GSDME

By Targets:	Apoptosis (1) Bcl-2 Family (2) Caspase (6) Isotope-Labeled Compounds (1) Microtubule/Tubulin (1) Parasite (3) PARP (3) PROTACs (1) Pyroptosis (7) Reactive Oxygen Species (ROS) (2) Reference Standards (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (5) Infection (3) Inflammation/Immunology (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111770

2-Bromohexadecanoic acid 5+ Cited Publications 2-Bromopalmitic acid; 2-Bromopalmitate	Pyroptosis	Infection Inflammation/Immunology Cancer
2-Bromohexadecanoic acid (2-Bromopalmitate; 2-BP) is a palmitoylation inhibitor targeting DHHC (Asp-His-His-Cys) protein palmitoyltransferase. 2-Bromohexadecanoic acid inhibits palmitoylation of GSDME-C during pyroptosis and inhibits BAK/BAX-Caspase 3-GSDME pathway-mediated pyroptosis .

HY-B0621

Triclabendazole 5 Publications Verification CGA89317	Parasite Caspase Bcl-2 Family PARP Pyroptosis	Infection
Triclabendazole is an orally active parasite inhibitor. Triclabendazole has anti-Leishmania activity and induces gasdermin E (GSDME)-dependent pyroptosis by caspase-3 activation. Triclabendazole can be used for the research of fasciola hepatica .

HY-B0621R

Triclabendazole (Standard) CGA89317 (Standard)	Reference Standards Parasite Caspase Bcl-2 Family PARP Pyroptosis	Infection
Triclabendazole (Standard) is the analytical standard of Triclabendazole. This product is intended for research and analytical applications. Triclabendazole is an orally active parasite inhibitor. Triclabendazole has anti-Leishmania activity and induces gasdermin E (GSDME)-dependent pyroptosis by caspase-3 activation. Triclabendazole can be used for the research of fasciola hepatica .

HY-RS05858

GSDME Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GSDME Human Pre-designed siRNA Set A contains three designed siRNAs for GSDME gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GSDME Human Pre-designed siRNA Set A GSDME Human Pre-designed siRNA Set A

HY-RS23287

Gsdme Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gsdme Rat Pre-designed siRNA Set A contains three designed siRNAs for Gsdme gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gsdme Rat Pre-designed siRNA Set A Gsdme Rat Pre-designed siRNA Set A

HY-RS16846

Gsdme Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gsdme Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gsdme gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gsdme Mouse Pre-designed siRNA Set A Gsdme Mouse Pre-designed siRNA Set A

HY-P10939

Ac-DMLD-CMK	Caspase Pyroptosis	Inflammation/Immunology Cancer
Ac-DMLD-CMK is a polypeptide targeting the mouse caspase 3-Gsdme signaling pathway. Ac-DMLD-CMK can specifically inhibit the activation of caspase 3 and Gsdme. Ac-DMLD-CMK blocks the cleavage of Gsdme by caspase 3, inhibits the occurrence of pyroptosis, thereby reducing renal tubular epithelial cell injury and the secretion of inflammatory cytokines. Ac-DMLD-CMK reduces the levels of serum creatinine and blood urea nitrogen in mice induced by Cisplatin (HY-17394) and alleviates the deterioration of kidney function. Ac-DMLD-CMK is promising for research of chemotherapy drug-induced nephrotoxicity .

HY-P10939A

Ac-DMLD-CMK TFA	Caspase Pyroptosis	Inflammation/Immunology Cancer
Ac-DMLD-CMK TFA is a polypeptide targeting the mouse caspase 3-Gsdme signaling pathway. Ac-DMLD-CMK TFA can specifically inhibit the activation of caspase 3 and Gsdme. Ac-DMLD-CMK TFA blocks the cleavage of Gsdme by caspase 3, inhibits the occurrence of pyroptosis, thereby reducing renal tubular epithelial cell injury and the secretion of inflammatory cytokines. Ac-DMLD-CMK TFA reduces the levels of serum creatinine and blood urea nitrogen in mice induced by Cisplatin (HY-17394) and alleviates the deterioration of kidney function. Ac-DMLD-CMK TFA is promising for research of chemotherapy drug-induced nephrotoxicity .

HY-N15380

4,4′-Secalonic acid D	PARP Reactive Oxygen Species (ROS) Caspase Apoptosis Pyroptosis	Cancer
4,4′-Secalonic acid D (Compound 12) is a PARP1 inhibitor. 4,4′-Secalonic acid D induces the accumulation of ROS and DNA damage, activates the *caspase-3/GSDME* pathway, and triggers apoptosis and pyroptosis of tumor cells by inhibiting PARP1. 4,4′-Secalonic acid D has anti-tumor activity .

HY-B0621S

Triclabendazole-d3 CGA89317-d₃	Parasite Microtubule/Tubulin Isotope-Labeled Compounds	Others
Triclabendazole-d₃ is the deuterium labeled Triclabendazole (HY-B0621). Triclabendazole is an orally active parasite inhibitor. Triclabendazole has anti-Leishmania activity and induces gasdermin E (GSDME)-dependent pyroptosis by caspase-3 activation. Triclabendazole can be used for the research of fasciola hepatica .

HY-175381

DeFer-2	PROTACs Pyroptosis Reactive Oxygen Species (ROS) Caspase	Cancer
DeFer-2 is a ferritin PROTAC degrader (K_d = 17.1 μM). DeFer-2 induces ferritin degradation, triggering caspase 3-GSDME-mediated pyroptosis in cancer cells through free iron accumulation and elevated ROS. DeFer-2 significantly inhibits tumor growth and prolongs survival in mice bearing B16F10 subcutaneous tumors. DeFer-2 can be used to study melanoma. (Pink: Oleic acid: HY-N1446, Blue: (S,R,S)-AHPC: HY-125845, Black: γ-Aminobutyric acid: HY-N0067, Blue + Black: (S,R,S)-AHPC-C3-NH2: HY-130711) .

Cat. No.	Product Name	Target	Research Area

HY-P10939

Ac-DMLD-CMK	Caspase Pyroptosis	Inflammation/Immunology Cancer
Ac-DMLD-CMK is a polypeptide targeting the mouse caspase 3-Gsdme signaling pathway. Ac-DMLD-CMK can specifically inhibit the activation of caspase 3 and Gsdme. Ac-DMLD-CMK blocks the cleavage of Gsdme by caspase 3, inhibits the occurrence of pyroptosis, thereby reducing renal tubular epithelial cell injury and the secretion of inflammatory cytokines. Ac-DMLD-CMK reduces the levels of serum creatinine and blood urea nitrogen in mice induced by Cisplatin (HY-17394) and alleviates the deterioration of kidney function. Ac-DMLD-CMK is promising for research of chemotherapy drug-induced nephrotoxicity .

HY-P10939A

Ac-DMLD-CMK TFA	Caspase Pyroptosis	Inflammation/Immunology Cancer
Ac-DMLD-CMK TFA is a polypeptide targeting the mouse caspase 3-Gsdme signaling pathway. Ac-DMLD-CMK TFA can specifically inhibit the activation of caspase 3 and Gsdme. Ac-DMLD-CMK TFA blocks the cleavage of Gsdme by caspase 3, inhibits the occurrence of pyroptosis, thereby reducing renal tubular epithelial cell injury and the secretion of inflammatory cytokines. Ac-DMLD-CMK TFA reduces the levels of serum creatinine and blood urea nitrogen in mice induced by Cisplatin (HY-17394) and alleviates the deterioration of kidney function. Ac-DMLD-CMK TFA is promising for research of chemotherapy drug-induced nephrotoxicity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N15380

4,4′-Secalonic acid D	Structural Classification Xanthones Animals Source classification Phenols	PARP Reactive Oxygen Species (ROS) Caspase Apoptosis Pyroptosis
4,4′-Secalonic acid D (Compound 12) is a PARP1 inhibitor. 4,4′-Secalonic acid D induces the accumulation of ROS and DNA damage, activates the *caspase-3/GSDME* pathway, and triggers apoptosis and pyroptosis of tumor cells by inhibiting PARP1. 4,4′-Secalonic acid D has anti-tumor activity .

Cat. No.	Compare	Product Name	Species	Source

HY-P704047

	GSDME Protein, Human (His) Inversely correlated with estrogen receptor expression 1	Human	E. coli
	GSDME Protein, Human (His) is the recombinant human-derived GSDME protein, expressed by E. coli, with N-6*His tag.

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HY-B0621S

Triclabendazole-d3
Triclabendazole-d₃ is the deuterium labeled Triclabendazole (HY-B0621). Triclabendazole is an orally active parasite inhibitor. Triclabendazole has anti-Leishmania activity and induces gasdermin E (GSDME)-dependent pyroptosis by caspase-3 activation. Triclabendazole can be used for the research of fasciola hepatica .

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HY-P80697

	*DFNA5/GSDME* Antibody (YA398)** DFNA5; ICERE-1; GSDME	WB, IP	Human
	DFNA5/GSDME Antibody (YA398) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DFNA5/GSDME.

HY-P86310

	*DFNA5/GSDME* Antibody (YA6002)** DFNA5; ICERE1; Non-syndromic hearing impairment protein 5; Inversely correlated with estrogen receptor expression 1; ICERE-1	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	DFNA5/GSDME Antibody (YA6002) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DFNA5/GSDME.

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HY-RS05858

GSDME Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
GSDME Human Pre-designed siRNA Set A contains three designed siRNAs for GSDME gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23287

Gsdme Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Gsdme Rat Pre-designed siRNA Set A contains three designed siRNAs for Gsdme gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16846

Gsdme Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Gsdme Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gsdme gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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