)** IgG4; Ig gamma 4 chain C region	WB, IHC-P	Human
	Human IgG4 Antibody (YA3327) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Human IgG4.

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