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Pathways Recommended:	GPCR/G Protein

Results for "

G protein-coupled receptor kinase 2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	G Protein-coupled Receptor Kinase (GRK) (8) Aurora Kinase (1) CXCR (1) IFNAR (1) Interleukin Related (1) JAK (1) Raf (2) ROCK (1) STAT (1) TNF Receptor (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (5) Inflammation/Immunology (1)

9

Inhibitors & Agonists

1

Peptides

2

Antibodies

Targets Recommended: Adhesion G Protein-coupled Receptors (AGPCRs) G Protein-coupled Receptor Kinase (GRK) Mas-related G-protein-coupled Receptor (MRGPR) GPR84 G protein-coupled Bile Acid Receptor 1 Orphan GPCR GPR55 GPR88 GPR171 GPR35 GPR119 GPR4 GPR139 GPR6 GPR65 GPR52 GPR68

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

GSK180736A 5+ Cited Publications	ROCK G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease
GSK180736A is potent *Rho-associated coiled-coil kinase* 1 (ROCK1) inhibitor with an IC₅₀ of 100 nM. GSK180736A is also a selective and ATP-competitive G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC₅₀** of 0.77 μM.

GRK2 Inhibitor 2	Aurora Kinase G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease
GRK2 Inhibitor 2 is an orally active and selective G protein-coupled receptor kinase 2 (GRK) inhibitor with an IC₅₀ of 19 nM. GRK2 Inhibitor 2 also inhibits Aurora-A with an IC₅₀ of 137 nM. GRK2 Inhibitor 2 can be used in the study of congestive heart failure (HF) .

(E/Z)-Locostatin (E/Z)-UIC-1005	Raf	Cancer
(E/Z)-Locostatin ((E/Z)-UIC-1005) is a racemic of Locostatin. Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice .

HY-W013411A

Locostatin UIC-1005	Raf G Protein-coupled Receptor Kinase (GRK)	Cancer
Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin can be used to synthesize chemical probes toward PEBP-proteins. Locostatin aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice .

CCG258208 hydrochloride GRK2-IN-1 hydrochloride	G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease
CCG258208 (GRK2-IN-1) hydrochloride is a potent and selective GRK2 (G protein-coupled receptor kinase 2) inhibitor (IC₅₀=30 nM) while maintaining 230-fold selectivity over GRK5 (IC₅₀=7.09 μM) and more than 2500-fold selectivity over GRK1 (IC₅₀=87.3 μM), PKA, and ROCK1. CCG258208 hydrochloride can be used in heart failure research .

CCG-224406	G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease
CCG-224406 is a selective *G protein-coupled* receptor kinase 2 (GRK2) inhibitor with the IC₅₀** values of 13 nM, greater than 700-fold selectivity over other GRK subfamilies, and no inhibition of ROCK1. CCG-224406 can be used for study of heart failure .

GRK2i	G Protein-coupled Receptor Kinase (GRK)	Others
GRK2i is a Gβγ-inhibitory peptide that selectively prevents Gβγ-mediated signaling. GRK2i corresponds to the Gβγ-binding domain of GRK2 (G-protein-coupled receptor kinase 2) .

CCG258208 GRKs-IN-1	G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease
CCG258208 (GRK2-IN-1) is a potent and selective GRK2 (G protein-coupled receptor kinase 2) inhibitor (IC₅₀=30 nM) while maintaining 230-fold selectivity over GRK5 (IC₅₀=7.09 μM) and more than 2500-fold selectivity over GRK1 (IC₅₀=87.3 μM), PKA, and ROCK1. CCG258208 can be used in heart failure research .

Paeoniflorin-6′-O-benzene sulfonate CP-25	IFNAR STAT TNF Receptor Interleukin Related CXCR JAK G Protein-coupled Receptor Kinase (GRK)	Inflammation/Immunology
Paeoniflorin-6′-O-benzene sulfonate (CP-25) is the inhibitor for G protein-coupled receptor kinase 2 (GRK2) that inhibits the translocation of GRK2 to the cell membrane, inhibits JAK1/STAT3 signaling pathway. Paeoniflorin-6′-O-benzene sulfonate inhibits IL-17A/CXCL2-induced proliferation of HaCaT. Paeoniflorin-6′-O-benzene sulfonate reduces the levels of inflammatory factors and chemokines such as IL-17A, IL-17F, IFN-γ, TNF-α, IL-22, IL-23, CXCL2, CXCL3 and CXCL9, alleviates Imiquimod (HY-B0180)-induced psoriasis in mouse model .

Cat. No.	Product Name	Target	Research Area

GRK2i	G Protein-coupled Receptor Kinase (GRK)	Others
GRK2i is a Gβγ-inhibitory peptide that selectively prevents Gβγ-mediated signaling. GRK2i corresponds to the Gβγ-binding domain of GRK2 (G-protein-coupled receptor kinase 2) .

Cat. No.	Compare	Product Name	Application	Reactivity

	GRK 2 Antibody (YA5226) ADRBK 1; ADRBK1; Adrenergic beta receptor kinase 1; Adrenergic beta receptor kinase 1; ARBK1_HUMAN; BARK 1; BARK; BARK1; Beta adrenergic receptor kinase 1; Beta ARK 1; Beta ARK1; Beta-adrenergic receptor kinase 1; Beta-ARK-1; FLJ16718; G protein coupled receptor kinase 2; G protein dependent receptor kinase 2; G-protein coupled receptor kinase 2; GRK 2; GRK2.	WB	Human
	GRK 2 Antibody (YA5226) is a mouse-derived and non-conjugated monoclonal antibody, targeting to GRK 2. It can be applicated for WB assays, in the background of human.

	GRK 2 Antibody (YA4885) ADRBK1; BARK; BARK1; GRK2; Beta-adrenergic receptor kinase 1; Beta-ARK-1; G-protein coupled receptor kinase 2	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat, Monkey
	GRK 2 Antibody (YA4885) is a mouse-derived and non-conjugated monoclonal antibody, targeting to GRK 2. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human, mouse, rat, monkey.

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