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Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

HIV-1 Protease

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HIV (73) HIV Integrase (1) HIV Protease (113) Ser/Thr Protease (1) Virus Protease (3) Antibiotic (1) Apoptosis (5) Autophagy (2) Bacterial (1) Calcium Channel (1) Cytochrome P450 (8) Dipeptidyl Peptidase (1) Drug Intermediate (6) Drug Metabolite (1) EBV (2) Endogenous Metabolite (8) ERK (3) Flavivirus (2) Fungal (1) HSV (2) Isotope-Labeled Compounds (15) JNK (1) MMP (4) NF-κB (1) P-glycoprotein (9) p38 MAPK (1) Phosphatase (3) Phospholipase (2) PKC (1) Reactive Oxygen Species (ROS) (1) Reference Standards (12) Renin (1) Reverse Transcriptase (3) SARS-CoV (21) Toll-like Receptor (TLR) (3)
By Research Areas:	Cancer (28) Cardiovascular Disease (3) Infection (123) Inflammation/Immunology (13) Metabolic Disease (1)

By Targets:

HIV (73)

HIV Integrase (1)

HIV Protease (113)

Ser/Thr Protease (1)

Virus Protease (3)

Antibiotic (1)

Apoptosis (5)

Autophagy (2)

Bacterial (1)

Calcium Channel (1)

Cytochrome P450 (8)

Dipeptidyl Peptidase (1)

Drug Intermediate (6)

Drug Metabolite (1)

EBV (2)

Endogenous Metabolite (8)

ERK (3)

Flavivirus (2)

Fungal (1)

HSV (2)

Isotope-Labeled Compounds (15)

JNK (1)

MMP (4)

NF-κB (1)

P-glycoprotein (9)

p38 MAPK (1)

Phosphatase (3)

Phospholipase (2)

PKC (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (12)

Renin (1)

Reverse Transcriptase (3)

SARS-CoV (21)

Toll-like Receptor (TLR) (3)

By Research Areas:

Cancer (28)

Cardiovascular Disease (3)

Infection (123)

Inflammation/Immunology (13)

Metabolic Disease (1)

132

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: HIV Protease HIV HIV Integrase Virus Protease HCV Protease Protease Activated Receptor (PAR) Ser/Thr Protease ClpP Serpin TMPRSS6 Enteropeptidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70626

**HIV-1 Protease**	HIV Protease	Infection
HIV-1 Protease is synthesized as part of a large Gag-Pol precursor protein. HIV-1 Protease is responsible for its own release from the precursor and the processing of the Gag and Gag-Pol polyproteins into the mature structural and functional proteins required for virus maturation .

HY-147650

HIV-1 protease-IN-5	HIV Protease	Infection
HIV-1 protease-IN-5 (Compound 13c) is a **HIV-1 protease inhibitor with an IC₅₀** of 1.64 nM. HIV-1 protease-IN-5 shows remarkable activity against wild-type and DRV-resistant HIV-1 variants .

HY-155691

HIV-1 protease-IN-12	HIV Protease	Infection
HIV-1 protease-IN-12 (compound 35b) is a **HIV-1 protease inhibitor with an IC₅₀** of 0.51 nM. HIV-1 protease-IN-12 also inhibits drug-resistant variant .

HY-155690

HIV-1 protease-IN-11	HIV Protease	Infection
HIV-1 protease-IN-11 (compound 34a) is a **HIV-1 protease inhibitor with an IC₅₀** of 0.41 nM. HIV-1 protease-IN-11 also exhibits significant activity against drug-resistant variant .

HY-144688

HIV-1 protease-IN-1	HIV	Infection
HIV-1 protease-IN-1 (Compound 1e) is a potent inhibitor of *HIV-1* protease with an IC₅₀ of 90 pM. HIV-1 protease-IN-1 demonstrates antiviral activity with EC₅₀ value of 89 nM against B-HIV. HIV-1 protease-IN-1 exhibits activity with EC₅₀ value of 13.59 nM against C-HIV strain ZM246. HIV-1 protease-IN-1 shows remarkable activity with EC₅₀ value of 8.23 nM against C-HIV strain Indie ^[1].

HY-146804

HIV-1 protease-IN-3	HIV HIV Protease	Infection
HIV-1 protease-IN-3 (compound 14) is a potent inhibitor of **HIV-1 protease (IC₅₀=71 nM; EC₅₀**=0.86 μM) .

HY-146012

HIV-1 protease-IN-4	HIV	Infection
HIV-1 protease-IN-4 (Compound II-22) is a potent *HIV-1* protease inhibitor. HIV-1 protease-IN-4 is a proagent of atazanavir. HIV-1 protease-IN-4 as a proagent that delivers the parent 1 to rat plasma with a 5-fold higher AUC and 67-fold higher C24 when compared to oral administration of the parent agent .

HY-149936

HIV-1 protease-IN-8	HIV Protease	Infection
HIV-1 protease-IN-8 (compound 34b) is a potent **HIV-1 protease inhibitor with an IC₅₀** value of 0.32 nM. HIV-1 protease-IN-8 displays IC₅₀s of 0.29 μM and 1.90 μM for wild-type HIV-1 (HIV-1_NL4-3) and drug-resistant variant (HIV-1_MDR), respectively. HIV-1 protease-IN-8 displays robust antiviral activity against both wild-type HIV-1 and drug-resistant variant .

HY-161270

HIV-1 protease-IN-13	HIV Protease	Infection
HIV-1 protease-IN-13 (compound 18d) is a potent **HIV-1 protease inhibitor with an IC₅₀** value of 0.54 nM. HIV-1 protease-IN-13 also shows potent activity against HIV-1DRVRS (DRV-resistant mutation) and HIV-1NL4_3 variant (wild type) .

HY-174998

HIV-1 protease-IN-15	HIV HIV Protease	Infection
HIV-1 protease-IN-15 (Compound 27) is an orally active and selective inhibitor targeting **HIV-1 protease with a pIC₅₀** value of 9.347. HIV-1 protease-IN-15 inhibits HIV protein maturation, blocks viral replication. HIV-1 protease-IN-15 is promising for research of HIV-1 infection .

HY-146888

HIV-1 protease-IN-2	HIV Protease	Infection
HIV-1 protease-IN-2 is a potent **HIV-1 protease inhibitor with an IC₅₀** of 2.53 nM. HIV-1 protease-IN-2 shows antiviral activity against DRV (Darunavir)-sensitive or DRV-resistant HIV-1 variants .

HY-169166

HIV-1 protease-IN-14	HIV Protease	Infection
HIV-1 protease-IN-14 (compound 5ae) is a potent **HIV-1 protease inhibitor with K_i** values of 0.28, 56.9 nM for WT HIV-1 PR, R41T HIV-1 PR, respectively. HIV-1 protease-IN-14 shows low cytotoxicity .

HY-155076

HIV-1 protease-IN-9	HIV Protease	Infection
HIV-1 protease-IN-9 (compound 5b) is a **HIV-1 protease inhibitor, with a K_i** of 0.028 nM. HIV-1 protease-IN-9 shows potent antiviral activity, with an IC₅₀ of 66.8 nM .

HY-155599

HIV-1 protease-IN-10	HIV PKC	Infection
HIV-1 protease-IN-10 (Compound 2) has *HIV-1* latency reversing activity (IC₅₀: 0.22 μM). HIV-1 protease-IN-10 binds to the PKCδ C1b domain (IC₅₀: 0.69 μM). HIV-1 protease-IN-10 has stability against esterase-mediated hydrolysis .

HY-150549

HIV-1 protease-IN-6	HIV Protease HIV	Infection Inflammation/Immunology
HIV-1 protease-IN-6 (compound 17d) is a potent **HIV-1 protease inhibitor, with an IC₅₀ of 21 pM and a K_i** of 4.7 pM, respectively. HIV-1 protease-IN-6 exhibits potent antiviral activity to DRV (darunavir)-resistant variant, even more than wild type virus .

HY-151250

HIV-1 protease-IN-7	HIV Protease	Infection
HIV-1 protease-IN-7 (compound 16) is an orally active **HIV-1 protease inhibitor (IC₅₀=3.52 nM, EC₅₀**=37 nM) .

HY-P3980

HIV-1, HIV-2 Protease Substrate	HIV Protease	Infection
HIV-1, HIV-2 Protease Substrate is the substrate of **HIV-1, **HIV-2 **protease. And there are 4 residues for conservative substitutions of the substrate binding residues of **HIV-1 *and HIV-2* protease .**********

HY-118057

L-739594	HIV	Inflammation/Immunology
L-739594 is a **HIV-1 protease inhibitor, with an IC₅₀** of 1.8 nM .

HY-125551

L-687908	HIV Protease	Infection
L-687908 is a **HIV-1 protease** inhibitor (CIC₉₅: 12 nM) .

HY-P4466

Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2	HIV Protease	Infection
Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 is a fluorogenic substrate of **HIV-1 protease*. Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 can be used to test HIV-1* protease activity .

HY-120863

(Rac)-PD 135390	Virus Protease	Infection
(Rac)-PD 135390 is a dipeptide and an **HIV-1 protease inhibitor with an IC₅₀** of 2 nM. (Rac)-PD 135390 can be utilized in antiviral research .

HY-105148

Mozenavir DMP-450	HIV HIV Protease	Infection
Mozenavir (DMP 450) is an orally active and highly selective inhibitor of **HIV-1 protease (K_i*=0.3 nM). Mozenavir blocks the cleavage and processing of viral polyproteins, inhibiting the replication and maturation of HIV-1. Mozenavir is promising for research of HIV* infection .

HY-152200

HIV-1 inhibitor-53	HIV Protease Reverse Transcriptase	Infection Inflammation/Immunology
HIV-1 inhibitor-53 is a *dual HIV-1* protease and reverse transcriptase** inhibitor. HIV-1 inhibitor-53 inhibits HIV-1 protease (PR) and reverse transcriptase (RT) activity with IC₅₀ values of 1.93 nM and 2.35 μM, respectively. HIV-1 inhibitor-53 can be used for the research of acquired immune deficiency syndrome (AIDS) .

HY-P1436

Acetyl-pepstatin	HIV	Infection
Acetyl-pepstatin is a potent classical inhibitor of aspartic proteases (PRs) with XMRV PR and HIV-1 PR K_i values of 712 nM and 13 nM .

HY-N10420

Hinokinin 1 Publications Verification (-)-Hinokinin	HIV Protease	Infection
Hinokinin (Compound 1) is a compound isolated from the stems of Hypoestes aristate. Hinokinin exhibits moderate activity of HIV-1 protease enzyme .

HY-N10420R

Hinokinin (Standard) (-)-Hinokinin (Standard)	Reference Standards HIV Protease	Infection
Hinokinin (Standard) is the analytical standard of Hinokinin. This product is intended for research and analytical applications. Hinokinin (Compound 1) is a compound isolated from the stems of Hypoestes aristate. Hinokinin exhibits moderate activity of HIV-1 protease enzyme .

HY-N11940

Acetyl-binankadsurin A	HIV Protease	Infection
Acetyl-binankadsurin A (compound 5) is a lignan isolated from Kadsura longipedunculata. Acetyl-binankadsurin A has low inhibitory activity against HIV-1 protease, with IC₅₀ >100 μg/mL .

HY-106395

Telinavir SC-52151	HIV Protease HIV	Infection
Telinavir (SC-52151) is a potent and selective **HIV protease** inhibitor. Telinavir inhibits lymphotropic, monocytotropic strains and field isolates of HIV type 1 (HIV-1), HIV-2, and simian immunodeficiency virus with EC₅₀s of 26 ng/mL (43 nM). Telinavir is highly protein bound in human plasma and exhibits low partitioning into erythrocytes .

HY-N2565

Rosamultin	HIV Protease Apoptosis	Infection
Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina?L. Rosamultin has inhibitory effects against **HIV-1 protease** . Rosamultin has the potential for treating H₂O₂-induced oxidative stress injury through its antioxidant and antiapoptosis effects .

HY-134851

HIV-1 inhibitor-6 1 Publications Verification	HIV	Infection
HIV-1 inhibitor-6 (compound 9), a diheteroarylamide-based compound, is a potent HIV-1 pre-mRNA alternative splicing inhibitor. HIV-1 inhibitor-6 blocks HIV replication. HIV-1 inhibitor-6 is active against wild-type HIV-1IIIB (subtype B, X4-tropic) and HIV-1 97USSN54 (subtype A, R5-tropic) with EC₅₀s of 0.6 μM and 0.9 μM, respectively. HIV-1 inhibitor-6 inhibits HIV strains resistant to agents targeting HIV reverse transcriptase, protease, integrase, and coreceptor CCR5 with EC₅₀s ranging from 0.9 to 1.5 μM .

HY-15899

Des(benzylpyridyl) Atazanavir	HIV Protease HIV Drug Metabolite	Infection
Des(benzylpyridyl) Atazanavir (compound M1) is a N-dealkylation product of Atazanavir (HY-17367) metabolite. Atazanavir is a highly selective **HIV-1 protease** inhibitor. Des(benzylpyridyl) Atazanavir may contribute to the effectiveness Atazanavir but also to the toxicity and interactions. Des(benzylpyridyl) Atazanavir can be used for further research of Atazanavir effects .

HY-130366

JG-365	HIV Protease	Others
JG-365 is an HIV-1 protease inhibitor that binds to the active site of HIV-1 protease.

HY-123415

PD 134922	HIV Protease Renin	Infection
PD 134922 is a potent renin and **HIV-1 protease inhibitor with an IC₅₀** of 15 nM against HIV-1 protease .

HY-125712

CGP 53820	HIV HIV Protease	Infection
CGP 53820 is an inhibitor for **HIV protease*, inhibits the complex of HIV-1* and HIV-2 protease with K_i of 9 and 53 nM for **HIV-1 protease and HIV-2 protease**. CGP 53820 can be used in AIDS research .

HY-116537

A76889	HIV Protease	Infection
A76889 is an HIV-1 protease inhibitor.

HY-P3934

HIV Protease Substrate I	HIV Protease	Infection
HIV Protease Substrate I is a chromogenic substrate of **HIV-1 protease*. HIV* Protease Substrate I has the cleavage site of HIV protease .

HY-170969

HIV-1 inhibitor-81	HIV HIV Protease	Infection
HIV-1 inhibitor-81 (Compound 14g) is an **HIV-1 protease inhibitor with a K_i** of 1.6 nM. HIV-1 inhibitor-81 exhibits certain antiviral activity, with an EC₅₀ of 250 nM for *HIV-1* .

HY-100212

JE-2147 AG1776; KNI-764	HIV HIV Protease	Infection
JE-2147 (AG1776) is a potent dipeptide protease inhibitor with a K_i of 0.33 nM for **HIV-1 protease. JE-2147 has effective activities against a wide spectrum of HIV-1, HIV-2*, simian immunodeficiency virus, and various clinical HIV-1* strains in vitro .

HY-125148

AQ148	HIV Protease	Infection
AQ148 is a **HIV-1 protease inhibitor (K_i=137 nM). The IC₅₀ values ??of AQ148 for the inhibition of HIV-1, HIV-2 and SIV** aspartic proteases are 1.5 μM, 3.4 μM and 5 μM, respectively .

HY-120331

U-89360E	HIV HIV Protease	Infection
U-89360E is an inhibitor for **HIV-1 protease*. U-89360E inhibits the protease* of HIV-1 wildtype, V82D mutant and V82N mutant with K_i of 20 nM, 560 nM and 2100 nM, respectively .

HY-P2138

U-85548E	HIV Protease	Others
U-85548E is an HIV protease inhibitor with nanomolar affinity for HIV-1 aspartic protease. By studying its structure-activity relationship, a potent nanomolar inhibitor with inhibitory effects on both HIV-1 and HIV-2 proteases was designed, and its binding mode was studied by X-ray crystallography and molecular modeling.

HY-N12716

Longipedunin A	HIV Protease	Infection
Longipedunin A is a **HIV-1 Protease inhibitor with an IC₅₀** value of 50 µg/mL .

HY-W702986

Hydroxy darunavir	HIV Protease	Infection
Hydroxy darunavir is a metabolite of the HIV-1 protease inhibitor Darunavir (HY-17040).

HY-N2786

8-Prenylluteone	HIV Protease	Infection
8-Prenylluteone is a **HIV-1 protease inhibitor, with an IC₅₀** of 4 μM .

HY-P4543

HIV-IN petide	HIV HIV Protease	Infection
HIV-IN petide is a competitive inhibitor of *HIV-1* protease (K_i=50 nM) .

HY-171835

DPC 684	HIV HIV Protease	Infection
DPC 684 is a potent and selective **HIV-1 protease inhibitor (IC₉₀ = 5.7-40 nM, Ki = 0.021 nM). DPC 684 competitively inhibits HIV-1 protease and blocks viral polyprotein cleavage. DPC 684 has low protein binding and broad-spectrum inhibition against a variety of wild-type and mutant HIV-1 proteases. DPC 684 has low protein binding and broad-spectrum inhibition (IC₉₀** = 1.9-6.3 nM). DPC 684 has research significance for HIV .

HY-120880

SKF107457	HIV Protease	Infection
SKF107457 is an **HIV-1 protease** inhibitor that can be used in AIDS research .

HY-129678

UK-88947 hydrochloride	HIV Protease HIV	Infection
UK-88947 hydrochloride is a protease inhibitor with activity in inhibiting the replication of human immunodeficiency virus HIV-1. UK-88947 hydrochloride can be added to cells before infection to block the early steps of HIV-1 replication. The use of UK-88947 hydrochloride shows its specific inhibitory effect on HIV-1. At the same time, when the virus infects cells, it inhibits the action of viral protease and affects the virus replication process .

HY-19194

A-80987	HIV Protease	Infection
A-80987 is an inhibitor of human immunodeficiency virus type 1 (HIV-1) protease .

HY-119337

CE-2072	Ser/Thr Protease	Infection
CE-2072 is an inhibitor of *serine proteases* neutrophil elastase and proteinase-3. CE-2072 inhibits HIV-1** production and p24 production in response to IL-18 or NaCl in infected U1 monocytic cells, reduces virus replication in infected peripheral blood mononuclear cells and blocks infection of permissive HeLa cells. CE-2072 suppresses activation of the HIV-1-inducing transcription factor NF-kB in U1 cells. CE-2072 is promising for research of HIV-1-related disease .

Cat. No.	Product Name	Target	Research Area

HY-151250

HIV-1 protease-IN-7	HIV Protease	Infection
HIV-1 protease-IN-7 (compound 16) is an orally active **HIV-1 protease inhibitor (IC₅₀=3.52 nM, EC₅₀**=37 nM) .

HY-P3980

HIV-1, HIV-2 Protease Substrate	HIV Protease	Infection
HIV-1, HIV-2 Protease Substrate is the substrate of **HIV-1, **HIV-2 **protease. And there are 4 residues for conservative substitutions of the substrate binding residues of **HIV-1 *and HIV-2* protease .**********

HY-P4466

Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2	HIV Protease	Infection
Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 is a fluorogenic substrate of **HIV-1 protease*. Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 can be used to test HIV-1* protease activity .

HY-P1436

Acetyl-pepstatin	HIV	Infection
Acetyl-pepstatin is a potent classical inhibitor of aspartic proteases (PRs) with XMRV PR and HIV-1 PR K_i values of 712 nM and 13 nM .

HY-P3934

HIV Protease Substrate I	HIV Protease	Infection
HIV Protease Substrate I is a chromogenic substrate of **HIV-1 protease*. HIV* Protease Substrate I has the cleavage site of HIV protease .

HY-P2138

U-85548E	HIV Protease	Others
U-85548E is an HIV protease inhibitor with nanomolar affinity for HIV-1 aspartic protease. By studying its structure-activity relationship, a potent nanomolar inhibitor with inhibitory effects on both HIV-1 and HIV-2 proteases was designed, and its binding mode was studied by X-ray crystallography and molecular modeling.

HY-P4543

HIV-IN petide	HIV HIV Protease	Infection
HIV-IN petide is a competitive inhibitor of *HIV-1* protease (K_i=50 nM) .

HY-120880

SKF107457	HIV Protease	Infection
SKF107457 is an **HIV-1 protease** inhibitor that can be used in AIDS research .

HY-P2054

Mvt-101	HIV Protease	Infection
Mvt-101 is a hexapeptide-based inhibitor of **HIV-1 protease*. Mvt-101 is also reduced-peptide-bond inhibitor. Mvt-101 inhibits reproduction of the HIV* virus by blocking protease action .

HY-P4019

Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2	HIV Protease	Others
Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 is a substrato peptídico of HIV-1 protease. Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 acts as the variable substrate in a peptidolytic assay to quantify the inhibition of the protease .

HY-P5415

DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS	HIV	Others
DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is a biological active peptide. (DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is also called HIV protease substrate I in some literature. It is widely used for the continuous assay for HIV protease activity. The 11-kD protease (PR) encoded by the human immunodeficiency virus 1 (HIV-1) is essential for the correct processing of viral polyproteins and the maturation of infectious virus, and is therefore a target for the design of selective acquired immunodeficiency syndrome (AIDS) therapeutics. The FRET-based fluorogenic substrate is derived from a natural processing site for HIV-1 PR. Incubation of recombinant HIV-1 PR with the fluorogenic substrate resulted in specific cleavage at the Tyr-Pro bond and a time-dependent increase in fluorescence intensity that is linearly related to the extent of substrate hydrolysis. The fluorescence quantum yields of the HIV-1 PR substrate in the FRET assay increased by 40.0- and 34.4-fold, respectively, per mole of substrate cleaved. Because of its simplicity and precision in the determination of reaction rates required for kinetic analysis, this substrate offers many advantages over the commonly used HPLC or electrophoresis-based assays for peptide substrate hydrolysis by retroviral PRs. Abs/Em = 340nm/490nm.)

HY-P4018

HIV Protease Substrate IV	HIV Protease	Infection
HIV Protease Substrate IV is a substrate of HIV protease. HIV Protease Substrate IV can be used to measure the activity of HIV (human immunodeficiency virus) -1 protease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10420

Hinokinin 1 Publications Verification (-)-Hinokinin	Infection Acanthaceae Classification of Application Fields Source classification Lignans Phenylpropanoids Hypoestes aristata (Vahl) Sol. ex Roem. & Schult. Plants Disease Research Fields	HIV Protease
Hinokinin (Compound 1) is a compound isolated from the stems of Hypoestes aristate. Hinokinin exhibits moderate activity of HIV-1 protease enzyme .

HY-N2565

Rosamultin	Infection Triterpenes Classification of Application Fields Terpenoids Source classification Rosaceae Potentilla anserina Linn. Plants Disease Research Fields	HIV Protease Apoptosis
Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina?L. Rosamultin has inhibitory effects against **HIV-1 protease** . Rosamultin has the potential for treating H₂O₂-induced oxidative stress injury through its antioxidant and antiapoptosis effects .

HY-78726

Fosamprenavir 4 Publications Verification Amprenavir phosphate; GW 433908	Infection Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Drug Intermediate HIV HIV Protease
Fosamprenavir is an orally active inhibitor targeting **HIV-1 protease** and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection .

HY-17431

Fosamprenavir Calcium Salt 4 Publications Verification GW433908G	Infection Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Drug Intermediate HIV HIV Protease
Fosamprenavir Calcium Salt (GW433908G) is an orally active inhibitor targeting **HIV-1 protease** and is a prodrug of Amprenavir (HY-17430). Fosamprenavir Calcium Salt is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir Calcium Salt can be used for the study of human immunodeficiency virus (HIV-1) infection .

HY-N10420R

Hinokinin (Standard) (-)-Hinokinin (Standard)	Acanthaceae Source classification Lignans Phenylpropanoids Hypoestes aristata (Vahl) Sol. ex Roem. & Schult. Plants	Reference Standards HIV Protease
Hinokinin (Standard) is the analytical standard of Hinokinin. This product is intended for research and analytical applications. Hinokinin (Compound 1) is a compound isolated from the stems of Hypoestes aristate. Hinokinin exhibits moderate activity of HIV-1 protease enzyme .

HY-N11940

Acetyl-binankadsurin A	Source classification Lignans Phenylpropanoids Plants Schisandraceae Kadsura longipedunculata Finet et Gagnep.	HIV Protease
Acetyl-binankadsurin A (compound 5) is a lignan isolated from Kadsura longipedunculata. Acetyl-binankadsurin A has low inhibitory activity against HIV-1 protease, with IC₅₀ >100 μg/mL .

HY-N12716

Longipedunin A	Source classification Lignans Phenylpropanoids Plants Kadsura longipedunculata Finet et Gagnep. Schisandraceae	HIV Protease
Longipedunin A is a **HIV-1 Protease inhibitor with an IC₅₀** value of 50 µg/mL .

HY-N2786

8-Prenylluteone	Flavonoids Erythrinasenegalensis DC. Leguminosae Source classification Plants Isoflavones	HIV Protease
8-Prenylluteone is a **HIV-1 protease inhibitor, with an IC₅₀** of 4 μM .

HY-N11288

Methyl salvionolate A	Labiatae Source classification Phenols Polyphenols Salvia yunnanensis C. H. Wright Plants	HIV
Methyl salvionolate A is a potent inhibitor of *HIV-1. Methyl salvionolate A inhibits P24* antigen in HIV-1 infected MT-4 cell with an EC₅₀ of 1.62 μg/ml. Methyl salvionolate A also inhibits HIV-1 reverse transcriptase, protease and integrase with IC₅₀s of 50.58, 10.73 and 7.58 μg/ml, respectively .

HY-17431R

Fosamprenavir Calcium Salt (Standard) GW433908G (Standard)	Natural Products Source classification Endogenous metabolite	Reference Standards Drug Intermediate HIV HIV Protease
Fosamprenavir Calcium Salt (GW433908G) (Standard) is the analytical standard of Fosamprenavir Calcium Salt (HY-17431R). This product is intended for research and analytical applications. Fosamprenavir Calcium Salt (GW433908G) is an orally active inhibitor targeting **HIV-1 protease** and is a prodrug of Amprenavir (HY-17430). Fosamprenavir Calcium Salt is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir Calcium Salt can be used for the study of human immunodeficiency virus (HIV-1) infection .

HY-N16050

Ethyl salvianolate A Ethyl salvionolate A	Simple Phenylpropanols Labiatae Source classification Salvia yunnanensis C. H. Wright Phenylpropanoids Plants	HIV Reverse Transcriptase HIV Integrase HIV Protease
Ethyl salvianolate A (Ethyl salvionolate A) is an anti-HIV-1 compound that can be extracted from the roots of Salvia yunnanensis. Ethyl salvianolate A inhibits P24 antigen in HIV-1 infected MT-4 cell cultures (EC₅₀: 1.44 μg/mL). Ethyl salvianolate A inhibits HIV-1 replicative enzymes, with IC₅₀s of 56.38 μM (Reverse transcriptase), 12.03 μM (Protease), 14.54 μM (Integrase), respectively .

HY-116700

Hinnuliquinone	Natural Products Nepenthes mirabilis (Lour.) Druce Source classification Plants Nepenthaceae	HIV Protease HIV
Hinnuliquinone is a C2-symmetric dimeric non-peptide fungal metabolite inhibitor of **HIV-1 protease*. Hinnuliquinone is a bis-indolyl-2,5-dihydroxybenzoquinone pigment, that can be isolated from Nodulisphorium hinnuleum* .

HY-N15294

3β-Hydroxy-27-p-Z-coumaroyloxyurs-12-en-28-oic acid	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Triterpenes Terpenoids Source classification Rubiaceae Plants	HIV HIV Protease
3β-Hydroxy-27-p-Z-coumaroyloxyurs-12-en-28-oic acid (compound 8) is a triterpenoid ester *HIV-1* protease inhibitor with the potential for use in the antiretroviral combination therapy of AIDS .

HY-N6773

Cytochalasin A	Infection Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields	HIV Protease Fungal
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of **HIV-1 protease (IC₅₀**=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives .

HY-N2006

Ganoderic acid B	Infection Triterpenes Classification of Application Fields Terpenoids Polyporaceae Source classification Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields	EBV HIV Protease
Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against **HIV-1 protease** (IC₅₀: 170 μM) .

HY-N0554

Escin IA 1 Publications Verification	Infection Triterpenes other families Classification of Application Fields Terpenoids Hippocastanaceae Aesculus hippocastanum Source classification Plants Disease Research Fields Cancer	HIV Protease
Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits **HIV-1 protease with IC₅₀** values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression .

HY-17367AR

Atazanavir sulfate (Standard) BMS-232632 sulfate (Standard)	Alkaloids Source classification Pyridine Alkaloids Endogenous metabolite	Reference Standards HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite
Atazanavir (sulfate) (Standard) is the analytical standard of Atazanavir (sulfate). This product is intended for research and analytical applications. Atazanavir (BMS-232632) sulfate, a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir sulfate is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 3.49 μM .

HY-N2006R

Ganoderic acid B (Standard)	Triterpenes Terpenoids Polyporaceae Source classification Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants	EBV Reference Standards HIV Protease
Ganoderic acid B (Standard) is the analytical standard of Ganoderic acid B. This product is intended for research and analytical applications. Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC₅₀: 170 μM) .

HY-N0554R

Escin IA (Standard)	Triterpenes other families Terpenoids Hippocastanaceae Aesculus hippocastanum Source classification Plants	Reference Standards HIV Protease
Escin IA (Standard) is the analytical standard of Escin IA. This product is intended for research and analytical applications. Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression .

HY-17367

Atazanavir Maximum Cited Publications 11 Publications Verification BMS-232632	Infection Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite Toll-like Receptor (TLR)
Atazanavir (BMS-232632) is a highly selective and orally active **HIV-1 protease inhibitor . Atazanavir is a substrate and inhibitor of CYP3A4, and an inhibitor of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀** of 3.49 μM. Atazanavir inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death .

HY-N1992

Theaflavin 3,3'-digallate 5 Publications Verification TF-3; ZP10	Infection Flavonoids Classification of Application Fields Flavanols Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Theaceae	Virus Protease HSV HIV Flavivirus
Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC₅₀ of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (K_d=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and *HIV-1* . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .

HY-N1941

Isosinensetin	Flavonoids other families Classification of Application Fields Flavones Source classification Plants Inflammation/Immunology Disease Research Fields	P-glycoprotein Bacterial HIV Protease Phosphatase Reactive Oxygen Species (ROS) NF-κB p38 MAPK ERK JNK Calcium Channel
Isosinensetin is a flavonoid compound and an inhibitor of **HIV-1 protease and PTP1B (IC₅₀: 2.61 µM; K_i: 0.92 µM). Isosinensetin inhibits P-glycoprotein (P-gp)** in MDR1-MDCKII cells. Isosinensetin has multiple activities such as anti-tumor, anti-viral, anti-inflammatory, and antioxidant effects. Isosinensetin can be used in the research of various diseases including cancer, inflammation, osteoporosis, diabetes, etc .

HY-17367A

Atazanavir sulfate Maximum Cited Publications 11 Publications Verification BMS-232632 sulfate	Infection Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite Toll-like Receptor (TLR)
Atazanavir (BMS-232632) sulfate is a highly selective and orally active **HIV-1 protease inhibitor . Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor of P-glycoprotein (P-gp). Atazanavir sulfate is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀** of 3.49 μM. Atazanavir sulfate inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death .

HY-17367R

Atazanavir (Standard) BMS-232632 (Standard)	Alkaloids Source classification Pyridine Alkaloids Endogenous metabolite	Reference Standards HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite
Atazanavir (Standard) is the analytical standard of Atazanavir. This product is intended for research and analytical applications. Atazanavir (BMS-232632) is a highly selective and orally active **HIV-1 protease inhibitor . Atazanavir is a substrate and inhibitor of CYP3A4, and an inhibitor of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀** of 3.49 μM. Atazanavir inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death .

HY-N1992R

Theaflavin 3,3'-digallate (Standard) TF-3 (Standard); ZP10 (Standard)	Flavonoids Flavanols Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Theaceae	Reference Standards Virus Protease HSV HIV Flavivirus
Theaflavin 3,3'-digallate (Standard) is the analytical standard of Theaflavin 3,3'-digallate. This product is intended for research and analytical applications. Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC₅₀ of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (Kd=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .

HY-N0556

Isoescin IA	Other Terpenoids Infection Aesculus chinensis Bunge Classification of Application Fields Terpenoids Hippocastanaceae Source classification Plants Disease Research Fields	HIV Protease
Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity .

HY-N10934

Ganoderic acid GS-1	Triterpenes Microorganisms Terpenoids Source classification	HIV Protease
Ganoderic acid GS-1, a highly oxygenated lanostane-type triterpenoid, has anti-HIV-1 protease activities with an IC₅₀ of 58 μM .

HY-N3502

20(21)-Dehydrolucidenic acid A	Infection Triterpenes Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields	HIV Protease
20(21)-Dehydrolucidenic acid A is a triterpenoid isolated from the fruiting body of the fungus Ganoderma sinense. 20(21)-Dehydrolucidenic acid A has weak anti-HIV-1 protease activity .

HY-N0556R

Isoescin IA (Standard)	Other Terpenoids Aesculus chinensis Bunge Terpenoids Hippocastanaceae Source classification Plants	Reference Standards HIV Protease
Isoescin IA (Standard) is the analytical standard of Isoescin IA. This product is intended for research and analytical applications. Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity .

HY-N2996

Ganodermanondiol	Infection Triterpenes Microorganisms Classification of Application Fields Terpenoids Polyporaceae Source classification Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields	HIV Protease
Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum .Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity . Ganodermanondiol shows significant anti-HIV-1 *protease* activity with an IC₅₀ of 90 μM . Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC₅₀ of 41.7μM .

HY-A0097A

Teicoplanin sodium Antibiotic MDL-507 sodium; MDL-507 sodium	Source classification Phenols Polyphenols Endogenous metabolite	Antibiotic HIV SARS-CoV
Teicoplanin sodium is a glycopeptide antibiotic indicated for use in serious infections caused by Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus and Enterococcus aureus.Teicoplanin sodium shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity .

Cat. No.	Compare	Product Name	Species	Source

HY-P701482

	OTUD2 Protein, Human YOD1; Ubiquitin thioesterase OTU1; DUBA-8; HIV-1-induced Protease 7; HIN-7; HsHIN7; OTU domain-containing protein 2	Human	E. coli
	OTUD2 is a key hydrolase in cellular processes that actively participates in endoplasmic reticulum-associated degradation (ERAD) by deubiquitinating misfolded luminal proteins. It trims ubiquitin chains from the substrate, helping them pass through the VCP/p97 pore. OTUD2 Protein, Human is the recombinant human-derived OTUD2 protein, expressed by E. coli , with tag free.

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Cat. No.	Product Name	Chemical Structure

HY-15148S1

Tipranavir-d7
Tipranavir-d₇ is deuterated labeled Tipranavir (HY-15148). Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of **HIV-1 protease*, exerts potent activity against multi-protease* inhibitor (PI)-resistant HIV-1 isolates with IC₅₀s of 66-410 nM . Tipranavir inhibits SARS-CoV-2 3CL ^pro activity .

HY-14588S

(rel)-Lopinavir-d8

(rel)-Lopinavir-d₈ ((rel)-ABT-378-d₈) is the deuterium labeled Lopinavir (HY-14588) . Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with K_is of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity . Lopinavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 14.2 μM .

HY-17367S

Atazanavir-d15
Atazanavir-d15 is the d₁₅ labled Atazanavir (HY-17367). Atazanavir is a selective HIV-1 protease inhibitor .

HY-17367S1

Atazanavir-d18
Atazanavir-d18 is the d₁₈ labled Atazanavir (HY-17367). Atazanavir is a selective HIV-1 protease inhibitor .

HY-78726S

Fosamprenavir-d4

Fosamprenavir-d₄ is the Deuterium-labeled Fosamprenavir (HY-78726). Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection .

HY-78726S2

Fosamprenavir-13C6

Fosamprenavir- ¹³C₆ is the ¹³C-labeled Fosamprenavir (HY-78726). Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection .

HY-14588S1

Lopinavir-d8

Lopinavir-d₈ (ABT-378-d₈) is the deuterium labeled Lopinavir. Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with K_is of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity . Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 14.2 μM .

HY-14588S2

Lopinavir-d7

Lopinavir-d₇ is deuterated labeled Lopinavir (HY-14588). Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with K_is of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity . Lopinavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 14.2 μM .

HY-15287S1

Nelfinavir-d4
Nelfinavir-d₄ is deuterated labeled Nelfinavir (HY-15287). Nelfinavir (AG-1341) is a potent and orally bioavailable **HIV-1 protease inhibitor (K_i*=2 nM) for HIV* infection. Nelfinavir is a broad-spectrum, anticancer agent .

HY-15287S

Nelfinavir-d3
Nelfinavir-d₃ (AG1341-d3) is the deuterium labeled Nelfinavir. Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent .

HY-17367S4

Atazanavir-d6
Atazanavir-d₆ is deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 3.49 μM .

HY-17367S3

Atazanavir-d5

Atazanavir-d₅ is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 3.49 μM .

HY-17367S2

Atazanavir-d9

Atazanavir-d₉ is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 3.49 μM .

HY-B0689S1

Indinavir-13C4,15N

Indinavir- ¹³C₄, ¹⁵N (MK-639 (free base)- ¹³C₄, ¹⁵N) is ¹³C and ¹⁵N labeled Indinavir. Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a K_i of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CL ^pro inhibitor .

HY-17367S5

Atazanavir-d24

Atazanavir-d₂₄ (BMS-232632-d₂₄) is deuterium labeled Atazanavir. Atazanavir (BMS-232632) is a highly selective and orally active HIV-1 protease inhibitor . Atazanavir is a substrate and inhibitor of CYP3A4, and an inhibitor of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 3.49 μM. Atazanavir inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death .

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