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HCMV

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (1) CDK (2) CMV (20) Dihydroorotate Dehydrogenase (2) DNA/RNA Synthesis (2) Drug Metabolite (1) EBV (2) Filovirus (1) Fluorescent Dye (1) Histone Demethylase (1) HIV (3) HSV (7) Influenza Virus (1) Isotope-Labeled Compounds (1) NOD-like Receptor (NLR) (1) PKC (1) ROR (2) SARS-CoV (1) Sirtuin (1) YB-1 (1)
By Research Areas:	Cancer (4) Infection (26) Inflammation/Immunology (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16721

Cyclopropavir Filociclovir; ZSM-I-62; MBX-400	CMV	Infection
Cyclopropavir (Filociclovir) is an orally active and broad-spectrum anti-herpesvirus compound. Cyclopropavir inhibits UL97 kinase activity. Cyclopropavir has antiviral activity against HCMV, MCMV, and HAdV6 viruses .

HY-131606B

Cidofovir diphosphate tri(triethylamine)	Drug Metabolite	Infection
Cidofovir diphosphate tri triethylamine is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate tri triethylamine is a selective inhibitor of viral DNA polymerases with K_i values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .

HY-12653

LDC4297 5 Publications Verification	CDK HIV HSV	Infection
LDC4297 is a selective inhibitor of CDK7 with an IC₅₀ value of 0.13 nM. LDC4297 inhibits human cytomegalovirus (HCMV) replication with an EC₅₀ value of 24.5 nM. LDC4297 shows broad antiviral activities to Herpesviridae, Adenoviridae, Poxviridae, Retroviridae and Orthomyxoviridae with EC₅₀ value of 0.02-1.21 μM. LDC4297 can be used for the research of infection .

HY-12653A

LDC4297 hydrochloride 5 Publications Verification	CDK HIV HSV	Infection
LDC4297 hydrochloride is a selective inhibitor of CDK7 with an IC₅₀ value of 0.13 nM. LDC4297 hydrochloride inhibits human cytomegalovirus (HCMV) replication with an EC₅₀ value of 24.5 nM. LDC4297 hydrochloride shows broad antiviral activities to Herpesviridae, Adenoviridae, Poxviridae, Retroviridae and Orthomyxoviridae with EC₅₀ values of 0.02-1.21 μM. LDC4297 hydrochloride can be used for the research of infection .

HY-19296

BDCRB 2-Bromo-5,6-dichloro-1-β-D-ribofuranosyl benzimidazole	CMV	Infection
BDCRB is a selective Human cytomegalovirus (HCMV) inhibitor through blocking the maturational cleavage of high-molecular-weight DNA. BDCRB shows a mean IC₅₀ of 0.03 μM for viral yield at 72 h postinfection .

HY-167900

CMV-423 RPR-111423	CMV	Infection
CMV-423 is an antiviral agent with potent in vitro activity against the beta-herpesvirus human cytomegalovirus (HCMV), human herpesvirus 6 (HHV-6) and 7 (HHV-7). CMV-423 can be utilized in antiviral research .

HY-146271

pUL89 Endonuclease-IN-2	CMV	Infection
pUL89 Endonuclease-IN-2 (Compound 15k) is a potent inhibitor of human cytomegalovirus (HCMV) pUL89 endonuclease with the IC₅₀ of 3.0 μM. Antiviral activities .

HY-146270

pUL89 Endonuclease-IN-1	CMV	Infection
pUL89 Endonuclease-IN-1 (Compound 13d) is a potent inhibitor of human cytomegalovirus (HCMV) pUL89 endonuclease with the IC₅₀ value of 0.88 μM and has antiviral activitiy .

HY-169220S

RORγ/DHODH-IN-1	ROR Dihydroorotate Dehydrogenase DNA/RNA Synthesis Isotope-Labeled Compounds	Infection
RORγ/DHODH-IN-1 (compound 1404), a deuterium labeled compound, is a dual RORγ and DHODH inhibitor with IC₅₀ values of 9.7 nM and 100 nM, repaectively. RORγ/DHODH-IN-1 blocks the replication of SARS-CoV-2, *HCMV, and non-enveloped DNA virus (HAdV5)* .

HY-131606

Cidofovir diphosphate	HSV CMV	Infection
Cidofovir diphosphate is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate is a selective inhibitor of viral DNA polymerases with K_i values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .

HY-P99621

Fiztasovimab NPC-21; EV2038	CMV	Infection
Fiztasovimab (NPC-21; EV2038) is a fully human IgG1λ mAb against human cytomegalovirus (hCMV). Fiztasovimab acts neutralizing activity by binding to the antigenic domain 1 of glycoprotein B on hCMV envelope. Fiztasovimab inhibits cell-to-cell transmission of hCMV .

HY-P4777

Dabcyl-RGVVNASSRLA-Edans Dabcyl-CMV-Edans	Fluorescent Dye	Infection
Dabcyl-RGVVNASSRLA-Edans (Dabcyl-CMV-Edans) is a fluorogenic substrate for human cytomegalovirus (HCMV) protease .

HY-114005

SB-734117	CMV	Infection
SB-734117 is a human cytomegalovirus (HCMV) replication inhibitor that prevents CREB and histone H3 post-translational modifications .

HY-160917

BAY-43-9695	CMV	Infection
BAY-43-9695 is a nonnucleosidic with activity against human cytomegalovirus (hCMV) with IC₅₀ of 0.95 and 1.1 μM, using the FACS and PRA methodes. BAY-43-9695 inhibits the HCMV replication with and without presence of serum proteins, with IC₅₀ of 0.53 and 8.42 μM. BAY-43-9695 is the metabolite of Tomeglovir (BAY38-4766) (HY-108261) .

HY-108261

Tomeglovir BAY 38-4766	CMV	Infection
Tomeglovir is a potent anti-CMV agent, inhibiting processing of viral DNA-concatemers, with IC₅₀s of 0.34 μM and 0.039 μM for HCMV and MCMV.

HY-16305

Maribavir Maximum Cited Publications 12 Publications Verification 1263W94; BW1263W94; GW257406X	EBV CMV	Infection
Maribavir is a potent inhibitor of histone phosphorylation catalyzed by wild-type pUL97 in vitro, with an IC₅₀ of 3 nM. Maribavir has potent antiviral activity against *HCMV* and Epstein-Barr virus (EBV).

HY-103365

BX-513 hydrochloride VUF2274 hydrochloride	CMV	Infection
BX-513 hydrochloride (VUF 2274 hydrochloride)is a novel inverse agonists acting on human cytomegalovirus (HCMV)-encoded receptor US28 with the IC₅₀ of 4.9 μM. BX-513 hydrochloride can be used for study of viral infection .

HY-N1127

Tricin 2 Publications Verification	CMV	Infection Cancer
Tricin is a natural flavonoid found in large amounts in wheat. Tricin inhibits *HCMV* replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells by upregulating the expression of FAK-targeting microRNA-7 .

HY-16305R

Maribavir (Standard)	EBV CMV	Infection
Maribavir (Standard) is the analytical standard of Maribavir. This product is intended for research and analytical applications. Maribavir is a potent inhibitor of histone phosphorylation catalyzed by wild-type pUL97 in vitro, with an IC₅₀ of 3 nM. Maribavir has potent antiviral activity against *HCMV* and Epstein-Barr virus (EBV).

HY-170547

DNA polymerase-IN-6	DNA/RNA Synthesis HSV Filovirus	Infection
DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, and inhibits *HCMV, HSV-1, HSV-2* and EBV with EC₅₀s of 0.33, 1.9, 0.76 and 0.066 µM, respectively .

HY-N1127S

Tricin-d6	CMV	Cancer
Tricin-d₆ is the deuterium labeled Tricin . Tricin is a natural flavonoid present in large amounts in Triticum aestivum. Tricin can inhibit human cytomegalovirus (HCMV) replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells via the upregulation of focal-adhesion-finase (FAK)-targeting microRNA-7 .

HY-N1127R

Tricin (Standard)	CMV	Infection Cancer
Tricin (Standard) is the analytical standard of Tricin. This product is intended for research and analytical applications. Tricin is a natural flavonoid found in large amounts in wheat. Tricin inhibits HCMV replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells by upregulating the expression of FAK-targeting microRNA-7 .

HY-12725

ML324 5+ Cited Publications	Histone Demethylase HSV CMV	Cancer
ML324 is a potent JMJD2 demethylase inhibitor with antiviral activity. ML324 also exhibits inhibition for the histone demethylase KDM4B, with an IC₅₀ of 4.9 μM. ML324 has potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression .

HY-122920

Soyasaponin II	HSV CMV Influenza Virus HIV NOD-like Receptor (NLR) YB-1	Infection Inflammation/Immunology
Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure .

HY-108254

Bisindolylmaleimide IV Arcyriarubin A	PKC CMV	Infection
Bisindolylmaleimide IV (Arcyriarubin A) is a potent protein kinase C (PKC) inhibitor, with IC₅₀s ranging from 0.1 to 0.55 μM. Bisindolylmaleimide IV also inhibits PKA (IC₅₀=3.1-11.8μM) . Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus *(HCMV)* replication in cell culture with an IC₅₀ of 0.2 μM .

HY-169222S

RORγ/DHODH-IN-2	Dihydroorotate Dehydrogenase ROR SARS-CoV	Infection
RORγ/DHODH-IN-2 (Compound 1311) is an orally active dual inhibitor of RORγ/DHODH with IC₅₀ values of 11.9 nM and 90 nM, respectively. RORγ/DHODH-IN-2 exhibits antiviral activity by inhibiting the activity of SARS-CoV-2, HCMV, HAdV5, and MPXV, with IC₅₀ values of 27 nM, 20 nM, 9.1 nM, and 1.8 nM, respectively .

HY-P5693

HBA(111–142)	Bacterial CMV HSV	Infection
HBA(111-142), an antimicrobial peptide, is a C-terminal 32-mer fragment of alpha-hemoglobin. HBA(111-142) has antibacterial activity against the ESKAPE panel of pathogens. HBA(111-142) forms amyloid fibrils, and has antiviral activities. HBA(111-142) inhibits measles and herpes viruses (HSV-1, HSV-2, HCMV) .

HY-163532

FLS-359	Sirtuin	Infection
FLS-359 is a selective, orally active allosteric modulator for sirtuin 2, with the IC₅₀ of 3 μM. FLS-359 exhibits antiviral activity against RNA and DNA virus, through inhibition of DNA/RNA replication .

Cat. No.	Product Name	Target	Research Area

HY-P4777

Dabcyl-RGVVNASSRLA-Edans Dabcyl-CMV-Edans	Fluorescent Dye	Infection
Dabcyl-RGVVNASSRLA-Edans (Dabcyl-CMV-Edans) is a fluorogenic substrate for human cytomegalovirus (HCMV) protease .

HY-P5693

HBA(111–142)	Bacterial CMV HSV	Infection
HBA(111-142), an antimicrobial peptide, is a C-terminal 32-mer fragment of alpha-hemoglobin. HBA(111-142) has antibacterial activity against the ESKAPE panel of pathogens. HBA(111-142) forms amyloid fibrils, and has antiviral activities. HBA(111-142) inhibits measles and herpes viruses (HSV-1, HSV-2, HCMV) .

Cat. No.	Product Name	Target	Research Area

HY-P99621

Fiztasovimab NPC-21; EV2038	CMV	Infection
Fiztasovimab (NPC-21; EV2038) is a fully human IgG1λ mAb against human cytomegalovirus (hCMV). Fiztasovimab acts neutralizing activity by binding to the antigenic domain 1 of glycoprotein B on hCMV envelope. Fiztasovimab inhibits cell-to-cell transmission of hCMV .

Tricin 2 Publications Verification	Infection Structural Classification Flavonoids Classification of Application Fields Flavones Agrostidoideae Source classification Phenols Polyphenols Plants Disease Research Fields Triticum aestivum L.	CMV
Tricin is a natural flavonoid found in large amounts in wheat. Tricin inhibits *HCMV* replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells by upregulating the expression of FAK-targeting microRNA-7 .

Soyasaponin II	Triterpenes Structural Classification Classification of Application Fields Leguminosae Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Glycine soja Sieb. Et Zucc.	HSV CMV Influenza Virus HIV NOD-like Receptor (NLR) YB-1
Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure .

Tricin (Standard)	Structural Classification Flavonoids Flavones Agrostidoideae Source classification Phenols Polyphenols Plants Triticum aestivum L.	CMV
Tricin (Standard) is the analytical standard of Tricin. This product is intended for research and analytical applications. Tricin is a natural flavonoid found in large amounts in wheat. Tricin inhibits HCMV replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells by upregulating the expression of FAK-targeting microRNA-7 .

Species:	Virus (3)
Tag:	Tag Free (1) Fc (2)
Source:	HEK293 (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P75161

	HCMV Glycoprotein B/gB Protein (HEK293, Fc) Human cytomegalovirus (HCMV) Glycoprotein B / gB Protein; Envelope glycoprotein B; UL55	Virus	HEK293
	The gB Protein is an envelope glycoprotein that plays a role in host cell entry, cell-to-cell viral transmission, and infected cell fusion.gB Protein interacts with heparin sulfate proteoglycan and forms an association with gH/gL heterodimer.HCMV Glycoprotein B/gB Protein (HEK293, Fc) is a recombinant Virus-derived HCMV Glycoprotein B/gB protein(with cleavage site mutated RTKR to TTQT), expressed by HEK293 , with C-hFc labeled tag.HCMV Glycoprotein B/gB Protein (HEK293, Fc), has molecular weight of 160-170 kDa.

HY-P74875

	HCMV Glycoprotein B/gB Protein (HEK293) Human cytomegalovirus (HCMV) Glycoprotein B / gB Protein	Virus	HEK293
	The gB Protein is an envelope glycoprotein that plays a role in host cell entry, cell-to-cell viral transmission, and infected cell fusion. gB Protein interacts with heparin sulfate proteoglycan and forms an association with gH/gL heterodimer. HCMV Glycoprotein B/gB Protein (HEK293) is a recombinant Virus-derived HCMV Glycoprotein B/gB protein(with cleavage site mutated RTKR to TTQT), expressed by HEK293 , with tag free. HCMV Glycoprotein B/gB Protein (HEK293), has molecular weight of 130-140 kDa.

HY-P76980

	HCMV Glycoprotein B/gB Protein (676a.a, HEK293, Fc) Human cytomegalovirus (HCMV) Glycoprotein B / gB Protein (ECD, Fc)	Virus	HEK293
	The gB Protein is an envelope glycoprotein that plays a role in host cell entry, cell-to-cell viral transmission, and infected cell fusion. gB Protein interacts with heparin sulfate proteoglycan and forms an association with gH/gL heterodimer. HCMV Glycoprotein B/gB Protein (676a.a, HEK293, Fc) is the recombinant Virus-derived HCMV Glycoprotein B/gB protein, expressed by HEK293 , with C-hFc labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-169220S

RORγ/DHODH-IN-1
RORγ/DHODH-IN-1 (compound 1404), a deuterium labeled compound, is a dual RORγ and DHODH inhibitor with IC₅₀ values of 9.7 nM and 100 nM, repaectively. RORγ/DHODH-IN-1 blocks the replication of SARS-CoV-2, *HCMV, and non-enveloped DNA virus (HAdV5)* .

HY-N1127S

Tricin-d6
Tricin-d₆ is the deuterium labeled Tricin . Tricin is a natural flavonoid present in large amounts in Triticum aestivum. Tricin can inhibit human cytomegalovirus (HCMV) replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells via the upregulation of focal-adhesion-finase (FAK)-targeting microRNA-7 .

HY-169222S

RORγ/DHODH-IN-2
RORγ/DHODH-IN-2 (Compound 1311) is an orally active dual inhibitor of RORγ/DHODH with IC₅₀ values of 11.9 nM and 90 nM, respectively. RORγ/DHODH-IN-2 exhibits antiviral activity by inhibiting the activity of SARS-CoV-2, HCMV, HAdV5, and MPXV, with IC₅₀ values of 27 nM, 20 nM, 9.1 nM, and 1.8 nM, respectively .

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HCMV

Inhibitors & Agonists

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