Tomeglovir (Synonyms: BAY 38-4766)

Name: Tomeglovir
Brand: MedChemExpress
SKU: HY-108261
Rating: 4.5 (1 reviews)

Cat. No.: HY-108261 Purity: 99.71%: Data Sheet
SDS

COA
Handling Instructions
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Tomeglovir is a potent anti-CMV agent, inhibiting processing of viral DNA-concatemers, with IC₅₀s of 0.34 μM and 0.039 μM for HCMV and MCMV.

For research use only. We do not sell to patients.

Tomeglovir Chemical Structure

CAS No. : 233254-24-5

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Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Tomeglovir is a potent anti-CMV agent, inhibiting processing of viral DNA-concatemers, with IC₅₀s of 0.34 μM and 0.039 μM for HCMV and MCMV.

IC₅₀ & Target

IC50: 0.34 μM (HCMV), 0.039 μM (MCMV)^[1]

In Vitro

Tomeglovir (BAY 38-4766) is a potent anti-CMV agent, with IC₅₀s of 0.34 μM and 0.039 μM for HCMV and MCMV. Tomeglovir also suppresses HELF and NIH 3T3 cells, with CC₅₀s of 85 μM and 62.5 μM, respectively^[1]. Tomeglovir (BAY 38-4766) inhibits HCMV Davis and various monkey CMV strains with EC₅₀s of 1.03 ± 0.57 μM and < 1 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tomeglovir (BAY 38-4766; 3, 10, 30, 100 mg/kg, p.o.) dose-dependently reduces MCMV-DNA in salivary glands, livers and kidneys of MCMV-infected NOD-SCID mice, and prolongs the survival of the mice. Tomeglovir (10, 25 and 50 mg/kg) shows antiviral activity in the hollow fiber mouse model^[1]. Tomeglovir (BAY 38-4766) shows antiviral activity in SCID mice with MCMV, and the LD₅₀ is >2000 mg/kg in mice and rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

441.54

Formula

C₂₃H₂₇N₃O₄S

CAS No.

233254-24-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(C)(CO)C(NC1=CC=C(NS(=O)(C2=C3C=CC=C(N(C)C)C3=CC=C2)=O)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 99.71%

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Data Sheet (276 KB) SDS (252 KB)

COA (251 KB) HNMR (390 KB) LCMS (100 KB)

Handling Instructions (2659 KB)

References

[1]. Weber O, et al. Inhibition of murine cytomegalovirus and human cytomegalovirus by a novel non-nucleosidic compound in vivo. Antiviral Res. 2001 Mar;49(3):179-89. [Content Brief]

[2]. Reefschlaeger J, et al. Novel non-nucleoside inhibitors of cytomegaloviruses (BAY 38-4766): in vitro and in vivo antiviral activity and mechanism of action. J Antimicrob Chemother. 2001 Dec;48(6):757-67. [Content Brief]

Cell Assay ^[2]	In order to evaluate drug toxicity, 96-well microtitre plates are prepared with 100 μL of EMEM/10 per well. After addition of 2 μL of 50 mM Tomeglovir stock solutions in duplicate into 198 μL in row 2, serial two-fold dilutions are made with 100 μL up to row 12 and 100 μL of a HELF, NHDF or 3T3 cell suspension (5 × 10³ cells/mL) are added per well. Row 1 serves as an untreated cell control. After incubation for 6 days at 37°C and 5% CO₂, the cells are washed once with phosphate-buffered saline (PBS), and 200 μL of a 10 μg/mL fluorescent dye solution in PBS, pH 7.2 (fluorescein diacetate) are dispensed per well. After 45 min, the fluorescence signal is measured with a Fluorskan Ascent fluorimeter (excitation filter 485 ± 11 nm, emission filter 530 ± 15 nm). The relative fluorescence units (RFUs) of treated cells are expressed as percentages of untreated cell controls and CC₅₀ values are determined graphically^[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[1]	Mice^[1] NOD/LtSz-scid/j mice, 20-30 g body weight, are anesthesized with 0.015-0.017 mL/g body weight Avertin 2.5% (Avertin 100% consists of 10 g tribromoethyl alcohol in 10 mL tertiary amyl alcohol). After shaving and cleaning the belly aseptically, the abdomens are opened and the fibers inserted intra-abdominally. The abdomens are closed with two suture layers. Only asymptomatic animals are included in the study. Starting 1 day after transplantation, the mice are treated with the Tomeglovir at indicated dosages twice daily for four consecutive days per os. In preliminary experiments, viral peak titers are observed on day 5 under these conditions^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References	[1]. Weber O, et al. Inhibition of murine cytomegalovirus and human cytomegalovirus by a novel non-nucleosidic compound in vivo. Antiviral Res. 2001 Mar;49(3):179-89. [Content Brief] [2]. Reefschlaeger J, et al. Novel non-nucleoside inhibitors of cytomegaloviruses (BAY 38-4766): in vitro and in vivo antiviral activity and mechanism of action. J Antimicrob Chemother. 2001 Dec;48(6):757-67. [Content Brief]

Tomeglovir Related Classifications

Infection

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tomeglovir233254-24-5BAY 38-4766CMVCytomegalovirusInhibitorinhibitorinhibit

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Tomeglovir (Synonyms: BAY 38-4766)

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Tomeglovir Related Antibodies

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Biological Activity

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References

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Tomeglovir Related Antibodies

Tomeglovir Related Classifications

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The molarity calculator equation

The dilution calculator equation

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